On episode #67 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 10/24 – 11/6/24.

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• Viral
• Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia(Nature)
• Bacterial
• Implementation of a Pharmacist-Driven Vancomycin Area Under the Concentration-Time Curve Monitoring Program Using Bayesian Modeling in Outpatient Parenteral Antimicrobial Therapy (OFID)
• Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin (Nature)
• Oral Versus Intravenous Antibiotic Therapy for Staphylococcus aureus Bacteremia or Endocarditis(CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Notes from the Field: Trichophyton mentagrophytes Genotype VII — New York City, April–July 2024 (CDC MMWR)
• Evaluation of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Recipients(Transplant Infectious Disease)
• Parasitic
• Outcomes of kidney transplant recipients exposed to Chagas disease under Benznidazole prophylaxis(Transplant Infectious Disease)
• Fake Aristotle Fakely Rails Against Fighting Inequality (Sententiae Antiquae)
• Need for a paradigm shift in soil-transmitted helminthiasis control (PLoS Neglected Tropical Diseases)
• Miscellaneous
• IDSA Advocacy Results in Big Win for ID in 2025 Final Medicare Rule (IDSA)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice

On episode #66 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 10/8 – 10/23/24.

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• Viral
• Prevalence of Human Papillomavirus (HPV) and HPV Type Distribution in Penile Samples in Young Men in Denmark: Results 10 Years After Implementation of a Girls-Only HPV Vaccination Program (JID)
• Primary Care Guidance for Providers of Care for Persons With Human Immunodeficiency Virus: 2024 Update by the HIV Medicine Association of the Infectious Diseases Society of America (CID)
• Bacterial
• Adjunctive linezolid versus clindamycin for toxin inhibition in β-lactam-treated patients with invasive group A streptococcal infections in 195 US hospitals from 2016 to 2021: a retrospective cohort study with target trial emulation (LANCET: Infectious Diseases)
• Time to turn off the toxins: adjuvant suppression of group A streptococcus (LANCET: Infectious Diseases)
• Comparing rates of recurrent infection for first occurrence of Clostridioides difficile between tapered oral vancomycin and standard vancomycin: a retrospective, propensity matched cohort study(Infection Control and Hospital Epidemiology)
• Evaluation of primary oral vancomycin prophylaxis against C. difficile infection during autologous stem cell transplantation (OFID)
• Oral Vancomycin to Prevent C. difficile in Stem Cell Transplant Recipients: The last frontier in antimicrobial prophylaxis (OFID)
• First Report of a Fatal Septicemia Case Caused by Vibrio metoecus: A Comprehensive Functional and Genomic Study (JID)
• Fungal
• The Last of US Season 2 (YouTube)
• A global chromoblastomycosis strategy and development of the global chromoblastomycosis working group(PLoS Neglected Tropical Diseases)
• Epidemiological and clinical features of a large blastomycosis outbreak at a paper mill in Michigan (CID)
• Do morphogenetic switching and intraspecies variation enhance virulence of Candida auris?
• (PLoS Pathogens)
• Parasitic
• Beyond Human Babesiosis: Prevalence and Association of Babesia Coinfection with Mortality in the United States, 2015–2022: A Retrospective Cohort Study (OFID)
• New WHO guidelines for treating rhodesiense human African trypanosomiasis: expanded indications for fexinidazole and pentamidine (LANCET: Infectious Diseases)
• Miscellaneous
• Social and Environmental Benefitsof Pediatric Infectious Disease Telemedicine (Journal of the Pediatric Infectious Diseases Society)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #65 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 9/26 – 10/7/24.

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• Viral
• Exploring viral respiratory coinfections: Shedding light on pathogen interactions
• (PLoS Pathogens)
• Bacterial
• ACG Clinical Guideline: Treatment of Helicobacter pylori Infection (American Journal of Gastroenterology)
• A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection
• (Science)
• The evidence base for the optimal antibiotic treatment duration of upper and lower respiratory tract infections: an umbrella review (LANCET: Infectious Diseases)
• Population Pharmacokinetic Modeling of Cefepime, Meropenem, and Piperacillin-Tazobactam in Patients With Cystic Fibrosis(JID)
• Establishment of Amblyomma maculatum Ticks and Rickettsia parkeri in the Northeastern United States (Emerging Infectious Diseases)
• DETICKT (DETICKT)
• Early Oral Step-Down Versus Continued Intravenous Antibiotic Treatment of Complicated Intra-Abdominal Infection(Surgical Infections)
• Fungal
• The Last of US Season 2 (YouTube)
• Candida auris: A focused review for emergency clinicians (American Journal of Emergency Medicine)
• Parasitic
• Ivermectin-based mass drug administration for scabies in northern India: a single-arm community intervention trial (OFID)
• Miscellaneous
• Out-BREAK! : An IDWeek 2023 escape room to break out of the educational mold (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #64 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 9/14 – 9/25/24.

Host: Daniel Griffin and Sara Dong

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• Viral
• Outcomes of Intravenous Immunoglobulin treatment of immunocompromised patients with viral respiratory infections (Annals of Allergy, Asthma & Immunology)
• Comparative Emergence of Maribavir and Ganciclovir Resistance for Treatment of Cytomegalovirus Infection (JID)
• Antibody persistence and safety of a live-attenuated chikungunya virus vaccine up to 2 years after single-dose administration in adults in the USA (LANCET Infectious Disease)
• Bacterial
• Determinant of 30-Day Mortality of Pulmonary Legionellosis (OFID)
• Donor-derived bartonellosis in Solid Organ Transplant recipients (American Journal of Transplantation)
• An Opt-Out Emergency Department Screening Intervention Leads to Major Increases in Diagnosis of Syphilis (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Fungal disease week (CDC)
• Bridging Echinocandin with Azole antifungal Therapy On Prevention Of Invasive Candidiasis Post Lung Transplantation (OFID)
• Early Introductions of Candida auris Detected by Wastewater Surveillance, Utah, USA, 2022–2023 (Emerging Infectious Diseases)
• Parasitic
• Toxoplasma gondii Infection of Alzheimer’s Disease Mice Reduces Brain Amyloid Density Globally and Regionally (JID)
• Miscellaneous
• Effect of Social Distancing Caused by Heavy Snowfall on Seasonal Influenza Epidemic in a Local Region in Japan (Pediatric Infectious Disease Journal)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #63 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/29/24 – 9/13/24.

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• Viral
• Postacute Sequelae of COVID (PASC or Long COVID): An Evidenced-Based Approach (OFID)
• A New Orthonairovirus Associated with Human Febrile Illness (NEJM)
• Farmed fur animals harbour viruses with zoonotic spillover potential(Nature)
• A Cross-Sectional Evaluation of the Virtual Outpatient Management of People With Mpox (OFID)
• A randomized, placebo-controlled, dose-escalation phase I/II multicenter trial of low-dose cidofovir for BK polyomavirus nephropathy (Transplant Infectious Disease)
• A Decade of Chronic Norovirus Infection Surveillance at the NIH Clinical Research Center: Clinical Characteristics, Molecular Epidemiology, and Replication (JID)
• Bacterial
• FDA clears newLyme disease test (CIDRAP)
• Lyme ImmunoBlot Receives FDA Clearance(Accesswire)
• The Utilization Of Echocardiography In Children With Staphylococcus aureus Bacteremia (Journal of Pediatric Infectious Diseases Society)
• Duration of antibiotic therapy for multidrug resistant Pseudomonas aeruginosa pneumonia: is shorter truly better?(BMC Infectious Diseases)
• Short Versus Long Antibiotic Duration in Streptococcus pneumoniae Bacteremia (OFID)
• FDA Marketing Authorization Enables Increased Access to First Step of Syphilis Diagnosis
• FDA)
• Clinical impact of pleural fluid Streptococcus pneumoniae PCR testing in children with complicated pneumonia (CID)
• Duration of antibiotic therapy for multidrug resistant Pseudomonas aeruginosa pneumonia: is shorter truly better? (BMC Infectious Diseases)
• Short Versus Long Antibiotic Duration in Streptococcus pneumoniae Bacteremia (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Incidence and risk factors for invasive fungal infections in patients initiating TNF-alpha inhibitors for inflammatory bowel disease and rheumatoid arthritis (CID)
• Parasitic
• Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2 in mice(Science Translational Medicine)
• Miscellaneous
• Successful Treatment of Refractory Cutaneous Protothecosis With MAT2203, an Oral Lipid Nanocrystal Formulation of Amphotericin B (OFID)
• The Impact of Infectious Diseases Scholarly Mentorship on Subsequent Infectious Disease Fellowship Application (CID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #62 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/15/24 – 8/28/24.

Host: Daniel Griffin and Sara Dong

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• Viral
• Clinician Specialty and HIV PrEP Prescription Reversals and abandonments (JAMA Network: JAMA Internal Medicine)
• The association between adherence to antiretroviral therapy and viral suppression under dolutegravir-based regimens (JIAS Journal of the International AIDS Society)
• Dexamethasone in adults with viral meningitis (CMI Clinical Microbiology and Infection)
• Oropouche Virus Disease Among U.S. Travelers — United States, 2024 (MMWR)
• Oropouche fever, the mysterious threat (LANCET: Infectious Diseases)
• Bacterial
• High rates of Non-susceptibility to common oral antibiotics in Streptococcus pneumoniae clinical isolates (OFID)
• New York State Department of Health Directs Providers to Discontinue Use of Ciprofloxacin to Prevent Meningococcal Disease Due to Increasing Antimicrobial Resistance (NY State: Department of Health)
• Tularemia Associated with Harbor Seal Necropsy — Kitsap County, Washington, October 2023 (MMWR)
• FDA Marketing Authorization Enables Increased Access to First Step of Syphilis Diagnosis (FDA)
• Clinical impact of pleural fluid Streptococcus pneumoniae PCR testing in children with complicated pneumonia (CID)
• The Role of the Gut, Urine and Vaginal Microbiome on the Pathogenesis of Urinary Tract Infection (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Two dose levels of once-weekly fosravuconazole versus daily itraconazole in combination with surgery in patients with eumycetoma in Sudan (LANCET Infectious disease)
• Parasitic
• Usefulness of real-time PCR for urogenital schistosomiasis in preschool children in Angola (PLoS Neglected Tropical Diseases)
• Helminth infection driven gastrointestinal hypermotility alterations in smooth muscle instead of enteric neurons (PLoS Pathogens)
• Die-off reaction of Demodex mites after treating demodicosis with oral ivermectin (JAAD case reports)
• Miscellaneous
• Prevalence of carbapenem-resistant gram negative bacteria among neonates suspected for sepsis in Africa (BMC Infectious Diseases)
• New era of targeted clinical guidelines: IDSA (CID)
• Defining the landscape of educational experiences in transplant infectious diseases (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #61 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/1/20 - 8/14/24. 

Host: Daniel Griffin and Sara Dong

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• Viral
• nPEP quick guide (AIDS Education & Training Center Program)
• Coformulated Bictegravir/Emtricitabine/Tenofovir Alafenamide PREP after sexual assault (OFID)
• Adopting Early Testing for Perinatal Hepatitis C (Journal of Pediatric Infectious Diseases Society)
• Bacterial
• Lower Rates of Staphylococcus aureus Bloodstream Infection in Patients on Hemodialysis Receiving Trimethoprim-Sulfamethoxazole Melioidosis Prophylaxis (OFID)
• Trimethoprim-Sulfamethoxazole for Staphylococcus Aureus Bacteremia Prophylaxis in Patients on Hemodialysis (OFID)
• Human monocytotropic ehrlichiosis(PLoS Neglected Tropical Diseases)
• Human granulocytotropic anaplasmosis (PLoS Neglected Tropical Diseases)
• Bifidobacterium and Lactobacillus Probiotics for Preterm Infants (JAMA Network: JAMA Pediatrics)
• Rapid Implementation of Blood Culture Stewardship (CID)
• BD BACTEC Blood Culture Bottle Shortage - (IDSA)
• Fungal
• The Last of US Season 2 (YouTube)
• Clinical characteristics and mortality risks among critically ill patients with culture-proven coccidioidomycosis(OFID)
• Poor Clinical and Microbiologic Outcomes in C. auris Bloodstream Infection (CID)
• Parasitic
• Soap is lethal for Schistosoma mansoni cercariae (PLoS Neglected Tropical Diseases)
• Treatment of uncomplicated hepatic cystic echinococcosis (Cochrane Library)
• Blood exposure to Babesia microti(Cambridge Core)
• Miscellaneous
• Absence of Cerebrospinal Fluid Pleocytosis in Encephalitis (CID)
• Encephalitis due to Infection with Normocellular Cerebrospinal Fluid (CID)
• Podoconiosis and mental health (PLoS Neglected Tropical Diseases)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #60 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 7/18/20 – 7/31/24.

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• Olympics
• Swimming in the Seine (NYTimes)
• Viral
• Twice-Yearlylenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women (NEJM)
• Consensus definitions of Cytomegalovirus Infection and Disease in Transplant Patients (CID)
• The recombinant shingles vaccine is associated with lower risk of dementia (Nature Medicine)
• Association of the incidence of postherpetic neuralgia with early treatment intervention of herpes zoster (International Journal of Infectious Diseases)
• Bacterial
• Updated guidelines for antimicrobial resistant gram-negative infections (IDSA)
• Put the Vanc Down, Flip it and Reverse it: Comparison of vancomycin and daptomycin (OFID)
• Durations of antibiotic treatment for acute otitis media and variability in prescribed durations (Journal of Pediatric Infectious Diseases Society)
• Fungal
• Adjunctive single-dose liposomal amphotericin to prevent cryptococcal meningitis in people with human immunodeficiency virus (HIV)–associated cryptococcal antigenemia and low plasma cryptococcal antigen (CrAg) titers(CID)
• Stagonospora cutaneous infection in a kidney transplant recipient: First human case (Transplant Infectious Disease)
• European Study of cerebral aspergillosis treated with Isavuconazole: an EFISG study (CID)
• Parasitic
• Rollout of world’s second malaria vaccine begins in Ivory Coast (Healio)
• Executive summary: Evaluation and management of delusional infestation(CID)
• Parasitic contamination of soil in the Southern United States (ASTMH)
• Miscellaneous
• The potential benefits of delaying seasonal influenza vaccine selections for the northern hemisphere: A retrospective modeling study in the United States (JID)

Music is by Ronald Jenkees

On episode #59 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 7/3/20 – 7/17/24.

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• Viral
• The potential interrelationship of coronary artery disease -herpes zoster (OFID)
• Bacterial
• Pharmacokinetics of intravenous antibiotics into the infected pleural space (Thorax)
• Are gas emissions from microbiology cultures significant contributes to global warming?(OFID)
• Is combination treatment of ampicillin and gentamicin right for Listeria monocytogenes infection (Infection)
• Screening organ donors and monitoring recipients for Bartonella quintana (OFID)
• Neglected Tropical Disease: Rocky Mountain spotted fever (PLoS Pathogen)
• Updated guidelines for antimicrobial resistant gram-negative infections (IDSA)
• Fungal
• Are fungal pathogenssmarter than we are? (microbeTV)
• What influences the waning of antibodies during cryptococcal meningitis? (JID)
• Parasitic
• Artificial Intelligence for filariasis diagnosis and monitoring (PLoS Neglected Tropical Diseases)
• Is artificial intelligence the end of filariasis? (PLoS Neglected Tropical Diseases
• Miscellaneous
• APACHE II severity of disease classification system (GlobalRxPh)
• Clinical practice guideline for complicated intra-abdominal infections (CID)
• Procalcitonin or C-reactive protein guided antimicrobial discontinuation to treat sepsis (Critical Care Medicine)
• The “plague” of plague for the Neolithic population (Nature)

Music is by Ronald Jenkees

On episode #58 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/20 – 7/3/24.

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• Viral
• Drink more coffee, reduces risk for SARS-C0V-2 infection (Cell & Bioscience)
• Cannabis, tobacco…smoking in general NOT good for preventing COVID-19 (JAMA Network OPEN)
• EBV and KSHV caused HIV associated cancers and lymphoproliferative disorders (Clinical Microbiology Reviews)
• Where in the CNS can dolutegravir, tenofovir, lamivudine and efavirenz be found? (JID)
• Therapeutic management of Varicella-Zoster virus meningitis (OFID)
• Bacterial
• Carbapenem use in extended-spectrum cephalosporin-resistant Enterobacterales infections (LANCET Infectious Diseases)
• IDSA guidelines (Columbia University)
• Guideline-Concordant Therapy for community-acquired pneumonia in the Hospitalized Population (OFID)
• Interpretive Criteria piperacillin/tazobactam susceptibility test for Enterobacterales (CID)
• FDA approval forCAPVAXIVE (FDA)
• 21 valent pneumococcal vaccine approved (Nature Reviews drug discovery)
• Antimicrobial resistant Staphylococcus aureus isolates (JAMA Network Open)
• Broad-spectrum antibiotic use for suspected community-onset sepsis (JAMA Network Open)
• Fungal
• The Last of Us ( Wikipedia)
• Challenges to vaccinating against coccidioidomycosis (OFID)
• Cryptococcosis: the story (OFID)
• Pneumocystis pneumonia: clinical spectrum, prophylaxis and delayed treatment (Intensive Care Medicine)
• Improve utilization of 1,3 β-D-glucan Testing(OFID)

Music is by Ronald Jenkees

On episode #57 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/6 – 6/19/24.

Host: Daniel Griffin

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• Viral
• Is letermovir or valganciclovir better to prevent CMV in kidney transplant recipients (JID)
• CMV antiviral therapy (GoodRx)
• Prevalence of and risk for CMV reactivation during COVID-19 pneumonia (PLoS One)
• Sofosbuvir off-label yellow fever treatment (OFID) Bacterial
• Preventing resistant gram negative bacteria through beta-lactam de-escalation in sepsis patients (CID)
• Competing risk analysis, survival analysis that aims to correctly estimate marginal probability of an event (Columbia University)
• Continuous or intermittent b-lactam infusion for critical sepsis (JAMA Network)
• Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock (JAMA Network)
• Phoenix sepsis score and risk in children with cancer (JAMA Network)
• New recognized spotted fever group Rickettsia in Northern California (Emerging Infectious Diseases)
• Screening for mycobacterium tuberculosis (Transplant Infectious Disease) Fungal
• Potential sexual transmission of Tinea pubogenitalis from TMWII (JAMA Dermatology)
• Household transmission of tinea infection (OFID)
• Drug-resistant oral candidiasis in HIV infected patients (BMC Infectious Disease) Parasitic
• Handheld digital microscope for rapid and comprehensive screening for urogenital and gastrointestinal schistosomiasis (American Journal of Tropical Medicine and Hygiene)
• Scorecard approach to eliminate onchocerciasis (Am J Trop Med Hyg) Miscellaneous
• Association between antibiotic receipt and provider rating (OFID)
• Infectious diseases and infection control prevention strategies when on ECMO (Perfusion)

Music is by Ronald Jenkees