On episode #95 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 11/20/25 – 12/3/25.

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• Viral
• Early low-dose dexamethasone is associated with shorter acute symptom duration in Chikungunya virus infection: a retrospective cohort study (BMC Infectious Diseases)
• Noninferiority of One HPV Vaccine Dose to Two Doses (NEJM)
• Evidence to Action — Single-Dose HPV Vaccination and Cervical HPV Infection (NEJM)
• Daily Mosnodenvir as Dengue Prophylaxis in a Controlled Human InfectionModel (NEJM)
• Universal Hepatitis B Vaccination at Birth—Risks of Revising the recommendation (JAMA)
• Correlates of HIV-1 control after combination immunotherapy (Nature)
• Human-to-Human Rabies Transmission via Solid Organ Transplantation from a Donor with Undiagnosed Rabies — United States, October 2024–February 2025 (CDC: MMWR)
• Cytomegalovirus-specific cell-mediated immunity for prediction of post-prophylaxis CMV disease in a phase 3 trial of letermovir vs valganciclovir prophylaxis in donor CMV-seropositive recipient CMV-seronegative kidney transplant recipients (CID)
• An Analysis of Cytomegalovirus-Specific Cell-Mediated Immunity in a Phase 3, Randomized, Placebo-Controlled Trial of Letermovir Prophylaxis in Cytomegalovirus-Seropositive Recipients of an Allogeneic Hematopoietic Cell Transplant (CID)
• Bacterial
• Infectious Diseases Society of America (IDSA) Position Statement: Why IDSA Did Not Endorse the Community-Acquired Pneumonia Guidelines 2025 Update (CID)
• Lyme DiseaseIncidence in Massachusetts, 2012-2024 (JAMA: Open Network)
• Fungal
• The Last of US Season 2 (YouTube)
• Aspergillosis-Attributable Mortality in the United States: Analysis of Death CertificateData (CID)
• Oral itraconazole versus oral voriconazole for treatment-naive patients with chronic pulmonary aspergillosis in India (VICTOR-CPA trial): a single-centre, open-label, randomised, controlled, superiority trial (LANCET: Infectious Diseases)
• Parasitic
• Loa loa encephalopathy following treatment with benzimidazole derivatives: A systematic review (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #94 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 11/11/25 – 11/19/25.

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• Viral
• Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus (Science Translational Medicine)
• Hepatitis B reactivation following switch away from tenofovir-containing anti-retroviral therapy in people living with HIV: A case series and lessons for practice (CID)
• Antimicrobial drug-resistant Neisseria gonorrhoeae (GC) infections in men using doxycycline postexposure prophylaxis. A substudy of the ANRS 174 DOXYVAC trial (CID)
• HIV Pre-exposure Prophylaxis Does Not Increase Gonorrhea and Chlamydia Incidence in Young Black and Hispanic Men who Have Sex With Men: An Observational Cohort Study (OFID)
• Bacterial
• Global and regional knowledge of antibiotic use and resistance among the general public: a systematic review and meta-analysis (CMI: Clinical Microbiology and Infection)
• Infant Botulism Outbreak Linked to Infant Formula, November 2025 (CDC: Botulism)
• Outbreak Investigation of Infant Botulism: Infant Formula (November 2025) (FDA)
• Vitamin D deficiency at hospital admission with community-acquired pneumonia is associated with increased risk of mortality: A Prospective Cohort Study (OFID)
• Bat-Associated Hemotropic Mycoplasmas in Immunosuppressed Children, Spain, 2024 (Emerging Infectious Diseases)
• A Multicomponent Intervention to Improve Maternal Infection Outcomes (NEJM)
• Fungal
• The Last of US Season 2 (YouTube)
• Increasing Fluconazole Resistance in Candida parapsilosis: A 10-Year Analysis of Blood Culture Isolates at a US Reference Laboratory (2015–2024) (JID)
• British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update (LANCET: Infectious Diseases)
• In Vivo Evolution of Candida auris Multidrug Resistance in a Patient Receiving Antifungal Treatment (JID)
• Parasitic
• Implications of a fatal anaphylactic reaction occurring 4 hours after eating beef in a young man with IgE antibodies to galactose-α-1,3-galactose (JACI: Journal of Allergy and Clinical Immunology In practice)
• WHO recommends R21/Matrix-M vaccine for malaria prevention in updated advice on immunization (WHO)
• Effectiveness of the RTS,S/AS01E malaria vaccine in a real-world setting over 1 year of follow-up after the three-dose primary schedule: an interim analysis of a phase 4 study in Ghana, Kenya, and Malawi (LANCET: Global Health)
• A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication? (PLoS Neglected Tropical Diseases)
• Miscellaneous
• IL12RB1 deficiency appearing in North America: expanding the clinical phenotypes (CID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #93 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 10/23/25 – 11/10/25.

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• Viral
• High Prevalence of Varicella Zoster Virus Infection among Persons with Suspect Mpox Cases during an Mpox Outbreak in Kenya, 2024 (ASTMH: AJTMH)
• Earlier initiation of treatment following HIV acquisition reduces non-AIDS-defining malignancy risk (CID)
• TWiV 1267: A cancer vaccine and an mpox treatment (MicrobeTV)
• Cancers Caused by HPV (CDC: Human Papillomavirus (HPV))
• Circulating tumor human papillomavirus DNA whole genome sequencing enables human papillomavirus-associated oropharynx cancer early detection (Journal of the National Cancer Institute)
• Impact of Vaccinating Adult Women Who Are HPV-Positive or with Confirmed Cervical SIL with the 9-Valent Vaccine—A Systematic Review (Viruses)
• ACIP Shared Clinical Decision-Making Recommendations (CDC: Advisory Committee on Immunization Practices (ACIP))
• HPV Vaccination Recommendations (CDC: Vaccines & Immunizations)
• Bacterial
• Consequences of Delaying Surgical Intervention in Patients with Native Joint Septic Arthritis (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia (PIC): a multicentre, double-blind, randomised controlled trial (LANCET: Respiratory Medicine)
• Nasal Iodophor to Reduce Candidozyma auris Nasal Carriage in Nursing Home Residents (OFID)
• Epidemiology of Invasive Fungal Disease in Pediatric Heart Transplant Recipients (Journal of Pediatric Infectious Diseases Society)
• Mapping the Geographic Distribution of Dimorphic Mycoses Using a US Commercial Insurance Database (OFID)
• Genomic Dynamics of the Emergent Candida auris: Exploring Climate-dependentTrends (OFID)
• Parasitic
• Evaluation of a One Health public health program based on minimum inputs to control Taenia solium in Madagascar (PLoS Neglected Tropical Diseases)
• Transplacental Transfer of Lumefantrine, Mefloquine, and Piperaquine: A Comparison of Concentrations in Mothers, Neonates, and Cord Blood (CID)
• Miscellaneous
• Amplifying Our Voices: Fostering Advocacy in Infectious Diseases Fellowship(OFID)
• Plant-Based Diets and Climate Change, A Perspective for Infectious Disease Provider (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #92 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 10/9/25 – 10/22/25.

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• Viral
• Long-term clinical, immunologic, and viral reservoir outcomes in children treated with VRC01LS and 10-1074 monoclonal antibodies in the Tatelo Study (CID)
• Resistance Analyses of Lenacapavir, Emtricitabine/Tenofovir Alafenamide and Emtricitabine/Tenofovir Disoproxil Fumarate in the PURPOSE 1 and 2 Studies (JID)
• Susceptibility of measles virus to WHO hand rubs, oral and surface disinfectants (OFID)
• Measles without rash during acute febrile illness surveillance in Tanzania, 2023-2024 (CID)
• The 2025 Centers for Disease Control and Prevention Non-Occupational HIV Post-Exposure Prophylaxis Guidelines (CID)
• Bacterial
• Paratyphoid fever and relapsing fever in 1812 Napoleon's devastated army (Current Biology)
• Mass Administration of Azithromycin to Infants in Mali to Reduce Mortality (NEJM)
• Efficacy and safety of tedizolid in the treatment of acute bacterial skin and skin-structure infections (CMI: Clinical Microbiology and Infection)
• Zoonotic Escherichia coli and urinary tract infections in Southern California (mBio)
• Cefdinir Versus Cephalexin for the Treatment of Uncomplicated Urinary Tract Infections (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Antagonistic in vitro interaction between olorofim and voriconazole against Aspergillus fumigatus (Journal of Antimicrobial Chemotherapy)
• Parasitic
• Miscellaneous
• CARB Your Enthusiasm: An Ethics-Informed Analysis for Clinicians of the US National Action Plan for Combating Antibiotic-Resistant BacteriaCID)
• Infection Control in Carceral Facilities (CID)
• Infection Prevention and Control in Carceral Settings (CID)
• The Challenge of Malignancies in HIV-1, Beyond Immune Activation and Back to Decreased Immune Surveillance (Journal of AIDS & Clinical Research)
• SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade (Nature)
• TWiV 1265: mRNA vaccines make cancer treatment great again (microbeTV)
• Infected With the Academic Bug (CID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #91 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 9/25/25 – 10/8/25.

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• Viral
• American Academy of Pediatrics
• Comparison of 2 Doses vs 1 Dose in the First Season Children Are Vaccinated Against Influenza(JAMA: Open Network)
• Flu and Children (CDC: Influenza (flu))
• Bacterial
• Performance of Different Versions of Duke Criteria in Diagnosing Infective Endocarditis in Patients With Intracardiac Prosthetic (OFID)
• 2023 Duke criteria on Infectious Disease (Puscast 28)
• Infective Endocarditis and Antimicrobial Timing: A Case for Delay? (OFID)
• Tularemia: A Storied History, An Ongoing Threat (CID)
• Tularemia Antimicrobial Treatment and Prophylaxis: CDC Recommendations for Naturally Acquired Infections and Bioterrorism Response — United States, 2025 (CDC: MMWR)
• Fungal
• The Last of US Season 2 (YouTube)
• Risk factors associated with progression to clinical Candida auris infection among adults with previous colonization—Florida, 2019–2023 (CID)
• Parasitic
• Public Health Response to the First Locally Acquired Malaria Outbreaks in the US in 20 Years (JAMA: Open Network)
• Miscellaneous
• Fever in sepsis revisited: Is a little heat what we need? (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #90 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 9/12/25 – 9/24/25.

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• Viral
• Crushed Bictegravir/Emtricitabine/Tenofovir Alafenamide (OFID)
• Tracking County-Level Measles Cases in the US (JAMA Nework)
• Tracking measles in US (Hopkins)
• Pediatric influenza-associated encephalopathy and acute necrotizing encephalopathy (MMWR)
• Clinical recommendations for Lenacapivir (MMWR) Bacterial
• Primary oral vancomycin prophylaxis to stem an outbreak of Clostridioides difficile infection in intensive care patients (Antimicrob Steward Healthc Epidemiol)
• Clinical features and treatment strategies of Q fever spinal infection (OFID) Fungal
• Last of Us Season 2
• The Pain is in the Brain (J Inf Dis) Parasitic
• Chagas Disease, an Endemic Disease in the United States (MMWR)
• Fixed-dose ivermectin for Mass Drug Administration (PLoS NTD)
• Outbreak of eosinophilic meningitis caused by the rat lungworm (Angiostrongylus cantonensis) in South Brazil (Am J Trop Med Hyg)
• Human monoclonal antibody MAM01 for protection against malaria in adults in the USA (Lancet Inf Dis)
• Permethrin-Treated Baby Wraps for the Prevention of Malaria (NEJM) Miscellaneous
• Ambient Documentation Technology in Clinician Experience of Documentation Burden and Burnout (JAMA Network Open)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #89 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/18/25 – 9/11/25.

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• Viral
• Antibody Responses are Sustained 2 Years Post-Mpox Infection but not Following Modified Vaccinia Ankara–Bavarian Nordic Vaccination (OFID)
• Intestinal mucosal immune responses to novel oral poliovirus vaccine type 2 in healthy newborns (CID)
• Efficacy of Baloxavir Treatment in Preventing Transmission of Influenza (NEJM)
• Fulminant Viral Myocarditis Associated with Thogotovirus (NEJM)
• Bacterial
• Risk factors for 30-Day mortality and the role of empirical therapy in Pseudomonas aeruginosa bloodstream infections(Infection)
• The Impact of a Nationwide Blood Culture Bottle Shortage in 2024 on Healthcare Facilities in the United States (CID)
• The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli(NPJ: antimicrobials and resistance)
• Preoperative Enterosignatures Predict Surgical Site Infections After Abdominal Surgery (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Association between Duration of Candidemia and Clinical and Healthcare Resource Utilization Outcomes among Hospitalized Adult Patients with Candidemia Who Received Empiric Treatment with an Echinocandin Across United States Hospitals (CID)
• Updating the epidemiology of blastomycosis and histoplasmosis in the United States, using national electronic health record data, 2013–2023 (JID)
• Parasitic
• Stocking African catfish in Lake Victoria provides effective biocontrol of snail vectors of Schistosoma mansoni (PLoS Neglected Tropical Disease)
• Miscellaneous

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #88 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 8/19/25 – 8/27/25.

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• Viral
• Respiratory Syncytial Virus Immunization Coverage Among Infants Through Receipt of Nirsevimab Monoclonal Antibody or Maternal Vaccination (CDC: MMWR)
• Bictegravir, emtricitabine, and tenofovir alafenamide versus ritonavir-boosted protease inhibitor-based antiretroviral therapy in people with HIV and viral suppression on second-line therapy in Haiti: an open-label, randomised, non-inferiority trial (LANCET: HIV)
• Interferon-α Nasal Spray Prophylaxis Reduces COVID-19 in Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial (CID)
• Bacterial
• Exposure to suppressive antibiotic therapy in women with recurrent urinary tract infections and severity of infections: a retrospective population-based cohort study (BMJ Open)
• Effectiveness and safety of antibiotics in kidney transplant recipients with asymptomatic bacteriuria: a systematic review and meta-analysis of randomized controlled trials (OFID)
• Epidemiological, temporal, and geographic trends of leptospirosis in the United States, 2014–2020 (PLoS Neglected Tropical Diseases)
• Performance of Tongue Swabs for Tuberculosis Diagnosis in Hospitalized Children Under 5 Years of Age (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Towards shorter therapy for candidaemia: defining uncomplicated candidaemia in adults (LANCET: Infectious Diseases)
• Parasitic
• Outcomes of Military Blood Donors at Joint Base San Antonio with Reactive Trypanosoma cruzi Antibody Screening (OFID)
• Cutaneous acanthamoebiasis: Two Cases Highlighting Diverse Histopathologic Findings (Journal of Cutaneous Pathology)
• Miscellaneous
• Linezolid-related Optic Nerve Disorders: Insight from a Pharmacovigilance Analysis of the U.S. FDA Adverse Event Reporting System (OFID)
• Extreme variability in linezolid concentrations in the ICU: A case for routine therapeutic drug monitoring (American Journal of Health-System Pharmacy)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #87 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 7/31/25 – 8/18/25.

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• Viral
• Adjuvanted recombinant zoster vaccine is effective against herpes zoster ophthalmicus, and is associated with lower risk of acute myocardial infarction and stroke in adults aged ≥50 years (CID)
• Bacterial
• Dalbavancin for Treatment of Staphylococcus aureus Bacteremia (JAMA)
• Propensity-Matched Comparison of Timely vs. Delayed Antibiotic Therapy in Stenotrophomonas maltophilia Pneumoni (OFID)
• The proportion of Treponema pallidum PCR-positive primary syphilis infections which are seronegative for syphilis (OFID)
• Cefixime versus benzathine penicillin G for the treatment of early syphilis (Journal of Antimicrobial Chemotherapy)
• Dalbavancin for Treatment of Staphylococcus aureus Bacteremia (JAMA)
• Fungal
• The Last of US Season 2 (YouTube)
• Parasitic
• Increasing Length of the Babesia Season in New England in the Climate Change Era (OFID)
• Ivermectin to Control Malaria (NEJM)
• Miscellaneous
• ACIP Recommendations Summary (CDC: Influenza)
• Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to frailty score (JID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #86 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 7/22 – 8/1/25.

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• Viral
• Long-term clinical sequelae among Sudan ebolavirus disease survivors 2 years post-infection (BMC Medicine)
• Bacterial
• War on AMR: High MDR carriage rates among war-injured Ukrainian refugees (CMI: Clinical Microbiology and Infection)
• Oral washes and tongue swabs for Xpert MTB/RIF Ultra-based tuberculosis diagnosis in people with and without the ability to make sputum (CID)
• Fungal
• The Last of US Season 2 (YouTube)
• Progression from Candida auris Colonization Screening to Clinical Case Status, United States, 2016–2023 (CDC: Emerging Infectious Diseases)
• Regional Emergence of Candida auris in Chicago and Lessons Learned From Intensive Follow-up at 1 Ventilator-Capable Skilled Nursing Facility (CID)
• Infection Control Guidance: Candida auris (CDC: Candida auris)
• Twice Weekly Sulfamethoxazole/Trimethoprim for Pneumocystis jiroveci Pneumonia Prophylaxis in Lung Transplant Recipients(Transplant Infectious Disease)
• Parasitic
• Toxoplasma gondii infection of neurons alters the production and content of extracellular vesicles directing astrocyte phenotype and contributing to the loss of GLT-1 in the infected brain (PLoS Pathogens)
• Baylisascariasis (Raccoon Roundworm Infection) in Two Unrelated Children (CDC: MMWR)
• Miscellaneous
• A Review of Alpha Gal Syndrome for the Infectious Diseases Practitioner (OFID)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.

On episode #85 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 7/3 – 7/21/25.

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• Viral
• Elimination of HIV Reservoirs Harboring Intact Proviruses (JID) Bacterial
• Expansion of tetM-Carrying Neisseria gonorrhoeae in the United States, 2018–2024 (NEJM)
• Study hints doxyPEP use coincides with rise in tetracycline-resistant gonorrhea in US (CIDRAP)
• Potential Impact of Doxycycline Post-Exposure Prophylaxis on Tetracycline Resistance in Neisseria gonorrhoeae and Colonization With Tetracycline-Resistant Staphylococcus aureus and Group A Streptococcus (CID)
• Methenamine hippurate asprophylaxis for recurrent urinary tract infections in older women – a triple-blind, randomised, placebo-controlled, phase IV trial (ImpresU). (CMI: Clinical Microbiology and Infection)
• Diagnosis and Management ofCommunity-acquired Pneumonia(American Journal of Respiratory and Critical Care Medicine)
• Complicated Urinary Tract Infections (cUTI): Clinical Guidelines for Treatment and Management (IDSA)
• The impact of an intervention to increase follow-up blood cultures for patients with Staphylococcus aureus bacteriuria (Antimicrobial Stewardship & Healthcare Epidemiology) Fungal
• The Last of US Season 2 (YouTube)
• Candida auris Containment Responses in Health Care Facilities that Provide Hemodialysis Services (CDC: MMWR)
• Candidozyma auris: an emerging threat (Reflections on Infectious Prevention and Control)
• Effects of postoperative antifungal therapy on the recurrence of Aspergillus infection after pulmonary aspergilloma resection (BMC Infectious Diseases)
• Triazole-resistant Aspergillus fumigatus in the Netherlands between 1994 and 2022: a genomic and phenotypic study (LANCET: Microbe)
• Large language models and their performance for the diagnosis of histoplasmosis (PLoS Neglected Tropical Diseases) Parasitic
• Field evidence of Trypanosoma cruzi infection, diverse host use and invasion of human dwellings by the Chagas disease vector in Florida, USA (PLoS Neglected Tropical Diseases)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.