Longevity guru Bryan Johnson (DON’T DIE is the #1 doc on Netflix) sits down with Bill for a great talk about whether it’s possible to live forever, anti-aging science, Bryan’s rigid routine that includes very controlled diet, sleep, and data-driven health interventions. Bill discusses his healthy routines while drinking and smoking and the guys differ on how much sacrifice is worth the potential gain. Also, stay tuned for Bryan’s “Johnson” measuring device during sleep, the importance of figuring out the actual age of your organs for longevity, how Bryan navigates his strict diet while out to dinner, and much, much more!  

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Introducing How People Treat You Differently After Weight Loss | The Oprah Podcast from The Oprah Podcast.

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In this episode of The Oprah Podcast, Oprah continues her conversation with Dr. Ania Jastreboff, an endocrinologist and associate professor at the Yale School of Medicine, about the anti-obesity GLP-1 medications that are changing the world of weight loss. Oprah and Dr. Ania talk about what happens to a person’s mental health, body image and how the world treats them after losing a significant amount of weight. Joined by clinical psychologist Dr. Rachel Goldman, assistant professor at NYU Grossman School of Medicine, Oprah and Dr. Ania speak to people using the GLP-1 medications like long-time Harpo producer, Brian Piotrowicz, who reveals how people treat him differently now that he’s lost a significant amount of weight in a short period of time. Several other guests from across the country also share how their lives have changed after GLP-1 weight loss including a woman who lost over 160 pounds. Finally, we will get an update from several guests that appeared on the ABC Oprah Special: Shame, Blame and the Weight Loss Revolution including high school student Maggie who lost over 100 pounds.

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DISCLAIMER: Please note, this is an independent podcast episode not affiliated with, endorsed by, or produced in conjunction with the host podcast feed or any of its media entities. The views and opinions expressed in this episode are solely those of the creators and guests. For any concerns, please reach out to [email protected].

PLEASE NOTE: THIS EPISODE WAS RECORDED BEFORE THE AWFUL EVENTS IN LOS ANGELES. Bill Maher and Sam Harris on why young women are dating older men, fashion & manufacturing in China, the nine-hour documentary Bill never saw, brands complicit with the wrong side of WW2, the banality of evil and how humans can rationalize horrific acts, how worldviews can make people do extreme things while feeling virtuous, Bill’s previous controversies, the recent report on the you-know-what virus, Bill’s raw milk theory, how once liberal media voices like Joe Rogan and Elon Musk were driven away by extreme politics, and the true equivalence of Elon’s wealth, which will blow you away. 

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Bill Maher and Two and a Half Men star Jon Cryer on border policies and media coverage, on how progressive issues influence elections, youth gender-affirming care, and social media “contagion” vs. authentic identity, how Jon grew up in a rough part of the Upper West Side, crime stories and colorful neighbors in 1970s–80s NYC, Jon’s acting journey, the podcast Jon produced, The Man Who Calculated Death, Jon’s on set experience with Charlie Sheen and how the show changed when Charlie relapsed, Elon Musk’s contributions to electric vehicles and space exploration vs. controversies regarding Twitter/X and political stances and much more!

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Bill and legendary comedian Paul Reiser go deep on all things comedy, from the early days at comedy clubs like Catch a Rising Star and the Improv, the terrible pay of early comedy, the difference between being “club funny” and what works on television, Richard Belzer, Jerry Seinfeld, Larry David, and the New York comedy scene, Paul’s experience with Woody Allen, the tension between performing “works in progress” versus polished final sets, the concept of soul mates, hiring young comedy writers, and the importance of spotting talent and the subtle spark that differentiates a promising writer or comedian from the rest.

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Bill Maher and actor (Shazam!) Zachary Levi on the insanity of cutting off family members at the holidays due to political disagreements, Zach’s vote for Trump and career implications, the importance of talking to the other side, the need for nuanced thinking, legacy media stoking divisions and fear, misinformation and extremism, Zach’s support of RFK Jr., open debate about medical issues, criticizing those who shut down questions as “anti-science,” the vilification of medical skeptics, skepticism or raises questions about medicine, spirituality and God, and finding common ground. 

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NOTE: This was recorded before the election.

Bill Maher and Jane Fonda on how Jane stays so energetic, smart health and how habits change with age, their mutual commitment to drinking only in moderation, the Barbarella Halloween costume of the moment, whether some issues are exaggerated or not in our modern media world, climate and other countries roles in fixing it, over-regulated California, a deep dive on Jane’s movies, meditation and mindfulness, and the people who inspired Jane the most.

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Stephen A. Smith and Bill on the bad things about certain sports, Aaron Judge's post-season struggles, PED’s in sports, nepo babies, boxing’s big problem, how the Dems lost America, identity politics versus big stuff like the economy, immigration, crime, dating preferences, Stephen’s Trump interactions, aging and attractiveness, and hope for the future. 

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For a very limited time, shop the biggest sale of the year and find your forever cookware @hexclad at https://www.hexclad.com/RANDOM #hexcladpartner 

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Our first guest ever William Shatner returns for a raucous and hilarious talk about how William's distinctive speech pattern would sound during intimate moments, the floating garbage heap in the ocean, why the environment wasn’t an issue in the election, the future of sanctuary cities, how food has no place in bed, how William and Bill never missed a performance, William’s Amsterdam experience, the Hollywood music party scene that they both missed, the seal that lives on Bill’s earthquake boat, and the joy of cutting your toenails. 

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Robert Zemeckis directed a lot of your favorite movies, including Forrest Gump, Back to the Future, Flight, and many more. Bill and Bob talk about his streak of hit movies, his work with actors like Tom Hanks, Michael J. Fox, his friendship with Spielberg, his process in making films, his new film Here and its unique premise involving a fixed camera perspective in one location over centuries, the use of advanced de-aging technology for actors like Tom Hanks and Robin Wright,  the cultural impact of movies like "Saving Private Ryan" and the resonance of WWII films, stagnation in cultural innovation in recent decades, especially in music and fashion, the impact of a religious upbringing, the significance of crafting strong endings in films, and looking back on Back to the Future through the lens of today’s environment

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