The number of people living with atrial fibrillation (AF) is increasing, and they have a higher rate of cardiovascular events, chronic kidney disease, and dementia compared with people without AF. Emelia J. Benjamin, MD, ScM, an epidemiologist and cardiologist, discusses current diagnosis and treatment of AF with JAMA Deputy Editor Mary McGrae McDermott, MD. Related Content:

• Atrial Fibrillation

Allogeneic stem cell transplantation is a potentially life-saving therapy for some patients with hematologic and bone marrow cancers and certain nonmalignant conditions such as sickle cell disease. Hermioni L. Amonoo, MD, MPP, MPH, of Harvard Medical School and Dana-Farber Cancer Institute, joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the process of allogeneic stem cell donation. Related Content:

• Allogeneic Stem Cell Donation

JAMA Senior Editor Derek Angus, MD, MPH, and JAMA Associate Editor Christopher Seymour, MD, MSc, discuss 4 critical care trials published in JAMA and simultaneously presented at the 2024 CCR Down Under meeting in Melbourne, Australia, with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content:

• Electronic Sepsis Screening Among Patients Admitted to Hospital Wards
• Early Restrictive vs Liberal Oxygen for Trauma Patients
• High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure
• Do Sepsis Alerts Help?
• Reevaluating Respiratory Support in Acute Respiratory Failure—Insights From the RENOVATE Trial and Implications for Practice
• Is High-Flow Oxygen the Standard for All Patients With Acute Respiratory Failure?
• Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis

Access to obstetric care in US hospitals has been declining, while maternal mortality is on the rise. A new research letter published in JAMA quantifies losses and gains of obstetric care at rural and urban short-term acute care hospitals in the US between 2010-2022. Author Katy Kozhimannil, PhD, MPA, discusses this and more with JAMA Deputy Editor Linda Brubaker, MD, MS. Related Content:

• Obstetric Care Access at Rural and Urban Hospitals in the United States

Ovarian aging is an important cause of infertility in women older than 35 years. Success rates of fertility treatment decline with age, most commonly due to declining ovarian function. Author Albert L. Hsu, MD, MS, of University of Cincinnati, Ohio, discusses this and more with JAMA Deputy Editor Kristin L. Walter, MD, MS. Related Content:

• Ovarian Aging and Fertility

Mpox is an evolving global health threat, and clinicians should be aware of characteristic signs and symptoms to ensure timely diagnosis and appropriate management. Author Jason Zucker, MD, MS, of Columbia University Irving Medical Center speaks with JAMA Deputy Editor Preeti Malani, MD, MSJ, about the transmission, diagnosis, management, and prevention of mpox. Related Content:

• Mpox Clinical Presentation, Diagnostic Approaches, and Treatment Strategies
• The Resurgence of Mpox in Africa
• Decline of Mpox Antibody Responses After Modified Vaccinia Ankara–Bavarian Nordic Vaccination
• WHO Announces Mpox Global Plan, Appeals for Funding

Calcific aortic stenosis affects approximately 12% of people >75 years in the US and worldwide leads to more than 100 000 deaths each year. Catherine M. Otto, MD, PhD, of the University of Washington School of Medicine, Seattle, discusses the symptoms, diagnosis, and treatment of aortic stenosis with JAMA Deputy Editor Kristin L. Walter, MD, MS. Related Content:

• Calcific Aortic Stenosis

CAR T cells are genetically engineered to express a receptor that recognizes and kills tumor cells. CAR T-cell products are now FDA approved for 6 hematologic malignancies. Author Jennifer N. Brudno, MD, National Cancer Institute, joins JAMA Deputy Editor Mary McGrae McDermott, MD, to discuss "CAR T Cells and T-Cell Therapies for Cancer: A Translational Science Review.” Related Content:

• CAR T Cells and T-Cell Therapies for Cancer
• Translational Science Reviews—A New JAMA Review

Peptic ulcer disease affects approximately 1% of the population in the US, and H pylori is a common cause of peptic ulcer disease. Author Nimish Vakil, MD, a gastroenterologist from the University of Wisconsin, Madison, discusses current evidence regarding diagnosis and treatment of peptic ulcer disease with JAMA Deputy Editor Mary McGrae McDermott, MD. Related Content:

• Peptic Ulcer Disease

High prescription costs are a major barrier to the optimal treatment of many health conditions. Prescribers need tools to help patients find the lowest drug costs. Author Hussain S. Lalani, MD, MPH, MSc, of Brigham and Women's Hospital and Harvard Medical School joins JAMA Senior Editor Anne R. Cappola, MD, ScM, to discuss "Strategies to Help Patients Navigate High Prescription Drug Costs." Related Content:

• Strategies to Help Patients Navigate High Prescription Drug Costs
• Strategies to Help Patients Afford Their Medicines in the US

Even though highly effective medications are currently available to prevent HIV, there are about 1.3 million new infections worldwide each year. Monica Gandhi, MD, MPH, of the University of California San Francisco joins JAMA Senior Editor Karen E. Lasser, MD, MPH, to discuss preexposure prophylaxis (PrEP) for HIV. Related Content:

• Preexposure Prophylaxis (PrEP) for HIV
• What Is Doxycycline Postexposure Prophylaxis?