Today’s show is brought to you by MYOXCIENCE Nutrition. In this episode Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases.

Crush your workouts with the Creatine+ Electrolyte Combo by MYOXCIENCE: https://bit.ly/Electrolyte-Stix-Jar *Save with code podcast at checkout

Link to show notes: https://bit.ly/4gdmxES

Key Takeaways: 

• 02:44 Pillars of health: eat, sleep, move, connect.
• 10:30 Eating protein and exercise can turn up mTOR.
• 15:20 High dietary protein and resistance training preserves muscle while aging.
• 19:20 Longevity research is underfunded.
• 25:10 Obesity was rare 50 years ago.
• 26:25 Fasting, and time restricting eating may not increase longevity.
• 30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan.
• 34:40 Resveratrol is not a longevity drug.
• 36:45 Spermidine is an autophagy booster.
• 38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan.
• 42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan.
• 44:45 Metformin does not corelate to reduced all-cause mortality.
• 47:30 NAD is a co-factor required for thousands of metabolic reactions.
• 52:55 Some epigenetic signatures are predictive of future health outcomes.
• 54:17 Facial imaging using AI can predict future health outcomes.
• 58:17 Dunedin Pace measures the rate of aging.
• 59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging.
• 01:04:00 Senescent cells are cells that do not do their job and refuse to die.
• 01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.

   

Today’s show is brought to you by MYOXCIENCE Nutrition. In this episode Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases.

Crush your workouts with the Creatine+ Electrolyte Combo by MYOXCIENCE: https://bit.ly/Electrolyte-Stix-Jar *Save with code podcast at checkout

Link to show notes: https://bit.ly/4gdmxES

Key Takeaways: 

02:44 Pillars of health: eat, sleep, move, connect. 10:30 Eating protein and exercise can turn up mTOR. 15:20 High dietary protein and resistance training preserves muscle while aging. 19:20 Longevity research is underfunded. 25:10 Obesity was rare 50 years ago. 26:25 Fasting, and time restricting eating may not increase longevity. 30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan. 34:40 Resveratrol is not a longevity drug. 36:45 Spermidine is an autophagy booster. 38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan. 42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan. 44:45 Metformin does not corelate to reduced all-cause mortality. 47:30 NAD is a co-factor required for thousands of metabolic reactions. 52:55 Some epigenetic signatures are predictive of future health outcomes. 54:17 Facial imaging using AI can predict future health outcomes. 58:17 Dunedin Pace measures the rate of aging. 59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging. 01:04:00 Senescent cells are cells that do not do their job and refuse to die. 01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.

Brian Sanders, creator of the film "Food Lies," discusses how traditional diets rich in animal-based nutrition contribute to better health and height.

Support your Intermittent Fasting lifestyle with the updated Berberine Fasting Accelerator by MYOXCIENCE: https://bit.ly/berberine-fasting-accelerator Use code podcast at checkout to save

Show Notes and Video: https://bit.ly/3yN22Om

Research Mentioned:

Grasgruber, P., Sebera, M., Hrazdíra, E., Cacek, J. & Kalina, T. Major correlates of male height: A study of 105 countries. Econ. Hum. Biol. 21, 172–195 (2016).

Time Stamps:

03:30 Cooking by the food pyramid led to chronic illness.

08:10 People eating traditional diets are lean, tall, and muscular.

09:20 Only vegan documentaries make it to mainstream.

13:25 Funding goes to developing meat and protein alternatives.

14:30 The top four industries in the US are sick care/pharma.

15:30 There is big money in blaming red meat for processed foods problems.

23:00 Cattle upcycle nutrition from inedible food, creating a high-quality food.

35:30 Blue Zone diets are animal-based, by calories.

37:50 Animal nutrition is the foundation of any healthy diet.

39:30 You can adapt to a plant-based diet for a year or two, tapping our biologic storage.

45:00 The optimal diet of any species is the one they lived on the longest.

45:50 The more animal protein a population eats, the taller they are.

52:15 The low meat intake results in stunted growth, shorter life expectancy, and higher infant mortality.

54:40 Food is protein, nutrients, and energy.

57:30 Eat animal foods with whole foods on the side.

57:50 In a low protein environment, all animals will overeat to ingest the required amount of protein.

01:03:00Food industry pays to keep you in the energy calorie paradigm.

01:06:30 High carb intake is linked with greater odds of dying from all causes, especially cancer.

01:15:40 Long term satiety is from protein and fat. Short term is from volume.

01:20:50 Seed oil trans fats are harmful.

01:25:30 Mental health is tied to food choices/consumption.

Rancher Michaela Mann discusses the balance between grass and grain finishing in cattle and challenges faced by U.S. agriculture including land loss and sustainability efforts. 

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Link to Video and Show Notes: https://bit.ly/3Ma0G3q

Connect with Michaela at D & D Beef: https://danddbeef.com *Save with code DDBEEF10

-----------------Show Notes-------------------

0:00 Intro 1:30 Ranchers care about their animals and treat them well. 7:30 Ranchers get emotionally attached to some of the animals. 8:30 Michaela’s goal for her animals is to have them only have one bad day. 10:20 The US has high processing standards. 11:30 Pre-slaughter stress changes the pH and changes the meat. 15:30 The beef calf stays with its mother for 6 to 8 months. 16:43 Northern states do not have year-long grass for grazing. 17:55 Grain finished cattle only had 11% grain in their diet. 18:20 80 to 90% of grass finished beef sold in the US is from overseas. 19:30 Antibiotics are only used when an animal is sick or injured. 22:38 Large meat packing plants test meat for antibiotics. 23:50 Older cows/bulls are used for cheaper grocery store meat or dog food. 30:30 Cattle dogs and flashing ear tags deter predators. 34:00 Bison are different to raise and harvest from cattle. 41:45 Regenerative and sustainable farming is done by most ranchers and farmers to some extent. 43:40 Ranching utilizes natural grassland and provides habitat for wildlife. 53:15 The US has lost 100,00 farms/ranches between 2011 and 2018. 53:30 Bill Gates is the largest landowner in the state of Nebraska. 56:30 The US has lost 31 million acres of ag land since 1982. 01:00:40 Avian flu can be a problem with poultry, but not in cattle production.

Learn the connections between mouth breathing, sleep disorder breathing, and their impact on nighttime urination, heart health, and overall sleep quality. 

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Link to Video & Research: Link to studies: https://bit.ly/3yF3G4H

Time Stamps: 

0:00 Intro 0:40 - Case Study: Client with Sleep Disordered Breathing 1:30 - Tips for Nasal Breathing and Sleep Optimization 2:31 - Connection Between Sleep Disordered Breathing and Nocturnal Polyurea 4:29 - Women, Sleep Apnea, and Overactive Bladder Syndrome 6:16 - Visual Explanation of Airway Obstruction 7:01 - Symptoms of Sleep Disordered Breathing 8:00 - Bon charge 8:46 - Importance of Addressing Sleep Disordered Breathing 9:31 - Introduction to Mouth Taping 10:13 - Impact of Mouth Breathing on Children 11:03 - Prevalence and Consequences of Sleep Apnea 12:45 - Immediate and Long-term Consequences of Sleep Apnea 13:41 - Link Between Leptin and Sleep Apnea 15:30 - Practical Solutions for Sleep Disordered Breathing 16:15 - Mechanical Impact of Mouth Breathing 17:05 - Research Supporting Mouth Taping 18:46 - Connection Between Obesity and Sleep Apnea 20:23 - Leptin and Breathing in Obesity 21:06 - Introduction to Mouth Taping and Myofunctional Therapy 23:00 How to use mouth tape during the day and night to train nasal breathing.

A reanalysis of the Minnesota Coronary Experiment, a large randomized controlled trial, which found that reducing saturated fat and replacing it with vegetable oils did not lower the risk of heart disease or death despite lowering cholesterol levels. Let's dive into the details.

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Link to show notes and research: https://bit.ly/46AI5qo

------------------------Show Notes----------------

0:00 Intro 2:26 Lower Saturated Fat isn’t better 3:04 Autopsy studies 4:09 Berberine  4:48 Data was omitted  5:05 Main finding of the study  8:20 Unpublished documents  9:06 Autopsy findings  11:00 Mortality rates 12:21 How much oil are we eating? 13:00 Concluding remarks 13:06 Mechanisms

A new study finds over 40% of cancer deaths in the US are preventable through lifestyle changes such as reducing smoking, alcohol consumption, and obesity, while promoting exercise and a healthy diet, with a specific focus on the protective benefits of exercise for women against breast cancer.

Sponsored:

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Link to Video and Show Notes: https://bit.ly/3zWVUUb

Research Mentioned:  

Islami, F. et al. Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, 2019. CA: A Cancer J. Clin. (2024) doi:10.3322/caac.21858.

Key Takeaways:

CNN Article Overview (00:53):

Specific Risk Factors (01:46):

Cancer Prevention Strategies (02:48):

Role of Exercise (04:25):

2019 Study Findings (06:15):

Alcohol Consumption Impact (10:07):

Diet and Cancer Risk (10:59):

Conclusion (11:53):

For the past 60 years the medical community has obsessively focused on lowering LDL-cholesterol levels…

Research shows these five preventable health conditions make LDL-Cholesterol more likely to cause artery plaque build-up, even if your LDL-Cholesterol levels are low.

Sponsored:

Crush your Workouts and stay hydrated this summer with the Electrolyte + Creatine Combo by MYOXCIENCE: https://bit.ly/electrolyte-stix

*Save with code podcast at checkout

Link to Video and Show Notes: https://bit.ly/3WfpI5R

Research Mentioned:

Zanoni, P., Velagapudi, S., Yalcinkaya, M., Rohrer, L. & Eckardstein, A. von. Endocytosis of lipoproteins. Atherosclerosis 275, 273–295 (2018).

Ference, B. A., Braunwald, E. & Catapano, A. L. The LDL cumulative exposure hypothesis: evidence and practical applications. Nat. Rev. Cardiol. 1–16 (2024) doi:10.1038/s41569-024-01039-5.

Time Stamps:

00:45 LDL's link with atherosclerosis is nuanced.

 02:30 Initial damage to the arterial wall makes LDL levels problematic.

03:45 Increases risk of arterial wall damage: elevated blood pressure, insulin resistance/diabetes, smoking/vaping, obesity, elevated blood viscosity, consuming oxidizableoils.

08:40 High LDL and high triglycerides suggest insulin resistance and increased cardiovascular risk.

09:50 Start with diet and exercise together.

11:20 Statins have concerning side effects.

13:15 Plaque formation begins early in life.

13:50 High LDL is found in centenarians.

14:44 Centenarians are metabolically healthy.

15:40 Your liver makes LDL cholesterol.

16:10 Every cell in your body requires cholesterol.

18:00  Diets high in seed oils make your LDL more likely to be oxidized.

20:55 30-50% of people who have heart attacks have optimal serum cholesterol.

New research suggests vitamin D and A work better when they're taken together. Here's more food for thought...

Support your Vitamin D, K2 + A Health with this combo by MYOXCIENCE: by MYOXCIENCE: https://bit.ly/vitamin-d-k-2-blend *Save with code podcast at checkout

Link to study: https://medicinskiglasnik.ba/article/36

------------Show Notes-------------------------

0:00 Intro 0:20 Vitamin D receptor binding requires vitamin A.  0:50 Retinol is found in animal-based products. Pre-vitamin A is from vegetables. 1:40 Pairing vitamin A and vitamin D supports immune system, brain, and blood sugar health. 2:40 Excessive supplemental vitamin A in pregnant women can affect fetal growth.   4:25 There are fewer micronutrients in your food. 5:45 Paired vitamin D and vitamin A balance the anti-inflammatory mechanisms of the immune system. 7:25 Mike suggests that you supplement with a retinol, not a beta carotenoid version of pre-vitamin A.

Mark Bell and Nsima Inyang delve into the transformative benefits of sunlight and outdoor activity for enhancing hormone levels, accelerating fat loss, and improving overall health.

Crush your Workouts and stay hydrated this summer with the Electrolyte + Creatine Combo by MYOXCIENCE: https://bit.ly/Electrolyte-Stix-Jar *Save with code podcast at checkout 

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Link to Video Interview: https://youtu.be/mX3Mt5glQKY

Time Stamps

0:00 Intro 2:30 Exercise snacks 4:30 Cardio helps you get shredded  5:30 Movement between sets 7:30 Exercise capacity  8:22 Fat loss and diet 10:40 How Nsima stays shredded  12:17 Cycling Carbs 13:26 Calories VS Carbs 15:45 Protein for muscle gain  18:00 How much protein do you need 19:41 Red meat VS Fish VS Chicken 25:00 Cheat meals 27:00 the power of being outside

A recent study has revealed the presence of microplastics in the male penis, linking these particles to erectile dysfunction.

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Link to Studies and Show Notes: https://bit.ly/3L3AGGn

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--------------Show Notes----------------------------

0:00 Intro 0:05 microplastic particles make their way to the male penis 0:49 study detected microplastic particles 1:46 microplastic particles in the carotid artery plaque 2:12 microplastics and erectile dysfunction 3:55 Study Title  4:11 Top prevention tips 4:58 face masks and microplastics  6:18 small plastics still absorbed  6:37 Key ways to avoid