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The Wholesome Fertility
Check out Michelle’s Latest Book: The Way of Fertility!
https://www.michelleoravitz.com/thewayoffertility
Instagram: @thewholesomelotusfertility Facebook: https://www.facebook.com/thewholesomelotus/ Transcript: Michelle (00:00) Welcome to the podcast, Dr. Jeff. Dr. Jeff (00:03) Thank you so much for having me. Nice to see you. Michelle (00:06) Nice to see you as well. So you definitely have a very long, impressive background. So I'd love for you to share your story on how you got to really to the anti-aging stem cells work that you do, So I'd love to just get a quick background so the listeners can hear. Dr. Jeff (00:26) Sure, thank you for that. It was by accident of sorts, maybe directed accident because I was practicing as a spinal neurosurgeon, taking care mainly of neck and back trouble, some other neurological issues, nerve problems, things like that. But my practice was highly consultative, a lot of opinions, second opinions. I was seeing patients who had neck and back problems that were perhaps... mistreated or not fully treated elsewhere. And I was kind of, I was kind of a catchall for that. But my patients came to me one at a time. And these are patients that had tried different things and they just didn't work adequately. Like physical therapy, like anti-inflammatories, like rest, like, you know, chiropractic, acupuncture, maybe spinal epidural injections or things like that. And they'd come in and say, well, you know, help for a minute, but just wasn't enough. I'm still having a lot of trouble with my neck or back or pinch nerve or whatever. And I say, well, the next thing on the menu is to talk about surgical options. And they'd say, well, I'm not that bad. So wait a minute. Okay, good. Cause I was hoping you would say you're not ready for that. Cause I really didn't want to offer that to you. Cause I've always been on the slow to operate side of things. So, a lot of them would say, well, how about lasers or how about. Michelle (01:37) Mm-hmm, yeah. Dr. Jeff (01:52) herbs or how about cannabis or how about stem cells? And I heard the stem cell one more than once and chance favors the prepared mind. So my undergraduate background is in molecular cell biology, which is kind of the stem cell, know, root of stem cell biology. And, you know, when you get whisked off from undergraduate to med school and residency and practice, you don't really get to apply that cool science. So the nerd part of me took over and said, I wonder what's happened in all these years since I went to undergraduate, you know? So instead of going to the Stodgy Neurosurgeon Convention every year, or more than one, where the same people pat themselves on the back for saying the same things for decades, I decided I'm going to open my mind and start going to stem cell and regenerative medicine meetings. Michelle (02:46) Mm-hmm. Dr. Jeff (02:46) So I can offer this to my spine patients. So I did that and I not only brought back a new tool to offer them, but it blossomed into so much more. You can't get access to regenerative medicine, stem cell medicine, and I'm using those phrases sort of interchangeably here, and not say, I'll help your knee or your ankle or your shoulder or your... autoimmune issues or other hyper inflamed states. Or, you you read more and you see accumulation of inflammation is really the aging process. And if you can fight against inflammation accumulating, you're fighting against aging. So the whole anti-aging umbrella opened up and here I am, you know, six years later where spinal medicine is only a small percentage of my practice and I love it. Michelle (03:33) Mm-hmm. Yeah. That's great. So, so for people listening, some people might be like, okay, I kind of heard about stem cells, but what exactly are they? So just for people listening for the first time, we're really not understanding that aspect of like what they are. Cause we hear about it a lot. And over the years, like you said, stem cell research has really drastically changed and has gone into so many different things. Sometimes we hear about like Dr. Jeff (03:45) So. Yeah. Michelle (04:12) you know, back in the day about them growing a liver, like, you know, the possibility of growing organs through stem cells. for people who are really new to this, I would love for you to break it down. Dr. Jeff (04:15) Yeah. Yeah. Yeah. sure, let's do stem cell 101. That's great. and being a fertility podcast, this is relevant probably more than any other area of medicine because fertility and creating an embryo is, you know, creating a group of stem cells that divide and grow into a fetus who's made of all stem cells, right? And then, Michelle (04:28) Hahaha Right. Dr. Jeff (04:54) then that fetus is born and it's a baby and the baby grows for 18, 20, 25 years, whatever. And that growth requires stem cells. And then after that, an adult has to maintain, has to replace, has to restore, has to regenerate and that requires stem cells. So what are these? They are cells from which other cells arise, from which other cells stem from. Okay? So, and they are... Michelle (05:20) Mm. Dr. Jeff (05:24) They are powerful because there are different types, right? We throw out the phrase stem cells, but when you're a one cell or a two cell or a four cell embryo, you have these omnipotent cells. They can form any part of your body. They are amazingly powerful. As those divide and differentiate, meaning take on some specific characteristics, they become less powerful and more directed, and those are called pluripotent. And a pluripotent might be able to regrow a limb. And as you, as you, and many of your listeners probably know, there are certain species that can still do that. Like a starfish, you cut off a leg of a starfish, it can regrow it. Or a tail of a lizard or a limb of an axolotl, which is a strain iguana like creature from Mexico. So there are many examples in biology where these pluripotent stem cells can be called upon. And you mentioned maybe regrowing a liver someday. that will probably require some knowledge of pluripotent stem cells, which are being looked at. However, after these stem cells sort of retain, we bank them in our body as adults, those are called multipotent. So they can't regrow a limb, they can't regrow an organ per se, although they can replace some organ cells and regenerate. And you were always replacing cells, we're replacing skin cells and you know, hair follicles and all kinds of things that require stem cells. If you have an injury and you cut yourself, you, require stem cells to help come repair that. and you know, we make new blood cells all the time that requires stem cells in our bone marrow. So we are using our stem cells. This is not new. We just know more about it now. And the whole move in regenerative medicine is, is to take Michelle (07:03) Mm. Dr. Jeff (07:19) a lesson from that biology and use it strategically to help somebody do something they need. Michelle (07:27) So interesting. So give us a couple of examples on how it works in the body. Like for somebody who needs it, for example, whereas like a therapy. Dr. Jeff (07:34) Well, the- Right. So the low hanging fruit as an example, are joint degeneration. Also called arthritis or osteoarthritis vaguely, or some people it's called bone on bone if it's bad enough. Right. And these are your painful joints. It could be from an old injury, an old arthroscopic surgery. It could be from just, you know, accumulated wear and tear. And this is a problem with the joints where the cartilage is, you know, down and the joint is painful. You can't use it as well stiffness, et cetera. And it slows people down. And when you slow people down, particularly in their older years, they're less mobile and then they can't maintain their bones, their bone density, AKA, you know, the one way to fight osteoporosis is weight bearing exercise. So if you can't, if your joints hurt, you're not going to do it. And muscle mass, cause both bone density and muscle mass are correlated with longevity. So if you keep moving. You maintain your muscles and bones, you'll live longer statistically. So in any event, we want to preserve joints. And that's kind of why I got into this field. I'm a structural guy of the spine and it easily extrapolates to the other joints. And most of the research, the well-published research comes from knees and other joints. And just parenthetically, most of the good published research that we follow, because we're not just shooting from the hip here. We do shoot some hips, but it comes from Asia and Europe. The United States is behind, although we can do these things. And, you know, we can talk about that later, but the short of it is we have a really good track record of helping people with degenerated joints in reducing pain and improving function. And we do have some examples with where we've done some MRIs. Michelle (09:09) Ha ha ha! Dr. Jeff (09:37) before and after and the after MRIs have shown some regrowth of like knee cartilage, for example, and things like that. you know, we're not allowed to make any claims because we're not yet approved for marketing claims, but I can show examples and I have to say like you invest in stocks, know, past performance does not guarantee future results or something like that, but in medicine, never, yeah, yeah. Michelle (10:01) Right, and each person is different and unique. Yeah. Dr. Jeff (10:05) But anyway, it's better, listen, if you want to try to avoid a joint replacement surgery, it's worth looking into. So whether it's spine or joints, so that's the easy stuff. Low hanging fruit, I call it. The other stuff is anything with an inflammatory problem in your body can potentially have benefits from regenerative medicine on its face being a natural anti-inflammatory. So for example, autoimmune problems with hyperinflammation. You know, like rheumatoid arthritis, thyroiditis, inflammatory bowel syndromes, MS, things that have an inflammatory component. Also, most diseases of aging are diseases of inflammation. So coronary artery disease, Alzheimer's, things like this, all have an inflammatory component. And this allows me to overlap into your area is there are some causes of fertility. issues that have an inflammatory component, whether it's a uterine issue or ovarian failure. And sometimes fighting that inflammation, whether it's through lifestyle changes, diet, exercise, mindfulness, sleep, reducing mental stress, all those things can help reduce the inflammation and help potentially lead to successful pregnancy. The same can go for use of regenerative biologics like stem cells, and they're not the only thing we use. And there are wonderful publications. And before we got on this, I refreshed my knowledge by doing a little homework. And there are even newer publications on use of these things to improve fertility. Now, most of these are from China because they are way ahead of us. But that doesn't mean they can't be applied here outside of China. Michelle (12:01) Interesting. So interesting. So how do they get these stem cells? Dr. Jeff (12:07) So stem cells and other related biologic material in the US comes from a well-regulated donor program. Typically the donors are women who are planning to have a C-section. Some of the labs even recruit the donors in the first trimester, make sure they're having a healthy pregnancy, they're not using substances they shouldn't be using, they take their prenatal vitamins, they're not in any high-risk behaviors. And at the time of the C-section, they simply, and once the mother is congratulated with her new baby, they take the amniotic fluid, they take the umbilical cord, they take the placenta and they put them on ice in a sterile fashion and they go to an FDA compliant certified lab that can test and screen the materials, make sure there's nothing in there, no diseases, no problems, and then make it available to clinics and end users like myself. So there are myths that all kinds of crazy stuff are happening out there, but not here in the US. We use highly regulated donor processes. Michelle (13:19) When you have the stem cells from donors, can they be multiplied or is it just like a finite amount? Whatever is there is there. Dr. Jeff (13:28) They can be, there are labs that put them in culture, would let them grow and divide and that's one thing that can be done. Now, just like anything, a copy of a copy of a copy tends to lose its vitality. So, things like telomere length, which is an aging marker, that changes with each division of a cell. So I don't like to use a divided material. Michelle (13:50) Mm-hmm. Dr. Jeff (13:58) I use just fresh first pass stuff. Maybe your listeners are a little young for this, but there's a really funny movie called Multiplicity, where Michael Keaton clones himself, and each clone is a little bit wonkier than the original. if you want a good laugh, yeah, check out that movie. But in short, I prefer the actual native original self. Michelle (14:15) Comedy used to be so much better. Right. Got it. Is this similar to cord blood, you know, when they, when the baby's born and they say, do you, you know, you can opt to do that and then store Dr. Jeff (14:27) When we do self, Yeah, let's tap into that for just a second and unpack it if it's okay. know, historically you would be offered to donate or not donate, but store your umbilical cord. And the purpose of that was, God forbid your child gets leukemia in seven years, you have a matched set of cells that they culture, they do divide. Michelle (15:01) Mm-hmm. Right. Dr. Jeff (15:02) and replace the child's bone marrow, you don't have to worry about a donor or a match. Now you can do that and you can also use, in some labs we'll use those umbilical cord cells as a source for any other future purpose, whether it's a joint problem or what have you, they're now doing that. In fact, you can use that for family members as well. So the reasons for a bank in your umbilical cord, and they probably won't tell you in the pamphlet, because it's not yet approved for marketing claims. Michelle (15:19) Mm-hmm. Mm-hmm. Dr. Jeff (15:31) is much more than just, you know, just in case there's a case of leukemia, you need a full bone marrow replacement. Michelle (15:39) So interesting. how, when you do have the stem cells, first of all, it must cost a fortune, it sounds like, it's limited. It's not something that you, because you're depending on donors. Dr. Jeff (15:52) No, well, there's a little bit more to it. And that, and I keep using the phrase stem cells and other biologics. Let's, let's talk about other biologics for a minute because some of these other biologics are less expensive and here in the U S it's, it's affordable. You don't have to necessarily leave the country and go to go to central America or, you know, Hong Kong to get this or Europe. A lot of the professional athletes historically went to Europe, but they're, they're getting it here, here in the U S too. Michelle (15:59) Okay. Mm-hmm. that's good. Dr. Jeff (16:22) But we found out that if we gave you stem cells, let's say you came over and I hooked up an IV and we gave you stem cells, in 10 to 14 days, those would be out of your system. However, the benefits would go on for weeks or months or even some of the benefits would be prolonged. So why is that? If the stem cells are gone, what's going on? Well, it turns out the stem cells aren't really doing all the work. The stem cells are delivering cell to cell communicating and influential Michelle (16:31) Mm-hmm. Dr. Jeff (16:52) biomolecules, peptides, growth factors, small RNAs from cell, from the stem cells to your cells, reinvigorating and activating your cells to do that work. And those, those communication packets are called extracellular vesicles or for short exosomes. And you may have seen this, a lot of estheticians use them. You know, they can do the atom to your microneedle facial. Michelle (17:11) Mm-hmm. Mm-hmm. Mm-hmm. Dr. Jeff (17:20) It's sort of an advanced vampire facial with these exosomes. So the exosomes are probably doing most of the work that the stem cells were doing. And there are advantages. They penetrate tissue better. They're easier to store and handle. They'll cross the blood brain barrier if you want them in your brain and nervous system. And they're less than half the price of stem cells. So we can do things that used to cost, you know, 20, $30,000 out of this country. for less than half of that here, because the big cost is the materials, these biologics. So what does it cost was your original question, but now that you know we're using these exosomes preferentially in a lot of these cases. And by the way, as an aside, all stem cells, sorry, start over, all cells make exosomes. We're using stem cell derived exosomes from amniotic fluid, which is quite abundant. So there are really no cells in this. Michelle (18:11) Mm-hmm. Mm-hmm. Dr. Jeff (18:19) There's no matching that needs to be done. and it's, it's wonderful. So, the, you know, for example, treating a knee, if we're trying to repair a knee, help someone heal a knee, we're asking their cells to do the work. We're just providing the, the, the re-instruction to tap back into the original factory that made that joint in the first place. And something that like that is kind of two doses of biologics, one above one below the knee. the injection, the facility and everything where we do it as sterile. All that is, you know, in the nine to 12,000, depending on what we're doing. So it's not, it's not crazy. And IVs, if we do an IV, that's anywhere from like 4,000 to 8,500, depending on the dose. Michelle (18:54) Mm-hmm. And how many times would somebody have to do that? Dr. Jeff (19:07) Maybe once. Usually the joints are one and done and then they go back to their normal wear and tear. So is it possible someone's going to come back in in 20 years and need it again maybe, but that's okay. We follow a French protocol that has published 15 year follow-up and we follow that protocol how they do it. And they've had over 82 % of the patients had wonderful results at the 15 year mark. We're waiting for them to publish the 20 year mark. Michelle (19:10) Mm-hmm. Mm-hmm. Dr. Jeff (19:35) So we're not making this up. We're just duplicating what's already been done and good science that's out there. Michelle (19:42) And for inflammatory conditions, autoimmune conditions, or even fertility, well, you know, because it's secondary to that a lot of times. Do you use IV? So really get it right into the bloodstream. Okay. Dr. Jeff (19:51) Right, right. Yeah, I would definitely. yeah. Yeah. And that's how we approach anti-aging anyway. People are biohackers, anti-agers that come in. This is what we do. And we, we do an IV. We, we try to figure out a dose that makes sense for that person based on the budget and their age and maybe their inflammatory markers and their blood tests and other things. And then we see how long it lasts. And some people get a year, two years. Some people get, you know, six months. Some people come in preventively and do every three months a lower dose. just, we customize it for the individual. Michelle (20:33) And that crosses the blood brain barrier. So it's good for brain health, really for just everything. The system. Dr. Jeff (20:37) Yeah. Anywhere there's an inflammatory burden, we'll do it. But exosomes do cross the blood-brain barrier. And let me go off script here for a second. For listeners that have been pregnant before, in later trimesters, a pregnant woman has glowing skin and her hair is growing wonderfully. And typically, there's not a lot of joint pain, maybe Michelle (20:43) Mm-hmm. Dr. Jeff (21:06) low back pain from carrying the weight, why is that woman in, you know, not having this great skin and all that, it's because that woman is getting a daily dose of stem cell derived exosomes because they also not only cross the blood brain barrier, they cross the placental barrier. So what we do is almost simulate that in a single dose. Michelle (21:25) Mm-hmm. Got it. That's so interesting. in that case, when you are doing IV, is that also one and done? Dr. Jeff (21:37) No, like I was saying, it depends on what benefits someone gets and for how long they last. It could be depending on the person's need. Now, if it's someone who's got an inflammatory problem and they're just trying to get pregnant, could be a one and done. If it's someone that has benefited from it and wants to do it repetitively, then we would help support that and make it available. Michelle (21:43) I see. Mm-hmm. Done. Have you heard of this being used and injected directly into like uterus or those areas or is it typically more like IV? Dr. Jeff (22:11) So not into the uterus, although there are examples in men of injecting the testes where they're not producing adequate sperm counts. I think IV would be a first. So I didn't read anything about ovarian injection yet. Could that be coming? Possibly. IV is obviously an easier thing to do. So I would try the IV first. But you're right, you're going to get a higher dose if you inject directly. Michelle (22:20) Mm-hmm. Or ovaries maybe? Mm-hmm. Dr. Jeff (22:40) That might be something to look at. haven't done it. We do have some sexual health shots we do at the exosomes now where we do P shots and O shots for men and women respectively for improvement in sensation, lubrication, that kind of. Michelle (22:53) Mm-hmm. I know that they do PRP with the ovaries and I think also uterus. So that's why I was asking because it's kind of similar, you doesn't have the same exact substance, but it's the idea of stimulating. Dr. Jeff (23:14) No, I completely agree with that. PRP is basically a very lower, it's the lowest end self-donated regenerative medicine. And it probably contains some cells and some exosomes in there. Michelle (23:21) Mm-hmm. Right. So interesting. that's really fascinating. for you specifically, like if people wanted to work with you, do they have to come visit you, your office, where you are? Dr. Jeff (23:38) Not necessarily. So, you know, most of what we do, we start out remotely. The vast majority of my patients come from somewhere other than Las Vegas, where I'm located, actually Henderson, Nevada, which is a suburb of Las Vegas. Most people start remotely. We do a lot of the blood tests or if they need MRIs or what have you remotely, and we only invite them to come to town if there's a reason to come to town. We do have some other colleagues in other parts of the states too that can do IVs. things like that so we can sometimes refer. Yeah. Michelle (24:09) Mm-hmm. It's really fascinating. It seems like state of the art. It's like the new thing that's coming out. Dr. Jeff (24:13) and It's a, and there are things coming. if you'll allow me to just jump there for a second. you know, we are working on some projects here at, at my practice. one of them involves exosomes that are stuffed with extra mitochondria. And for those of you that don't know, that's a small part within the cell. It's kind of a cell within the cell. we learned in high school biology, it was the powerhouse of the cell. made the energy, but it actually does much more. Michelle (24:22) of course. Yeah. Hmm Dr. Jeff (24:46) And some causes of infertility relate to poor mitochondrial activity in the cells of the ovaries and things like that. So we're looking at exosomes that could be overstuffed with, that can donate more mitochondria. So that could be very useful. There are many other reasons to do that as well. And then we're even involved in a project that may be useful to help patients with cancer. And this is a particular exosome. that comes from a certain type of immune cell, a T cell in our body, whose job is to identify, circulate around the body, identify, and then selectively remove or kill an abnormal cell like a cancer cell. So imagine that as an augmentative therapy or even as a preventative. Yeah, so we're hot on that trail. That's coming soon to a, to a re-celebrate clinic near you. Michelle (25:36) That's fantastic. I love that. That's awesome. That's really amazing. And what have you seen so far in regards to fertility? you seen people do this treatment and it work? with fertility, there's so many different reasons for why. I mean, it could be so many different. It's really a range of underlying conditions, but what have you noticed so far? Dr. Jeff (26:03) Correct. So honestly, I don't have a fertility practice that's pretty far afield from what I do. I do a lot of structural work, a lot of joints, a lot of spine. We do some autoimmune and a few other things. But I have talked to colleagues, fertility specialists in the past, and we've talked about exosomes. I was at a biohacking conference in Texas last year. Michelle (26:11) Yeah. Dr. Jeff (26:32) the Dave Asprey event and someone came up to me and asked me about fertility. So I know it's on my radar. It's just not something we put out there necessarily. had one gentleman that had low sperm count. We had talked about doing something for him, but he didn't do it yet. Michelle (26:34) Mm-hmm. But have you seen or through colleagues or any studies that have shown even just IV, doing this with IV that it's helped? Dr. Jeff (27:00) I've only read the abstract of some of the Chinese studies because we don't always get the full article translated. But most of those studies speak to direct injection. They have a lot of animal studies. So I don't have information on the clinical use of... Michelle (27:07) Okay. Dr. Jeff (27:25) exosomes personally for fertility, but I know that others have talked to me about it. So it's being done. And I, I did look it up online before we met today and you can actually find, there was a clinic in Europe that was advertising it for this purpose for fertility. Yeah. Michelle (27:31) Mm-hmm. Interesting. Yeah, which I'm sure people don't really have to go all the way to Europe. I'm sure also if you get the IV and your body's going through this anti-aging and your mitochondria are benefiting and also, which is very much linked to aging eggs. So you want to like revitalize and reawaken and also lower inflammation that also helps with egg quality and sperm quality. Dr. Jeff (27:54) and Michelle (28:08) So this is just definitely something that I found when I saw you, I was like, this is really interesting. I think that it's something that people should be hearing about. And I'm sure I wouldn't be surprised if in the future, a lot of fertility clinics are going to start looking into this as well. Dr. Jeff (28:26) Yeah, no, the one that was advertising is an international fertility group, I think, in Eastern Europe. And they specifically have a webpage on this. Now, we can't have those webpages here in the US because we are not yet approved for marketing claims. Michelle (28:32) Mm-hmm. Mm-hmm. Right. It's so interesting how all that works. But yeah, this is great. This is a really interesting topic and really great information. I love like cutting edge stuff. I love that it's kind of like to be continued because you're still like, You already have learned so much, but of course, there's so much more coming, which is exciting. I find it really exciting. Dr. Jeff (29:00) Yeah. I do too. have this renewed interest. know, I'm, I'm a self admitted nerd. So this is, gets me back into things that are very exciting. I don't get to do the same thing day after day anymore. that's, that's. Michelle (29:19) I love that. Yeah, for sure. So awesome. So for people who want to learn more about you and what you do, how can they find you? Dr. Jeff (29:30) Check out Re-Celebrate because you're celebrating the renewal of your cells. That's spelled R-E-C-E-L-L-E-B-R-A-T-E. And that is our website is recelebrate.com. Instagram is recelebrate at recelebrate it. LinkedIn, Pinterest, YouTube, but just type in recelebrate, you'll find it. Michelle (29:52) Awesome. And you'll find it also in the episode notes. So I'll share all the links in there, as well as information about Dr. Jeff. So this is a great conversation. This is really, really great. And I appreciate you coming on and explaining it so nicely and really breaking it down for us, you know, people that don't have that background. So thank you so much for coming on today, Dr. Jeff. Dr. Jeff (30:03) Yeah. you It's been my pleasure, thank you for having me.Check out Michelle’s Latest Book: The Way of Fertility!
https://www.michelleoravitz.com/thewayoffertility
Instagram: @thewholesomelotusfertility Facebook: https://www.facebook.com/thewholesomelotus/ Transcript: Michelle (00:00) Welcome to the podcast, Karin. Caryn Johnson (00:02) Thank you. Thank you for having me. Michelle (00:05) It's so nice to meet you. And I know that you do a lot of amazing work helping women I also know that you have your own story that you can share. And I would love to hear your story and really what got you inspired to do the work that you're doing. Caryn Johnson (00:21) Yeah, absolutely. So I'm here to share really the start of how I got to where I am today. And that really is rooted in finding out that I couldn't get pregnant. So we can start there and then we can get into all of the details together. But my husband and I met when I was young, early 20s. And by the time we got married many years later, we were already most right away to start having a family. There was a piece of me inside that knew that I was gonna have some sort of issue. I don't know, you already mentioned that you do visualizations to me before we started. So, you know, like I just had this feeling whether I manifested it for myself or not. I, you know, we did the full year of trying to get pregnant to no success and then went back to our doctor. Michelle (01:03) Yeah, yeah. Caryn Johnson (01:18) my typical OB-GYN and started the path of IUIs, did four IUIs, had beautiful eggs, each IUI, and reacted to the medicine quite well, but never got a positive from any of those. So we were recommended to move towards IVF. found a reproductive endocrinologist in Chicago, which is where I was located at the time. started the path to IVF and went through the process of an egg retrieval. Ended up seeing similar to what we saw in the IUIs, which was that my reproductive system performed quite well. And I was able, they were able to retrieve just about 30 eggs from one retrieval, which is quite high, borderline too high, but. just shows like the reaction to the medicine and the overall viability of my reproductive system. Of that, I had really normal odds and was able to bank close to 14, I believe, quality grade embryos. So I was really excited to move into implantation because at that point, I just really thought like whatever was unexplained is just kind of, you know, over to the side now. you know, all these things are just working out in my favor. So this is gonna be, you know, it for me, which a lot of women I feel like go into IVF feeling like the IVF center is like the place where you get your baby, which isn't always true. So. I started doing implantations and I started losing babies. Prior to that point, I had never even tested positive in any sort of like regard for a pregnancy test. And I wasn't one of those that, you know, jumped right off birth control, you know, to move into conception. I hadn't been on birth control for many, many, many, many years, you know, prior to this point. But the implantations started failing and My doctor said, this embryo was only attached for two hours, maybe a couple of hours is what they said. I just thought, how on earth, like why on earth would something attach for just a couple of hours and then that be the situation where It just doesn't work out from there. Like what is happening? And you know, got immediately, the immediate response was bad odds. You know, this happens, miscarriage happens. Just keep going. You know, one in four, in eight, you you get all the stats and there's definitely a piece of that when you're not working with really good quality embryos. But you know, I was, I knew that everything was genetically great. knew. and had no reason to believe that my body wasn't in working order to, you know, produce a pregnancy. So I just started pushing harder and getting a little bit more more fearful of continuing down the path of losing babies because I just, it hit me so hard. Even the loss of two hours, I mean, I just like, I've never felt sorrow like that. And I didn't, I just didn't feel like myself or really anyone should have to like continue down that path for like the sake of odds. So I started doing my own research and I was at the time experiencing some issues in my digestive system. I also now looking back had a definite cortisol issue. which relates into the picture, but I was a CMO at Vital Proteins at the time, which is that blue tub collagen company. And so I had a high stress level and I knew that something was going on in my digestive system. This was, you know, 2016, 2015, 2016, 2017. So. Michelle (05:39) yeah. Caryn Johnson (05:58) almost prior to when we really started, you know, as a world, as a community talking about the microbiome and gut health. But I sought out a naturopath who ended up doing a blood panel on me and told me that I had, you know, hundreds of food sensitivities, which is a a classic sign of gut dysbiosis, but at the time it wasn't translated back to like an issue in the microbiome. It was treated as like, yes, you have all of these, you have all of these issues with, you know, different foods, just avoid them. And that will be the solve versus, why do you have like, you know, why do you have a hundred things that you can't eat? Michelle (06:42) Hmm. Caryn Johnson (06:46) like watermelon seeds up to your typical gluten, et cetera. So I just started doing my own research online and I found a book called, Is My Body Baby Friendly? It's written by Dr. Alan Beer, who is now deceased, but it's over 700 pages of the science of how the immune system works with your reproductive system, your hormones, et cetera. in order to effectively procreate or in order for conception and implantation to occur. And that's when I realized there was something greater going on in my body outside again of just my reproductive system that we just hadn't figured out yet. So I read the book Front to Back. It's a very science heavy book. So I had to do a lot of like thinking about new terms and figuring and trying to remember what I was learning. At the end of the book, there was a recommendation at the time, there are more doctors now, but at the time for three doctors that practice this type of medicine, which is the field of reproductive immunology. And so, Michelle (08:01) Mm-hmm. Caryn Johnson (08:03) One of those doctors, Dr. Joanne Kwok-Kam of Rosalind Franklin ended up being in my backyard essentially 45 minutes away in the Chicago area. So I took that as a sign that I needed to call and get additional help above and beyond my RE who was doing the IVF. And I called over there and was immediately put on a six month wait list. So proceeded with the next round of IVF because I was already on some hormones. So I was already going through the round. I had at that point only done my own research. So I wasn't really sure what was going on in my body or if I could believe what I had read because my doctors that were helping me with the IVF weren't really like saying that They believed in the immunology side of things. They hadn't seen enough research, et cetera. So I wasn't really getting support on what I was researching. So it was around the holidays, October-ish, when I ended up calling into the clinic and I ended up getting a call right around Thanksgiving that they had a cancellation and I got moved up on the wait list. So I ended up getting into the reproductive immunology clinic many months before they said I would two weeks before my next IVF transfer and that was just an awesome Hail Mary. They did a full ultrasound. So tip to toe thyroid, you know, your whole stomach area inside and outside. And then they do the craziest blood panel that I've ever done. don't know how you can even draw that much blood, but vials and vials of blood to look at immune markers in addition to hormone markers, vitamin markers, and your typical blood panel. And they called me back 48 hours later and said, need to cancel this implantation. You have the highest level of antibodies that we've ever seen. not that we've ever seen, but that we're able to track. So you're past like where the chart goes essentially. So if you proceed with your implantation, it's almost definitely gonna end in a miscarriage because your body is gonna fight it off. And at that point I was terrified because that was like the first real something's actually wrong with you that I had heard. Michelle (10:21) wow. Wow. Caryn Johnson (10:50) Everything else was just unexplained, unexplained, unexplained. And I just went into shock. I didn't know what to do. I didn't know who to believe. You know, I had two sets of doctors saying different things. So I proceeded with the implantation and I ended up implanting both a boy and a girl embryo. And then started treatment right away on my immune system through the reproductive immunologist. So what they did was they put me on a series of pretty intense medications to quiet my immune system. And then I did what is called IVIG, which are blood transfusions or infusions that essentially look to wash your blood of the antibodies that are over protecting the immune system. So I went into this protocol and I ended up getting pregnant. It was positive right away. we saw, so the clinic ended up treating me one to three times a week with this IVIG infusion, which they're about two to three hours long based on, they're based on body weight. Michelle (11:50) Mm-hmm. Caryn Johnson (12:14) I was in their office, you know, at least one to two times a week, also for an ultrasound. So I knew by five weeks that both embryos had attached. you know, at that point, my immune markers were even more all over the place. We couldn't get my immune system to a stable level by any means. And I ended up losing the girl embryo at seven weeks. her heartbeat slowed and then ultimately it stopped, which is one of the symptoms or issues when you have an autoimmune issue going into a pregnancy. So, you know, that was so sad and devastating and she was higher up in the womb than the boy embryo. So at that point, It was pretty much 50-50 odds of if she was going to end up coming out and bringing him with her or if she was going to be what's called a vanishing twin, which is when your body reabsorbs the pregnancy for the sake of the other pregnancy, which is really the best case scenario because then you don't lose the other baby. Michelle (13:18) my gosh. Caryn Johnson (13:36) I was put on bed rest. This was the start of my bed rest between six and seven weeks, which continued until I gave birth, basically. I was able to go to work, but that was pretty much it. And I lived in fear that we were going to lose a little boy, but I ended up reabsorbing the girl embryo. So she never came out and we just really aggressively treated my immune system. which held on until 34 weeks when I went into basically how the immune system works during the pregnancy is during the first trimester, there is more inflammation that can be in the body and then it has to subside for the second trimester to continue successfully and then your inflammation increases and that's eventually causes or is part of why you go into labor. But my inflammation and my immune system increased really fast. my water broke early and I ended up having him, you know, early but he was healthy because some of the immune medications included steroids. So he was a little bit bigger than, you know, your typical 34, 35 weaker. But I was able to carry my son and that really started my story of what the heck happened and why is autoimmunity so under researched when it comes to your reproduction and your fertility chances and how can I actually do more now that I have my children here. Michelle (15:06) Mm-hmm. Mm-hmm. Mm-hmm. Caryn Johnson (15:33) to support other women so they don't have to go through this amount of trauma, right? But also this amount of like research and advocacy for themselves because at the end of the day, like we just can't expect that from everyone and we shouldn't. We should be able to support. Yeah, so I'll take a breath there. Michelle (15:40) Mm-hmm. Yeah. Wow, that's incredible story. And I mean, it's it's mind boggling, you know, that, nobody really talks about something that is so prevalent. And I do see that a lot, actually. And it could be the reason why you have unexplained infertility or why transfers don't work. And I speak to Amy Ralph, Amy Ralph, she's a Caryn Johnson (16:19) Yeah. Michelle (16:20) she does the same thing, Chinese medicine. And she talks about this a lot. She says, if you miscarry or you have repeated transfer failures with a good embryo and your doctor doesn't look into like what your lining is doing and how your immune system is working, then go to a different doctor because it's so important to look into that because you could spend so much time. and you can spend so much money and just so many precious years going through so much loss for something that could be treated but can also be prevented. So I'd love to actually get your input on what you've discovered and how the gut relates to it but maybe other things that you've noticed or learned for the listeners. Caryn Johnson (16:59) Absolutely. Yeah, absolutely. And I think what you're saying is just incredibly important. Like the immune system, I feel like is the secret starting point to a lot of issues. And what's happening in medicine right now is a lot of women are walking away with an unexplained infertility diagnosis, but they're accepting that as a diagnosis, right? When it's not, it's just, it's not an answer. And if you look underneath kind of that answer, you see a lot of crazy statistics, such as over 65 % of women who have unexplained infertility actually have an issue in their immune system. And then similarly over 60 % have an issue in their metabolic system. So blood sugar, insulin, know, early signs of PCOS, et cetera. And then. Michelle (18:05) You Caryn Johnson (18:10) When you look, you see that there are deep, deep nutrient deficiencies happening in this group of women as well. So you're looking at vitamin D deficiencies, vitamin B deficiencies, magnesium, omegas. All of these start with modulations that occur in the immune system as well. So when you think about it on a deeper level and from the research that I've done, Michelle (18:23) Mm-hmm. Mm-hmm, yeah. Caryn Johnson (18:39) you're looking at something that's happened to you before it's affecting your hormones and triggering one of these other issues in your reproductive system. So like for instance, not only do I have, you know, autoimmune infertility, I do carry PCOS and adenomyosis as well. And for me, and based on the research that I've done, those are secondary factors. to my immune system modulating and creating an overly inflammatory environment in my body, which then produced those issues. So we're not going up far enough in the chain of our bodies as to understanding our full systems. And again, it kind of goes back to like what's happening in medicine, which is that our doctors are Classically trained in our reproductive organs, right? So they know our uterus they know our ovaries they understand how those work, but we need to get into you know, a new phase where we have Practitioners that understand how all of the systems are working together in our body Including our immune system and our endocrine system because they do have such a big and almost starting impact Michelle (19:57) Mm-hmm. Yeah. Caryn Johnson (20:07) on what's happening with our fertility. Michelle (20:10) yeah, I completely agree. And I also I'm wondering, like, what have you seen? Because I think that when you talked about the food sensitivities, you were saying that it's okay, I'm allergic to so many things, or I'm sensitive to so many things, but why? So like, what are the things that you've seen that cause it to begin with? Caryn Johnson (20:28) Yeah. Yeah. So there are a couple of things that I see as a starting factors. One is overall stress. So if you can't keep your stress in check, you can't keep your cortisol levels in check, then your adrenal function will not perform in the rest of your hormones will not function correctly, which then trickles into some of these other problems. and then you get into other factors like what you're putting in your body. the nutrition that you have or you don't have. They're saying the American diet is still between 60 and 80 % processed food. So we're putting still mostly junk into our systems that's modulating and creating these environments that we don't want. Number three is dysbiosis of the gut, right? Which is a huge factor in Michelle (21:13) Mm-hmm. Yeah. Caryn Johnson (21:31) overall well-being and then your chances at fertility because what happens is that if your gut is in dysbiosis, your mucosal lining is disrupted and all of the toxins that are supposed to be in this like, think of it like pipe in your body, piped to get to the outside are now permeating that pipe and moving into your system and causing again, these major inflammation issues. these, this uproar of immune response that is hard to counteract. You know, once you have that level of bacteria and then toxins that are entering the bloodstream. And then the last kind of reason that you would be kind of in this situation is just based on what's going on in your environment. So are you living in a city, you know, that a lot of people in Detroit, for instance, there's a bigger rate of infertility there versus, you know, your non-city residents. It's also based on the toxins that enter your home. So are you getting rid of your plastics? Are you looking at the cleaning supplies you're using, the makeup you're putting on your face? It seems simple, but this toxic overload, again, Michelle (22:52) Mm-hmm. Caryn Johnson (22:55) creates this inflammatory response, which modulates your immune system. So those are really the four categories that kind of put you in this place. And then it kind of gets into epigenetics, which is like, you know, you've created this new world for yourself that your body has become. And, you know, is it going to be like that or are you going to be able to get yourself out of it? Michelle (23:23) Yeah. my God. It's so important and it's true. We hear all the different factors and actually those toxins and the endocrine disruptors can be found in food, I mean, through pesticides and that can also impact your gut dysbiosis. so it's just, it's like an entangled web and it really is like a reflection of how we're living today and what's allowed in this country, which Caryn Johnson (23:38) Yeah. Yeah. Michelle (23:50) I'm starting to get more and more frustrated with, you know, the fact that other countries are protecting their citizens more from chemicals and pesticides and things that are harming not only our health and chronic disease, also future. it's, it's unbelievable. And for that reason, I often tell people just go gluten free. It's not that. Caryn Johnson (23:58) Yeah. Gosh, get me started on glyphosate. It's so sad. Mm-hmm. Michelle (24:16) It's not that wheat is bad. And actually, as a matter of fact, a lot of people don't have those same responses if they go to Spain or Italy, even though it's not considered GMO, they have genetically modified it over the years. So there's so many aspects. So sometimes I'm just like, just remove it, And I see people feeling a lot better. Caryn Johnson (24:26) Right. Yeah. Michelle (24:41) just from that, and especially with autoimmune conditions, actually that like going gluten free can really help. That's what I've seen. Caryn Johnson (24:50) Yeah, no, definitely. It's just our food source is really sad. And it's just, it's so hard to pinpoint at the end of the day because no one really has the exact answer. But I just like, you see the data, like women who are eating on a Mediterranean diet have a lower risk of endometriosis. Michelle (24:55) Yeah. Mm-hmm. Caryn Johnson (25:15) women who have like vitamin sources through green leafy vegetables don't have as much PMS. So like the correlations are there. It's just like, how do we get people to make better decisions for their body and understand like, don't be me, don't make bad decisions and then get into a position where you can't have the life that you wanted or dreamed of, or you have to fight so hard for it because Michelle (25:16) Right. Yes. Mm-hmm. Caryn Johnson (25:43) of choices you made earlier in your life from lack of knowledge, you know? Michelle (25:47) Right. Yeah, totally. And then I also look at the nervous system, which is what you're, I feel like it's really linked to the cortisol issue, like the high stress, because we're constantly being bombarded with too much information. Really, I think too much information that our nervous system is able to translate. And I think that takes a trickle down effect into our bodies. I'm very big on like mind body because of that, you know, like that, that's one aspect, but of course, I mean, there's so many Caryn Johnson (26:02) Mm-hmm. Yeah. Michelle (26:16) Like I said, it's like a web and every single piece matters. And that's what you were talking about before with medicine, looking at the body as a whole, as a functioning system, rather than just one part. Caryn Johnson (26:21) you Right, right. And just going back to your comment on cortisol, you know, a lot of it does start with cortisol because if you put yourself into too high of a cortisol state, your body doesn't produce enough hormones. It basically triggers all of your other hormones to act inappropriately. It goes into your progesterone receptor. Michelle (27:00) Mm-hmm. Yeah. Caryn Johnson (27:00) pretends it's progesterone and then it goes on your thyroid and says slow down, slow down. Your body doesn't have enough energy for this and your thyroid slows. So it's really like easy to dismiss like, yeah, I'm so stressed but I don't have to be stressed today and to understanding like if your body is in a constant state of stress, like the impact it can truly have on your system and on your hormones because Michelle (27:27) Mm-hmm. Caryn Johnson (27:30) I guess also people think of like cortisol is like over here and then estrogen and progesterone as like over here because they work through different axes of the body, right? But it's all related because if you knock one off, you're messing with the others. So I just, I wish people ultimately would understand that cortisol is a huge starting factor to their fertility journey as well. Michelle (27:38) Mm-hmm. Right. Yes. Caryn Johnson (27:57) and to a hormone journey if they're not on the road to fertility. Michelle (28:02) Yes, because ultimately the body's always going to favor survival. And when you're in high cortisol, your body's basically or something is signaling your body to let it know it's not safe. So when you're constantly in this state of feeling unsafe, your body's going to worry about other things and put off other factors that it would normally pay attention to when you do feel safe. Caryn Johnson (28:08) Yeah. Right. Michelle (28:32) And being in this chronically is just not conducive to high vitality period. Caryn Johnson (28:32) Right. Yeah, I feel like at least we're in a better state of mind, like as a world where, you know, 10 years ago it was chic and cool to be like chronically stressed and like drinking like three cups of coffee in the morning and like running yourself ragged. Like I feel like everyone understands a little bit more that they shouldn't. It's just about like knowing your body and actually being able to say to yourself like, no, this isn't how I should. Michelle (28:52) It's true. Yeah, that's a good point. Yeah. Caryn Johnson (29:09) be feeling. This isn't how I want to keep stress or maintain like my day-to-day life. Michelle (29:17) No doubt that we are getting educated like never before. like, it's, it's one of those things that when like the information comes out and we start to open our eyes, it's painful because we're realizing things that are not working. However, even though it's painful, it's actually helping us in the long run. And it's kind of like the, blessing and the curse of social media and all of the technology, but the blessing is information. Caryn Johnson (29:28) Right. Yeah. Michelle (29:45) that is very important for us to know it's important for us to receive. So that aspect of it is really important. And then talk to us about your supplement product bond. And I know that you created that based on really your own frustration and it's become your baby. And I want to know what specifically or how does that address autoimmunity conditions for people who are going through that or? Caryn Johnson (30:03) Yeah. Michelle (30:14) least thinking maybe to look into their immunity in regards to their fertility, listening to this. Caryn Johnson (30:21) Yeah, absolutely. So I launched Bond just about a year ago. I concepted it. took a year prior to that from concept to launch. So really it started in the world of advocacy for me. I was just really looking to help other women getting involved in some Facebook groups, some communities. you know, there's not a lot of knowledge, a lot of people talking about this yet. There certainly wasn't, you know, even just a few years ago. so I, I took a speaking opportunity in Detroit and I went to Wayne State University, which is where they do a lot of the research for autoimmune infertility. the main head of that clinic asked me to come and speak to the researchers because they do all of this research and it's isolated into their facility. They don't actually see the impact of what's going on with women who are going through this. Michelle (31:24) Mm-hmm. Caryn Johnson (31:25) so I got to share my story and, you know, had a really nice day there learning and seeing their facility, their lab, what's going on. And on the drive home is really when it clicked for me that there's a lack of, or there's a gap in what's going on research wise and, know, what's being discussed and what's being carried out and brought to. the consumer or the public's attention. And I just felt like if I didn't take a larger stand to do something bigger to help women, that we'd be many, many more years behind even. So I went back to my house in Chicago, sat in my basement and did just clinical research for months. And I logged over 300 clinical studies, all centered around the immune system and how it relates to hormones to the reproductive system and built my thinking for original skews, which were, which are daily balance, which is our best seller conception boost, vitality, and cycle care on this thinking first. so it really started with research before it was brought forward to healthcare practitioners and then formulated out. And a lot of the research that went into each of the products is above and beyond supporting the reproductive organs. So when you look at daily balance as a whole, it has 15 vitamins and nutrients in it. And a lot of those vitamins and nutrients were chosen to not only support hormone balance, but to take that up a level and to support the immune system as it relates to being a predecessor to hormone balance. So adding a vitamin D, which is a huge hormone regulator, putting fiber, five grams of it into a supplement so that women are potentially protecting their gut lining better and producing those short chain fatty acids that are going to protect their gut in a way that just probiotics don't. Adding in a probiotic blend that we studied as being healthy strains, or not healthy strains, but strains from healthy fertile women. So really focusing on these immune factors and how they pull into the world of fertility. But to the public now, you know, almost simplifying that message and making it more of like the underlying theme because we're still not necessarily totally there. so the ingredients exists in these formulas with so much thinking and thought as it relates to the whole body. and then the formulas come out and, they're focused on hormone balance, right? As well as we have a conception product, and then we have our cycle care product, which is focused on, PMS support. So PMS, symptom alleviation, and then hormone detoxification. Michelle (34:16) Mm-hmm. Caryn Johnson (34:44) So they all have an immune angle, also address a hormonal need. And the other great thing too is that you can shop at a discount as a special thanks for listening to us here. You can head over to the link. We'll link it here with this podcast episode and use the code, the wholesome to get 20 % off your order. Michelle (34:54) Awesome. And do you have information on your site, just like support for people wanting to learn more? Caryn Johnson (35:00) Yeah. Yeah, absolutely. we're starting to add more and more to our site. I wrote a white paper on how the microbiome affects fertility that you can download off of our website as well to get more information. And yeah, we share a lot on social too with, you know, article connections there. So that's another great way to keep up with kind of like up and coming research that we're seeing. Michelle (35:32) Mm-hmm. Caryn Johnson (35:33) But yeah, I would say too, just going back to one other thing you mentioned earlier on the, on the doctor front, the best thing to do as a consumer, like when you're hitting these issues is to bring the articles in and show them to your doctor and choose advocacy for yourself. Because I found that the response from them is far greater when you have data in your hands as to why you want to. Michelle (35:51) Mm-hmm. Yeah. Caryn Johnson (36:03) add a supplement, think about a different form of medication, think about a different program that might make sense for your system. So I would say, you know, that is as important as ever. And, you know, what we try to do more and more is link that PIMD article, like when we post something so that you can find the actual source and see for yourself, you know? Michelle (36:24) Mm-hmm. Yeah. Caryn Johnson (36:31) read the information and make smart decisions. Michelle (36:31) Mm-hmm. I love that. That's great. I'm all about empowerment. think that we need a lot of that now. So this is great information. I really appreciate you sharing your story for people listening. And for people who want to find you and learn more, how can they find you? Caryn Johnson (36:41) Yeah. Thank Sure, so our website is bond.life. Our Instagram is underscore bond life and we're, you know, a newer company. I'm still really involved on our social. So we love to take DMs and interact with people one-on-one that way. If you have any questions or want to get into, you know, what you might be experiencing and what our different products are, like we're happy to get into it with you and. I will say for anyone that wants to shop on bond on our website, absolutely love to support you. And again, really the place to start with, with us is our daily balance product. has the baseline of nutritionals you need to support your nutrients stores, your hormonal balance, and of course, your immune system. that is our purple bag on the website there. But Michelle, thank you so much for having me. I really appreciate this opportunity. Michelle (37:57) Yeah, it was great having you on and having this conversation, which I feel like is so important because it is kind of like the big question mark that a lot of people are facing when they're trying to conceive. So thank you so much for coming on. Caryn Johnson (38:09) Yeah, you're welcome.Your feedback is valuable to us. Should you encounter any bugs, glitches, lack of functionality or other problems, please email us on [email protected] or join Moon.FM Telegram Group where you can talk directly to the dev team who are happy to answer any queries.