In this week's podcast we'll discuss another step forward in stamping out high-risk myeloma. Then we'll hear about the plasmin-cleaved von Willebrand factor, or VWF, in microthrombosis. Finally we'll hear about new insights into the origins of sickle cell pain. 

Featured Articles:

• Daratumumab, carfilzomib, lenalidomide, and dexamethasone with tandem transplant for high-risk newly
  diagnosed myeloma
• Plasmin-cleaved von Willebrand factor as a biomarker for microvascular thrombosis
• Sickle cell disease iPSC-derived sensory neurons exhibit increased excitability and sensitization to patient
  plasma

In this week's episode we’ll discuss the utility of MRD in identifying patients with NPM1 AML who benefit from allogeneic transplant in first remission, learn more about the contribution of circulating hematopoietic stem/progenitor cell subsets to human hematopoietic hemostasis, and discuss the role of Let-7 miRNAs in regulation of BCL11A transcription and hemoglobin switching. 

Featured Articles:

• Postinduction molecular MRD identifies patients with NPM1 AML who benefit from allogeneic transplant in first remission
• let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching 
• Circulating Hematopoietic Stem/Progenitor Cell subsets contribute to human hematopoietic homeostasis

In this week's epside we'll learn about ADAMTS recovery after caplacizumab therapy in patients with immune thrombotic thrombocytopenic purpura. Then, we'll hear about preclinical characterization of sonrotoclax, a potential second-generation BCL2 inhibitor. Finally we'll hear about new insights into the etiology of Castleman disease where researchers describe the unusual occurrence of idiopathic multicentric Castleman disease in identical twins. 

Featured Articles: 

• ADAMTS13 recovery in acute thrombotic thrombocytopenic purpura after caplacizumab therapy
• Sonrotoclax overcomes BCL2 G101V mutation–induced venetoclax resistance in preclinical models of
  hematologic malignancy
• Single-cell landscape of idiopathic multicentric Castleman disease in identical twins

In this week's episode, we’ll discuss the findings from a study assessing responses after treatment with tisagenlecleucel [LM1] in adults with relapsed/refractory follicular lymphoma, learn more about the association between high microRNA-145 plasma levels and decreased risk of future incident venous thromboembolism, and discuss how epigenetic and immunogenetic signatures can be used in the prediction of outcomes for high-count monoclonal B lymphocytosis.

Featured Articles: 

• Durable Response After Tisagenlecleucel in Adults With Relapsed/Refractory Follicular Lymphoma: ELARA Trial Update 
• Prediction of outcomes for high-count monoclonal B lymphocytosis using an epigenetic and immunogenetic signature 
• High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: The HUNT study 

In this week's episode, we'll discuss gut microbiota exploitation by CPX-351 in acute myeloid leukemia. Then we'll learn about optimizing anti-myeloma immunity. New research shows that regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation. Finally we'll discuss among pediatric patients with ITP or other autoimmune cytopenias, which ones will go on to develop systemic lupus? 

Featured Articles: 

• CPX-351 exploits the gut microbiota to promote mucosal barrier function, colonization resistance, and immune homeostasis
• Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation
• Antinuclear antibody–associated autoimmune cytopenia in childhood is a risk factor for systemic lupus erythematosus

In this week's episode we’ll discuss the mechanism by which Jak2V617F clonal hematopoiesis promotes arterial thrombosis, discuss how Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome, and learn more about the clinical and functional features of RAC2-related immunodeficiency.

Featured Articles:

• Jak2V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk
• Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome
• Clinical and functional spectrum of RAC2-related immunodeficiency
  

  
  

In this week's episode we'll discuss molecular mimicry in aplastic anemia, novel experiments show that antigens associated with viral infections can mimic epitopes presented on hematopoietic progenitor cells. Then, we'll learn about prophylaxis with subcutaneous emicizumab in infants with hemophilia. Finally we'll see how hydroxyurea is associated with a significant reduction in infections among children with sickle cell anemia in Uganda.

Articles featured this week:

• Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular
  mimicry
• Emicizumab prophylaxis in infants with hemophilia A (HAVEN 7): primary analysis of a phase 3b open-label
  trial
• Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

In this bonus episode of Blood Podcast, Associate Editor, Dr. Freda Stevenson is joined by Drs. Karin Tarte, Andrea Radtke, and Leandro Cerchietti to discuss the Review Series on the influence of the tumor microenvironment on the pathogenesis of B-cell lymphomas.

Find the full review series in Blood Journal volume 143 issue 12. 

In this week's episode we’ll discuss the findings from a study assessing the utility of free light chain mass spectrometry in AL amyloidosis, learn more about distinct single-cell RNA-sequencing signatures of bone marrow T cells of AML patients in remission after an allogeneic stem cell transplant, and discuss why von Willebrand factor clearance is critical for the protective effect of ADAMTS13 in mice with sickle cell anemia.

Articles featured in this episode: 

• Clearance of VWF by hepatic macrophages is critical for the protective effect of ADAMTS13 in sickle cell anemia mice 
• Complete responses in AL amyloidosis are unequal: the impact of free light chain mass spectrometry in AL amyloidosis
• The remission status of patients with AML post-alloSCT is associated with a distinct single-cell bone marrow T-cell signature 

In this week's episode we'll discuss eculizumab in stem cell transplant-associated thrombotic microangiopathy. Then, we'll learn about reclassifying malignant monocytosis, these newly classified cases have distinct mutational and transcriptional profiles. Finally, we'll hear about targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development.

Articles featured in this episode:

•  A prospective multi-institutional study of eculizumab to treat high-risk stem cell transplantation–associated TMA
•  Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022
•  Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria
  
  

In this week's episode we’ll learn more about rare relapse-initiating stem cells in patients with MDS or AML in complete remission post-transplantation, discuss the role of interferon α in erythropoiesis in sickle cell disease, and learn more about how TNFα promotes clonal dominance of KIT D816V+ cells in mastocytosis.