On episode #72 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/2/25 – 1/15/25.

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• Viral
• Human infection with a novel tickborne Orthonairovirus species in China(NEJM)
• Antiviral medications for treatment ofnonsevere influenza(JAMA Network: JAMA Internal Medicine)
•  Xofluza (GoodRx)
• NoroSTATData Table (CDC Norovirus)
• The discovery of the 27-nm Norwalk virus: an historic perspective (JID)
• Why the “Ferrari of viruses” is surging through the northern hemisphere (Science)
• Bacterial
• Beta-lactams toxicity in the intensive care unit: an underestimatedcollateral damage?
• (Microorganims)
• What is the most effective antibiotic monotherapy for severe Pseudomonas aeruginosa infection? (CMI: Clinical Microbiology and Infection)
• Doxycycline postexposure prophylaxis and bacterial sexually tansmitted infections among individuals using HIV preexposure prophylaxis(JAMA Network: JAMA Internal Medicine)
• Fungal
• The Last of US Season 2 (YouTube)
• Epidemiology and prognostic factors associated with mold-positive blood cultures: 10-year data From a french prospective surveillance program (2012–2022) (CID)
• Parasitic
• Safety and efficacy of immunization with a late-liver-stage attenuated malaria parasite
• (NEJM)
• Dr. Glaucomflecken explains: late-liver-stage attenuated malaria vaccine (YouTube)
• Dr. Glaucomflecken X NEJM (YouTube)
• Albendazole–ivermectin co-formulation for the treatment of Trichuris trichiura and other soil-transmitted helminths: a randomised phase 2/3 trial (LANCET: Infectious Diseases)
• Miscellaneous
• A comparison of peripherally insertedcentral catheter materials(NEJM)
• Considering Islamic frameworks to infectious disease prevention (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #71 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 12/19/24 – 1/1/25.

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• Viral
• Routine detection of viruses through metagenomics: where do we stand? (ASTMH)
• Rapid selection of HIV-2 capsid mutations in salvage therapy with Lenacapavir-containing regime (CID)
• Bacterial
• Ancient genomes reveal a deep history of treponemal disease in the Americas (Nature)
• The utility of Interferon-γ release assays in the diagnosis of tuberculosis in patients With cancer(Transplant Infectious Disease)
• A meta-analysis of Levofloxacin for contacts of multidrug-resistant tuberculosis (NEJM Evidence)
• Tularemia— United States, 2011–2022 (CDC: MMWR)
• Incorporating incubation period distributions to precisely estimate the association between rainfall and Legionella infection (JID)
• Fungal
• The Last of US Season 2 (YouTube)
• Candida albicans recovered from persistent candidemia exhibit enhanced virulence traits (JID)
• Mapping the geographic distribution of dimorphic mycoses using a U.S. commercial insurance database (OFID)
• Comparative efficacy and safety of treatment regimens for Pneumocystis jirovecii pneumonia in people living with HIV – A systematic review and network meta-analysis of randomized controlled trials (CMI: Clinical Microbiology and Infection)
• Outbreak of Blastomycosis Among Paper Mill Workers — Michigan, November 2022–May 2023 (CDC: MMWR)
• Parasitic
• Acanthamoeba Infection in a hematopoietic cell transplant recipient: challenges in diagnosis, management, and source identification (Transplant Infectious Disease)
• Congenital toxoplasmosis: Fewer clinical signs at 3 years of age over the last 15 years but stable risk of materno-fetal transmission (CID)
• Miscellaneous
• Detection of prions in wild pigs (Sus scrofa) from areas with reported chronic wasting disease cases, United States (CDC Emerging Infectious Diseases)
• Addition of macrolide antibiotics for hospital treatment of community-acquired pneumonia (JID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #70 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 12/5/24 – 12/18/24.

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• Viral
• Epidemiology of Dengue— Puerto Rico, 2010–2024(CDC MMWR)
• Takeda Announces Voluntary Withdrawal of U.S. Biologics License Application (BLA) for Dengue Vaccine Candidate TAK-003(Takeda)
•  Global health and economic burden of chikungunya from 2011 to 2020 (BMJ Global Health)
• Bacterial
• Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis (JAMA Network)
• Say it ain’t Steno: a microbiology nudge comment leads to less treatment of Stenotrophomonas maltophilia respiratory colonization(Infection Control & Hospital Epidemiology)
• Guidelines for the Prevention, Diagnosis, and Management of Urinary Tract Infections in Pediatrics and Adults(JAMA Network)
• Epidemiology and Outcomes of Antibiotic De-escalation in Patients with Suspected Sepsis in US Hospitals (CID)
• Effectiveness of ceftazidime–avibactam versus ceftolozane–tazobactam for multidrug-resistant Pseudomonas aeruginosa infections in the USA (CACTUS): a multicentre, retrospective, observational study (LANCET Infectious Diseases)
• Bedaquiline Monotherapy for Multibacillary Leprosy (NEJM)
• Fungal
• The Last of US Season 2 (YouTube)
• Histoplasmosis Associated With Bat Guano Exposure in Cannabis Grower (OFID)
• Parasitic
• TWiV 1175: A hitchiker’s guide to virology(microbeTV)
• Diverse RNA viruses of parasitic nematodes can elicit antibody responses in vertebrate hosts (Nature Microbiology)
• Neurocysticercosis school outbreak in Belgium (LANCET)
• Miscellaneous
• Maintenance of Certification: Is a Knowledge-Based Assessment Really Necessary? (CID)
• Living happily ever after? The hidden health risks of Disney princesses (BMJ)
• How to transport a polar bear, and other idiosyncrasies in providing emergency medical services in the Arctic (BMJ)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #69 of the Infectious Disease Puscast, Sara reviews the infectious disease literature for the weeks of 11/21 – 12/4/24.

Host: Sara Dong

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• Viral
• Antiretroviral Drugs for Treatment and Prevention of HIV in Adults(JAMA Network)
• Human Parvovirus B19 Infections Among Pregnant Persons — Minnesota, January–September 2024 (CDC MMWR)
• Maribavir for refractory cytomegalovirus infection (with or without resistance) in solid organ transplant recipients (Journal of Heart and Lung Transplantation)
• Bacterial
• Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of InvasiveGroup A Streptococci Infection (CID)
• Resurgence of pediatric Mycoplasma pneumoniae infections in Southeast Texas, Nov 2023-June 2024 (Journal of Pediatrics Infectious Diseases Society)
• Fungal
• The Last of US Season 2 (YouTube)
• Alternative Pneumocystis Pneumonia Prophylaxis in Solid Organ Transplants(Transplant Infectious Disease)
• Mortality in chronic pulmonary aspergillosis: a systematic review and individual patient data meta-analysis (LANCET: Infectious Diseases)
• Parasitic
• Waterborne Disease Outbreaks Associated with Splash Pads — United States, 1997–2022
•  (CDC MMWR)
• Miscellaneous
• Skin Color Representation in Infectious Disease Textbooks (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #68 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 11/7 – 11/20/24.

Host: Daniel Griffin and Sara Dong

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• Viral
• Comparative Emergence of Maribavir and Ganciclovir Resistance in a Randomized Phase 3 Clinical Trial for Treatment of Cytomegalovirus Infection (JID)
• Yellow fever breakthrough infections after yellow fever vaccination: a systematic review and meta-analysis (LANCET Microbe)
• Serological evidence of natural exposure to rabies in rural populations in Gabon (PLoS Neglecgted Tropical Diseases)
• Bacterial
• Azithromycin Exposure in a 10-Day Window of Myocardial Infarction and Short- and Long-Term Outcomes (JACC Advances)
• Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections (NEJM)
• The Long and Winding Road: Three-year Mortality Following Prescription of Multi-drug Antibiotic Treatment for Mycobacterium avium complex Pulmonary Disease in United States Medicare Beneficiaries with Bronchiectasis (OFID)
• Oral Versus Intravenous Antibiotic Therapy for Staphylococcus aureus Bacteremia or Endocarditis (CID)
• Carbapenem-resistant Enterobacteriales in solid organ transplant recipients (American Journal of Transplantation)
• Fungal
• The Last of US Season 2 (YouTube)
• Adaptation of Candida albicans to specific host environments by gain-of-function mutations in transcription factors(PLoS Pathogens)
• Diagnostic Test Accuracy of the Fungitell Serum (1→3)-β-D-Glucan Assay for the Diagnosis of Pneumocystis jirovecii Pneumonia: A Systematic Review and Meta-Analysis (CMI: Clinical Microbiology and Infection)
• Do patients with candidemia need an ophthalmologic examination? (OFID)
• Parasitic
• Progress Toward Global Dracunculiasis (Guinea Worm Disease) Eradication (CDC MMWR)
• The gut microbiota is essential for Trichinella spiralis—evoked suppression of colitis (PLoS Neglected Tropical Diseases)
• Symptomatic Entamoeba dispar Infections Among Men Who Have Sex With Men, New York City, 2018control (OFID)
• Angiostrongylus cantonensis Meningoencephalitis in Three Pediatric Patients in Florida, USA (Journal of the Pediatric Infectious Diseases Society)
• Miscellaneous 
• Snake phobia among the general population of Tamil Nadu, India(PLoS Neglected Tropical Diseases)
• Remote Practice of Infectious Diseases Through Telemedicine: Improving Access for Patients and Appeal for Physicians (OFID)
• Gauging Medical Students’ Interests in Infectious Diseases (CID)
• Shaping the Future of Infectious Diseases: The Journey to Promote Value, Opportunity, and Positive Messaging (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #67 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 10/24 – 11/6/24.

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• Viral
• Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia(Nature)
• Bacterial
• Implementation of a Pharmacist-Driven Vancomycin Area Under the Concentration-Time Curve Monitoring Program Using Bayesian Modeling in Outpatient Parenteral Antimicrobial Therapy (OFID)
• Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin (Nature)
• Oral Versus Intravenous Antibiotic Therapy for Staphylococcus aureus Bacteremia or Endocarditis(CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Notes from the Field: Trichophyton mentagrophytes Genotype VII — New York City, April–July 2024 (CDC MMWR)
• Evaluation of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Recipients(Transplant Infectious Disease)
• Parasitic
• Outcomes of kidney transplant recipients exposed to Chagas disease under Benznidazole prophylaxis(Transplant Infectious Disease)
• Fake Aristotle Fakely Rails Against Fighting Inequality (Sententiae Antiquae)
• Need for a paradigm shift in soil-transmitted helminthiasis control (PLoS Neglected Tropical Diseases)
• Miscellaneous
• IDSA Advocacy Results in Big Win for ID in 2025 Final Medicare Rule (IDSA)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice

On episode #66 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 10/8 – 10/23/24.

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• Viral
• Prevalence of Human Papillomavirus (HPV) and HPV Type Distribution in Penile Samples in Young Men in Denmark: Results 10 Years After Implementation of a Girls-Only HPV Vaccination Program (JID)
• Primary Care Guidance for Providers of Care for Persons With Human Immunodeficiency Virus: 2024 Update by the HIV Medicine Association of the Infectious Diseases Society of America (CID)
• Bacterial
• Adjunctive linezolid versus clindamycin for toxin inhibition in β-lactam-treated patients with invasive group A streptococcal infections in 195 US hospitals from 2016 to 2021: a retrospective cohort study with target trial emulation (LANCET: Infectious Diseases)
• Time to turn off the toxins: adjuvant suppression of group A streptococcus (LANCET: Infectious Diseases)
• Comparing rates of recurrent infection for first occurrence of Clostridioides difficile between tapered oral vancomycin and standard vancomycin: a retrospective, propensity matched cohort study(Infection Control and Hospital Epidemiology)
• Evaluation of primary oral vancomycin prophylaxis against C. difficile infection during autologous stem cell transplantation (OFID)
• Oral Vancomycin to Prevent C. difficile in Stem Cell Transplant Recipients: The last frontier in antimicrobial prophylaxis (OFID)
• First Report of a Fatal Septicemia Case Caused by Vibrio metoecus: A Comprehensive Functional and Genomic Study (JID)
• Fungal
• The Last of US Season 2 (YouTube)
• A global chromoblastomycosis strategy and development of the global chromoblastomycosis working group(PLoS Neglected Tropical Diseases)
• Epidemiological and clinical features of a large blastomycosis outbreak at a paper mill in Michigan (CID)
• Do morphogenetic switching and intraspecies variation enhance virulence of Candida auris?
• (PLoS Pathogens)
• Parasitic
• Beyond Human Babesiosis: Prevalence and Association of Babesia Coinfection with Mortality in the United States, 2015–2022: A Retrospective Cohort Study (OFID)
• New WHO guidelines for treating rhodesiense human African trypanosomiasis: expanded indications for fexinidazole and pentamidine (LANCET: Infectious Diseases)
• Miscellaneous
• Social and Environmental Benefitsof Pediatric Infectious Disease Telemedicine (Journal of the Pediatric Infectious Diseases Society)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #65 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 9/26 – 10/7/24.

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• Viral
• Exploring viral respiratory coinfections: Shedding light on pathogen interactions
• (PLoS Pathogens)
• Bacterial
• ACG Clinical Guideline: Treatment of Helicobacter pylori Infection (American Journal of Gastroenterology)
• A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection
• (Science)
• The evidence base for the optimal antibiotic treatment duration of upper and lower respiratory tract infections: an umbrella review (LANCET: Infectious Diseases)
• Population Pharmacokinetic Modeling of Cefepime, Meropenem, and Piperacillin-Tazobactam in Patients With Cystic Fibrosis(JID)
• Establishment of Amblyomma maculatum Ticks and Rickettsia parkeri in the Northeastern United States (Emerging Infectious Diseases)
• DETICKT (DETICKT)
• Early Oral Step-Down Versus Continued Intravenous Antibiotic Treatment of Complicated Intra-Abdominal Infection(Surgical Infections)
• Fungal
• The Last of US Season 2 (YouTube)
• Candida auris: A focused review for emergency clinicians (American Journal of Emergency Medicine)
• Parasitic
• Ivermectin-based mass drug administration for scabies in northern India: a single-arm community intervention trial (OFID)
• Miscellaneous
• Out-BREAK! : An IDWeek 2023 escape room to break out of the educational mold (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #64 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 9/14 – 9/25/24.

Host: Daniel Griffin and Sara Dong

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• Viral
• Outcomes of Intravenous Immunoglobulin treatment of immunocompromised patients with viral respiratory infections (Annals of Allergy, Asthma & Immunology)
• Comparative Emergence of Maribavir and Ganciclovir Resistance for Treatment of Cytomegalovirus Infection (JID)
• Antibody persistence and safety of a live-attenuated chikungunya virus vaccine up to 2 years after single-dose administration in adults in the USA (LANCET Infectious Disease)
• Bacterial
• Determinant of 30-Day Mortality of Pulmonary Legionellosis (OFID)
• Donor-derived bartonellosis in Solid Organ Transplant recipients (American Journal of Transplantation)
• An Opt-Out Emergency Department Screening Intervention Leads to Major Increases in Diagnosis of Syphilis (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Fungal disease week (CDC)
• Bridging Echinocandin with Azole antifungal Therapy On Prevention Of Invasive Candidiasis Post Lung Transplantation (OFID)
• Early Introductions of Candida auris Detected by Wastewater Surveillance, Utah, USA, 2022–2023 (Emerging Infectious Diseases)
• Parasitic
• Toxoplasma gondii Infection of Alzheimer’s Disease Mice Reduces Brain Amyloid Density Globally and Regionally (JID)
• Miscellaneous
• Effect of Social Distancing Caused by Heavy Snowfall on Seasonal Influenza Epidemic in a Local Region in Japan (Pediatric Infectious Disease Journal)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #63 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/29/24 – 9/13/24.

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• Viral
• Postacute Sequelae of COVID (PASC or Long COVID): An Evidenced-Based Approach (OFID)
• A New Orthonairovirus Associated with Human Febrile Illness (NEJM)
• Farmed fur animals harbour viruses with zoonotic spillover potential(Nature)
• A Cross-Sectional Evaluation of the Virtual Outpatient Management of People With Mpox (OFID)
• A randomized, placebo-controlled, dose-escalation phase I/II multicenter trial of low-dose cidofovir for BK polyomavirus nephropathy (Transplant Infectious Disease)
• A Decade of Chronic Norovirus Infection Surveillance at the NIH Clinical Research Center: Clinical Characteristics, Molecular Epidemiology, and Replication (JID)
• Bacterial
• FDA clears newLyme disease test (CIDRAP)
• Lyme ImmunoBlot Receives FDA Clearance(Accesswire)
• The Utilization Of Echocardiography In Children With Staphylococcus aureus Bacteremia (Journal of Pediatric Infectious Diseases Society)
• Duration of antibiotic therapy for multidrug resistant Pseudomonas aeruginosa pneumonia: is shorter truly better?(BMC Infectious Diseases)
• Short Versus Long Antibiotic Duration in Streptococcus pneumoniae Bacteremia (OFID)
• FDA Marketing Authorization Enables Increased Access to First Step of Syphilis Diagnosis
• FDA)
• Clinical impact of pleural fluid Streptococcus pneumoniae PCR testing in children with complicated pneumonia (CID)
• Duration of antibiotic therapy for multidrug resistant Pseudomonas aeruginosa pneumonia: is shorter truly better? (BMC Infectious Diseases)
• Short Versus Long Antibiotic Duration in Streptococcus pneumoniae Bacteremia (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Incidence and risk factors for invasive fungal infections in patients initiating TNF-alpha inhibitors for inflammatory bowel disease and rheumatoid arthritis (CID)
• Parasitic
• Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2 in mice(Science Translational Medicine)
• Miscellaneous
• Successful Treatment of Refractory Cutaneous Protothecosis With MAT2203, an Oral Lipid Nanocrystal Formulation of Amphotericin B (OFID)
• The Impact of Infectious Diseases Scholarly Mentorship on Subsequent Infectious Disease Fellowship Application (CID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #62 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/15/24 – 8/28/24.

Host: Daniel Griffin and Sara Dong

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• Viral
• Clinician Specialty and HIV PrEP Prescription Reversals and abandonments (JAMA Network: JAMA Internal Medicine)
• The association between adherence to antiretroviral therapy and viral suppression under dolutegravir-based regimens (JIAS Journal of the International AIDS Society)
• Dexamethasone in adults with viral meningitis (CMI Clinical Microbiology and Infection)
• Oropouche Virus Disease Among U.S. Travelers — United States, 2024 (MMWR)
• Oropouche fever, the mysterious threat (LANCET: Infectious Diseases)
• Bacterial
• High rates of Non-susceptibility to common oral antibiotics in Streptococcus pneumoniae clinical isolates (OFID)
• New York State Department of Health Directs Providers to Discontinue Use of Ciprofloxacin to Prevent Meningococcal Disease Due to Increasing Antimicrobial Resistance (NY State: Department of Health)
• Tularemia Associated with Harbor Seal Necropsy — Kitsap County, Washington, October 2023 (MMWR)
• FDA Marketing Authorization Enables Increased Access to First Step of Syphilis Diagnosis (FDA)
• Clinical impact of pleural fluid Streptococcus pneumoniae PCR testing in children with complicated pneumonia (CID)
• The Role of the Gut, Urine and Vaginal Microbiome on the Pathogenesis of Urinary Tract Infection (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Two dose levels of once-weekly fosravuconazole versus daily itraconazole in combination with surgery in patients with eumycetoma in Sudan (LANCET Infectious disease)
• Parasitic
• Usefulness of real-time PCR for urogenital schistosomiasis in preschool children in Angola (PLoS Neglected Tropical Diseases)
• Helminth infection driven gastrointestinal hypermotility alterations in smooth muscle instead of enteric neurons (PLoS Pathogens)
• Die-off reaction of Demodex mites after treating demodicosis with oral ivermectin (JAAD case reports)
• Miscellaneous
• Prevalence of carbapenem-resistant gram negative bacteria among neonates suspected for sepsis in Africa (BMC Infectious Diseases)
• New era of targeted clinical guidelines: IDSA (CID)
• Defining the landscape of educational experiences in transplant infectious diseases (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.