Amid the desperation of war-starved Netherlands, a doctor defies conventional wisdom to save gravely ill children, uncovering a treatment that sparks both hope and controversy. Years later, in 1967, a young female researcher detects a strange, pulsing signal—could it be mundane interference or evidence of alien life? From lifesaving breakthroughs to cosmic discoveries, this story celebrates the determination of pioneers who challenge convention and pursue truth against the odds.

A mathematician searching for love discovers that relationships aren’t always as simple as equations—are his calculations the issue, or is there something deeper at play? Meanwhile, at an engineering conference, a young researcher’s seemingly minor mistake uncovers a scandal of epic proportions. Can numbers find love or unveil problems? From personal dilemmas to professional revelations, this episode dives into the unexpected ways numbers can change lives.

In 2016, Niall McCann was left with a bruised spinal cord when he crashed his speed glider into the side of a mountain at 50mph.

He shares his journey to recovery and some unexpected life lessons he has had to navigate, from soiling himself in inconvenient places and not being able to control his flatulence, to having to re-learn how to have sex again.

We also hear from a Mountain Rescue medic on what looked like an “unsurvivable” situation and Niall’s surgeon on fixing his “exploded” spine.

Perhaps you couldn't drift off, or maybe you woke in the middle of the night and then couldn't nod off again. In this edition of Inside Health we're talking all about insomnia. It’s an issue that may affect many of us at some point in our lives – but for some it goes beyond a short period of not being able to sleep and becomes something more serious. James is joined by a trio of experts ready to answer to them: Dr Allie Hare, president of the British Sleep Society and consultant physician in sleep medicine at the Royal Brompton Hospital, Colin Espie, a professor of sleep medicine at Oxford University and Dr Faith Orchard, a lecturer in psychology at Sussex University. We’re going to find out why we get insomnia, when to seek help and how much factors like ageing, menopause, needing the loo or shift work matter. And we'll look at the latest advice and treatments. Can insomnia be fixed?

Dr Chris van Tulleken shares stories from the making of his chart-topping podcast, Fed. In conversation with Leyla Kazim, at Hay Festival 2024.

In Fed, Dr Chris van Tulleken, investigated the entangled web of forces that shape what ends up on our plates. And he focused his investigation around one foodstuff in particular. The most widely eaten meat on our planet, a staple of nearly every diet and a global food production phenomenon: the humble chicken, Chris dug into the history of our relationship with this extraordinary animal, to try to get to the truth of why we eat so much of it, and what that means for the birds, for us, and for the planet.

In this lively conversation, recorded live at Hay festival 2024, Chris talks to Leyla Kazim about the hidden stories behind the globalised food networks of today. From industrial-scale farming, to food labelling, to ethical dilemmas, environmental quandaries, and the complexities of the world of fast food. Plus tales from the adventure that ran through the whole series: raising his own tiny flock of broiler chickens, in his back garden.

From the Hay Festival, James and a panel of experts explain what we can all do to help ourselves age well.

We discover what’s going on in our bodies when we age, the difference between biological and chronological age, as well as getting the audience moving for a physical test.

James is joined by gerontologist Sarah Harper from the University of Oxford, biomedical scientist Georgina Ellison-Hughes from King’s College London, and doctor Norman Lazarus to understand how exercise, diet, and mental health all have a part to play in how we age.

Throbbing head, nausea, dizziness, disturbed vision – just some of the disabling symptoms that can strike during a migraine attack. This neurological condition is far more common than you might think, affecting more people than diabetes, epilepsy and asthma combined.

While medications, to help relieve the symptoms of migraine, have been around for some time, they haven’t worked for everyone. And what happens in the brain during a migraine attack was, until recently, poorly understood.

Peter Goadsby is Professor of Neurology at King's College London’s Institute of Psychiatry, Psychology & Neuroscience and is a true pioneer in the field of migraine.

Over the course of his career, he has unravelled what happens in the brain during a migraine attack and his insights are already benefiting patients - in the form of new medications that can not only treat a migraine, but also prevent it from occurring.

Peter shares this year’s Brain Prize, the world's largest prize for brain research, with three other internationally renowned scientists in the field.

Kip Thorne is an emeritus professor of theoretical physics at Caltech, the California Institute of Technology, and someone who has had a huge impact on our understanding of Einsteinian gravity. Over the course of his career Kip has broken new ground in the study of black holes, and been an integral parts of the team that recorded gravitational waves for the very first time – earning him a share in the 2017 Nobel Prize for Physics.

He went on to promote physics in films: developing the original idea behind Christopher Nolan’s time-travel epic Interstellar and, since then, advising on scientific elements of various big-screen projects; including, most recently, the Oscar-winning Oppenheimer.

In a special edition of The Life Scientific recorded in front of an audience of London’s Royal Institution, Prof Jim Al-Khalili talks to Kip about his life and career, from his Mormon upbringing in Utah to Hollywood collaborations – all through the lens of his unwavering passion for science.

It's summer - no really - and although the weather might have been mixed, the sporting line-up has been undeniably scorching - from the back-and-forth of Wimbledon, to the nail-biting Euros, to the current pageantry of the Summer Olympics.

Next month the 2024 Paralympic Games get underway in Paris, involving the world’s very best para athletes; and Professor Vicky Tolfrey is at the forefront of the science that makes their sporting dreams a reality.

Vicky is the Director of the Peter Harrison Centre for Disability Sport at Loughborough University, a hub for elite para-sport research. She’s worked with stars from the worlds of wheelchair athletics, basketball, rugby and tennis, amongst others – and in 2017, became the first European recipient of the International Paralympic Committee’s prestigious Scientific Award.

She tells Professor Jim Al-Khalili about her work with elite para athletes, her experiences at major international sporting events, and her childhood dreams of becoming an Olympian herself.

The engineering industry, like many other STEM sectors, has a problem with diversity: one that Dawn Bonfield believes we can and must fix, if we're to get a handle on much more pressing planetary problems...

Dawn is a materials engineer by background, who held roles at Citroën in France and British Aerospace in the UK. But, after having her third child, she made the difficult decision to leave the industry - as she thought at the time, for good. However a short spell working in post-natal services and childcare gave her new skills and a fresh perspective. This led to Dawn rehabilitating the struggling Women in Engineering Society and creating ‘International Women In Engineering Day’, which has just celebrated its 10th anniversary.

Today, she’s Professor of Practice in Engineering for Sustainable Development at King’s College London, and the founder of Magnificent Women: a social enterprise celebrating the story of female engineers over the past century. She’s also President of the Commonwealth Engineers’ Council and has had her work supporting diversity and inclusion recognised with an MBE.

Dawn talks to Professor Jim Al-Khalili about why 'inclusive engineering' should not be dismissed as tokenism, and why she's optimistic about the engineering sector's power to change the world.

In recent decades, we have taken huge steps forward in treating formerly fatal viruses - with pharmacological breakthroughs revolutionising treatment for conditions such as HIV, hepatitis and herpes. Raymond Schinazi has played a big role in that revolution.

Ray was born in Egypt, where his mother’s brush with a potentially deadly illness during his childhood inspired a fascination with medicine. His childhood was scattered; after his family were forced to leave their homeland and travelled to Italy as refugees, Ray ended up on a scholarship to a British boarding school - and subsequently went on to study and flourish in the world of chemistry and biology.

Today, Ray is the director of the Laboratory of Biochemical Pharmacology at Emory University in Atlanta, where he also set up the renowned Center for AIDS Research. His work in the early days of HIV studies led to drugs that many with the virus still take today; while his contribution to developing a cure for Hepatitis C has saved millions of lives around the world.

Speaking to Jim al-Khalili, Ray reflects on his route to success and explains why he is confident that more big breakthroughs are on the horizon.