What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive? 

Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride. 

From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with her Seven Tenets of Aging. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level. 

What You’ll Learn: 

• The Seven Tenets of Aging and how they’ll change your approach to health 

• Why indulging in “bad” habits doesn’t have to sabotage your longevity 

• Biochemical secrets to combat oxidative stress, glycation, and cellular junk 

• The real story behind NAD, circadian rhythms, and the tools for better sleep 

• How to create a personalized health plan that’s sustainable, effective—and fun 

Resources:  

• Supplement Protocol One-Sheet for this episode: https://www.instagram.com/dave.asprey/?hl=en

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Kaufmann Protocol Website: https://kaufmannprotocol.com 

• Sandra Kaufmann’s Book – Why We Age and How to Stop It: https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047 

• Sandra Kaufmann’s Instagram: https://www.instagram.com/kaufmannantiaging/?hl=en 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

 SPONSORS:  

Leela Quantum | Head to https://leelaq.com/DAVE for 10% off. 

Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 

Timestamps: 

• 00:00 Trailer 

• 00:45 Guest Introduction 

• 02:30 Longevity Insights 

• 04:22 Personal Stories 

• 08:00 Pharmaceuticals 

• 12:26 Diet and Lifestyle 

• 18:19 Seven Tenets 

• 22:04 Sleep and Circadian Rhythms 

• 26:41 NAD and Supplements 

• 37:46 Blood Sugar and AGEs 

• 47:09 Microcirculation 

• 49:08 NRS and Imports 

• 49:18 Celebrex Medication 

• 50:03 Celebrex Benefits 

• 50:41 Alzheimer’s and Celebrex 

• 51:28 Antioxidants 

• 54:26 Stem Cells and Exosomes 

• 58:03 Laser Skin Treatments 

• 01:07:34 Hormones and Longevity 

• 01:20:03 Lithium for Mood 

• 01:27:45 Gender and Longevity 

• 01:32:39 Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is there actual “magic” on this planet, or is it just in the movies? 

Dr. Barry Morguelan, a top surgeon and one of only nine living grandmasters of an ancient Lao Tzu lineage, joins Dave to share secrets that have been hidden for 5,000 years. Together, they explore how the principles behind quantum physics, energy mastery, and timeless healing techniques can revolutionize your health, mindset, and life. 

From breaking rocks with energy to healing broken bones with focused intent, Dr. Barry reveals the extraordinary power of the “Great 8” — a framework to unlock your potential in relationships, creativity, health, intelligence, and more. This episode is packed with incredible stories, actionable wisdom, and a secret GIFT to help you start your own journey toward unparalleled vitality and longevity! 

What You’ll Learn: 

• The 8 ancient secrets to mastering energy, healing, and peak performance 

• How you can harness quantum physics for success 

• Why energy techniques can REVERSE aging and boost health naturally 

• The science of serendipity and how you can harness it daily 

• How to grow stronger, smarter, and healthier every day with simple practices 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Follow Dr. Barry on Instagram: https://www.instagram.com/energyforsuccess.official?igsh=eGcwZWhid3Q1M2Rm&utm_source=qr

• Explore the Great 8 and Get Your Free Gift: https://energyforsuccess.com/dave/ 

• Learn More About Energy Practices: https://energyforsuccess.com/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

 SPONSORS:  

- Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. 

- Calroy | Head to https://calroy.com/dave for an exclusive discount. 

Timestamps: 

• 00:00 Trailer 

• 01:10 Introduction to Dr. Barry and His Journey 

• 06:16 The Turning Point: Mrs. Rodriguez’s Story 

• 09:04 Exploring Alternative Medicine Around the World 

• 13:02 Discovering Ancient Chinese Healing Techniques 

• 16:39 The Power of Quantum Physics and Lao Tzu’s Teachings 

• 27:25 Personal Experiences with Energy Healing 

• 36:35 The Great Eight: Structuring Your Day for Success 

• 36:51 Introduction to Energy for Success 

• 37:17 Understanding the Great Eight 

• 38:23 The Matrix and Animal Brain 

• 44:39 The Importance of Serendipity 

• 49:35 Four Categories of People 

• 53:02 Personal Experiences and Lessons 

• 58:34 The Power of Energy Practices 

• 01:07:06 Conclusion and Call to Action 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What happens when nearly 60 years of combined biohacking expertise collide in one podcast? 

Peter Diamandis is a world-renowned futurist, space entrepreneur, and innovator behind groundbreaking ventures like the XPRIZE and Abundance 360. Dave sits down with Peter to combine their nearly 60 years of biohacking expertise, delivering the ultimate playbook for living longer and healthier.

They dive into revolutionary AI-driven health solutions, mindset shifts that fuel vitality, and practical routines you can start today. Peter, the author of The Longevity Guidebook, shares deeply meaningful tools and tips to expand your healthspan for decades to come. 

What You’ll Learn: 

• The top AI tools reshaping health and longevity 

• Simple daily habits that improve energy, sleep, and brain performance 

• Why mindset is the key to adding years to your life 

• The cutting-edge science of age reversal and functional health 

• How Peter and Dave biohack their routines for peak performance 

Resources:  

• 2025 Biohacking Conference: https://biohackingconference.com/2025 

• Peter Diamandis’s New Book: https://longevityguidebook.com/home-blk-nav 

• Peter Diamandis’s Website: https://www.diamandis.com/ 

• Peter Diamandis’s Purpose Finder (MTP): https://purposefinder.ai/ 

• Danger Coffee: https://dangercoffee.com 

• Dave Asprey’s Website: https://daveasprey.com 

• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books 

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

• Own an Upgrade Labs: https://ownanupgradelabs.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 

SPONSORS:  

-Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off. 

-LMNT | Free LMNT Sample Pack with any drink mix purchase by going to drinklmnt.com/dave. 

Timestamps: 

• 00:00 Open 

• 00:53 Introduction to Peter Diamandis 

• 01:54 Peter’s Longevity Journey 

• 03:26 Tracking Sleep and Biohacking 

• 05:49 The Importance of Deep Sleep 

• 07:22 Thinking Big and Longevity 

• 10:36 Russian Innovations in Sleep 

• 25:29 AI and Longevity 

• 29:01 Gene Editing and Epigenetics 

• 35:13 Light Therapy and Routines 

• 43:07 Gut Health and Endotoxins 

• 44:17 Exploring Conscious Pain Practices 

• 45:51 Hacking Hot Tubs for Health Benefits 

• 46:28 The Science Behind Dopamine Reset 

• 46:43 Introduction to Fountain Life 

• 48:41 Advanced Diagnostics and AI Integration 

• 50:29 Therapeutics and Cutting-Edge Treatments 

• 51:41 The Evolution of Longevity Companies 

• 55:30 The Future of Longevity and Healthspan 

• 01:01:27 The Role of AI in Health and Longevity 

• 01:07:31 Personal Longevity Practices and Insights 

• 01:16:43 Finding Your Purpose for Longevity 

• 01:24:01 Final Thoughts and Resources 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if you could ditch your glasses forever by simply doing a 10-minute exercise each day? 

In this episode, Dave sits down with Dr. Bryce Appelbaum, a visionary in vision biohacking, to uncover how simple techniques can transform your eyesight. From near-far focusing to eye stretches, these exercises don’t just improve your vision—they enhance your brain’s performance, energy, and overall health. 

Dr. Bryce shares his own journey of overcoming severe vision challenges, the science behind vision training, and how anyone can rewire their brain for sharper sight. If you’re dealing with nearsightedness, eye strain, or just want to keep your eyes sharp as you age, this episode shares simple ways to improve how you see the world—literally! 

What You’ll Learn: 

• Why vision training is the next frontier in biohacking 

• Three free techniques to improve your vision naturally 

• How your eyesight affects brain performance and energy levels 

• Why kids and adults need to get outside for better eye health 

• How to train your eyes to stop relying on glasses 

Go to www.screenfit.com/enroll and use code DAVE ($200 OFF with the code) 

Or 

Visit myvisionfirst.com/dave/ for 5000$ off the premium concierge program! 

Sponsors

Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.

Resources:  

• 2025 Biohacking Conference – https://biohackingconference.com/2025 

• Screenfit- Visit https://www.screenfit.com/enroll and use code DAVE ($200 OFF with the code, from $497 to $297) 

• MyVisionFirst – Visit https://myvisionfirst.com/dave/ and apply now to get $5000 off 

• Danger Coffee – https://dangercoffee.com 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Timestamps: 

• 00:00 Intro 

• 00:29 Dave Asprey’s Vision Journey 

• 04:33 Understanding Vision Beyond 20/20 

• 08:01 Impact of Environment on Vision 

• 22:47 Exercises to Improve Vision 

• 27:29 Effective Eye Exercises for Better Vision 

• 27:46 Daily Routine for Eye Health 

• 29:12 Peripheral Vision Training 

• 31:15 Vision and Body Connection 

• 33:38 Handling Visual Overload 

• 35:04 Vision Training Benefits 

• 39:25 Neuroplasticity and Vision 

• 45:22 Vision Training for All Ages 

• 46:38 Practical Vision Improvement Tips 

• 54:24 Final Thoughts on Vision Training 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the secret to living to 250 was simply sitting in the garden? 

In this episode, Dave sits down with Christian Drapeau, a leading expert in stem cell science, to explore the plants and natural practices that could unlock extreme longevity. From goji berries to reishi mushrooms, these age-old remedies do more than nourish—they activate your body’s innate repair system, boosting stem cells and accelerating healing. 

Christian dives into the fascinating stories behind these plants, their ancient origins, and how modern science is proving their power to extend life. He also shares how anyone—regardless of age—can tap into these natural tools to transform their health and longevity. Imagine harnessing the same methods as a Chinese healer reportedly living to 250 years old. Could these practices be the missing link to longer, healthier lives? 

What You’ll Learn: 

• The surprising plants that naturally stimulate stem cells 

• How stem cells repair and rejuvenate your body from the inside out 

• Why fasting can reset your cellular health 

• Practical tips to harness your body’s natural ability to heal 

• The secrets to improving recovery, energy, and longevity 

Resources:  

• 2025 Biohacking Conference - STEMREGEN is the Title Sponsor – https://biohackingconference.com/2025 

• STEMREGEN Website - Visit stemregen.co/dave and save 20% on STEMREGEN! 

• Christian Drapeau’s Website - https://christiandrapeau.com  

• Danger Coffee – https://dangercoffee.com 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors: 

Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  

Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. 

Timestamps: 

• 00:00 Intro 

• 00:57 Meet Christian Drapeau: Stem Cell Expert 

• 02:22 Understanding the Innate Repair System 

• 04:26 Stem Cells and Aging: The Science Explained 

• 05:27 Fasting and Stem Cell Rejuvenation 

• 08:34 STEMREGEN: Activating Your Body’s Stem Cells 

• 12:09 Historical Longevity Practices 

• 17:59 Enhancing Stem Cell Function: Lifestyle Tips 

• 22:45 The Role of PEMF in Stem Cell Activation 

• 26:45 The Importance of Immediate Recovery 

• 27:22 Stem Cells and Longevity 

• 28:13 The Bank Account Analogy of Aging 

• 29:05 Stem Cells and Age-Related Diseases 

• 30:42 Mind Over Matter: The Brain’s Role in Stem Cell Release 

• 32:51 The Quantum Mechanics of Stem Cells 

• 36:22 The Role of Science in Understanding Reality 

• 42:24 Biological Clocks and Stem Cells 

• 46:08 Future of Stem Cell Research and Applications 

• 49:36 Practical Applications and Success Stories 

• 52:23 Conclusion and Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Are we protecting our kids—or unknowingly putting their health at risk? 

Dr. Joel “Gator” Warsh isn’t just another pediatrician; he’s a bold voice speaking out on the vaccine debate that’s dividing parents, doctors, and society. In this episode, we pull back the curtain on one of the most censored and controversial topics of our time. 

With his integrative and functional approach, Dr. Warsh unpacks the startling rise in chronic illnesses among children and questions if we’re truly asking the hard questions about vaccine safety and efficacy. This isn’t about taking sides—it’s about uncovering the truths every parent needs to know. 

Dave and Dr. Warsh dive deep into the science, the myths, and the hidden risks Big Pharma doesn’t want you to hear about. Whether you’re a parent, a skeptic, or just someone seeking the truth, this episode will give you the tools and insights to navigate this complex issue with confidence. 

What You’ll Learn: 

• The alarming rise in chronic illnesses and what might be driving it 

• Why vaccine safety studies may not tell the whole story 

• The critical questions every parent should ask before vaccinating 

• How toxins in our environment are impacting our kids’ health 

• Practical steps to protect your children in today’s world 

 Resources:  

• 2025 Biohacking Conference – https://biohackingconference.com/2025 

• Dr. Joel “Gator” Warsh’s Book: Parenting at Your Child’s Pace – https://www.amazon.com/Parenting-Your-Childs-Pace-Pediatricians/dp/1454952490 

• Dr. Joel “Gator” Warsh’s Website – https://www.integrativepediatrics.com 

• Dr. Joel “Gator” Warsh on Instagram – https://www.instagram.com/drjoelgator 

• Danger Coffee – https://dangercoffee.com 

• Dave Asprey’s Website – https://daveasprey.com 

• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

• Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

• Own an Upgrade Labs – https://ownanupgradelabs.com 

• Upgrade Labs – https://upgradelabs.com 

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors: 

-STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order. 

-BON CHARGE | Go to https://boncharge.com/ and use coupon code DAVE to save 15%. 

Timestamps: 

• 00:00 Intro 

• 00:40 Personal Health Journey and Pediatric Concerns 

• 01:41 Interview with Dr. Joel Gator Warsh 

• 02:49 Rising Chronic Diseases in Children 

• 04:03 Factors Contributing to Health Issues 

• 10:13 Debating Vaccine Safety and Efficacy 

• 30:32 Historical Context and Vaccine Research 

• 44:18 Introduction to Dr. Joe Dispenza and Meditation 

• 45:13 Genetics and Vaccine Controversies 

• 46:16 The Importance of Individualized Medicine 

• 49:02 Western Medicine’s Flaws and Alternatives 

• 50:07 Childhood Health Crisis and Solutions 

• 50:52 Pharmaceutical Industry Critique 

• 52:09 The Role of Parents and Doctors in Child Health 

• 01:04:43 The Influence of Big Pharma on Medicine 

• 01:19:56 Balancing Vaccination Decisions 

• 01:25:44 Conclusion and Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your hearing isn’t just about sound—it’s the key to sharper focus, deeper connections, and increased awareness. In this episode, Dave explores the cutting-edge world of hearing technology with Brandon Sawalich, CEO of Starkey, and reveals how you can gain superhuman hearing with almost no effort.

“Listening” to this episode is going to be one of the best things for your hearing. But why? Because your hearing isn’t just about detecting sounds—it’s about transforming the way you experience the world. Imagine real-time translation in 75 languages, tuning out noise pollution, and amplifying what truly matters—all while protecting your brain from cognitive decline and boosting your overall performance.

Brandon shares the groundbreaking innovations that redefine what hearing devices can do. From biohacking your auditory environment to integrating AI for mood and health tracking, this conversation will change how you think about your ears, your brain, and your future.

What You’ll Gain from This Episode:

• Discover how superhuman hearing enhances focus and reduces mental fatigue

• Learn why better hearing can slow brain aging and improve mental health

• Get an inside look at AI-powered hearing technology that’s changing lives

• Understand the surprising connection between hearing and peak performance

• Find out how upgrading your hearing can unlock new opportunities for success

Sponsor: 

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.

-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

Resources:

• Starkey Hearing Technologies – Explore AI-powered hearing aids and innovations: https://www.starkey.com

• Starkey Blog – Stay updated on the latest in hearing health: https://www.starkey.com/blog

•   Starkey Instagram - https://www.instagram.com/starkeyhearing/

• Danger Coffee – Clean, mold-free coffee for sustained energy: https://dangercoffee.com

• Dave Asprey’s Website – Explore biohacking tools, books, and more: https://daveasprey.com

• Dave Asprey’s Book: Smarter Not Harder – Biohacking made simple: https://daveasprey.com/books

• Dave Asprey’s Linktree – Access all Dave’s platforms: https://linktr.ee/daveasprey

• Upgrade Collective – Join live podcast recordings: https://www.ourupgradecollective.com

• Own an Upgrade Labs – Franchise opportunities for cutting-edge health labs: https://ownanupgradelabs.com

• Upgrade Labs – The ultimate biohacking experience: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback for advanced cognitive enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 Introduction to Hearing Loss

• 01:23 Dave Asprey’s Personal Hearing Journey

• 02:47 Guest Introduction: Brandon Sawalich

• 03:45 Advancements in Hearing Technology

• 06:47 The Importance of Hearing for Brain Health

• 17:32 Hearing Aids as Performance Enhancers

• 25:32 Future Innovations in Hearing Technology

• 27:03 Detecting Lies with Technology

• 27:26 The Science of Sleep Enhancement

• 29:57 Innovation and Risk-Taking in Business

• 32:18 Addressing EMF Concerns with Hearing Aids

• 34:26 Ethical Considerations in Technology

• 37:06 Empowering Users with AI and Hearing Technology

• 43:38 Future of Biohacking and Hearing Superpowers

• 44:57 Conclusion and Final Thoughts

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Fear is quietly running your life—and it’s holding you back from the purpose and success you deserve. In this episode, we revisit Dave chatting with one of the keynote speakers for the Biohacking Conference 2025, Ryan Holiday, the bestselling author of Courage Is Calling, to tackle the one thing standing between you and your potential: fear. 

Why should you listen? Because fear is the root cause of procrastination, self-doubt, and the endless excuses that keep you stuck. Ryan reveals why courage isn’t just about bravery—it’s about making the hard choices that align with your purpose, even when the stakes are high. 

Drawing on powerful examples from history and modern life, Ryan explains how fear can be transformed into a catalyst for action and why embracing discomfort is the key to unlocking true freedom. If you’ve ever felt paralyzed by uncertainty, this episode will give you the tools and perspective to take control, face your fears, and create the life you’re meant to live. 

Why This Episode Matters: 

• You’ll discover how fear sneaks into your decisions—and how to stop it 

• Learn why courage is the ultimate skill for success and fulfillment 

• Get actionable advice to break through self-imposed limits 

• Understand the psychology of fear and how to use it as fuel 

• Hear real-life stories of people who overcame fear to achieve greatness 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

Ryan Holiday’s Website – https://ryanholiday.net 

Daily Stoic Website – https://dailystoic.com/ 

Ryan Holiday’s Book: Courage Is Calling – https://a.co/d/czEfCXC 

Ryan Holiday’s Instagram – https://www.instagram.com/ryanholiday 

Danger Coffee – https://dangercoffee.com 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors 

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 

-Pendulum | Go to https://pendulumlife.com/ and use code Asprey20 for your first month of GLP-1 or any Pendulum formula. 

Timestamps: 

• 00:00 – Intro 

• 00:44 – Discussing Ryan Holiday’s Work 

• 02:37 – The Concept of Courage 

• 08:09 – Fear and Courage in History 

• 12:41 – Stoic Philosophy and Modern Applications 

• 21:50 – The Four Virtues and Their Interrelation 

• 28:39 – Challenges in Admitting Mistakes 

• 35:21 – Navigating Business Risks During a Pandemic 

• 36:44 – The Essence of Courage in Business and Life 

• 37:03 – Reed Hastings and the Duality of Courage 

• 40:06 – Moral Courage: Lessons from History 

• 43:35 – The Debate on Mandates and Personal Freedom 

• 45:22 – Balancing Public Health and Individual Rights 

• 58:29 – The Role of Responsibility in Society 

• 01:09:01 – The Importance of Intellectual Courage 

• 01:12:04 – Reaching Audiences in a Noisy World 

• 01:13:27 – Final Thoughts and Encouragement 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today we are bringing back one of our all-time favorite episodes with James Altucher. 

Dave sits down with James, an entrepreneur, bestselling author, and master experimenter, to uncover why the 10,000-hour rule might just be holding you back. Instead of grinding your way to expertise, James reveals his 10,000 Experiment Rule—a game-changing approach to mastering any skill faster than you thought possible. 

From comedy stages to boardrooms, James has redefined success through relentless experimentation and bold pivots. In this electrifying conversation, he exposes the toxic allure of “failure porn” and why glorifying failure might be sabotaging your growth. You’ll learn why skipping the line isn’t just possible—it’s essential for thriving in a world obsessed with rigid rules. 

This episode dives deep into the power of curiosity, the art of experimentation, and the strategies James uses to crush the myth of conventional wisdom. Whether you’re stuck in a career rut, looking to start something new, or just want to optimize your life, James delivers unfiltered insights to help you rewrite the rules. 

What You’ll Learn: 

• Why the 10,000-hour rule is outdated—and what actually works 

• How “failure porn” is dragging you down (and how to escape it) 

• The 10,000 Experiment Rule that accelerates skill mastery 

• Bold strategies to break through limits and skip the line in any industry 

• Why curiosity is the ultimate superpower for growth and success 

• Practical steps to monetize your passion and build a life you love 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

James Altucher’s Website – https://www.jamesaltucher.com 

The James Altucher Show Podcast – https://podcasts.apple.com/us/podcast/the-james-altucher-show/id794030859 

Danger Coffee – https://dangercoffee.com 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors 

-Calroy | Head to https://calroy.com/dave for an exclusive discount. 

-Viome | Go to https://viome.com/dave to save $110 on the Full Body Intelligence Test. 

Timestamps: 

00:00 Introduction to The Human Upgrade Podcast 

00:38 Meet James Altucher: Entrepreneur and Author 

01:02 The Comedy Journey: From Advice to Stage 

02:06 The Controversial New York Article 

03:42 Facing Backlash and Public Reaction 

10:46 The 10,000 Experiment Rule 

15:44 Skipping the Line: Challenging Conventional Wisdom 

23:35 The Importance of Loving What You Do 

31:30 A Chance Encounter with Howard Schultz 

32:11 The Plus Minus Equals Technique 

33:26 Applying Techniques to Chess Mastery 

34:43 The Importance of Curiosity 

36:30 Experimenting with Comedy 

38:44 The Concept of Failure Porn 

40:39 The Hero’s Journey in Business 

44:42 Living an Experimental Life 

47:10 Frame Control in High-Stakes Situations 

53:43 Advice for Parents and Kids 

55:29 Conclusion and Book Promotion 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Can you use hate to make the world a better place?  

Daryl Davis, a world-class jazz musician, didn’t just confront hate—he dismantled it. By sitting down with over 200 Ku Klux Klan members, he inspired them to leave their robes behind. But this isn’t just a story about racism or redemption; it’s a story about the incredible power of human connection and the lessons it holds for all of us. 

In this special episode, Dave explores how Daryl turned impossible conversations into transformative breakthroughs. Together, they unpack the mindset shifts, emotional intelligence, and fearless curiosity that can break down barriers of all kinds—whether they’re rooted in bias, fear, or misunderstanding. 

Daryl’s approach to erasing hate is so unique, so impactful, that it may just change how you view conflict, compassion, and even your own health. 

What You’ll Learn: 

• How Daryl’s global upbringing shaped his fearless approach to conflict 

• Why eliminating hate starts with understanding, not opposition 

• The neuroscience of compassion and how it rewires your brain 

• How forgiveness can transform your health and happiness 

• A step-by-step framework for tackling impossible conversations 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

Daryl Davis's Book: Klan-destine Relationships (Go read it for free at your local library instead of buying on Amazon :)) 

Daryl Davis's Website – https://www.daryldavis.com 

Daryl Davis on Instagram – https://www.instagram.com/realdaryldavis/ 

Danger Coffee – https://dangercoffee.com 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors: 

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. 

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. 

Timestamps: 

• 00:00 A Shocking Parade Experience 

• 00:38 Meeting the KKK: First Impressions 

• 01:06 Introducing Daryl Davis 

• 03:46 Daryl’s Unique Upbringing 

• 09:52 Confronting Racism: A Lifelong Quest 

• 14:16 The Power of Travel and Perspective 

• 18:25 A High School Encounter with Nazis 

• 21:12 Confronting the Klan Leader 

• 30:57 Changing Minds: A Personal Approach 

• 36:30 The Illusion of Latent Genes 

• 42:08 Collecting Klan Robes: A Symbolic Victory 

• 46:17 Facing the Klan: Staying Grounded 

• 48:27 Challenging Beliefs: Confronting Hate 

• 49:15 The Journey to Writing ‘Clandestine’ 

• 50:26 Introducing ‘The Klan Whisperer’ 

• 51:35 Reflections on Racism and History 

• 57:29 The Power of Forgiveness 

• 59:28 Freedom of Speech and Its Limits 

• 01:02:21 Personal Stories of Racism 

• 01:13:16 Cultural Understanding and Misunderstandings 

• 01:25:16 The Impact of Music on Memory 

• 01:29:02 Final Thoughts and Upcoming Events 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is AI About to Replace Your Doctor? Or Save Your Life? 

The tools that are reshaping healthcare will redefine medicine—and your life—in ways you’ve never imagined. Will artificial intelligence and regenerative therapies like stem cells and exosomes make doctors obsolete? Or will they finally unlock the secrets to living to 180? 

In this episode, Dave sits down with Dr. Pradeep Albert, a leader in regenerative medicine and AI-driven imaging, to explore the intersection of technology, longevity, and healing.  

Dr. Albert shares groundbreaking insights on how AI is revolutionizing medical diagnostics, replacing outdated systems, and empowering patients to take control of THEIR OWN health. He also dives deep into regenerative therapies—how PRP, exosomes, and stem cells are changing the game for injuries, inflammation, and aging.  

Can AI improve patient-doctor relationships? Are doctors becoming coaches instead of gatekeepers? And most importantly, how can you leverage these tools to outlive your peers and enhance every aspect of your health? 

What You’ll Learn: 

• Why 50% of people won’t make it past 76—and how to beat the odds 

• How AI is already better than doctors at diagnosing certain conditions 

• The truth about PRP, exosomes, and stem cells—and when to use each 

• The three rules of longevity every person needs to know 

• How your mindset and epigenetics can help you live longer and healthier 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

Dr. Pradeep Albert’s Book: Exosomes, PRP, and Stem Cells…Medicine – https://www.amazon.com/Exosomes-Stem-Cells-Musculoskeletal-Medicine/dp/B0C2S59S8K 

Dr. Pradeep Albert’s Book: Lifespan Decoded –https://lifespandecoded.com/ 

Dr Pradeep Albert’s Website – https://drpradeepalbert.com/ 

Danger Coffee – https://dangercoffee.com 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors: 

ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

OneSkin | Go to https://oneskin.co/ and use code ASPREY15 for 15% off your purchase. 

Timestamps: 

• 00:00 – Introduction to AI in Medicine 

• 00:36 – The Role of AI in Longevity 

• 00:51 – Meet Dr. Pradeep Alpert 

• 01:11 – AI’s Impact on Healthcare 

• 02:07 – Changing Role of Doctors 

• 05:01 – AI in Medical Imaging 

• 06:37 – Orthopedics and AI 

• 09:19 – Longevity and Epigenetics 

• 14:16 – The Importance of Mindset 

• 29:08 – Trust in the Medical System 

• 43:18 – DIY Health and Longevity 

• 44:21 – The Future of Insurance and Medical Costs 

• 45:45 – Advancements in Imaging Technology 

• 47:26 – The Art of Physical Examination 

• 50:21 – Regenerative Medicine: PRP, Exosomes, and Stem Cells 

• 01:00:23 – Challenges in the US Medical System 

• 01:07:54 – The Role of AI in Medicine 

• 01:18:14 – Final Thoughts and Book Promotion 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.