Drs. Karl and Spencer discuss the concept of "microdosing" GLP-1 receptor agonists along with talk about the new top line results from REDEFINE which studied the new drug CagriSema.

Drs. Karl and Spencer chat with Dr. Lauren Colenso-Semple all about how the menstrual cycle and how it should affect your workout programming.

Should you change your workouts around your menstrual cycle? 

Find out by listening!

Check out her instagram

Read her paper on exercise and menstrual cycles

Read her paper on protein synthesis throughout the menstrual cycle

Drs. Karl and Spencer discuss the topline results from Surmount 5 which put Zepbound (tirzepatide) against Wegovy (semaglutide) for weight loss. They also discuss some news around compounded GLP-1s.

Learn:

Weight loss and glycemic differences between tirzepatide and semaglutide

What the FDA is thinking for compounded GLP-1s

If you're not on Dr. Spencer's virtual clinic waitlist, click here

Drs. Karl and Spencer chat with Dr. Shivani Misra, a metabolic specialist physician researcher from the UK, all about the various forms of diabetes mellitus.

Learn:

• The types of diabetes mellitus
• The monogenic forms (some what refer to as MODY)
• The differences within type 2 diabetes
• Whether CGMs (continuous glucose monitors) are useful
• If low carb could help some

Follow Dr. Misra on X/Twitter 

Drs. Karl and Spencer chat with AtlasMD - Dr. Josh Umbehr all about making healthcare cheaper using direct primary care.

Learn:

• How cheap labs and and meds should be
• How cutting out the middlemen can help healthcare and decrease costs

Find AtlasMD here

Drs. Karl and Spencer discuss the brand new 3 year study of tirzepatide in those with prediabetes along with a discussion on semaglutide treating osteoarthritis.

Learn:

• If people lose weight and keep it off with tirzepatide
• How many people regain weight after stopping the medicine
• Long-term side effects
• If semaglutide helps with osteoarthritis

Click here to read the tirzepatide study

Click here to read the semaglutide study

Drs. Karl and Spencer invite Dr. Andrea Love back to the podcast to discuss a recent Joe Rogan podcast with Calley and Casey Means along with the concept of Make America Healthy Again and RFK jr.

Learn:

What the docs agree with.

What they don't agree with.

Is raw milk okay?

Are cancer rates rising?

and more

Follow Dr. Andrea here 

https://www.instagram.com/dr.andrealove

Drs. Karl and Spencer discuss all things cortisol and poke fun at the influencers who try to fear monger exercise due to cortisol increases.

Learn:

What is cortisol and what does it do?

Is  cortisol bad?

Should you worry about cortisol increases with exercise?

Should you take supplements to lower cortisol?

and more

Drs. Karl and Spencer discuss their ideal healthcare delivery system.

Learn:

Spencer's journey building and selling Sequence and what he wants to do next.

How Dr. Karl believes healthcare should be and what he's doing next.

Click here to get on Dr. Spencer's waitlist

Drs. Karl and Spencer discuss BS supplements claiming to be like Ozempic along with discuss some new obesity drugs coming down the pipeline that were announced in phase 1 and 2 trials.

Are there any supplements that can mimic Ozempic?

What is amylin and how does it help with weight and sugars?

What is this new oral drug "amycretin" in phase 1 trials?

and more

Drs. Karl and Spencer chat with Dr. Jen Gunter all about menopause.

Learn:

How it's diagnosed.

When and when not to treat.

The various treatment.

If it is indicated for cardiovascular disease prevention or body composition.

Whether or not you should get labs.

See more at Dr. Gunter's website