- 24 minutes 23 secondsHow To Reverse Your Age For $5 Day (Budget Biohacking) : 1562
I have spent $2.5 million on this body, and Bryan Johnson spends about $5,400 a day on his. But does it need to be that expensive to biohack? So I gave myself a challenge: build a complete anti-aging protocol for $5/day, where every single thing on it has to be validated in humans, not mice. I could not spend the five dollars. In this video I'll show you the entire list and the two most powerful things I found… which cost nothing at all.
You'll Learn:
- How to build a science-backed longevity routine for less than $5 a day
- Why omega-3s, GlyNAC, and magnesium may help slow aging and support cellular repair
- How creatine, vitamin D, and L-theanine support brain health, muscle function, and focus
- Why blackout curtains, red light, and blue-light-blocking glasses can improve sleep and circadian health
- How walking, morning sunlight, fiber, and quality sleep can improve longevity without expensive supplements
- What Dave learned from spending $2.5 million on biohacking and why preventing damage is cheaper than repairing it
Timestamps:
00:00 — The $5/Day Challenge
02:50 — Omega-3s: Aging Clock
04:24 — GlyNAC: Master Antioxidant
06:06 — Magnesium for Sleep
07:50 — Creatine: Brain and Muscle
09:39 — Vitamin D and Theanine
12:09 — Light: Curtains and Bulbs
15:52 — Free: Walking, Sun, Fiber
19:00 — The Full Cost Summary
20:09 — Why I Spent Millions
Thank you to our sponsors!
-Echo | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.
-MyVitalC | Visit www.myvitalc.com/davesfav to unlock Dave’s discount
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-iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestorelaser.com/DAVE
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
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X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/
Try TrueDark glasses: https://truedark.com
Try Danger Coffee: https://dangercoffee.com/discount/davetube
Try Suppgrade Labs: https://shopsuppgradelabs.com/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Join my Substack: https://substack.daveasprey.com
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
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25 October 2026, 2:30 am - 1 hour 15 minutesAvoid THESE "Healthy" Superfoods : 1561
We just had to bring this one back for you. Today, we’re digging once again into specifics about food that you haven’t heard on the show before. This one may very well influence you to rethink your “healthy” diet and change how you feel about food completely. To get there, I’m excited to welcome back Teri Cochrane, an integrative practitioner and pioneer in personalized healthcare.
Teri is the founder of the Global Sustainable Health Institute® and developer of The Cochrane Method®, a future-facing algorithm for decoding the human body. Teri is also one of the world’s leading experts on dietary amyloids, which is a topic I love talking about.
In today’s episode, we get into what amyloids are and how they turn on viruses, cause cancer, and shorten our lives. We also explore the dangers of oxalates and histamines, plus hacks to reduce and release them. Teri and I both have our own recipes for releasing oxalates that you can try at home (they’re surprisingly simple).
We talk about how dirty poultry is killing us—and how superfoods like kale and almonds aren’t any better. We break down the benefits of regenerative farming, and share ways to make your dollar stretch if you can’t afford grass-fed meat. Plus, Teri tells us what she personally eats.
Timestamps:
00:00 — Intro
02:01 — The Big 4 Metabolic Impairments
08:21 — The Dangers of Oxalates
12:02 — The Fifth Disruptor: Histamine
16:22 — Becoming Your Own Body Interpreter
28:41 — How Do We Get Off Oxalates?
35:41 — Dave’s Recipe for Releasing Oxalates
44:40 — Hacks for Histamines
50:32 — Amyloid 101: What You Should Know
56:56 — Should You Beware of B6?
59:54 — What’s the Best Kind of Protein?
Thank you to our sponsors!
-Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.
-BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.
-Neuronic | Go to www.neuronic.online Code DAVE for $100 off
-iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE irestorelaser.com/DAVE
Resources
Website: tericochrane.com
Instagram: @tericochranebeyondnutrition
YouTube: @TeriCochrane
The Global Sustainable Health Institute: globalsustainablehealthinstitute.com
Read: The Wildatarian Diet by Teri Cochrane
What You Eat is Turning Your Genes On and Off – Teri Cochrane – #646
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
YouTube: https://www.youtube.com/c/daveaspreybpr
Danger Coffee: https://dangercoffee.com/discount/dave15?
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Join my Substack: https://substack.daveasprey.com
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
23 October 2026, 1:30 am - 56 minutes 1 secondHow to Trigger Flow States From The 5 Brain Chemicals You Need : 1559
The Neuroscience of Flow, Peak Performance, Psychedelics, Trauma, Intuition & Consciousness with Steven Kotler
Host Dave Asprey sits down with Steven Kotler, New York Times bestselling author and leading researcher in the neuroscience of flow, to explore how altered states of consciousness influence peak performance, mental health, creativity, intuition, and our perception of reality.
Steven Kotler is a bestselling author of 17 books, including The Art of Impossible and We Are as Gods, and the founder of the Flow Research Collective. For decades, he has studied the neurobiology of peak performance, working with elite athletes, military personnel, and high-performing professionals to understand how people can reliably access flow states.
Dave and Steven begin by exploring the neuroscience of flow and why it may be one of the most powerful altered states available without drugs. Steven explains how dopamine, norepinephrine, serotonin, anandamide, and endorphins contribute to the flow experience, why his research suggests caffeine can increase flow susceptibility, and how chasing the neurochemical high of peak performance can become dangerous.
They discuss the darker side of flow training, including its potential risks for people prone to mania, the importance of recovery, and why attempting to remain in a flow state indefinitely can undermine performance. Steven shares how his training programs approach sleep, attention, and behavioral changes to help people access flow more consistently.
The conversation then moves into psychedelics, ketamine-assisted therapy, and the neuroscience of trauma. Steven introduces emerging research suggesting that unresolved emotional patterns may involve the brain's predictive processing systems. Dave shares a personal experience involving Joe Rogan and how revisiting an early childhood memory changed his emotional response to public criticism.
Dave and Steven also explore how the brain constructs reality, including the neuroscience of perception, sensory processing, and the flexible boundary between ourselves and our environment. They discuss how flow alters our sense of self, why the brain predicts what we experience before we consciously perceive it, and how these mechanisms may help explain certain spiritual and out-of-body experiences.
Finally, Steven reveals new research investigating the neurological connections between flow, intuition, synchronicity, and purpose. He discusses emerging theories of consciousness, the role of information processing in subjective experience, and how artificial intelligence may change the future of human performance.
You'll Learn:
- How flow states influence dopamine, norepinephrine, serotonin, anandamide, and endorphins, and why Steven's research suggests caffeine may help make the brain more susceptible to flow.
- Why chasing the neurochemical high of flow can become dangerous, how flow training may affect people prone to mania, and why sleep and recovery are essential for sustained peak performance.
- How ketamine-assisted therapy may help uncover forgotten emotional experiences and why Steven believes the brain's predictive processing systems play an important role in trauma.
- How the brain constructs our perception of reality, why sensory information reaches consciousness at different speeds, and what happens to our sense of self during altered states.
- Why flow may enhance intuition and how emerging neuroscience research is investigating connections between synchronicity, purpose, and the brain's information-processing systems.
- How Steven is using neuroscience, artificial intelligence, and years of flow training data to develop more accessible methods for improving focus, learning, and performance.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Steven Kotler, Dave Asprey, flow state, neuroscience of flow, peak performance, Flow Research Collective, dopamine, caffeine and flow, altered states, consciousness, psychedelics, ketamine therapy, trauma, predictive processing, neuroplasticity, intuition, synchronicity, brain science, mental performance, cognitive enhancement, flow triggers, serotonin, anandamide, meditation, human optimization, artificial intelligence, We Are as Gods, The Art of Impossible
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Resources:
• Explore Steven Kotler's books, research, and flow training programs at https://www.flowresearchcollective.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
Thank you to our sponsors!
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save
- OneSkin | For a limited time try the new OS-01 FACE RICH CREAM with 15% off at oneskin.co/DAVE
- Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.
Timestamps:
00:00 — Trailer
01:12 — Intro
05:08 — Psychedelics and Peak Performance
11:10 — Trance, Voices, and Shamanism
18:00 — Dangers of Flow Training
24:00 — Ketamine and Innate Intelligence
30:00 — The Prediction Problem
35:25 — Embodied Cognition
46:30 — Consciousness and Synchronicity
50:20 — New Books and Research
53:00 — Flow for the Many
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
22 October 2026, 7:30 am - 48 minutes 46 secondsThe 6-Minute Morning Routine That Can Change Your Life : 1558
The Miracle Morning, Visualization, Affirmations, Meditation, Morning Routines, Productivity & the Psychology of Success with Hal Elrod
Host Dave Asprey sits down with Hal Elrod, bestselling author of The Miracle Morning and personal development expert, to explore morning routines, visualization, affirmations, meditation, productivity, circadian rhythms, habit formation, and the psychology of success.
Hal Elrod is the creator of The Miracle Morning, a bestselling book and personal development method that has helped millions improve their daily habits. After surviving a devastating car accident at age 20 and later battling life-threatening cancer, Hal developed a philosophy centered on resilience, personal responsibility, and consistent daily practices.
Dave and Hal challenge the idea that success requires waking up at 5 AM. They discuss chronotypes, circadian biology, and why morning routines should work with your natural sleep patterns. Hal introduces his six-part SAVERS framework, explaining how meditation, affirmations, visualization, exercise, reading, and journaling can transform your morning in as little as six minutes.
They explore how smartphones disrupt attention, why visualization works best when paired with mental rehearsal, and how these techniques can help overcome procrastination. Hal shares how he used visualization to train for a 52-mile ultramarathon, while Dave discusses advanced meditation, neurofeedback, and the role of emotional states in mental performance.
The conversation also challenges traditional positive affirmations. Hal explains why unrealistic statements often fail and shares a three-step method for setting commitments, identifying motivations, and taking action. Dave connects these practices to consciousness, altered states, and the relationship between intention and human performance.
Finally, Hal reflects on surviving cancer and a near-fatal car accident, sharing how his daily practices helped him build resilience. Dave and Hal discuss the balance between disciplined action, belief, and the mental states that influence our ability to achieve meaningful goals.
This episode is essential listening for anyone interested in morning routines, visualization, affirmations, meditation, productivity, habit formation, circadian rhythms, overcoming procrastination, mental performance, emotional resilience, consciousness, and the science of personal development.
You'll Learn:
- Why waking up at 5 AM isn't necessary for success and how to build a morning routine around your natural circadian rhythm and chronotype
- How Hal Elrod's six SAVERS practices can improve daily focus, discipline, and emotional well-being in as little as six minutes
- Why checking your smartphone first thing in the morning can undermine attention, productivity, and your ability to respond intentionally throughout the day
- How to use visualization and detailed mental rehearsal to overcome procrastination, strengthen motivation, and follow through on difficult goals
- Why traditional positive affirmations often fail and how to create actionable affirmations based on specific commitments, meaningful reasons, and daily behaviors
- How meditation, emotional states, and intentional daily habits helped Hal navigate life-threatening health challenges and develop greater resilience
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords:
Hal Elrod, Dave Asprey, The Miracle Morning, Miracle Morning routine, SAVERS method, six minute morning routine, morning habits, 5 AM wake up, circadian rhythm, sleep chronotypes, visualization techniques, mental rehearsal, positive affirmations, actionable affirmations, meditation, morning meditation, overcoming procrastination, habit formation, productivity habits, goal setting, self discipline, emotional resilience, neurofeedback, altered states, consciousness, biohacking
Resources:
• Explore Hal Elrod's Miracle Morning method, books, documentary, and app at https://miraclemorning.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
Thank you to our sponsors!
-Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh
-Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save.
-BodyHealth |Visit BodyHealth.com and use code DAVE20 for 20% off your first purchase.
-Quantum Upgrade | Go to QuantumUpgrade.io/DAVE. to claim your 15-day free trial
Timestamps:
00:00 — Trailer
01:30 — Intro & Miracle Morning
05:03 — The SAVERS Acronym
10:38 — Social Media & Smartphones
16:30 — Combining SAVERS & Visualization
22:08 — The Ultramarathon Story
28:24 — Affirmations & State
34:10 — Manifestation & Consciousness
37:26 — Near-Death & Miracles
42:30 — Perception & Brain Power
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
20 October 2026, 7:30 am - 13 minutes 4 seconds400mg Before Bed Improves Deep Sleep by 1700% : 1557
Try TrueDark glasses: https://truedark.com
Try Danger Coffee: https://dangercoffee.com/discount/davetube
Try Suppgrade Labs: https://shopsuppgradelabs.com/
I slept 8 hours a night and got 5 minutes of deep sleep, and no doctor could help me. Then I found a molecule that hits the same receptor as Valium but WITHOUT sedating you. 400 mg before bed, stacked with four things that cost nothing, took me from 5 minutes to 90. Here's all five, plus WHY it’s mission critical you get this precious deep sleep (hint: it has to do with your memory as you age).
Thank you to our sponsors!
-ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.
-Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh
-Fatty15 | Go to fatty15.com/DAVE to get an additional 15% off their 90-day Starter Kit
-iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE
Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr
The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/
Danger Coffee: https://dangercoffee.com/discount/dave15?
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Join my Substack: https://substack.daveasprey.com
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
18 October 2026, 8:30 am - 1 hour 45 minutesJohn Gray: Why Men Stop Wanting Their Wives : 1556
The king is back! You probably recognize his name as the author of the famous book, Men Are From Mars, Women Are From Venus.
But what's especially exciting is how John has evolved his insights to address the changing dynamics between men and women in the modern world, as he highlighted in his 2020 book, Beyond Mars and Venus: Relationship Skills for Today's Complex World.
Now, why is this episode a must-listen? Well, John isn't just a relationship expert; he's also a seasoned biohacker who understands the profound impact of our environment – including relationships – on our hormones, happiness, and dopamine levels. In essence, he's been biohacking before it even had a name. With decades of wisdom, he offers invaluable insights into navigating the complexities of male-female relationships in today's world.
Delve into the fundamental differences between men and women, the importance of appreciation in relationships, what truly motivates men, and practical tips on boosting testosterone and managing emotions. We also explore how men and women process feelings differently, the art of setting boundaries, and the language of love as the language of hormones.
Get ready for a masterclass in understanding the dynamics of modern relationships and how to create lasting happiness.
Timestamps:
00:00 — Intro
04:57 — Hormones Drive Relationships
08:29 — Emotional Manipulation & Control
20:42 — Detachment & The Cave
31:37 — Listening Without Losing It
39:49 — When Negativity Never Passes
46:54 — Fasting & Testosterone Science
01:04:23 — Languages of Love & Hormones
01:14:54 — Surviving Public Attacks
01:31:41 — Porn, Polarity & Reassurance
01:44:00 — Wrap-Up
Thank You To Our Sponsors!
- Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh
- The One Device | Use code DAVE for $10 off at theonedevice.com/dave
- Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
- iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE
Resources:
• Learn More About John’s Work At: https://www.marsvenus.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
Timestamps:
00:00 — Intro
04:57 — Hormones Drive Relationships
08:29 — Emotional Manipulation & Control
20:42 — Detachment & The Cave
31:37 — Listening Without Losing It
39:49 — When Negativity Never Passes
46:54 — Fasting & Testosterone Science
01:04:23 — Languages of Love & Hormones
01:14:54 — Surviving Public Attacks
01:31:41 — Porn, Polarity & Reassurance
01:44:00 — Wrap-Up
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
16 October 2026, 8:30 am - 40 minutes 18 secondsSleep Expert: 80% of Sleep Problems Come From THIS : 1555
Sleep Anxiety, Insomnia, Circadian Rhythms, Chronotypes, Sleep Trackers & How to Sleep Better with Dr. Michael Breus
Host Dave Asprey sits down with Dr. Michael Breus, clinical psychologist, sleep specialist, and internationally recognized sleep expert known as The Sleep Doctor, to explore insomnia, sleep anxiety, circadian rhythms, chronotypes, nighttime awakenings, temperature regulation, sleep medications, wearable sleep trackers, and the science of improving sleep quality.
The conversation challenges conventional thinking about sleep, including whether everyone needs eight hours, why trying harder to fall asleep can make insomnia worse, and how the body's internal clock influences energy, productivity, and recovery.
Dr. Breus explains why he believes fear and anxiety contribute to a substantial proportion of sleep problems. He describes how worrying about falling asleep, waking up at 3 a.m., or feeling exhausted the next day can create a cycle of stress that makes restful sleep increasingly difficult. Dave and Michael explore how cognitive behavioral therapy, emotional regulation, and changing your relationship with sleep may help break that cycle without relying exclusively on medication.
They also examine the science of chronotypes, the biological differences that influence when people naturally feel alert or sleepy. Michael explains why aligning sleep, work, meals, and exercise with your individual circadian rhythm may improve sleep efficiency and daytime performance. Dave shares how changing his exposure to artificial light and adjusting his daily routines helped him shift from being a night owl to maintaining an earlier bedtime.
The discussion then turns to the three physiological conditions Michael considers essential for falling asleep: lowering core body temperature, reducing heart rate, and decreasing anxiety. He explains why simply turning down the thermostat may not be enough to cool your body under the covers, how temperature-controlled mattresses can support thermoregulation, and why something as simple as warming your feet may help your body release heat.
Dave and Michael also discuss blue light, nighttime lighting, and the environmental signals that regulate circadian timing. They examine why light exposure, meal timing, exercise, temperature, and social interaction can influence the body's internal clock, along with the limitations of conventional blue-light-blocking glasses.
The conversation explores why sleeping pills may fail to address the underlying causes of chronic insomnia, how nighttime awakenings can trigger negative thinking, and why the fear of being tired may sometimes become more disruptive than the tiredness itself. Dave shares his experience deliberately restricting sleep while building his businesses, and Michael explains the difference between temporarily functioning with less sleep and maintaining healthy sleep habits over the long term.
They also challenge the growing obsession with sleep scores, deep sleep measurements, and wearable tracking devices. Michael explains why consumer sleep trackers cannot provide the same measurements as a clinical sleep study, why individual sleep-stage estimates should be interpreted cautiously, and why how you feel in the morning remains an important indicator of sleep quality.
Finally, Dave and Michael examine emerging research on creatine supplementation and sleep deprivation, including whether creatine can temporarily support cognitive performance after insufficient sleep. They discuss the potential benefits, limitations, and risks of using supplements to compensate for lost sleep, emphasizing why improving sleep quality should remain the priority.
This episode is essential listening for anyone interested in insomnia, sleep anxiety, waking up at 3 a.m., circadian rhythms, chronotypes, sleep optimization, blue light, temperature regulation, sleep medications, cognitive behavioral therapy, wearable sleep trackers, deep sleep, creatine, cognitive performance, longevity, and the science of getting better sleep.
You'll Learn:
- Why Dr. Michael Breus believes fear and anxiety contribute to many sleep problems, and how worrying about sleep can make insomnia worse
- How your chronotype influences your ideal bedtime, wake-up time, energy levels, and the amount of sleep you may need
- Why lowering body temperature, heart rate, and anxiety can help you fall asleep faster and improve sleep quality
- How nighttime light exposure, meal timing, exercise, and bedroom temperature influence circadian rhythms and sleep
- Why waking up at 3 a.m. can trigger negative thinking, and how changing your response to nighttime awakenings may help
- What sleep trackers get wrong about deep sleep, how to interpret your sleep data, and whether creatine can help when you're sleep-deprived
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Michael Breus, Dr. Michael Breus, The Sleep Doctor, Dave Asprey, The Human Upgrade, sleep expert, insomnia, sleep anxiety, sleep disorders, sleep problems, sleep quality, sleep optimization, how to fall asleep, waking up at 3am, circadian rhythm, chronotypes, sleep cycles, sleep deprivation, deep sleep, REM sleep, blue light, blue light blocking glasses, bedroom temperature, thermoregulation, sleep trackers, Oura Ring, sleep scores, cognitive behavioral therapy, sleeping pills, creatine, cognitive performance, biohacking, longevity
Resources:
• Learn More About Michael’s Work At: http://chronoquiz.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
Thank you to our sponsors!
- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- fatty15 | Go to fatty15.com/DAVE to get an additional 15% off their 90-day Starter Kit.
- MOD | Visit https://mod.com/ for a consultation and get 10% off your first order plus free shipping with promo code DAVE.
Timestamps:
00:00 — Trailer
01:27 — Intro
02:46 — Chronotypes & Sleep Compression
05:00 — Blue Light Glasses Debate
07:50 — Night Owls & Morning Meetings
12:15 — Circadian Time Cues
14:21 — Temperature & Thermoregulation
19:58 — EMFs & Sleep Sensitivity
25:01 — Sleep Research & Fear
30:28 — Sleep Deprivation Experiment
36:15 — Trackers & Creatine
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
15 October 2026, 8:30 am - 49 minutes 29 secondsThe Science Behind Joint and Cartilidge Repair : 1554
Explore Calroy's vascular health and joint support supplements, including Arterosil, Vascanox, and Cartigenix, at https://calroy.com/dave
Cartilage Regeneration, Joint Pain, Nitric Oxide, Blood Flow, Muscle Strength & Longevity with Kiran Krishnan
Host Dave Asprey sits down with Kiran Krishnan, research microbiologist, systems biology researcher, and co-founder of Microbiome Labs, to explore cartilage regeneration, joint pain, osteoarthritis, nitric oxide, vascular health, inflammation, muscle growth, gut health, bone density, and the biological mechanisms that influence how the body ages.
Kiran Krishnan is a research microbiologist, health and wellness expert, and entrepreneur who specializes in the human microbiome, gut health, inflammation, and systems biology. Over the past 20 years, he has founded several successful health and supplement companies, including co-founding and leading Microbiome Labs, a leading microbiome therapeutics brand among healthcare professionals. He is also a co-founder and partner in three other health companies. Kiran has conducted and published scientific research, contributed chapters to scientific textbooks, holds global patents, and is a sought-after speaker on human health and the microbiome.
His latest work explores the relationship between blood vessel health, chronic inflammation, and the body's ability to repair damaged cartilage. Through research involving compounds designed to support vascular function, nitric oxide production, and joint health, Kiran is investigating whether age-related tissue degeneration can be slowed or potentially reversed.
Dave opens the conversation by sharing his lifelong struggle with joint pain, including an arthritis diagnosis at age 14 and three knee surgeries. Kiran explains why cartilage degeneration may begin long before symptoms appear and how declining blood flow, damaged microvessels, and chronic inflammation can interfere with the body's natural cartilage repair mechanisms.
They explore the role of the endothelial glycocalyx, the protective lining inside blood vessels, and why nitric oxide production becomes increasingly important with age. Kiran explains how impaired circulation can affect everything from joint lubrication and cartilage health to cognitive performance, digestion, muscle recovery, and sexual function.
Kiran also discusses research involving Cartigenix, a joint support supplement developed using compounds from Boswellia and celery seed. He describes clinical trials involving patients with osteoarthritis, including reported improvements in joint pain, inflammation, and cartilage regeneration, even among older adults with advanced joint degeneration. Dave and Kiran examine how Cartigenix, Arterosil, and Vascanox target different aspects of joint and vascular health, while distinguishing the Cartigenix trial results from the proposed benefits of combining all three products.
The conversation then shifts to practical strategies for improving circulation and metabolic health. Dave and Kiran discuss why walking after meals may help regulate blood sugar, how the cephalic response prepares the digestive system for food, and why excessive endurance exercise may create trade-offs for recovery and long-term health.
They also challenge conventional thinking about muscle growth and longevity. Kiran explains why functional strength may matter more than muscle size, how nitric oxide and microcirculation influence the delivery of amino acids to muscle tissue, and why maintaining healthy blood vessels could be an overlooked factor in preserving strength as you age.
Finally, Kiran previews emerging research on bone regeneration, gut health, and a new postbiotic-based formulation being developed for bone health, particularly during perimenopause and menopause. He shares early findings involving bone repair and osteocyte production, while Dave explains why maintaining strong bones, healthy joints, and efficient circulation should be foundational priorities for anyone interested in longevity.
This episode is essential listening for anyone interested in cartilage regeneration, osteoarthritis, chronic joint pain, nitric oxide, blood circulation, vascular health, inflammation, muscle growth, strength training, gut health, bone density, menopause, cellular repair, supplements, biohacking, and the science of maintaining physical performance as you age.
You’ll Learn:
- Why cartilage breaks down with age and how impaired blood flow and chronic inflammation interfere with joint repair
- What Kiran's clinical research suggests about cartilage regeneration and joint recovery in people with osteoarthritis
- How nitric oxide and the endothelial glycocalyx influence circulation, cardiovascular health, cognitive function, and longevity
- Why functional strength may be more important than muscle size for healthy aging, and how blood flow affects muscle growth and recovery
- How walking after meals, supporting digestion, and improving vascular function may benefit blood sugar regulation and gut health
- What emerging research suggests about bone regeneration, postbiotics, and maintaining bone density during menopause and aging
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Kiran Krishnan, Dave Asprey, The Human Upgrade, cartilage regeneration, cartilage repair, joint pain, osteoarthritis, arthritis, knee pain, joint health, bone on bone arthritis, Cartigenix, Calroy, Arterosil, Vascanox, nitric oxide, blood flow, vascular health, endothelial glycocalyx, chronic inflammation, Boswellia, muscle growth, muscle strength, strength training, muscle recovery, gut health, microbiome, bone density, bone regeneration, longevity, anti aging, biohacking
Resources:
• Grab A Discount On Calroy's Vascular Health And Joint Support Supplements, Including Arterosil, Vascanox, and Cartigenix, at https://calroy.com/dave
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
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Timestamps:
00:00 — Trailer
01:05 — Intro
04:44 — The Glycocalyx Explained
10:30 — Why Joints Degrade
15:16 — Rebuilding Cartilage
21:17 — Nitric Oxide & Gut Health
26:28 — Hacking the Cephalic Response
31:23 — Strength vs. Size for Longevity
37:47 — Muscle Building Supply System
42:51 — New Bone Regeneration Product
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13 October 2026, 8:30 am - 18 minutes 34 secondsYour Brain Has a Focus Switch (Here's How to Turn It On) : 1553
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This video reveals that the brain has a documented neurological focus state driven by prefrontal cortex activation and norepinephrine signaling that most people access accidentally but can learn to trigger reliably. Dave explains the biological mechanism and the specific supplement and behavioral stack that activates this state within 20 minutes.
You'll Learn:
- Why your brain has a neurochemical "focus switch" and how to flip it on in about 20 minutes, with no extra willpower or motivation
- How norepinephrine and dopamine work together to lock you into deep focus, and what happens when only one of them is present
- Why chronic stress, poor sleep, and sitting all day drain the exact chemicals your focus depends on
- How L-tyrosine gives your brain the raw materials to make focus chemicals, and the dose and timing that work
- Why the 1:2 ratio of caffeine to L-theanine beats coffee alone for working memory, accuracy, and calm, sustained concentration
- Which options like modafinil and Rhodiola rosea support norepinephrine and dopamine, and how they compare
- How morning light and five minutes of movement set your focus chemistry for the entire day
- Why focus is never about effort, and how the right chemistry makes deep work feel effortless
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Timestamps:
00:00 — The Focus Switch
01:44 — Habit One: Chronic Stress
03:38 — Habit Two: Bad Sleep
04:58 — Habit Three: Sitting
06:21 — Norepinephrine and Dopamine
09:40 — L-Tyrosine
10:41 — Caffeine and L-Theanine
12:30 — Modafinil and Rhodiola
14:42 — The 20-Minute Protocol
17:34 — The Right Fuel
Connect with Dave Asprey!
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11 October 2026, 8:30 am - 11 minutes 10 secondsInfections & Cancer, Finasteride Side Effects, Blueberry Benefits, Vitamin D & Fertility, and CoQ10 : 1552
Infections Were Linked to About 1 in 8 Cancer Cases Worldwide
A new global analysis estimates that infections were responsible for roughly 2.3 million new cancer cases in 2024, about 12% of all cancers worldwide. H. pylori and HPV were the largest contributors, followed by hepatitis B, Epstein-Barr virus, and hepatitis C. Host Dave Asprey explores how persistent infections can contribute to cancer through chronic inflammation, DNA damage, altered immune surveillance, and other biological pathways. He explains why this does not mean cancer is contagious or that infection inevitably leads to cancer, but argues that identifying, preventing, and treating infections such as H. pylori, hepatitis B, and hepatitis C can be an overlooked part of a long-term prevention strategy.
Sources:
-IARC: Global Burden of Cancer Attributable to Infections in 2024
-PubMed: Global Burden of Cancer Attributable to Infections in 2024
~~~~
What We Really Know About Persistent Finasteride Side Effects
Finasteride reduces the conversion of testosterone into DHT by inhibiting 5-alpha reductase, but that enzyme also participates in pathways involved in neuroactive steroids. Some former users report persistent sexual, cognitive, mood, and physical symptoms after stopping the drug, a collection of symptoms commonly called post-finasteride syndrome. Small studies have reported differences in neurosteroids, gene expression, androgen signaling, and peripheral nerve function among symptomatic former users, but these studies cannot establish that finasteride caused those changes or determine how common persistent symptoms are. Host Dave Asprey examines the evidence between the two extremes, neither dismissing persistent symptoms nor assuming that finasteride permanently damages everyone who takes it. European regulators have also recognized suicidal ideation as a possible adverse effect of oral finasteride, although its frequency remains unknown.
Sources:
-EMA: Finasteride and Dutasteride Safety Review
-PubMed: Neuroactive Steroids After Finasteride Discontinuation
PubMed: Neuroactive Steroids and Features in Post-Finasteride Patients
PubMed: Differential Gene Expression in Post-Finasteride Syndrome
~~~
One Cup of Blueberries a Day Improved Measures of Vascular Function
In a six-month randomized controlled trial involving 115 adults with metabolic syndrome, consuming the equivalent of one cup of blueberries per day improved endothelial function and a measure of arterial stiffness, while a half-cup dose did not produce the same effects. Host Dave Asprey explains why describing blueberries simply as “antioxidants” misses much of their biology. Anthocyanins and other polyphenols can interact with gut microbes and influence vascular, inflammatory, and nitric oxide-related signaling. He also examines a small smoothie experiment showing that the polyphenol oxidase found in bananas sharply reduced the circulating metabolites of certain flavan-3-ols, while emphasizing that the experiment did not prove bananas erase the benefits of blueberries.
Sources:
-American Journal of Clinical Nutrition: Blueberries and Cardiometabolic Function
-Food & Function: Polyphenol Oxidase and Flavan-3-ol Bioavailability
~~~
Vitamin D Matters to Male Reproductive Biology, But It Is Not a Fertility Treatment
Vitamin D receptors are present throughout the male reproductive system, and vitamin D signaling may influence processes involved in sperm motility and fertilization. Observational research has linked low vitamin D with poorer sperm motility, but clinical outcomes are less straightforward. In a randomized trial of 330 vitamin D-insufficient infertile men, supplementation raised vitamin D levels but did not improve overall semen parameters. Researchers observed potentially interesting signals involving spontaneous pregnancy and live birth among a subgroup of men with low sperm counts, but those findings require confirmation. Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense while arguing that male fertility needs to be evaluated as a larger system involving metabolic health, sleep, heat exposure, medications, hormones, micronutrients, toxins, oxidative stress, and semen testing.
Sources:
-PubMed: Vitamin D Supplementation, Semen Quality and Live Birth Rate
~~~
CoQ10 Shows Why a Great Mechanism Does Not Guarantee a Great Treatment
CoQ10 plays a central role in mitochondrial energy production and electron transport, making it an appealing candidate for diseases involving mitochondrial dysfunction, oxidative stress, and neuronal energy failure. Early biological reasoning and smaller studies looked promising, but larger clinical trials have repeatedly failed to show the expected neurological benefits. A randomized trial of 600 people with early Parkinson’s disease found no evidence that high-dose CoQ10 slowed disease progression, while a large Huntington’s disease trial was stopped early for futility. A Phase II ALS trial also found insufficient evidence to justify moving to a larger Phase III study. Host Dave Asprey uses CoQ10 as a broader lesson in biohacking: a supplement can have a legitimate biological function while still failing to improve the clinical outcome you care about.
Sources:
-PubMed: High-Dose CoQ10 in Early Parkinson Disease
-Neurology: CoQ10 in Huntington Disease
-PubMed: Phase II CoQ10 Trial in ALS
~~~
This episode is designed for biohackers, longevity enthusiasts, men thinking about hair loss or fertility, and anyone trying to distinguish a compelling biological mechanism from a proven intervention. Host Dave Asprey examines how chronic infections contribute to cancer risk, what the evidence really says about persistent finasteride symptoms, why blueberries may influence vascular health through polyphenol signaling, where vitamin D fits into male fertility, and why CoQ10 is a powerful example of promising biology failing to translate into clinical outcomes. The larger lesson is simple: understand the mechanism, look for meaningful human outcomes, measure your own biology, and avoid confusing a plausible explanation with proof that an intervention works.
Keywords: infection cancer risk, cancer causing infections, H pylori cancer, HPV cancer, Epstein Barr virus cancer, chronic infection cancer, finasteride side effects, post finasteride syndrome, finasteride neurosteroids, allopregnanolone finasteride, DHT hair loss, blueberries cardiovascular health, blueberries endothelial function, blueberry polyphenols, anthocyanins gut microbiome, banana smoothie polyphenols, polyphenol oxidase, vitamin D male fertility, vitamin D sperm quality, male infertility, CoQ10 mitochondria, CoQ10 Parkinson’s disease, CoQ10 neurodegeneration, mitochondrial health, biohacking research roundup
Thank you to our sponsors!
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Resources:
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Timestamps:
00:00 — Intro
00:45 — Infections From 2024
02:15 — Finasteride Concerns
04:38 — Blueberries and Bananas
06:40 — Vitamin D and Fertility
08:18 — CoQ10 Trial Failures
09:47 — Takeaway
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9 October 2026, 8:30 am - 1 hour 4 minutesHow to Unlock Psychic Abilities to Know When You’ll Die : 1551
Get a free digital and audiobook copy of Angelic Attendants at https://askjulieryan.com/request-ebook/
Psychic Abilities, Medical Intuition, Energy Healing, Remote Viewing & What Happens When We Die with Julie Ryan
Host Dave Asprey sits down with Julie Ryan, psychic, medical intuitive, inventor, author, entrepreneur, and host of the Ask Julie Ryan podcast, to explore intuition, consciousness, energetic healing, remote viewing, communication with spirits, past lives, dreams, and what Julie says happens as people approach death.
Julie Ryan is a psychic and medical intuitive who says she can sense medical conditions, facilitate energetic healings, communicate with spirits, scan animals, access past lives, and tell how close someone may be to death. She is also an inventor, author, radio host, podcaster, and serial entrepreneur who has founded nine companies across five industries. Her surgical device inventions are sold globally, and unlike many people working in the intuitive space, Julie says her psychic and medical intuitive abilities were learned.
Her book Angelic Attendants: What Really Happens As We Transition From This Life Into The Next explores what she describes as the process of dying, including the presence of angels, deceased family members, friends, pets, and other experiences that may occur near the end of life.
Julie explains how she went from building companies and inventing surgical devices to learning psychic and medical intuitive skills she now teaches to others. She describes how she believes people can remotely sense information about the body, distinguish intuition from ordinary thoughts, and develop abilities that often get ignored or shut down as people grow older.
Dave and Julie explore what it means to “scan” someone from a distance, how Julie says she perceives injuries and illness inside the body, and why she sees intuition as another form of information processing rather than something reserved for a small group of gifted people. Julie also explains why visual, auditory, and kinesthetic learners may experience intuitive information differently.
They also discuss energetic healing, emotional trauma, brainwave patterns, spiritual experiences during surgery, communication with deceased loved ones, and the role dreams may play in receiving intuitive information. Dave shares his own experiences with intuition, altered brain states, grief, and the peaceful death of his mother.
This episode is essential listening for anyone interested in psychic abilities, intuition, consciousness, energy healing, remote viewing, medical intuition, dreams, the afterlife, grief, near-death awareness, spirituality, neuroscience, and the possibility that human perception may extend beyond what most people are trained to notice.
You’ll Learn:
- How Julie says psychic and medical intuitive abilities can be learned and trained
- How she remotely “scans” the body and interprets information about illness, injury, and healing
- How to tell the difference between intuition and ordinary thoughts or emotions
- What Julie says happens spiritually during surgery, dreams, and communication with deceased loved ones
- How her 12 phases of transition may indicate when someone is approaching death
- Why Dave believes intuition and science can overlap, especially in observation, discovery, and consciousness research
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Julie Ryan, psychic abilities, psychic powers, medical intuitive, medical intuition, intuition, intuitive abilities, energy healing, energetic healing, remote viewing, consciousness, spirituality, afterlife, what happens when you die, death and dying, near death, spirit communication, communicating with spirits, deceased loved ones, past lives, psychic training, intuitive training, spiritual healing, dreams, vivid dreams, grief, angels, guardian angels, consciousness research, neuroscience, brainwaves, psychic brain, spiritual experiences, emotional healing, energy medicine, mind body connection, holistic healing, biohacking, human potential, Dave Asprey, The Human Upgrade
Resources:
• Get A Free Digital And Audiobook Copy Of Angelic Attendants At https://askjulieryan.com/request-ebook/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
Thank you to our sponsors!
- Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- Caldera + Lab | If you're looking for one simple product that actually makes a difference, that's The Great, visit CalderaLab.com/DAVE and use code DAVE for 20% off your first order.
- Calroy | Learn more about Selentra HP and get your exclusive discount at calroy.com/dave
Timestamps:
00:00 — Trailer
01:00 — Psychic Powers
03:52 — Scanning Through Spirit
07:02 — First Intuitive Knowing
14:10 — Fairies and Elementals
17:29 — No Evil Spirits
23:11 — Medical Intuition
32:00 — The Energy Field Membrane
37:43 — Spirits in the Operating Room
46:17 — Dreams, Mold, and Lyme
54:04 — What Happens as We Die
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8 October 2026, 8:30 am - More Episodes? Get the App