‘Thelma’ star June Squibb joins the show. Over grilled cheese, June tells me about exotic dancing for her audition for ‘Gypsy’ on Broadway, getting her first Oscar nomination in her eighties for ‘Nebraska,’ and how Beanie Feldstein helped her get her first leading role.  This episode was recorded at Zinc Cafe & Bar in West Hollywood, CA.

Learn more about your ad choices. Visit podcastchoices.com/adchoices

Introducing Could fasting extend your lifespan? | Dr. Valter Longo and Prof. Tim Spector from ZOE Science & Nutrition.

Follow the show: ZOE Science & Nutrition

How old are you? A better question might be: how old do you feel? While your birthday says one thing, your biological age—the health of your cells—might tell a very different story. And here’s the best part: unlike your chronological age, your biological age can go down.

But how? For years, fasting has been celebrated as a key to longevity. Yet the challenge of skipping meals is enough to make most of us shy away. What if you could trick your body into reaping the rewards of fasting—without starving yourself? 

This week, we’re joined by Dr. Valter Longo, Director of the Longevity Institute at USC and one of TIME’s 50 most influential people in healthcare. Valter’s groundbreaking research on ageing and his FMD program have transformed how we think about health and longevity. Joining him is Tim Spector, ZOE’s co-founder and one of the world’s top 100 most-cited scientists.

🥑 Make smarter food choices. Become a member at zoe.com - 10% off with code PODCAST

🌱 Try our new plant based wholefood supplement - Daily 30+

*Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system

Follow ZOE on Instagram.

Timecodes:

00:00 Dr. Valter Longo on fasting and biological age reversal

01:18 Quickfire questions: Can fasting slow aging?

02:29 Surprising discoveries about rejuvenating the body

03:39 The difference between chronological and biological age

05:20 Can a single gene mutation extend lifespan?

06:29 What twins teach us about aging and longevity

08:19 Are biological age tests reliable?

10:27 Dr. Longo explains the fasting mimicking diet

12:43 Can fasting help regenerate damaged organs?

15:42 The science behind nutrient sensing and aging

18:19 Why does your body shift into "maintenance mode" during fasting?

22:04 Genetics vs. lifestyle: Which impacts aging more?

24:24 The role of fasting in longevity: Insights from lab studies

28:30 Time-restricted eating: What’s the ideal fasting window?

31:16 Does extreme fasting increase long-term health risks?

35:52 The fasting mimicking diet: How it works

41:07 Long-term studies on fasting: What’s next for science?

45:41 Reversing kidney damage with fasting research

47:10 Can a fasting protocol improve biological age by years?

55:08 Is a holistic approach to diet and fasting the key to longevity?

📚Books by our ZOE Scientists

The Food For Life Cookbook

Every Body Should Know This by Dr Federica Amati

Food For Life by Prof. Tim Spector

Free resources from ZOE

Live Healthier: Top 10 Tips From ZOE Science & Nutrition

Gut Guide - For a Healthier Microbiome in Weeks 

Studies references in today’s episode

Programmed longevity, youthspan, and juventology, 2018, published in Aging Cell 

Yeast Chronological Lifespan: Longevity Regulatory Genes and Mechanisms, 2022, published in Cells 

Chronological Aging in Saccharomyces cerevisiae, 2012, published in Subcell Biochemistry

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population, 2014, published in Cell Metabolism 

Growth Hormone Receptor Deficiency is Associated With a Major Reduction in Pro-aging Signaling, Cancer and Diabetes in Humans, 2012, published in Science Translational Medicine 

Have feedback or a topic you'd like us to cover? Let us know here.

Episode transcripts are available here.

DISCLAIMER: Please note, this is an independent podcast episode not affiliated with, endorsed by, or produced in conjunction with the host podcast feed or any of its media entities. The views and opinions expressed in this episode are solely those of the creators and guests. For any concerns, please reach out to [email protected].

Oscar-winning actor Kathy Bates joins the show. Over pizza and a caprese salad, Kathy tells me about who she wishes was her Oscar date the year she won, an iconic drink with Meryl Streep and why she's having the most fun she's ever had leading the Paramount + reboot of 'Matlock.' This episode of Dinner’s On Me was recorded at La Bettola di Terroni in Larchmont Village, CA.

Learn more about your ad choices. Visit podcastchoices.com/adchoices

Cabaret star, actor and producer Bridget Everett joins the show. Over some deliciously hot griddle cakes, Everett tells me about the special connection she has to her HBO show “Somebody Somewhere,” why “Sex and the City” co-creator Michael Patrick King is such an important person to her, and the interesting place she put her late mother’s ashes. This episode was recorded at Salt’s Cure in Hollywood, CA.

Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week, we revisit my conversation with “Griselda” and “Modern Family” star Sofia Vergara. Over pizza and “fuzzy orange juice,” Sofia tells me what it was like to produce and star in the Netflix series “Griselda,” which was 15 years in the making. Plus, we get into Ed O’Neill’s voicemails and why marshmallows were hidden on the “Modern Family” set. This episode was recorded at Dante in Beverly Hills, CA.

Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week, we revisit my conversation with “Modern Family” and “Married…with Children” star Ed O'Neill. Over some fancy sandwiches, Ed talks about dodging a career in organized crime, hanging out with Tennessee Williams, Lucille Ball and so much more. This episode was recorded at Lunetta in Santa Monica.

Learn more about your ad choices. Visit podcastchoices.com/adchoices

Today, we’re bringing you my conversation with former President Bill Clinton from earlier this month in Little Rock, Arkansas. We sat down to talk about the 20th anniversary of The Clinton Library and his newest book, “Citizen: My Life After the White House,” a front-row, first-person chronicle of his post-presidential years and the most significant events of the twenty-first century.

This was recorded on December 6th, 2024 in Little Rock, AR.

Learn more about your ad choices. Visit podcastchoices.com/adchoices

"Agatha All Along” star Kathryn Hahn joins the show. Over stuffed grape leaves and shawarma rubbed oyster mushrooms, Hahn tells me how her career has climbed after 40 (dubbed her “Hahnissance”), the amazing moments she improvised in “Step Brothers” and we retell our pilates meet-cute. This episode was recorded at Mazal in Lincoln Heights, CA.

Learn more about your ad choices. Visit podcastchoices.com/adchoices

"No Good Deed” star Lisa Kudrow joins the show. Over tagliatelle and scallops, Kudrow tells me the origin story of her "Friends" character Phoebe Buffay, how “The Comeback” was inspired by reality TV, and we get into her new Netflix series “No Good Deed” opposite Ray Romano. This episode was recorded at Novikov in Beverly Hills, CA.

Learn more about your ad choices. Visit podcastchoices.com/adchoices

Academy Award winning actor Marcia Gay Harden joins the show. Over sushi, Marcia Gay Harden tells me about being in the original cast of Broadway’s “Angels in America,” going back to catering after Coen Brothers film “Miller’s Crossing,” and a very good Mike Nichols apology story. This episode was recorded at Ocean Prime in Beverly Hills, CA.

Learn more about your ad choices. Visit podcastchoices.com/adchoices

"Suits” star Patrick J. Adams joins the show. Over grilled prawns and focaccia, Adams tells me about conquering his stage anxiety during “Take Me Out,” renewed “Suits” fandom on Netflix, and the story behind his matching tattoo with wife Troian Bellisario. This episode was recorded at Marco Polo at the Silver Lake Pool & Inn in Silver Lake, CA.

Learn more about your ad choices. Visit podcastchoices.com/adchoices