Friends,

I recently sat down with Dr. Colleen Cutcliffe, CEO of Pendulum Therapeutics, for a discussion about probiotics, metabolism, and a potential natural alternative to GLP-1 drugs like Ozempic. Here's why I'm excited to share this with you...

The Backstory

A month ago, I ran into a friend who had slimmed down and was looking fit. These days, I’ve had a good dozen or so friends lose weight with GLP-1 drugs, so I was surprised when she told me it wasn’t Ozempic but Pendulum's new GLP-1 probiotic. Her chocolate cravings (her usual downfall) had changed entirely. Instead of demolishing a whole bar, she could have one bite and walk away satisfied.

I've known Pendulum for years (we invested at True), and I've personally used their glucose control product with great success. However, I had lost touch with Colleen and didn’t realize they had a new GLP-1 product — so I asked her to come on the podcast and discuss it.

Note: Peter Attia did a much longer and more thorough deep-dive with Colleen, found here

What Makes This Different?

In my interview with Colleen, she explained how their probiotic actually helps your body produce its own GLP-1 hormone naturally. The science is fascinating – they've identified specific strains of bacteria that, when delivered to your gut's distal colon, help stimulate natural GLP-1 production. No shots, no prescription.

The results are pretty impressive; 91% of users reported reduced food cravings after six weeks*, and the higher the initial cravings, the more significant the improvement.

Why This Matters

Over the last year+, I've watched friends scramble to find GLP-1 prescriptions, hitting up sketchy compounding pharmacies, or paying astronomical prices when their insurance won't cover them. It's wild out there.But obesity isn't just about weight – it's tied to heart disease, diabetes, cancer, and even cognitive decline (some scientists are calling Alzheimer's "Type 3 diabetes"). We need better solutions that are both accessible and backed by science.

Join Our Mini-Trial

Sadly, the trial is now closed — thanks to all who participated!

What's Next?

We'll be collecting data throughout the trial and sharing the results with participants. Stay tuned for updates on how the community is progressing.

Exciting stuff ahead! As always, I'd love to hear your thoughts and experiences if you decide to participate.

Until next time, be well,

*based on a consumer survey of 274 people

This is the podcast of the full article found here.

Very Important Note:All future episodes of Diggnation will be posted to the official Diggnation channels, not here on the Kevin Rose Show feed. Get your favorite feed (Youtube, Spotify, Apple, RSS) right here on the new website — www.diggnation.show

Also, looking for fun clips?

* Diggnation Instagram

* Diggnation TikTok

In this inaugural AMA episode of The Kevin Rose Show, Kevin dives deep into personal growth, mental health, and the entrepreneurial journey, sifting through over 100 audience-submitted questions. Joined by his friend Chris Hutchins, the conversation touches on childhood trauma, managing stress, and the balance between building wealth and maintaining personal relationships. Kevin shares candid insights on his therapy practices, including Internal Family Systems (IFS), and provides advice on establishing boundaries, avoiding burnout, and staying creative amidst the chaos of a busy life.

Listeners will also get a peek into Kevin’s fitness routine, crypto strategy, and tips on fostering creativity in children. Whether you're looking for actionable advice on entrepreneurship, exploring the future of AI and digital minimalism, or just trying to figure out how to juggle family and business, this episode is packed with raw, honest insights and plenty of wisdom for listeners of all backgrounds. Don't miss this in-depth AMA with Kevin Rose as he tackles life, business, and everything in between.

Episode links

* Saying No/Proper Boundaries blog post

* Carissa Sikora Medium

* I Don’t Want to Talk About It

* Crucial Conversations

* The Anxious Generation

* Internal Family Systems (IFS) Therapy

* Stillwater (Apple TV show)

* Windows Qualcomm Snapdragon ARM-based Laptop

* Nothing Ear

* SAY Coffee

* Madison Reed Hair Dye

* Light Phone

* Cursor

* Chris Hutchins podcast

* I checked with Attia’s folks, no concerns about me proceeding with a vasectomy from a hormone or longevity POV. A high-quality doctor is very important (*not health advice; talk to your own doctor).

Episode Topics

[00:01:24] - What is Kevin's approach to childhood trauma?

[00:07:06] - What practices does Kevin use to juggle high stress and long hours?

[00:12:09] - How would Kevin build wealth from scratch today?

[00:24:33] - What led to Kevin's physical transformation?

[00:28:25] - How does Kevin maintain relationships with his wife and kids during travel?

[00:30:09] - What traits does Kevin look for in founders when investing?

[00:31:32] - What are Kevin's headphone preferences?

[00:33:15] - What financial advice does Kevin have for a middle-class family in the Bay Area?

[00:35:05] - What's Kevin's next big idea in public markets?

[00:37:22] - Would Kevin dye his hair or beard?

[00:38:25] - What cultural shifts is Kevin paying attention to?

[00:40:03] - What are Kevin's thoughts on education for children?

[00:41:20] - What is Kevin's current crypto investing strategy?

[00:41:40] - Does Kevin regret promoting NFTs?

[00:43:05] - How does AI impact product development?

[00:44:26] - How would Kevin balance career and family time in a hypothetical scenario?

[00:46:00] - How would Kevin spend a day with no commitments?

[00:48:20] - Is Kevin considering a vasectomy?

[00:49:05] - What was Kevin's experience with a medium?

[00:50:42] - How does Kevin prepare his kids for adulthood?

[00:53:13] - Does Kevin ever wish he didn't have the entrepreneur's curse?

[00:53:54] - How does Kevin approach introducing technology to his kids?

[00:55:27] - How does Kevin choose what to work on?

[00:56:44] - What are Kevin's thoughts on saunas?

[00:58:10] - What is Kevin's current tech stack?

[00:58:40] - How does Kevin like living in a big city again?

[01:00:57] - What advice does Kevin have for someone stuck in a high-paying job?

[01:02:24] - How does Kevin decide who to take advice from?

[01:03:10] - What are Kevin's thoughts on patience versus drive?

Thanks for listening; let’s do these every couple of months!

In this captivating episode of The Random Show, Tim Ferriss and Kevin Rose reunite for a freewheeling conversation that spans cutting-edge science, personal growth, and technological marvels. The duo dives into Tim's recent sabbatical, exploring the creative process behind his upcoming book and the challenges of maintaining work-life balance. They candidly discuss their experiences with alternative therapies, including Kevin's intriguing foray into ketamine treatment and Tim's insights on ayahuasca ceremonies, offering a nuanced perspective on these controversial topics.

The conversation takes several unexpected turns, from the latest breakthroughs in AI-generated imagery (complete with amusing demonstrations) to the potential game-changing impacts of the protein Klotho on cognitive health and longevity. Tim and Kevin also open up about their personal lives, touching on the complexities of modern dating, the pursuit of mindfulness, and the ongoing quest to find meaning in a rapidly changing world. Packed with practical advice, thought-provoking ideas, and plenty of laughs, this episode showcases why The Random Show is a source of inspiration and entertainment for listeners seeking to expand their horizons.

Links From the Show

* Fino Toothbrush

* Blood Meridian by Cormac McCarthy

* The Bear by Andrew Krivak

* The Well of Being: A Children’s Book for Adults

* The Birth of Sake (Documentary)

* Outdoorsman Atlas Trainer Frame System

* PicStudio.ai

Show Chapters

[00:00] - Introduction and Opening Banter

[01:00] - Tim's Podcast Sabbatical and Book Writing

[04:00] - AI Image Generation Demonstration

[09:10] - Discussion on Podcasting Challenges and Future

[10:00] - Kevin Demonstrates Fino Toothbrush Device

[13:30] - Kevin's Vampire Facial Experience

[18:20] - Tim's Dating Life and Approach

[24:40] - Recommendations: Books, Documentaries, and Media

[29:50] - Ketamine Therapy Discussion

[35:30] - Klotho Protein and Alzheimer's Research

[41:20] - Funding Scientific Research

[45:00] - Tim's Experiences with Ayahuasca and Supernatural Phenomena

[51:30] - The Birth of Sake Documentary

[54:15] - High Ren Music Video Recommendation

[56:40] - Matthew Perry and Ketamine Risks

[62:00] - Kevin's Experience with a Medium

[68:30] - Tim's Thoughts on Balance and Leisure

[73:50] - Debate on "Chilling Out" and Personal Growth

[79:00] - Closing Thoughts and Show Wrap-up

Buckle up; in this episode, we explore the emerging field of ketamine therapy for mental health treatment with Dr. Jennifer Ellice, a board-certified emergency physician based in Los Angeles. Dr. Ellice, who studied at Princeton University and the University of Rochester School of Medicine before completing her residency at the Warren Alpert Medical School of Brown University, brings extensive experience in emergency medicine since 2008 to her current specialization in ketamine therapy as the Co-Founder of Golden Afternoon.

The conversation delves into ketamine's potential for treating depression, anxiety, PTSD, and chronic pain while addressing common misconceptions and safety concerns. Dr. Ellice discusses the medical applications of ketamine beyond its traditional use as an anesthetic, drawing on her diverse medical background.

Viewers will gain access to the clinical process, from patient screening to administration methods, and witness an unprecedented insider's view as Kevin allows cameras to document his experience during a live ketamine booster therapy session. This rare, unfiltered look into an actual treatment aims to demystify the process, reduce stigma, and potentially help those suffering from mental health issues see ketamine therapy as a viable option. Kevin's willingness to share this deeply personal experience underscores the importance of open dialogue about mental health treatments and advancing public understanding of innovative therapies.

This episode aims to provide a balanced, scientific perspective on a promising but complex treatment option in modern psychiatry, guided by Dr. Ellice’s unique blend of emergency medicine expertise and cutting-edge mental health treatment knowledge.

Links

* Golden Afternoon

* How to Change Your Mind

* Andrew Huberman — Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity

Show Topics

* Introduction to Dr. Jennifer Ellis and her credentials

* Overview of ketamine's history in medicine

* Explanation of ketamine as an anesthetic and its use in emergency medicine

* Introduction to ketamine's potential for treating mental health conditions

* Discussion of ketamine's effects on the brain and neuroplasticity

* Comparison of ketamine to traditional antidepressants

* Explanation of different administration methods (IV, intramuscular, intranasal)

* The importance of proper dosing and medical supervision

* Description of a typical ketamine therapy session

* Addressing safety concerns and potential side effects

* Discussion of ketamine's addictive potential

* The concept of "time on brain" and why it matters in treatment

* Exploration of ketamine's effectiveness for various conditions (depression, anxiety, PTSD, chronic pain)

* The role of set and setting in ketamine therapy

* Integration of ketamine therapy with other forms of treatment

* The importance of patient screening and selection

* Legal status and insurance coverage for ketamine therapy

* Potential future developments in ketamine therapy and psychedelic medicine

* Kevin’s first-hand account of a ketamine therapy session

* Post-session integration and the importance of follow-up care

* Discussion of potential long-term effects and benefits of ketamine therapy

The following podcast is a conversation with my friend and colleague Chris Hutchins. In this episode, we discuss a long-form article I just published on my investing playbook. The title of the article is "The Calculated Contrarian: Extreme Security, Extreme Risk, Extraordinary Returns."View the full article hereMore on Chris and his podcast here.

Remember, this is my personal playbook. I'm sharing it for information purposes only, not financial advice. You should always consult with a professional financial advisor before making investment decisions.

The article is broken into several sections:* Timing the Market* How I think about investing bucket allocations* Where I Invest* Index Fund* Bonds and Cash Management: My Financial Shock Absorbers* High-risk* Stock Picking* Risk Management and the Importance of a Moat* Angel Investing: The High-Stakes Poker of Investing* Gold and Bitcoin: Your Financial Apocalypse Insurance* The Importance of Self-Custody and Physical Redemption* Retirement Accounts* When to Buy More* Conclusion

www.kevinrose.com

Dream reading is no longer science fiction. Sleep damage reversal could be a reality. And nightmares? They might become controllable. Dr. Matt Walker unveils these groundbreaking possibilities in sleep science. From antioxidant therapies (Kevin is backing a study here) to brain-zapping sleep enhancers, we're exploring innovations that are revolutionizing our understanding of sleep.

Dr. Matt Walker, is the Professor of Neuroscience and Psychology at UC Berkeley and founder of the Center for Human Sleep Science.

Links from the episode:- Kevin’s SubStack Newsletter- Why We Sleep Org (nonprofit)- Oura Ring- Somnee Sleep Device

To receive new posts and support my work, consider becoming a free or paid subscriber.

Topics with timestamps:

Topics with timestamps:

[00:00:00] - Introduction and catching up[00:04:40] - Changes in sleep science since Dr. Walker's book publication [00:19:30] - Predicting dreams using brain scanning and machine learning [00:25:20] - The function of dreaming and emotional processing [00:31:20] - Clinical approaches to preventing nightmares [00:35:30] - Ethical concerns about dream prediction technology [00:38:50] - Sleep quality benchmarks and content-based measurements [00:42:40] - Updates on caffeine consumption and sleep [00:52:30] - Temperature regulation for better sleep [01:00:00] - Sleep trackers: accuracy and best practices[01:07:40] - Kevin to fund the sleep study through Substack subscribers [01:09:00] - Details on how listeners can contribute to funding the study[01:12:10] - Discussion of a parasympathetic nervous system stimulation device [01:13:30] - Explanation of the vagus nerve and its role in sleep[01:19:00] - Supplements and sleep aids: what works and what doesn't [01:24:30] - Sex, self-stimulation, and sleep quality [01:27:30] - The impact of sauna usage on sleep (potential future study) [01:32:40] - Brain stimulation techniques for enhancing sleep[01:00:50] - Proposal for a study to mitigate sleep deprivation effects [01:04:00] - Discussion of potential funding methods[01:07:40] - Breakdown of the proposed sleep deprivation study methodology[01:54:30] - Introduction to, StimScience, and the Somnee device [02:05:40] - Closing remarks and information on Dr. Walker's sleep foundation

Alex Albrecht joins Kevin for a reunion-style episode of Diggnation, and it’s like they never left. Kevin and Alex kick things off by discussing everything from past moments on Diggnation to current events like WWDC announcements, and the evolution of Tesla and Boeing, the latest from Apple.

Guest Bio and Links:

Alex Albrecht is known for his significant contributions to technology and entertainment. He is a podcast host, television personality, and tech entrepreneur. Alex gained popularity as the co-host of "The Screen Savers" on TechTV and later co-created and co-hosted the popular podcasts "Diggnation" and "The Totally Rad Show." He has also ventured into directing, writing, and game development.

Listeners can learn more about Alex Albrecht at his website, and on X @alexalbrecht 

Resources:

Kevin's Newsletter: Join 100,000+ subscribers 

Show Notes: 

* (0:00) Introduction

* (0:50) LMNT: Electrolyte drink mix. Grab a free sample pack

* (2:18) Manscaped: 20% off precision-engineered grooming tools

* (8:25) Welcome back to Diggnation!

* (14:35) WWDC announcements and Apple's strategies 

* (24:50) Apple watch vitals

* (33:49) Facet: Personalized financial planning. Get your $250 enrollment fee waived

* (35:38) Notion: Try Notion AI for free

* (35:42) Nvidia hits 3 trillion market cap

* (41:45) Chat GPT becomes Sentient… What do you do?

* (47:15) GameStop and the Wallstreetbets 

* (56:30) Alex shares plan to move to Italy 

* (1:03:10) Boeing concerns 

* (1:10:30) Downfall: The Case Against Boeing

* (1:15:00) Teslas supercharging infrastructure  

* (1:20:50) Sweaty pits? Get botox

* (1:26:39) Apologies and closing   

Connect with Kevin:

Website: kevinrose.com 

Instagram: @KevinRose

X: @KevinRose

YouTube: @KevinRose

Alex Albrecht joins Kevins to take a trip down memory lane. They reminisce about Diggnation, and their wildest drunken moments, including the infamous Reno episode and various escapades during live shows. Kevin and Alex share their experiences with Bitcoin mining, discussing their investments' highs and lows, and the perpetual f*ckery of sobriety. Tune in next week for part II, Diggnation style!

Guest Bio and Links:

Alex Albrecht is known for his significant contributions to technology and entertainment. He is a podcast host, television personality, and tech entrepreneur. Alex gained popularity as the co-host of "The Screen Savers" on TechTV and later co-created and co-hosted the popular podcasts "Diggnation" and "The Totally Rad Show." He has also ventured into directing, writing, and game development.

Listeners can learn more about Alex Albrecht at his website, and on X @alexalbrecht 

Partners:

Dram: Try the Kevin Rose Show sparkling drink sampler + 20% off everything

DeleteMe: 20% off removing your personal info from the web 

CoPilot: Free 2 months of Kevin’s favorite personal finance app

Resources: 

Enjoy 30 Free Guided Meditation Sessions with The Way App

Show Notes: 

* (0:00) Introduction

* (0:55) Dram: Try the Kevin Rose Show sparkling drink sampler + 20% off everything

* (2:17) DeleteMe: 20% off removing your personal info from the web 

* (4:30) Reno’s drunken chaos 

* (9:00) Hair of the dog 

* (14:55) Reminiscing time in Japan 

* (17:25) Tokyo high-rise party

* (21:10) CoPilot: Free 2 months of Kevin’s favorite personal finance app

* (22:08) Enjoy 30 Free Guided Meditation Sessions with The Way App

* (23:33) Latest for Alex 

* (23:50) Bitcoin mining stories 

* (34:30) Reflecting on health and aging

* (35:19) “Look, if we're lucky, we've got 20 more years of being healthy and able to do whatever we want.”

* (41:10) 90 days without alcohol  

* (48:30) The perpetual f*ckery of sobriety  

* (51:30) Tune in 7/9/24 for a classic Diggnation

Connect with Kevin:

Website: kevinrose.com 

Instagram: @KevinRose

X: @KevinRose

YouTube: @KevinRose

Kevin sits down with the renowned author and motivational speaker Simon Sinek. They discuss the importance of understanding one's "why," the journey of building impactful leadership, and the nuances of personal and professional growth. They also explore the dynamics of leadership, the importance of building trust, and the role of vulnerability in personal and professional relationships. Lastly, Simon discusses the 10,000-hour rule and breaks down finite and infinite games in terms of business. 

Guest Bio and Links:

Simon Sinek is a renowned author, motivational speaker, and organizational consultant. He is known for popularizing the concept of "Why," his insights on leadership, culture, and business have inspired millions worldwide. His TED Talk on "How Great Leaders Inspire Action" is one of the most viewed talks on the platform.

Listeners can learn more about Simon Sinek at his website, on IG @simonsinek, and on YouTube @SimonSinek

Partners:

Manscaped: 20% off precision-engineered grooming tools

LMNT: Electrolyte drink mix. Grab a free sample pack

Facet: Personalized financial planning. Get your $250 enrollment fee waived

Resources:

Kevin's Newsletter: Join 100,000+ subscribers

Simon’s Blog: The Optimism Company Blog

Simon’s Books

Simon Sinek: The Number One Reason Why You’re Not Succeeding | E145 | The Diary of a CEO 

It’s not about the nail

Finite and Infinite Games: A Vision of Life as Play and Possibility by James P. Carse 

Show Notes: 

* (0:00) Introduction

* (1:00) Manscaped: 20% off precision-engineered grooming tools

* (2:15) LMNT: Electrolyte drink mix. Grab a free sample pack

* (3:45) The success of "Start With Why"

* (5:45) The beginning of ‘why, what, how’ 

* (11:55) How to help coach someone to find their ‘why’  

* (14:30) The problem of pursuing a dream job

* (18:30) The importance of vulnerability in leadership

* (22:17) Facet: Personalized financial planning. Get your $250 enrollment fee waived

* (23:52) Kevin's Newsletter: Join 100,000+ subscribers   

* (24:50) “To be uncomfortable is probably the single greatest asset you could ever, you know this because nobody who's ever achieved anything in the world did it smoothly.” -S.Sinek

* (27:05) The three most important words for an entrepreneur to learn

* (31:55) The problems with problem-solving mode  

* (32:30) It’s not about the nail

* (34:15) How to listen vs. trying to fix everything during a conflict  

* (36:30) How to find ‘your why’

* (38:35) Simon explains how to find your why through the friends exercise 

* (40:35) “Because what they're doing is articulating the value you have in their life, which is the thing you give to the world, which is your why. And if you do this with multiple friends, you will get very similar, if not the exact same answer, because who you are in the world is the space you fill in all of these people's lives.” (friendship exercise) -S.Sinek  

* (41:55) Question: Can you have multiple ‘whys’ in life?

* (42:45) Using pattern recognition to find your ‘why’ 

* (49:45) The concept of human skills versus hard skills 

* (52:00) Kevin and Simon discuss conflict resolution 

* (58:15) How to deal with being socially awkward 

* (1:08:00) Elon Musk purchasing Twitter  

* (1:12:55) What’s next for Simon 

* (1:14:25) The 10,000 hour rule

* (1:20:00) The concept of finite and infinite games 

Connect with Kevin:

Website: kevinrose.com 

Instagram: @KevinRose

X: @KevinRose

YouTube: @KevinRose