On our Novo Nordisk episode, we covered the business of Ozempic, the GLP-1 taking the world by storm. On this episode, we dive into the science of the molecule semaglutide (and its predecessor liraglutide) with the world expert on the topic, Lotte Bjerre Knudsen. Lotte is Novo Nordisk’s Chief Scientific Advisor, and led the research group back in the early 1990s that first invented the molecule. A few topics from our conversation:

• The science behind what is happening in the body that causes weight loss while on Ozempic
• What it was like in the 1990s and 2000s believing in a drug for a problem that the rest of the industry (including her own company) had written off
• How weight loss was actually a goal from the very start — not just a side effect of diabetes medication like you often read today!

Sponsors:

• Quartr

We’re joined by Imprint cofounder and Thrive General Partner Gaurav Ahuja to dive deeper into the modern payments ecosystem and Visa’s current place within it. Gaurav was one of our research sources for the Visa episode, and we wanted to bring his insights to you all too. We discuss whether Visa really should be worried about eroding interchange fees, the impact of realtime payments systems, opportunities for startups and whether the Visa / Mastercard duopoly could really be overthrown. Tune in and enjoy!

Links:

• https://www.federalreserve.gov/paymentsystems/files/Avg_IF_by_PCN.pdf

Sponsors:

• Quartr

We sit down with Morgan Housel, who is one of our very favorite authors and has also become a good friend of the show over the past few years. Morgan’s last book The Psychology of Money had a huge impact on both of our personal financial philosophies (and by extension Acquired’s!), and Morgan was kind enough to give us an advance copy of his new book launching tomorrow, Same as Ever. It’s equally as good, and maybe even more relevant in the current environment for thinking about what’s not going to change as we cycle through vastly different macro financial environments. Tune in and enjoy!

Links:

• Morgan’s new book Same as Ever
• The Psychology of Money
• Morgan’s blog on Collaborative Fund and on Twitter
• Morgan’s new podcast!

Sponsors:

• Quartr

While preparing for our Porsche episode with Doug DeMuro, we had a lot more than Porsche to discuss… but the episode was already over 3 hours! We decided to save the rest for its own episode, released here on ACQ2. Doug helped us understand what’s going on with the car industry supply chain in 2023, the transition to electric vehicles, the car dealership business model, and how most consumer car purchase decisions really get made.

We also got to talk with Doug about his business empire. In addition to his YouTube channel with ~5 million subscribers, Doug started a car marketplace called “Cars and Bids”. Earlier this year, Doug took a $37 million investment from The Chernin Group, and Doug walked us through that transaction and what it’s been like going from “indie creator” to a large and more professionalized organization. And of course, there’s some discussion on our Porsche episode together.

Links:

• Cars and Bids!
• Doug on YouTube and Twitter

Sponsors:

• Quartr

We sit down with RunwayML’s CEO Cristobal Valenzuela to discuss the incredible tools they’re bringing to film and video creators (including last year’s Best Picture “Everything Everywhere All at Once” from A24), and the history + current state of the “visual” branch of generative AI. We cover how they’ve gone to market with both creators and enterprises, the potential for much more radical future use cases, and the company’s recent $141m strategic raise from Google, Nvidia + Salesforce and the context of the current AI fundraising landscape. Tune in!

Links:

• Runway
• Follow Cris on Twitter

Sponsors:

• Quartr

We sit down with Crusoe Energy CEO Chase Lochmiller to talk about the two “hard to imagine” tasks they’ve undertaken: 1) building a new AI cloud infrastructure provider from scratch, and 2) colocating and powering it with stranded energy from some of the harshest and most remote locations on earth.

Crusoe’s cloud of course has to compete with (and in many cases exceed) the price/performance curves of cloud incumbents like AWS, Azure and Google in processing AI workloads. And the way it does so is by building data centers literally on top of oil flares (and other wasted energy sources) that otherwise comprise multiple percentage points of annual global greenhouse gas emissions. In other words — methane that previously just got lit on fire is now powering your favorite AI startup’s training workloads!

We cover what it actually takes to build and operate a public cloud, the latest Nvidia networking and server innovations and what they mean for GPU data centers, and how to set up a company to pursue something “hard” like this across the team, operations and capital raising fronts. Tune in!

Links:

• Crusoe Energy and Crusoe Cloud
• Follow Crusoe and Chase on Twitter

Sponsors:

• Quartr

Every now and then, we come across super interesting and under-the-radar (at least to us!) public markets folks like NZS Capital who make us think differently about the art of investing. TDM is another one of those groups — founded 18 years ago in Australia, they’ve compounded a single, private pool of capital at 26% per annum over nearly two decades. That’s Warren & Charlie territory!

TDM recently published a memo comparing the current “post ZIRP bubble” market with what happened in the years following both the dot-com crash and the GFC in 2008. As always, past performance isn’t necessarily predictive of the future, but what happened back then surprised us and might surprise you too. More importantly, it gave us the perfect excuse to sit down with TDM cofounder Tom Cowan and share the conversation with you all. Tune in and learn alongside us!

Links:

• TDM’s 2023 Market Memo
• The current BVP Cloud Index
• Follow TDM on Twitter or LinkedIn

Sponsors:

• Quartr

How do you build defensible business value in an era when, as AngelList CEO Avlok Kohli said on our last ACQ2 episode, the “cost of intelligence is going to zero”? Longtime friend of the show Jake Saper and his partners at Emergence Capital have been refining their thesis for this brave new world of Generative AI in B2B, and we sit down with him to discuss. We cover topics including:

• When do exactly correct answers matter, and when do they not?
• When are human-in-the-loop systems necessary?
• When do startups have an advantage vs. incumbents, and vice-versa?
• Where can companies capture value on a durable basis?
• When do you need proprietary data in order to be defensible?

Whether you’re building or investing in existing businesses from the “pre-AI” era or brand new startups that are native to GPT, this episode has plenty of takeaways you should consider. Tune in!

Links:

• Jake’s recent blog post on Generative AI and B2B
• Follow Jake on Twitter

Sponsors:

• Quartr

Since joining AngelList as CEO in 2019, Avlok Kohli has presided over perhaps the most unexpected and astounding transformation in the venture ecosystem: taking AngelList from an SPV provider to a company that is quickly becoming the software platform for the entire industry.

Today, AngelList provides investors and founders with the infrastructure they need to launch and scale a startup or fund, and supports over $15B of assets (including David’s own Kindergarten Ventures!). We sit down with Avlok to discuss how it all happened (and happened so fast), and - also unexpectedly and astoundingly - how generative AI is about to transform their entire business and the venture ecosystem again. Tune in!

Links:

• Visit AngelList to get started
• Follow Avlok on Twitter

Sponsors:

• Quartr

David Hsu has one of the most interesting founders journeys in tech today. After growing up in Silicon Valley, he left to study both philosophy and computer science at Oxford in the UK, then returned immediately afterward to found an internal enterprise tools company. Fast forward to today, and Retool is a multi-billion dollar valuation juggernaut that — almost uniquely for this era — operates at roughly cashflow breakeven while still growing rapidly. On this episode David shares his thoughts on finding product-market fit through sales, the dangers of product-led growth, how to get $1-5 million in ARR with just 5-10 people on the team. Tune in!

Sponsors:

• Quartr

Links:

• Retool!
• Follow David H. on Twitter

Ben and David joined Sam and Shaan of "My First Million" to talk about scaling to a large podcast, the company they would like to own, the CEO's you don't want to compete against, and the 100+ year history of Nintendo. 

If you liked this and want more of Sam and Shawn, subscribe to the MFM YouTube channel here.

Sponsors:

• Quartr

Links:

* Hampton

* Wait But Why

* Marques Brownlee

* Nintendo

* NVIDIA

------

Show Notes:

(01:45) - Intro to Acquired

(10:00) - How to scale to a big podcast

(14:05) - How big do you have to be to be at the top of the business category?

(23:55) - What commonalities are there between weird companies?

(27:40) - How to tell a real from a fake contrarian

(34:45) - Nintendo

(37:45) - Which company would you most want to own?

(40:45) - Who would you least want to compete against?

(52:30) - Business ideas

(56:40) - Will you ever sell Acquired?

(58:20) - Best ways to make money as a podcast