In a recent Viewpoint published in JAMA, Michael Pencina, PhD, of Duke University, argued for a federated registration system for AI tools deployed in health systems. He joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss his article, the Coalition for Health AI (CHAI), and more. Related Content:

• Health Systems Are Struggling to Keep Up With AI—A National Registration System Could Help
• A Federated Registration System for Artificial Intelligence in Health

Cardiologist Amit Khera, MD, chair of the American Heart Association’s recent flagship meeting, discusses some of the most important clinical studies presented at the conference with JAMA Medical News Director Jennifer Abbasi. They touch on antiobesity drugs, new compounds to reduce lipoprotein(a), AI tools, and more. Related Content:

• Lp(a) Reduction, GLP-1s for Heart Failure, and More—Highlights From the AHA Scientific Sessions

In resource-limited settings, an integrated AI tool allows novice users to improve gestational age estimates. Jeffrey Stringer, MD, University of North Carolina, joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss "Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps." Related Content:

• The Low-Cost, Battery-Powered AI-Enabled Ultrasound Device That Could Improve Global Obstetric Care
• Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps

Effective communication is essential in medicine, yet language barriers can result in suboptimal care. AI holds promise for bridging these gaps, enhancing outcomes, and reducing disparities. Casey Lion, MD, MPH, from the University of Washington School of Medicine, joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, to discuss AI as an interpreter in the clinic. Related Content:

• Researcher Explores Using AI to Overcome Language Barriers With Patients
• Artificial Intelligence for Language Translation

How Antibiotic Underuse Is Driving Antimicrobial Resistance; What to Know About the XEC SARS-CoV-2 Variant Related Content:

• UN Meeting Highlights Antimicrobial Resistance “Epiphany”—Lack of Antibiotic Access Is a Key Driver
• What to Know About XEC, the New SARS-CoV-2 Variant Expected to Dominate Winter’s COVID-19 Wave

A recent Special Communication published in JAMA points out that the FDA has already approved nearly 1000 devices using AI. Author Robert M. Califf, MD, commissioner of the US Food and Drug Administration, joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss AI regulation. Related Content:

• FDA Commissioner Robert Califf on Setting Guardrails for AI in Health Care
• JAMA AI Interview With Robert M. Califf, MD
• FDA Perspective on the Regulation of Artificial Intelligence in Health Care and Biomedicine

A recent JAMA Cardiology essay argues that medicine is not just a technical endeavor, it's also a moral endeavor, and a robot does not have moral agency. Coauthor Sarah C. Hull, MD, MBE, of Yale School of Medicine, joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, to discuss the use of AI in managing decision-making in cardiac care. Related Content:

• AI Can’t Worry About Patients, and a Clinical Ethicist Says That Matters
• Echoes of Concern—AI and Moral Agency in Medicine

Widespread adoption of AI raises questions about accountability, transparency, and reproducibility. Marcia McNutt, PhD, president of the National Academy of Sciences, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss advancing scientific knowledge in the age of AI. Related Content:

• National Academies President on How to Use Generative AI Responsibly in Scientific Research

Researchers Are Exploring the Role of Shingles—and a Protective Role of Shingles Vaccine—in Dementia; Could the Body Roundness Index One Day Replace BMI? Related Content:

• Researchers Are Exploring the Role of Shingles—and a Protective Role of Shingles Vaccine—in Dementia
• Could the Body Roundness Index One Day Replace the BMI?

Getting genuinely useful new technologies, from wearables to clinical decision support, into the clinic has proven to be surprisingly challenging. Tanzeem K. Choudhury, PhD, of Cornell Tech joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss how to take research into the real world in a way that is scalable and affordable. Related Content:

• How Health and Technology Sectors Can Collaborate on Better AI-Assisted Wearables

What hard lessons did the US Department of Veterans Affairs (VA) learn in 3 decades of EHR development, and what can it teach us about building better AI in medicine? Stephen Fihn, MD, MPH, of the University of Washington, and formerly a leader in the VA’s EHR efforts, joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss his experience at the VA building decision support tools and other technology. Related Content:

• The VA Was an Early Adopter of Artificial Intelligence to Improve Care—Here’s What They Learned
• Hello, World—Introducing JAMA+ AI