Humans construct their physical worlds in part by designing and constructing new tools, habitations, and in due course diverse buildings and, in some cases, towns and cities and construct their symbolic worlds by putting words together to tell stories, articulate plans, tell lies, seek truth, and much more. This talk offers hypotheses that address a key question for anthropogeny: How did biological evolution yield humans with the “construction-ready brains” and bodies that made us capable of the cultural evolution that created the diversity of our mental and physical constructs that we know today? Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40161]

Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]

This talk provides a deep time perspective for assessing the behavioural implications of the creation of the earliest known structure and the technologies used in its making. Evidence for the earliest structure appears relatively late, about 500,000 years ago in Zambia, and before the evolution of Homo sapiens. The next oldest structures were made by Neanderthals in Europe, 176,000 years ago. The site in Zambia preserves rare evidence for the shaping and fitting together of two tree trunks to make a stable framework. The process of combining parts to make a whole reflects a conceptually new approach to technology, one which remains central to everything we make as humans, including structures. Did the invention of combinatorial technology require the use of language to discuss and evaluate diverse ways to form new constructs and constructions? This question arises from the extended planning and expertise needed in the making of combinatorial tools.    Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40160]

Dennis O. Clegg, Ph.D., discusses treatments for age-related macular degeneration (AMD), a condition that causes vision loss. Clegg explains that while patients often report improved vision after receiving implants, objective tests don't always confirm this. He explores the potential differences in patients' responses based on genetics and disease progression. There is also an ongoing challenge in finding the best ways to reduce immune rejection of these treatments. New trials are underway to test implants in earlier stages of the disease, and researchers are looking at different strategies like localized immunosuppression. Additionally, some studies suggest that secretions from retinal cells may help preserve vision. Overall, there are many open questions, but advances in the field offer hope for better AMD treatments. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39459]

At a global level, Homo sapiens have reshaped the planet Earth to such an extent that we now talk of a new geological age, the Anthropocene. But each of us shapes our own worlds, physically, symbolically, and in the worlds of imagination. This symposium focuses especially on one form of construction, the construction of buildings, while stressing that such construction is ever shaped by diverse factors from landscape to culture and the construction of history embodied in it - and more. After a brief look at birds building their nests as an example of variation on a species-specific Bauplan, we sample a broad sweep of cultural evolution and niche construction from the earliest stone tools of Neanderthals and Homo sapiens through the Neolithic and the rise of cities to the formal and informal architecture of the present day. Finally, we explore the ways artificial intelligence may further change how humans construct their mental and physical worlds. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40169]

As distinct from the buildings of termites (interesting though these are), bird nests offer a more apropos point of comparison for human buildings – they are conducted by single vertebrate (or a few) and can be adapted to varied circumstances, with even a small effect of social learning. However, the basic Bauplan remains species-specific, unlike the creativity of the human architect. Since nonhuman primates lack interesting building skills, and so we suggest that bird nest construction may come to play a similar comparative role for architectural design. The static Bauplan of birds can be compared to the near-stasis of human tool use until the end of the Paleolithic, challenging us to assess the changes in human practice that unlocked an increasingly rapid process of cultural evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40159]

Our respiratory system provides oxygen to and removes carbon dioxide from the body. To function properly, the lungs need to fill up with fresh air upon inhalation. Unfortunately, for a variety of medical reasons, the amount of air that reaches the lungs can be insufficient, causing respiratory distress. Healthcare providers often administer liquid drugs in the trachea to ensure prompt relief. In this program, Emilie Dressaire, professor of mechanical engineering at UC Santa Barbara, discusses how the liquid drugs make their way down to the lungs. To answer open questions on drug delivery, her team has built an experimental system that is currently in Space. She presents the journey from UCSB to the International Space Station and shares the first results. Series: "GRIT Talks" [Science] [Show ID: 40087]

Every building – from the Parthenon to the Great Mosque of Damascus to a typical Georgian house – was influenced by the energy available to its architects. This talk offers a historical perspective on a topic of great relevance today, the linkage of architecture and energy. It provides a useful complement to the non-urban perspective on ecology offered by the talk on “The indigenous architecture of Australia.” Architecture has been shaped in every era by our access to energy, from fire to farming to fossil fuels. The talk will discuss a range of buildings of the past fifteen thousand years from Uruk, via Ancient Rome and Victorian Liverpool, to China's booming megacities. If we are to avoid catastrophic climate change one important ingredients is to design beautiful but also intelligent buildings, and to retrofit - not demolish - those that remain. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40166]

How secure are computers and how does artificial intelligence impact security? In this program, Christopher Kruegel, professor of computer science at UC Santa Barbara, explores two key questions related to security and artificial intelligence. First, how AI can help to improve security. For decades, security solutions have leveraged traditional machine learning models. Not surprisingly, recent advances in AI have opened up exciting new opportunities. Second, the security of AI systems themselves. Like any other software application, they can be exploited. Given their often-critical role, it is imperative to secure AI against attacks such as training data poisoning and adversarial inputs. Series: "GRIT Talks" [Science] [Show ID: 40086]

Human "place-making" began over a million years ago when early humans made the hearth the center of social life. By 450,000 years ago, they were using caves in southwest Asia and sometimes buried their dead beneath the floor, linking memory-making with place-making. Hunter-gatherers started settling seasonally around 24,000 years ago, with permanent stone settlements by 13,000 BCE. Large, co-resident communities became common in the Holocene. The Neolithic (9600-6000 BCE) saw major social, economic, and cultural innovations, including architecture, monuments, and symbolic systems. Neolithic societies, with their complex economic relations, proto-urban patterns, and ritualistic architecture, were the first "imagined communities," deeply tied to memory and social symbolism. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40163]

Proteins are large biomolecules that play critical roles in a host of cellular processes, from cell signaling to regulating the immune system. However, these life-giving proteins can form toxic aggregate species that have been linked to several neurodegenerative diseases, including Alzheimer’s Disease and Parkinson’s Disease. In this program, UC Santa Barbara professor Joan-Emma Shea discusses the tau protein as a model system to study neurodegeneration. Shea says this protein plays a functional role in stabilizing microtubules in brain cells, but it can also self-assemble to form amyloid fibrils (large “clumps” of Tau proteins). There are several neurodegenerative diseases linked to tau assembly, including Alzheimer’s Disease, Pick’s Disease, and chronic traumatic encephalopathy, and they are collectively known as tauopathies. Shea discusses new insights into tauopathies and targets for therapeutics. Series: "GRIT Talks" [Science] [Show ID: 40083]