Paul Saladino MD podcast

Paul Saladino, MD

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. I hope you’ll join me on this journey.

  • 2 hours 16 minutes
    250. When You Should Worry About LDL Cholesterol with Mike Fave

    Today, Paul and Mike unpack their opinions about lipids. They talk about true risk for cardiovascular disease, primary versus secondary prevention, lipid lowering drugs, and share their thoughts on a recent podcast episode with Peter Attia.

    *Produced by Mountain Valley Media

    00:06:08 Blood markers & imaging techniques of metabolic function 

    00:14:38 Gene mutations

    00:20:28 LDL & Plaque burden

    00:27:23 Money in statins

    00:31:38 Downsides of lowering LDL

    01:21:23 The downsides of popular cholesterol lowering drugs

    01:41:07 Should we fear heart attacks?

    01:45:23 PCSK9 Inhibitors

    01:52:43 Risk profile of Statins 

    01:53:02 Risk vs. reward of Ezetimibe

    02:04:02 Primary vs. secondary prevention


    Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Podcast:

    Work With Mike:

    19 July 2024, 3:53 am
  • 58 minutes 33 seconds
    249. Bloodwork Review: April 2024

    This week, Paul shares his most recent set of bloodwork in totality. He shares what he decides to order and why, and what bloodwork you may consider getting yourself. He also unpacks the importance of cortisol to DHEA sulphate radio and his cholesterol results.

    00:00:00 Podcast begins

    00:01:40 Traditional bloodwork 

    00:05:40 MTHFR polymorphism: Does Paul take supplements?

    00:10:10 Glucose & creatine

    00:14:10 Electrolytes & insulin

    00:23:10 Thyroid panel

    00:26:18 Cortisol to DHEA sulphate ratio

    00:32:20 Cholesterol panel

    00:46:10 Hormones & Other results

    00:50:20 Iron panel

    00:52:40 What bloodwork should you get?


    July 2022 Bloodwork:

    August 2022 Bloodwork:

    December 2022 Bloodwork:

    March 2023 Bloodwork:

    DEXA scan reveals “side effects” of red meat:

    Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study:

    Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studies:

    Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease: the Kitava study:

    The effect of HMG-CoA reductase inhibitors on cognition in patients with Alzheimer's dementia: a prospective withdrawal and rechallenge pilot study:

    Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study:

    Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults:

    Low-Density Lipoprotein Cholesterol Is Predominantly Associated With Atherosclerotic Cardiovascular Disease Events in Patients With Evidence of Coronary Atherosclerosis: The Western Denmark Heart Registry:

    Get your bloodwork from

    13 April 2024, 11:30 am
  • 1 hour 41 minutes
    248. Why I Built a Food Company with Anthony Gustin

    While the food industry continues to follow its convenience, profit, addiction business model Paul and Anthony explain the ethos behind and process of creating Lineage Provisions, a radically transparent food company determined to play their part in elevating and celebrating food quality.

    Check out Lineage Meat Sticks here: *Produced by Mountain Valley Media 00:00:00 Podcast begins 00:03:00 The devaluation of food preparation in modern society 00:09:00 how supply chain issues contribute to poor food quality 00:17:50 Why it’s so hard to raise pork and chicken on their ancestral diet 00:28:47 Ads 00:45:21 Why most “grass-finished” beef isn’t what you think it is 01:05:09 Lineage Ad 01:13:21 Paul’s beef with seafood 01:21:20 Testing for PFAs 01:25:17 What to expect from Lineage Provisions 01:28:45 Answering FAQs about Lineage Provision’s meat sticks Buy Lineage Beef Sticks:

    27 March 2024, 1:42 pm
  • 1 hour 7 minutes
    247. Gary Brecka: Tap Water is Lowering Your IQ!

    Paul has Human Biologist and founder of 10X Health Systems Gary Brecka on the podcast this week. As a previous life insurance adjuster, he talks about longevity through the lens of maintenance, being nutritionally optimal, and biohacking. They touch on adequate water filtration, all things genes & methylation, and food sourcing in the US.

    *Produced by ⁠Mountain Valley Media

    00:00:00 Podcast begins

    00:01:23 What is fluoride and is it harmful?

    00:07:30 How to filter your water

    00:09:00 Western medicine & longevity

    00:27:00 Food sourcing and big food

    00:30:50 Cyanocobalamin

    00:34:55 Folic acid

    00:42:00 Gathering objective & subjective data

    00:49:00 The importance of gene testing & methylation

    19 March 2024, 6:11 pm
  • 30 minutes 16 seconds
    246. Some things I'm experimenting with lately...

    On today’s podcast, Paul shares some new things he’s been experimenting with lately including eating more heart, supplementing with creatine, attempting to incorporate white rice as a carb source, and most excitingly, the launch of his new company: Lineage.

    *Produced by ⁠Mountain Valley Media 00:00:00 The importance of heart & riboflavin 00:08:30 Pauls new company: Lineage 00:10:50 Thoughts on creatine 00:19:10 Paul’s experience with white rice & potatoes 00:24:45 Paul experimenting with supplements for methylation Check out Lineage Meat Sticks: References: Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C-T polymorphism:

    19 February 2024, 12:00 pm
  • 1 hour 54 minutes
    245. Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Lab Podcast

    This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose.

    *Produced by ⁠Mountain Valley Media 00:00:00 Podcast begins 00:04:00 Mike’s background 00:05:15 Diving into fructose 00:13:00 Thoughts on honey and other carb sources 00:27:30 Robert Lustig rebuttal: is fructose addictive? 00:37:40 Fructose & fiber 00:47:00 How fructose affects the mitochondria 00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia 00:56:17 Is insulin the bad guy? 01:12:20 How insulin relates to diabetes, obesity, and insulin resistance 01:23:30 Balancing protein, fat and carbohydrates 01:30:00 Is fructose making us fat? 01:46:00 Final thoughts Connect with Mike: References: Review article: fructose malabsorption and the bigger picture: A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: Glucagon and type 2 diabetes: the return of the alpha cell: Insulin, growth hormone and sport: Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: Fructose metabolism in humans – what isotopic tracer studies tell us: Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: Review article: fructose malabsorption and the bigger picture: Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress:

    25 January 2024, 8:52 pm
  • 1 hour 17 minutes
    244. Longevity Alert: The Dark Side of Olive Oil Revealed with Brad Marshall

    On this week's podcast, Brad Marshall, evolutionary biologist, talks with Paul about how signaling to our body that winter is coming is not advantageous for humans and why humans may want to stop consuming olive oil. They do a deep dive into the human metabolism, what European diets are truly like, and touch on other kinds of oils & fats as well.

    *Produced by ⁠Mountain Valley Media

    00:00:00 Podcast begins

    00:02:50 Brad’s weight loss journey

    00:10:50 The human metabolism

    00:15:10 How olive oil makes us fat

    00:34:24 Deep dive into European diets

    00:48:50 PREDIMED trial comparing different types of olive oil

    00:51:05 De novo lipogenesis (DNL)

    00:53:50 What happens when humans eat canola oil

    00:59:20 A story about the Inuit & long-term ketosis

    01:07:20 Takeaways about olive oil

    Connect with Brad:


    Diabetes prevalence, 2021:

    Trends of overweight, obesity and anthropometric measurements among the adult population in Italy: The CUORE Project health examination surveys 1998, 2008, and 2018:


    Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030:

    Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study:

    Quality of Dietary Fat Intake and Body Weight and Obesity in a Mediterranean Population: Secondary Analyses within the PREDIMED Trial:

    9 January 2024, 1:39 am
  • 36 minutes 33 seconds
    243. Responding to Layne Norton on SEED OILS

    This episode is my response to Layne’s video about seed oils. Due to the pervasive mainstream support for seed oils, I believe it’s extremely important to shed some light on the hidden truth behind these oils. There is a lot of conflicting evidence on seed oils out there. Looking at the totality of the evidence can be very misleading, so we must look at the details. By thoroughly breaking down each trial from Layne’s video, we can see massive flaws in the methods and designs of each study. Trans fat consumption by the control group and multifactorial interventions in the experimental group were the primary confounding variables. In this video, Paul references several studies suggesting different ways in which seed oils are harmful to humans. He always appreciate differing views and these discussions because it’s how we all learn. He has hope that a respectful debate will happen in the future so that we can dive deeper into this important subject. He strongly believe that seed oils are evolutionarily inconsistent, these are not the fats that humans have evolved on. In fact, we have evolved by consuming ample amounts of animal fats, rich in saturated fats. Saturated fats have been shown to lower markers of heart disease and they are an amazing source of essential vitamins like A, D3, K2, E. It's always meat / organs / fruit / honey / raw dairy. This is an ANIMAL-BASED diet, and I believe this is the most optimal diet for humans on the planet. Check out my ANIMAL-BASED CALCULATOR here:

    Listen on YouTube:

    Sign-up for Animal Based 30: 00:00 Intro 02:57 Randomized controlled trials in humans 03:47 Flaws found in the studies 04:42 Reviewing each trial 16:10 What’s the takeaway 19:45 Studies against seed oils 26:30 Toxic compounds in seed oils 27:32 Responding to Layne’s claims 36:10 Closing thoughts References: Meta-analysis of RCT by C. Ramsden - Meta-analysis of RCT by S. Hamley - PUFA increases lipid peroxidation - Linoleic acid metabolites in metabolic syndromes - Lower saturated fat increases oxidized LDL - More linoleic acid increases oxidized LDL - OXLAMs in atherosclerosis - Oxidized LDL and metabolic syndrome - De novo lipogenis through oxidized LDL and linoleic acid - Lower linoleic acid reduces oxidized metabolites - Soybean oil increase Lp-PLA2 and oxidized LDL - Saturated fat lowers Lp(a) - Benzene in seed oils - Heavy metals in seed oils - Phthalates in seed oils -

    27 December 2023, 7:14 pm
  • 1 hour 13 minutes
    242. Debunking Cholesterol Myths: New Study Reveals Surprising Findings! With Dave Feldman

    Today, Paul has Dave Feldman on the podcast to discuss, in depth, a recent study that he conducted about LDL and cardiovascular risk and what this may mean for the future of medicine.

    *Produced by Mountain Valley Media

    00:03:30 The genesis of Dave’s most recent study

    00:07:00 is FH a phenotype or genotype polygenetic vs monogenetic

    00:22:30 Dave’s overall perspective while conducting studies

    0:24:00 Diving into Dave Feldman’s most recent study: Does APOE-B cause atherosclerosis

    00:42:30 How the medical community has received this study

    00:46:30 Do credentials matter?

    00:58:30 Thoughts on Statins

    01:04:45 What alters lipid levels

    01:13:30 Connect with Dave


    Twitter: @realdavefeldman

    Instagram: @realdavefeldman


    19 December 2023, 1:45 pm
  • 1 hour 55 minutes
    241. Coke’s secret playbook to keep you addicted to sugar with Calley Means

    Paul sits down in person with Calley Means to talk about the ins and outs of food industry corruption. Calley shares his firsthand experience as a previous consultant for Coca Cola, and unearths their strategies in keeping Americans addicted to sugar.

    *Produced by Mountain Valley Media

    00:02:00 The truth about Ozempic

    00:08:15 Calley’s experience working for Big Pharma

    00:27:45 When is Western medicine necessary?00:32:00 Addiction & targeting children

    00:42:00 The infertility crisis

    00:46:00 How Big Pharma manipulates the narrative

    01:06:10 Food Compass & Dariush Mazaffarian

    01:12:00 The path forward for medical professionals

    01:35:20 Politics & disrupting the nutritional space

    01:40:40 Ideas

    01:45:40 Seed oils in infant formula

    01:52:00 Conclusion & how to connect with



    12 December 2023, 2:45 pm
  • 1 hour 12 minutes
    240. Cancer-causing chemicals in your food and drinking water with Zach Bush

    On this week’s podcast, Paul has the pleasure of speaking to triple board certified doctor, Zach Bush, who is the founder of Farmers Footprint nonprofit. They deep dive into how to protect ourselves from glyphosate, how to truly connect with nature, and what the path forward may look like for humanity.

    *Produced by Mountain Valley Media

    00:02:10 The history of glyphosate

    00:19:15 The glyphosate timeline

    00:24:00 Glyphosate & cancer maps

    00:27:08 Social political conflict driven by food systems

    00:31:10 The silver lining & the path forward

    00:46:15 Healing by respecting & reaccepting nature

    01:07:00 Zach’s nonprofit: The Farmer's Footprint

    Link to Farmer’s Footprint Giving Tuesday Campaign where people can donate.

    Giving Tuesday 2023

    Connect with Zach:

    Zach’s Nonprofit:



    Intelligence of Nature:

    Journey of Intrinsic Health:

    28 November 2023, 1:56 pm
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