With accelerating global adoption of AI, countries are developing ethical AI frameworks to prevent harm to the most vulnerable populations. Maria Villalobos-Quesada, PhD, from the University of Barcelona, discusses this and more with JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH. Related Content:

• Study Finds Limited Evidence to Support More Than 40 Predictive Machine Learning Algorithms Used in Primary Care
• Availability of Evidence for Predictive Machine Learning Algorithms in Primary Care
• The Need for Continuous Evaluation of Artificial Intelligence Prediction Algorithms

American Indian and Alaska Native communities have higher rates of suicide than any other racial or ethnic group in the US. A recent study published in JAMA Network Open describes an AI-based suicide screening tool investigated in an American Indian community. Author Emily Haroz, PhD, of Johns Hopkins Bloomberg School of Public Health, joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH. Related Content:

• How AI Could Help Clinicians Identify American Indian Patients at Risk for Suicide
• Performance of Machine Learning Suicide Risk Models in an American Indian Population

How can hospitals use early warning score tools to risk stratify patients without adding to alarm fatigue? Dana Edelson, MD, MS, of the University of Chicago joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss a recent study published in JAMA Network Open that she coauthored, comparing 6 early warning scores designed to recognize clinical deterioration in hospitalized patients. Related Content:

• Researchers Compared Hospital Early Warning Scores for Clinical Deterioration—Here’s What They Learned
• Early Warning Scores With and Without Artificial Intelligence

Why COVID-19 Vaccines Don’t Stop Transmission; Hospital-at-Home—But Make It Virtual Related Content:

• In Search of COVID-19 Vaccines That Elicit Mucosal Immunity and Stop Transmission
• The Next Step in Hospital-at-Home Care Could Be Virtual

Chatbots may have a role in enhancing clinical care, but the best way to apply them remains a work in progress. Jonathen Chen, MD, PhD, and Ethan Goh, MD, MS, of Stanford, join JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, to discuss their randomized clinical trial published in JAMA Network Open investigating the use of chatbots in clinical practice. Related Content:

• An AI Chatbot Outperformed Physicians and Physicians Plus AI in a Trial—What Does That Mean?
• Large Language Model Influence on Diagnostic Reasoning

In a recent Viewpoint published in JAMA, Michael Pencina, PhD, of Duke University, argued for a federated registration system for AI tools deployed in health systems. He joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss his article, the Coalition for Health AI (CHAI), and more. Related Content:

• Health Systems Are Struggling to Keep Up With AI—A National Registration System Could Help
• A Federated Registration System for Artificial Intelligence in Health

Cardiologist Amit Khera, MD, chair of the American Heart Association’s recent flagship meeting, discusses some of the most important clinical studies presented at the conference with JAMA Medical News Director Jennifer Abbasi. They touch on antiobesity drugs, new compounds to reduce lipoprotein(a), AI tools, and more. Related Content:

• Lp(a) Reduction, GLP-1s for Heart Failure, and More—Highlights From the AHA Scientific Sessions

In resource-limited settings, an integrated AI tool allows novice users to improve gestational age estimates. Jeffrey Stringer, MD, University of North Carolina, joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss "Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps." Related Content:

• The Low-Cost, Battery-Powered AI-Enabled Ultrasound Device That Could Improve Global Obstetric Care
• Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps

Effective communication is essential in medicine, yet language barriers can result in suboptimal care. AI holds promise for bridging these gaps, enhancing outcomes, and reducing disparities. Casey Lion, MD, MPH, from the University of Washington School of Medicine, joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, to discuss AI as an interpreter in the clinic. Related Content:

• Researcher Explores Using AI to Overcome Language Barriers With Patients
• Artificial Intelligence for Language Translation

How Antibiotic Underuse Is Driving Antimicrobial Resistance; What to Know About the XEC SARS-CoV-2 Variant Related Content:

• UN Meeting Highlights Antimicrobial Resistance “Epiphany”—Lack of Antibiotic Access Is a Key Driver
• What to Know About XEC, the New SARS-CoV-2 Variant Expected to Dominate Winter’s COVID-19 Wave

A recent Special Communication published in JAMA points out that the FDA has already approved nearly 1000 devices using AI. Author Robert M. Califf, MD, commissioner of the US Food and Drug Administration, joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss AI regulation. Related Content:

• FDA Commissioner Robert Califf on Setting Guardrails for AI in Health Care
• JAMA AI Interview With Robert M. Califf, MD
• FDA Perspective on the Regulation of Artificial Intelligence in Health Care and Biomedicine