Psychopharmacology and Psychiatry Updates

Psychopharmacology and Psychiatry Updates

Psychopharmacology Institute

11 minutes 40 seconds

KarXT: A New Dawn in Antipsychotic Treatment
In this episode, we explore KarXT, a groundbreaking experimental antipsychotic that works through the cholinergic system rather than dopamine pathways. Could this novel approach revolutionize schizophrenia treatment by offering similar efficacy to current antipsychotics but without the motor side effects?

Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.
26 January 2025, 5:00 pm
10 minutes 50 seconds

Rethinking Agitation Management: From Force to Partnership
In this episode, we explore evidence-based pharmacologic strategies for managing acute agitation in emergency settings, challenging the stigmatizing concept of “chemical restraints” and providing practical approaches to achieve optimal patient outcomes. Did you know that many agitated patients can actively participate in medication decisions, even during a crisis?

Faculty: Scott Zeller, M.D. Host: Richard Seeber, M.D.
21 January 2025, 5:00 pm
10 minutes 56 seconds

COVID Brain Fog: Repurposing Famotidine
In this episode, we explore how famotidine, a common heartburn medication, might help treat post-COVID brain fog. New research suggests this H2 blocker could improve cognitive function in recovering patients. But how does a stomach acid reducer potentially clear mental haziness?

Faculty: Scott Beach, M.D. Host: Richard Seeber, M.D.
16 January 2025, 5:00 pm
11 minutes 45 seconds

Beyond Restraints: De-Escalation in Behavioral Emergencies
In this episode, we explore nonpharmacologic strategies for managing agitated patients, focusing on verbal de-escalation techniques. Did you know that using physical restraints adds an average of four hours to an emergency department stay? Dr. Scott Zeller shares evidence-based approaches to transform crisis intervention in emergency settings.

Faculty: Scott Zeller, M.D. Host: Richard Seeber, M.D.
11 January 2025, 5:00 pm
13 minutes 34 seconds

Rethinking Antipsychotic Dosing: Lessons from the RADAR Trial
In this episode, we explore the RADAR trial's findings on antipsychotic dose reduction in schizophrenia. Can patients with chronic schizophrenia safely reduce or discontinue their antipsychotic medications without increasing relapse risk? The trial's results challenge common assumptions about medication reduction and provide crucial guidance for clinical practice.

Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.
6 January 2025, 5:00 pm
11 minutes 6 seconds

Unraveling Agitation: Mania vs. Substance Use
In this episode, we explore the challenges of diagnosing and managing agitation in emergency settings, focusing on mood disorders and substance use. Dr. Scott Zeller shares insights on differentiating acute mania from substance-induced psychosis. How can clinicians navigate the complex interplay between psychiatric symptoms and substance effects in emergencies?

Faculty: Scott Zeller, M.D. Host: Richard Seeber, M.D.
1 January 2025, 5:00 pm
11 minutes

Pushing the Boundaries: Exploring High-Dose Antipsychotics
In this episode, we explore the use of high-dose olanzapine as a potential alternative to clozapine for treatment-resistant schizophrenia. We discuss a systematic review that examines the efficacy and safety of olanzapine doses above the FDA-approved maximum. Could high-dose olanzapine be a viable option when patients refuse clozapine?

Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.
27 December 2024, 5:00 pm
15 minutes 19 seconds

The Psychodynamic Prescriber
In this episode, we explore how integrating psychodynamic principles into pharmacotherapy can enhance treatment outcomes. We discuss seven key features of psychodynamic psychotherapy and their application in routine psychiatric practice. How might understanding a patient's fantasies about their illness impact their response to medication?

Faculty: David Mintz, M.D. Host: Richard Seeber, M.D.
22 December 2024, 5:00 pm
9 minutes 43 seconds

From Inpatient to Outpatient: Initiating Benzodiazepine Tapering
In this episode, we explore strategies for discontinuing benzodiazepines in hospitalized elderly patients. We discuss a recent Israeli study that tested two interventions during inpatient stays. Can a simple hospital-based intervention lead to successful long-term medication changes?

Faculty: Paul Zarkowski, M.D. Host: Richard Seeber, M.D.
17 December 2024, 5:00 pm
14 minutes 14 seconds

The Power of Alliance in Psychopharmacology
In this episode, we explore the critical role of therapeutic alliance in psychopharmacology. We discuss how factors like empathy, communication, and shared decision-making can significantly impact treatment outcomes. Did you know that a doctor's warm voice can increase appointment adherence by 162%?

Faculty: David Mintz, M.D. Host: Richard Seeber, M.D.
12 December 2024, 5:00 pm
8 minutes 27 seconds

Antipsychotics in Youth: Balancing Metabolic Risk
In this episode, we explore the cardiac and metabolic safety profile of antipsychotics in youth, based on a World Health Organization Safety Database analysis. We discuss age-dependent risks, specific medication concerns, and the importance of monitoring. How can clinicians balance the benefits of antipsychotics with potential cardiometabolic risks in young patients?

Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.
7 December 2024, 5:00 pm
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