As we prepare to step into 2025, the possibilities for applied AI are reshaping industries in profound ways.

 In this episode, a16z General Partners Julie Yoo and Angela Strange, and Partner Joe Schmidt, dive into the transformative power of AI across healthcare, fintech, and traditional service sectors.

We explore:

• Super Staffing for Healthcare: How AI can address critical clinical labor shortages and augment care delivery at scale.
• Regulation Becomes Code: The potential for AI to simplify and streamline compliance, making systems safer and more efficient.
• Romanticizing Inorganic Growth: The opportunity for AI-powered startups to redefine service industries through workflow automation and strategic acquisition.

With insights from a16z’s Bio + Health, Fintech, and Apps teams, this episode unpacks the ideas that will revolutionize traditional systems and unlock opportunities in 2025.

Check out the full 50 Big Ideas for 2025 at a16z.com/bigideas.

Resources: 

Find Angela on X: https://x.com/astrange

Find Julie on X: https://x.com/julesyoo

Find Joe on X: https://x.com/joeschmidtiv

Link to article 'The Messy Inbox Problem: Wedge Strategies in AI Apps': https://a16z.com/the-messy-inbox-problem-ai-apps-wedge-strategies

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

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Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The AI race is on, and 2025 could be its most transformative year yet.

In this episode, a16z General Partners Anjney Midha and Jennifer Li, and Partner Alex Immerman dive into the trends reshaping AI and its impact on search, infrastructure, and devices.

We explore:

• How AI-native tools like ChatGPT and Perplexity are challenging Google’s search dominance.
• The rise of infrastructure independence as governments prioritize compute, energy, and data.
• The future of smaller, on-device AI models driving privacy, performance, and new consumer applications.

With insights from a16z’s Growth and Infrastructure teams, this episode unpacks the forces driving AI innovation—and the opportunities founders and nations could seize to lead in the next wave of technology.

Stay tuned for more in this four-part series, and explore the full 50 Big Ideas for 2025 at a16z.com/bigideas.

Resources: 

Find Alex on X: https://x.com/aleximm

FInd Anjney on X: https://x.com/AnjneyMidha

FInd Jennifer on X: https://x.com/JenniferHli

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

As 2025 begins, industries are evolving at unprecedented speed: robots are revolutionizing manufacturing, terabytes of earth observation data are driving new possibilities, and gaming technology is transforming how we design, train, and innovate across sectors.

In this episode, a16z General Partner Erin Price-Wright, Engineering Fellow Millen Anand, and Partner Troy Kirwin discuss the trends reshaping the future of hardware, software, and beyond.

We explore:

• How robots and full-stack engineers are driving the next industrial renaissance.
• The explosion of Earth observation data and its potential to revolutionize industries.
• How gaming technology is moving beyond entertainment to reshape training, design, and more.

This is just the beginning of our four-part series on 50 Big Ideas for 2025—don’t miss the full list at a16z.com/bigideas.

Resources: 

Find Erin on X: https://x.com/espricewright

Find Millen on LinkedIn: https://www.linkedin.com/in/millen-anand/

Find Troy on X: https://x.com/tkexpress11

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this episode of Web3 with a16z, Shopify CEO and cofounder Tobias Lütke joins a16z cofounder Ben Horowitz for a conversation recorded live at the a16z crypto Founders Summit.

Together, they explore what it takes to build a breakout startup in a competitive market, the changing landscape of retail, and how to drive workplace change while navigating corporate culture and calls for activism.

Tobias shares the story behind Shopify's growth from a snowboarding store to a global ecommerce platform serving millions of merchants, discusses the moral imperative of creating great software, and offers insights on leadership, innovation, and embracing negativity as a tool for progress.

The episode also touches on the intersection of AI and crypto, the power of decentralization, and the next wave of technologies reshaping business and commerce.

Resources:

Find Ben on X: https://x.com/bhorowitz

Find Toni on X: https://x.com/tobi

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Did you know the U.S. nurse labor market is over $600 billion annually, but the dedicated software market for nurses is almost zero?

In this episode General Partners Alex Rampell, David Haber, and Angela Strange discuss how AI is revolutionizing labor by automating tasks traditionally done by humans.

They’ll trace the evolution of cloud eras — from the original to financial services-enabled to the current AI-enabled outcomes era — showcasing how AI is creating unprecedented opportunities, allowing startups to outpace incumbents. They also explore how this shift will reshape industries, where we are in the adoption curve and what companies need to succeed, and the gaps where the a16z Enterprise team would love to see more innovation.

Resources:

• AI Turns Capital to Labor:  https://a16z.com/ai-turns-capital-to-labor/
• The Messy Inbox Problem: https://a16z.com/the-messy-inbox-problem-ai-apps-wedge-strategies/
• Vertical SaaS: Now with AI Inside: https://a16z.com/vertical-saas-now-with-ai-inside/
• BarbAIrians at the Gate: The Financial Opportunity of AI: https://a16z.com/financial-opportunity-of-ai/

Stay Updated:

• Let us know what you think: https://ratethispodcast.com/a16z
• Find a16z on Twitter: https://twitter.com/a16z
• Find a16z on LinkedIn: https://www.linkedin.com/company/a16z
• Subscribe on your favorite podcast app: https://a16z.simplecast.com/
• Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.a

Over half of Americans live in childcare deserts, while 90% of brain development happens before the age of five. All the while, education and childcare remain among the most resistant sectors to technological change. Billions of dollars have been spent, but outcomes continue to lag. Why?

In this episode, we dive into the systemic issues—misaligned incentives, political resistance, and the lack of a shared vision around the purchase of an education. We also explore how technology and entrepreneurial innovation may be shifting the tide.

You’ll hear from Anurupa Ganguly (Prisms), Chris Bennett (Wonderschool), Anna Edwards (Whiteboard Advisors), and a16z General Partner Jeff Jordan discuss the criticality of early childhood education, how public-private partnerships are required for scale, and how we can engage risk-averse decision-makers. 

Listen to learn how the next generation can reclaim the American dream.

Resources: 

Find Jeff on Twitter: https://x.com/jeff_jordan

Find Chris on Twitter: https://x.com/8ennett

Find Anna on LinkedIn: https://www.linkedin.com/in/annakimseyedwards/

Find Anurupa on Twitter: https://x.com/aganguly26

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This episode was originally published on our sister podcast, web3 with a16z. If you’re excited about the next generation of the internet, check out the show: https://link.chtbl.com/hrr_h-XC

We've heard a lot about the premise and the promise of prediction markets for a long time, but they finally hit the main stage with the most recent election. So what worked (and didn't) this time? Are they really better than pollsters, is polling dead? 

So in this conversation, we tease apart the hype from the reality of prediction markets, from the recent election to market foundations... going more deeply into the how, why, and where these markets work. We also discuss the design challenges and opportunities (including implications for builders throughout). And we also cover other information aggregation mechanisms -- from peer prediction to others -- given that prediction markets are part of a broader category of information-elicitation and information-aggregation mechanisms. 

Where do domain experts, superforecasters, pollsters, and journalists come in (and out)? Where do (and don't) blockchain and crypto technologies come in -- and what specific features (decentralization, transparency, real-time, open source, etc.) matter most, and in what contexts?  Finally, we discuss applications for prediction and decision markets -- things we could do right away to in the near-future to sci-fi -- touching on trends like futarchy, AI entering the market, DeSci, and more.  

Our special expert guests are Alex Taborrok, professor of economics at George Mason University and Chair in Economics at the Mercatus Center; and Scott Duke Kominers, research partner at a16z crypto, and professor at Harvard Business School  -- both in conversation with Sonal Chokshi. 

As a reminder: None of the following should be taken as business, investment, legal, or tax advice; please see a16z.com/disclosures for more important information. 

Resources:
(from links to research mentioned to more on the topics discussed)

• The Use of Knowledge in Society by Friedrich Hayek (American Economic Review, 1945)
• Everything is priced in by rsd99 (r/wallstreetbets, 2019)
• Idea Futures (aka prediction markets, information markets) by Robin Hanson (1996)
• Auctions: The Social Construction of Value  by Charles Smith
• Social value of public information by Stephen Morris and Hyun Song Shin (American Economic Review, December 2002)
• Using prediction markets to estimate the reproducibility of scientific research by Anna Dreber, Thomas Pfeiffer, Johan Almenberg, Siri Isaksson, Brad Wilson, Yiling Chen, Brian Nosek, and Magnus Johannesson (Proceedings of the National Academy of Sciences (November 2015)
• A solution to the single-question crowd wisdom problem by Dražen Prelec, Sebastian Seung, and John McCoy (Nature, January 2017)
• Targeting high ability entrepreneurs using community information: Mechanism design in the field by Reshmaan Hussam, Natalia Rigol, and Benjamin Roth (American Economic Review, March 2022)
• Information aggregation mechanisms: concept, design, and implementation for a sales forecasting problem by Charles Plott and Kay-Yut Chen, Hewlett Packard Laboratories (March 2002)
• If I had a million [on deciding to dump the CEO or not] by Robin Hanson (2008)
• Futarchy: Vote values, but bet beliefs by Robin Hanson (2013)
• From prediction markets to info finance by Vitalik Buterin (November 2024)
• Composability is innovation by Linda Xie (June 2021)
• Composability is to software as compounding interest is to finance by Chris Dixon (October 2021)
• resources & research on DAOs, a16z crypto

Stay Updated: 

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Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Sales is evolving. AI-native systems are replacing traditional CRM tools, capturing unstructured insights from emails, Slack, surveys, and more in real time. These systems automate early-stage tasks like prospecting and qualification, enabling sales teams to focus on high-value work—while AI provides live coaching and drives decisions across sales, marketing, and product teams.

In this episode, a16z partners Joe Schmidt and Marc Andrusko explore the evolution of sales tools and strategies, sharing their insights on what’s driving this shift.

Is this the “Death of a Salesforce”? Perhaps that’s an overstatement. But one thing is clear: the future belongs to those who leverage data and AI to drive decisions—not just activities.

Resources:

Find Marc Andrusko on X: https://x.com/mandrusko1

Find Joe Schmidt on X: https://x.com/joeschmidtiv

Read the original article: https://a16z.com/ai-transforms-sales/

Stay Updated: 

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Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

What if the biggest challenge of our time isn’t living longer, but living better? 

In this episode, we’re tackling one of humanity’s greatest accomplishments—and perhaps its most overlooked challenge: longevity. As more people live past 100, our systems—healthcare, finance, career planning, and even our cultural perceptions of aging—need a fundamental overhaul. 

We’re joined by Dr. Andrew Scott, author of The Longevity Imperative, and Vijay Pande a16z’s Bio & Health general partner, to explore how a shift from “sick care” to “health care” could transform our lives. Together, we discuss the implications of longer lifespans, from the individual choices that can improve our healthspans to the economic and societal shifts required to sustain a healthier, more productive aging society. 

Join us as we reimagine the future of aging, where living to 100 can be more than survival—it can be a life well-lived.

Resources: 

Find Andrew on X: https://x.com/profandrewscott?lang=en

Find Vijay on X: https://x.com/vijaypande

Learn more about The Longevity Imperative:

https://profandrewjscott.com/the-longevity-imperative/

Stay Updated: 

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Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

America is a country of immense wealth, but our manufacturing infrastructure is struggling to keep pace.

In this episode, we discuss the overlooked crisis of American manufacturing and what it means for our national resilience. a16z’s Oliver Hsu hosts a conversation with founders Jordan Black (Senra Systems), Chris Power (Hadrian), and Bryon Hargis (Castelion) on why we need to revive our industrial base — and fast.

From outdated regulations to the adoption of automation, they break down the “death by a thousand paper cuts” that has left our production capabilities lagging behind. Yet, it’s not all grim: these founders share how their companies are taking bold, vertically integrated approaches to reinvent the sector and reclaim America's industrial edge.

Resources:

Find Chris on X: https://x.com/2112Power

Find Jordan on X: https://x.com/jordan__black

Find Bryon on X: https://x.com/hargsb

Find Oliver on X: https://x.com/oyhsu

Stay Updated: 

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Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

2024 has been a milestone year for autonomous tech. 

Waymo’s fully autonomous driver has surpassed 20 million miles, while FAA approvals now allow commercial drones to fly without visual observers, advancing air autonomy in unprecedented ways.

In this special live recording from SF Tech Week, a16z partner Erin Price-Wright moderates a panel of experts from three key domains—air, land, and sea—to explore the latest real-world deployments of autonomous systems, the impact of new chips on cost and efficiency, building full-stack solutions, managing risk, and the evolving role of regulation in driving these technologies forward.

Joining the conversation is Macario Namie, CMO of Skydio, discussing the transition from consumer drones to enterprise and government use; Vijay Patnaik, Head of Product at Applied Intuition, who shares insights on developer tools and software for autonomous vehicles; and Peter Bowman-Davis, engineering fellow at a16z, diving into maritime autonomy based on his work at Saronic.

Resources: 

Find Macario on LinkedIn: https://www.linkedin.com/in/macario-namie-bb529/

Find Vijay on LinkedIn: https://www.linkedin.com/in/vijaysaipatnaik/

Find Peter on LinkedIn: https://www.linkedin.com/in/peter-bowman-davis/

Find Erin on Twitter: https://x.com/espricewright

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.