What exactly is a GLP1 medication? In this episode, Shoshana interviews endocrinologist Rekha Kumar about the market for obesity medicine. Rekha explains how medicines like Ozempic and Wegovy work by regulating insulin and blood sugar management for patients with Type 2 diabetes. They also talk about why physicians need to be cautious about prescribing GLP1 to treat inflammation. After the interview, Shoshana shares a talk from Dhruv Khullar on the role GLP1 can play in treating addiction.

Talk featured

Can Ozempic end addiction? | Dhruv Khullar

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When was the last time you just ... played? Creative health scientist Katina Bajaj thinks adults are in a "play deprivation crisis," where we've replaced our fun-loving human nature with optimization and efficiency. She makes the case that play isn't a reward for productivity but rather a survival skill — and invites you to rediscover the freedom of not knowing where something will end up.

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In this special episode recorded at Aspen Ideas Health, Shoshana interviews Jessica Malaty Rivera, an epidemiologist and science communicator, on how trust in healthcare systems are cultivated—and easily broken down—in times of crisis. Then after their conversation, Shoshana shares a talk from Hamish McKenzie, the cofounder of Substack, on the different media systems emerging and how independent creators are changing the way people receive their news.

Talk featured

This is what the future of media looks like | Hamish McKenzie

This episode was filmed at Aspen Ideas: Health

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From group chats to video calls, technology should make social connection easier than ever. So, why is everyone so lonely?

In this episode, Sabrina sets out to investigate the "loneliness epidemic" that is sweeping the globe and impacting her friends and cohosts. She interviews Professor Fay Bound-Alberti, author of "A Biography of Loneliness: The History of an Emotion" to understand what loneliness is, where it comes from, and whether there is a "cure". In the process, Taha and Melissa challenge Sabrina to tackle her own loneliness through a sidequest that reveals just how hard connection can be in modern life.

Hear more episodes of Corner Piece on your favorite podcast app or here: https://link.mgln.ai/L3EFz6

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Where does pain originate? According to Rachel Zoffness, a scientist and psychologist who studies pain, research shows that pain originates in the brain. In this episode Rachel joins Shoshana to talk about how stress and anxiety can amplify pain. They also discuss the ways medical programs fall short when they don’t teach biopsychosocial pain education and how understanding pain can help you regain power over your body.

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Your belly and your brain speak to each other, says obesity researcher Mads Tang-Christensen. Offering scientific proof that obesity is a disease influenced by genetics and the environment, he introduces a molecule discovered in both the brain and gut that helps control appetite -- and which could be engineered to promote healthy weight loss for those living with obesity.

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Women and girls with autism spectrum disorder often don’t display the behaviors people typically associate with neurodivergence, greatly impacting when, how -- and if -- they are diagnosed. Autism acceptance advocate Kate Kahle makes the case for more research into this gender discrepancy, sharing her personal experience with masking, being diagnosed as a teenager and how it allowed her to better understand herself. “Autism is not a disease, and it doesn’t need to be cured,” she says. “It’s just a different way some brains can work.”

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When does vision loss become blindness? Writer, audio producer and editor Andrew Leland explains how his gradual loss of vision revealed a paradoxical truth about blindness -- and shows why it might have implications for how all of us see the world.

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Have we misunderstood pain? Researcher and physician Amy Baxter unravels the symphony of connections that send pain from your body to your brain, explaining practical neuroscience hacks to quickly block those signals. Her groundbreaking research offers alternatives for immediate pain relief -- without the need for addictive opioids. (Followed by a Q&A with TED current affairs curator Whitney Pennington Rodgers)

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Ever had a hard time doing daily household tasks -- cooking, cleaning, laundry -- and felt like a terrible person for struggling in the first place? Therapist KC Davis is here to flip that negative internalized script with a simple yet perspective-shifting fact that may change your approach to life. Learn a gentler, more practical approach to mental health as Davis shares hard-won wisdom and helpful shortcuts on how to get by when you feel like you've barely got it together.

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Silvana Konermann and the team at Arc Institute are trying to crack one of science's most difficult problems: why complex diseases like Alzheimer's and cancer remain so stubbornly unsolvable, even as research advances. Her solution is a universal “virtual cell” — an AI model trained on a billion biological experiments that can read the language of human cells, predict what's going wrong and reveal how to fix it. In conversation with TED’s Chris Anderson, Konermann explores how this work could fundamentally change the way we discover drugs and treat disease. (This ambitious idea is part of The Audacious Project, TED’s initiative to inspire and fund global change.)

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