In this podcast, I had the pleasure of sitting down with Casey Means to discuss the importance of removing processed foods and prioritizing unprocessed animal and plant foods in our diets… Casey and her brother Calley Means are leading the fight against processed food companies and have done a remarkable job in educating Americans about the importance of a whole-food diet that prioritizes unprocessed animal and plant foods… 00:00 Intro 01:42 Podcast begins 02:09 Casey’s story 13:24 The dark side of pharmaceutical companies 21:12 The root cause of most chronic diseases today 23:09 How to correct metabolic dysfunction 36:17 How processed foods break our metabolisms 48:16 What food should you eat? 57:06 Are seed oils healthy? 01:06:59 What about fruit? 01:30:13 The importance of sleep & sunlight Disclaimer: Dr. Paul Saladino received his medical degree from the University of Arizona Medical School.  His use of “doctor” or “Dr.” in relation to himself solely refers to that degree.  Dr. Saladino is a licensed physician in California, but he no longer practices in any state and does not see patients so he can focus on educating people as a full time activity. This video is for general informational purposes only.  It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation.  It does not create a doctor-patient relationship between Dr. Saladino and you.  You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation.  Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. ‌

In this podcast, Paul had the pleasure of sitting down with Alex Clark to talk about health, processed foods, the flaws of western medicine, and dating advice for men… 00:00 Intro 02:11 Podcast begins 03:14 Roundtable hearing against processed foods 21:05 American cereals are toxic 26:49 How Alex overcame her health issues 43:43 Flaws of Western Medicine 49:49 Dating advice for men

Today, Paul and Mike unpack their opinions about lipids. They talk about true risk for cardiovascular disease, primary versus secondary prevention, lipid lowering drugs, and share their thoughts on a recent podcast episode with Peter Attia.

*Produced by Mountain Valley Media

00:06:08 Blood markers & imaging techniques of metabolic function 

00:14:38 Gene mutations

00:20:28 LDL & Plaque burden

00:27:23 Money in statins

00:31:38 Downsides of lowering LDL

01:21:23 The downsides of popular cholesterol lowering drugs

01:41:07 Should we fear heart attacks?

01:45:23 PCSK9 Inhibitors

01:52:43 Risk profile of Statins 

01:53:02 Risk vs. reward of Ezetimibe

02:04:02 Primary vs. secondary prevention

Resources:

Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Podcast:

https://www.youtube.com/watch?v=JcEmSgbMfco&t=2933s

Work With Mike: https://mikefave.com/

This week, Paul shares his most recent set of bloodwork in totality. He shares what he decides to order and why, and what bloodwork you may consider getting yourself. He also unpacks the importance of cortisol to DHEA sulphate radio and his cholesterol results.

00:00:00 Podcast begins

00:01:40 Traditional bloodwork 

00:05:40 MTHFR polymorphism: Does Paul take supplements?

00:10:10 Glucose & creatine

00:14:10 Electrolytes & insulin

00:23:10 Thyroid panel

00:26:18 Cortisol to DHEA sulphate ratio

00:32:20 Cholesterol panel

00:46:10 Hormones & Other results

00:50:20 Iron panel

00:52:40 What bloodwork should you get?

References:

July 2022 Bloodwork: https://www.youtube.com/watch?v=NuD9lWHMup8&t=669s

August 2022 Bloodwork: https://www.youtube.com/watch?v=1br0cDkYv3Y

December 2022 Bloodwork: https://www.youtube.com/watch?v=LQE3mrwaE8c

March 2023 Bloodwork: https://www.youtube.com/watch?v=vonHW14TTdg

DEXA scan reveals “side effects” of red meat: https://www.youtube.com/shorts/ZgRoz60ugnc

Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study: https://pubmed.ncbi.nlm.nih.gov/20498139/

Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studies: https://pubmed.ncbi.nlm.nih.gov/7270479/

Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease: the Kitava study: https://pubmed.ncbi.nlm.nih.gov/8077891/

The effect of HMG-CoA reductase inhibitors on cognition in patients with Alzheimer's dementia: a prospective withdrawal and rechallenge pilot study: https://pubmed.ncbi.nlm.nih.gov/22921881/

Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study: https://pubmed.ncbi.nlm.nih.gov/17327867/

Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults: https://www.nature.com/articles/s41598-018-38461-y

Low-Density Lipoprotein Cholesterol Is Predominantly Associated With Atherosclerotic Cardiovascular Disease Events in Patients With Evidence of Coronary Atherosclerosis: The Western Denmark Heart Registry: https://pubmed.ncbi.nlm.nih.gov/36621817/

Get your bloodwork from ultalabs.com

While the food industry continues to follow its convenience, profit, addiction business model Paul and Anthony explain the ethos behind and process of creating Lineage Provisions, a radically transparent food company determined to play their part in elevating and celebrating food quality.

Check out Lineage Meat Sticks here: lineageprovisions.com/psmdyt *Produced by Mountain Valley Media 00:00:00 Podcast begins 00:03:00 The devaluation of food preparation in modern society 00:09:00 how supply chain issues contribute to poor food quality 00:17:50 Why it’s so hard to raise pork and chicken on their ancestral diet 00:28:47 Ads 00:45:21 Why most “grass-finished” beef isn’t what you think it is 01:05:09 Lineage Ad 01:13:21 Paul’s beef with seafood 01:21:20 Testing for PFAs 01:25:17 What to expect from Lineage Provisions 01:28:45 Answering FAQs about Lineage Provision’s meat sticks Buy Lineage Beef Sticks: https://lineageprovisions.com/products/classic-meat-sticks

Paul has Human Biologist and founder of 10X Health Systems Gary Brecka on the podcast this week. As a previous life insurance adjuster, he talks about longevity through the lens of maintenance, being nutritionally optimal, and biohacking. They touch on adequate water filtration, all things genes & methylation, and food sourcing in the US.

*Produced by ⁠Mountain Valley Media

00:00:00 Podcast begins

00:01:23 What is fluoride and is it harmful?

00:07:30 How to filter your water

00:09:00 Western medicine & longevity

00:27:00 Food sourcing and big food

00:30:50 Cyanocobalamin

00:34:55 Folic acid

00:42:00 Gathering objective & subjective data

00:49:00 The importance of gene testing & methylation

On today’s podcast, Paul shares some new things he’s been experimenting with lately including eating more heart, supplementing with creatine, attempting to incorporate white rice as a carb source, and most excitingly, the launch of his new company: Lineage.

*Produced by ⁠Mountain Valley Media 00:00:00 The importance of heart & riboflavin 00:08:30 Pauls new company: Lineage 00:10:50 Thoughts on creatine 00:19:10 Paul’s experience with white rice & potatoes 00:24:45 Paul experimenting with supplements for methylation Check out Lineage Meat Sticks: https://lineageprovisions.com/password References: Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C-T polymorphism: https://pubmed.ncbi.nlm.nih.gov/16380544/

This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose.

*Produced by ⁠Mountain Valley Media 00:00:00 Podcast begins 00:04:00 Mike’s background 00:05:15 Diving into fructose 00:13:00 Thoughts on honey and other carb sources 00:27:30 Robert Lustig rebuttal: is fructose addictive? 00:37:40 Fructose & fiber 00:47:00 How fructose affects the mitochondria 00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia 00:56:17 Is insulin the bad guy? 01:12:20 How insulin relates to diabetes, obesity, and insulin resistance 01:23:30 Balancing protein, fat and carbohydrates 01:30:00 Is fructose making us fat? 01:46:00 Final thoughts Connect with Mike: Mikefave.com https://m.youtube.com/@MikeFaveSimplified References: Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/ A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061790/ A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/ The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: https://journals.physiology.org/doi/full/10.1152/ajpendo.00165.2014?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770506/ The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934 The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934 Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984/ Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: https://pubmed.ncbi.nlm.nih.gov/9216960/ Glucagon and type 2 diabetes: the return of the alpha cell: https://pubmed.ncbi.nlm.nih.gov/25344790/ Insulin, growth hormone and sport: https://pubmed.ncbi.nlm.nih.gov/11431133/ Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881846/ Fructose metabolism in humans – what isotopic tracer studies tell us: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/ Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1433856/ Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: https://pubmed.ncbi.nlm.nih.gov/19637282/ Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/

On this week's podcast, Brad Marshall, evolutionary biologist, talks with Paul about how signaling to our body that winter is coming is not advantageous for humans and why humans may want to stop consuming olive oil. They do a deep dive into the human metabolism, what European diets are truly like, and touch on other kinds of oils & fats as well.

*Produced by ⁠Mountain Valley Media

00:00:00 Podcast begins

00:02:50 Brad’s weight loss journey

00:10:50 The human metabolism

00:15:10 How olive oil makes us fat

00:34:24 Deep dive into European diets

00:48:50 PREDIMED trial comparing different types of olive oil

00:51:05 De novo lipogenesis (DNL)

00:53:50 What happens when humans eat canola oil

00:59:20 A story about the Inuit & long-term ketosis

01:07:20 Takeaways about olive oil

Connect with Brad:

https://www.youtube.com/@fireinabottle3410

References:

Diabetes prevalence, 2021: https://ourworldindata.org/grapher/diabetes-prevalence

Trends of overweight, obesity and anthropometric measurements among the adult population in Italy: The CUORE Project health examination surveys 1998, 2008, and 2018: https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0264778.g004

OBESITY AMONG CHILDREN IN EUROPE: https://landgeist.com/2023/02/18/obesity-among-children-in-europe/

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030: https://pubmed.ncbi.nlm.nih.gov/29886156/

Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study: https://www.lipidjournal.com/article/S1933-2874(18)30362-3/fulltext

Quality of Dietary Fat Intake and Body Weight and Obesity in a Mediterranean Population: Secondary Analyses within the PREDIMED Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315420/

This episode is my response to Layne’s video about seed oils. Due to the pervasive mainstream support for seed oils, I believe it’s extremely important to shed some light on the hidden truth behind these oils. There is a lot of conflicting evidence on seed oils out there. Looking at the totality of the evidence can be very misleading, so we must look at the details. By thoroughly breaking down each trial from Layne’s video, we can see massive flaws in the methods and designs of each study. Trans fat consumption by the control group and multifactorial interventions in the experimental group were the primary confounding variables. In this video, Paul references several studies suggesting different ways in which seed oils are harmful to humans. He always appreciate differing views and these discussions because it’s how we all learn. He has hope that a respectful debate will happen in the future so that we can dive deeper into this important subject. He strongly believe that seed oils are evolutionarily inconsistent, these are not the fats that humans have evolved on. In fact, we have evolved by consuming ample amounts of animal fats, rich in saturated fats. Saturated fats have been shown to lower markers of heart disease and they are an amazing source of essential vitamins like A, D3, K2, E. It's always meat / organs / fruit / honey / raw dairy. This is an ANIMAL-BASED diet, and I believe this is the most optimal diet for humans on the planet. Check out my ANIMAL-BASED CALCULATOR here: https://www.paulsaladinomd.co/ab-guide

Listen on YouTube: https://www.youtube.com/watch?v=8QhWNBXamCM&t=1s

Sign-up for Animal Based 30: https://heartandsoil.co/animalbased30/ 00:00 Intro 02:57 Randomized controlled trials in humans 03:47 Flaws found in the studies 04:42 Reviewing each trial 16:10 What’s the takeaway 19:45 Studies against seed oils 26:30 Toxic compounds in seed oils 27:32 Responding to Layne’s claims 36:10 Closing thoughts References: Meta-analysis of RCT by C. Ramsden - https://www.ncbi.nlm.nih.gov/pmc/arti... Meta-analysis of RCT by S. Hamley - https://www.ncbi.nlm.nih.gov/pmc/arti... PUFA increases lipid peroxidation - https://www.ncbi.nlm.nih.gov/pmc/arti... Linoleic acid metabolites in metabolic syndromes - https://www.ncbi.nlm.nih.gov/pmc/arti... Lower saturated fat increases oxidized LDL - https://pubmed.ncbi.nlm.nih.gov/14739... More linoleic acid increases oxidized LDL - https://pubmed.ncbi.nlm.nih.gov/9488997/ OXLAMs in atherosclerosis - https://www.ncbi.nlm.nih.gov/pmc/arti... Oxidized LDL and metabolic syndrome - https://pubmed.ncbi.nlm.nih.gov/19802... De novo lipogenis through oxidized LDL and linoleic acid - https://pubmed.ncbi.nlm.nih.gov/27020... Lower linoleic acid reduces oxidized metabolites - https://www.ncbi.nlm.nih.gov/pmc/arti... Soybean oil increase Lp-PLA2 and oxidized LDL - https://pubmed.ncbi.nlm.nih.gov/28503... Saturated fat lowers Lp(a) - https://pubmed.ncbi.nlm.nih.gov/9327759/ Benzene in seed oils - https://pubmed.ncbi.nlm.nih.gov/11064... Heavy metals in seed oils - https://www.mdpi.com/2076-3417/13/5/3020 Phthalates in seed oils - https://pubmed.ncbi.nlm.nih.gov/37726...

Today, Paul has Dave Feldman on the podcast to discuss, in depth, a recent study that he conducted about LDL and cardiovascular risk and what this may mean for the future of medicine.

*Produced by Mountain Valley Media

00:03:30 The genesis of Dave’s most recent study

00:07:00 is FH a phenotype or genotype polygenetic vs monogenetic

00:22:30 Dave’s overall perspective while conducting studies

0:24:00 Diving into Dave Feldman’s most recent study: Does APOE-B cause atherosclerosis

00:42:30 How the medical community has received this study

00:46:30 Do credentials matter?

00:58:30 Thoughts on Statins

01:04:45 What alters lipid levels

01:13:30 Connect with Dave

References:

Twitter: @realdavefeldman

Instagram: @realdavefeldman

Youtube: youtube.com/@realdavefeldman

https://citizensciencefoundation.org/