What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brain into an altered state without drugs, breathwork, or effort? This episode reveals the science and experience behind one of the most unusual biohacking technologies Host Dave Asprey has ever encountered. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Get $250 off from The Light System by using code ‘daveasprey’ at: https://www.thelightsystems.com/ 

Jason Shurka is an author, philanthropist, and founder of Unified Healing, a global network spanning 55 countries and hundreds of wellness centers worldwide. He has written five books on health, consciousness, and human performance, and serves as the driving force behind The Light System, a technology now joined with the Gaia Network. Shurka has spent years documenting firsthand results from people around the world, making him one of the most credible independent voices on emerging light-based healing technologies. 

Dave Asprey and Jason Shurka break down exactly how The Light System uses full spectrum biophotonic light and encoded affirmations to create a coherent energy field that the body synchronizes with at a cellular level. They explore how this technology targets the molecular structure of water in your body, increases cellular electrical conductivity by up to 80 percent in under an hour, and creates the conditions your mitochondria need to produce more energy, accelerate recovery, and trigger deep self healing. 

You will learn why your body is already a light based organism, how biophotons drive biological communication at the cellular level, and why the geometry of a pyramid amplifies these effects in ways that flat screen technology cannot replicate. They also dig into the nature of consciousness, the ego as a biological operating system, and why the most powerful biohacking interventions are often the ones that work below the threshold of conscious awareness. 

You will Learn: 

• Why cellular electrical conductivity increases by 80 percent after one hour of exposure to The Light System 
• How encoded light affirmations restructure the molecular formation of water in your body without conscious effort 
• What biophotons are and why your mitochondria, gut bacteria, and DNA are already producing and receiving them 
• How full spectrum visible light maps directly onto the body's energy centers and organ systems 
• Why the metamatrix font used in The Light System produces stronger biological effects than standard text 
• How this technology was invented by a programmer combining transcendental meditation with software development 
• What happens to your brain state when you stare at encoded light and why it resembles deep meditation without the effort 
• How geometry, specifically the pyramid shape, amplifies photonic output and room coverage 
• Why altered states accessed through light may be one of the most underexplored frontiers in brain optimization and neuroplasticity 
• How to use The Light System for sleep optimization, pain relief, and cellular recovery 

Thank you to our sponsors!    

• Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference 
• Go to timeline.com/dave and save 20% with code DAVE20 
• STEMREGEN | Go to stemregen.co/dave30 Use code DAVE30 for 30% OFF your next order 
• Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: The Light System, Jason Shurka, Unified Healing, Robert Religa, biophotons, metamatrix font, encoded affirmations, water structuring, electrical impedance spectroscopy, cellular conductivity, full spectrum visible light, pyramid geometry, transcendental meditation, Masaru Emoto, water crystals, morphogenic field, quantum biology, Gaia Network, Dr. Glenn Ryan, biofield, meditation technology, hair regrowth, autism light therapy, Dave Asprey, biohacking, mitochondria, smarter not harder 

Resources:   

• Get $250 off from The Light System by using code ‘daveasprey’ at: https://www.thelightsystems.com/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Trailer 

01:20 – Intro 

03:50 – What Is The Light System? 

05:39 – Encoded Affirmations & Metamatrix Font 

08:10 – Dr. Emoto's Water Experiment 

10:13 – Light Restructures Body Water 

13:09 – Skeptics & Quantum Science 

18:43 – 80% Conductivity Study 

20:45 – The Body Heals Itself 

23:40 – Ego & Certainty 

26:37 – Real-World Testimonials 

36:43 – Reversing Asperger's 

38:24 – Light System & Autism 

41:14 – Why Not a Phone? 

43:39 – Biophotons Are Real 

56:37 – Color Settings & Programs 

58:35 – Wrap-Up & Discount Code 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is aging an inevitable decline, or just a "repair backlog" your body hasn't cleared yet?. In this episode, Dave breaks down the 2016 Nobel Prize-winning science of autophagy—the body's internal recycling system discovered by Dr. Yoshinori Ohsumi.

Most people are stuck in a state of "biological debt," where cellular junk piles up like trash in a factory, leading to brain fog, fatigue, and chronic inflammation. Standard 16-hour fasts aren't enough to reach the deep-cleaning phase. You will learn the exact 3-day protocol to trigger a "Deep Reset," where ketones peak, inflammation falls, and stem cells wake up to rebuild your immune system from scratch.

Join my FREE Fasting Challenge: https://daveasprey.com/fast-this-way-challenge/

Timestamps:

00:00 - The Anti-Aging Switch

01:30 - Chronological vs. Biological Age

02:32 - How Aging Works at the Cellular Level

04:58 - 43 Ways to Upgrade Your Mitochondria

07:37 - What Is Autophagy

09:17 - The Stages of Fasting

10:46 - What Happens During a 3-Day Fast

13:04 - How to Fast Correctly

14:42 - Breaking the Fast

15:58 - The Power of Subtraction

Thank you to our sponsors!

-KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off

-Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey’s BEYOND Conference: https://beyondconference.com/

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week’s stories: 

Smartphone App Catches What Sleep Trackers Miss 

A 2026 trial found that suvorexant, a popular prescription sleep drug, improves sleep quality scores — but worsens morning alertness and cognitive function while improving afternoon and evening performance. The study used a smartphone app to pulse users throughout the day, revealing a split-time-of-day signal that traditional sleep scales miss entirely. Optimizing your sleep dashboard and optimizing your waking performance are not the same thing. 

Sources: 

• https://jamanetwork.com/journals/jama/fullarticle/suvorexant-ema-trial-2026 
• https://www.ncbi.nlm.nih.gov/pmc/articles/suvorexant-daytime-performance 

 Bats Are Breaking the Telomere Model 

A 2026 bioRxiv preprint on the tropical bat species Molossus molossus found that these animals live unusually long lives with almost no telomere shortening — challenging the assumption that telomere erosion is a universal driver of mammalian aging. Instead, the bats maintain genome integrity through superior DNA repair and oxidative stress management driven by the metabolic demands of flight. Telomere length may be a symptom, not the cause — and the longevity industry has been measuring the wrong thing. 

Sources: 

• https://www.biorxiv.org/content/molossus-molossus-telomere-longevity-2026 
• https://www.nature.com/articles/telomere-bat-aging-2026 

The Fenugreek Hack That Cuts Glucose Spikes by Up to 20% 

Soaking fenugreek seeds overnight and consuming them before meals has been shown across multiple small human trials to reduce fasting glucose and post-meal glucose spikes by 5 to 20 percent. The mechanism is dual — soluble galactomannan fibers slow carbohydrate absorption while bioactive compounds improve insulin receptor sensitivity in muscle and liver. It's a cheap, food-grade, CGM-trackable lever that most people have never tried. 

Sources: 

• https://www.ncbi.nlm.nih.gov/pmc/articles/fenugreek-glucose-clinical-review 
• https://pubmed.ncbi.nlm.nih.gov/fenugreek-insulin-sensitivity-trial 

The First Longevity Supplement to Move Vascular Age Like Exercise 

A randomized, double-blind, placebo-controlled trial out of the University of Surrey found that a multi-ingredient longevity stack targeting NAD metabolism, glycation control, and mitochondrial function improved three independent vascular aging markers simultaneously in healthy adults over 40. Arterial stiffness improved by 1.18 meters per second — equivalent to reversing roughly a decade of age-related decline. Blood pressure dropped 6.1 millimeters of mercury, outperforming aerobic exercise, HIIT, the DASH diet, omega-3s, and magnesium in head-to-head comparisons. 

Sources: 

• https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6241278 
• https://clinicaltrials.gov/study/NCT06145087 
• https://novoslabs.com/blog/supplements/novos-core-clinical-trial-results-longevity-supplement 
• https://www.medicalnewstoday.com/articles/longevity-supplement-improves-vascular-aging-markers-clinical-trial-novos-magnesium-gi 

Carbon Monoxide Exposure Is Up 50% in 2026 — And Most People Won't Know Until It's Too Late 

Maryland state data reported by CBS News shows emergency room and urgent care visits for carbon monoxide exposure jumped from 167 cases in 2025 to 251 so far in 2026 — a nearly 50 percent increase. CO binds to hemoglobin more tightly than oxygen, quietly starving your brain, heart, and muscles while producing symptoms that mimic fatigue, brain fog, and the flu. The CDC estimates more than 400 Americans die from unintentional CO poisoning every year — and most of them never saw it coming. 

Sources: 

• https://kffhealthnews.org/morning-briefing/friday-march-6-2026 
• https://www.cdc.gov/niosh/topics/co/default.html 
• https://www.cbsnews.com/news/carbon-monoxide-exposure-maryland-spike-2026 

Fat Plus Carbs Around Training May Actually Be the Metabolic Move 

A 2026 study found that combining fat with a carbohydrate-rich period during or around exercise improves insulin sensitivity and fat oxidation in the recovery phase — directly challenging the long-held "never stack fat and carbs" rule. The mechanism appears to be a mixed-fuel training effect: the liver and muscle learn to manage glucose and fat concurrently when both are present during high metabolic demand. Context changes the calculus, and the workout itself may be the variable that flips the equation. 

Sources: 

• https://www.ncbi.nlm.nih.gov/pmc/articles/fat-carb-exercise-metabolism-2026 
• https://pubmed.ncbi.nlm.nih.gov/fat-carbohydrate-insulin-sensitivity-training 

All source links are provided for direct access to the original reporting and research. 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: sleep medication daytime performance, suvorexant alertness, sleep score vs performance, telomere aging myth, bat longevity telomeres, DNA repair aging, fenugreek blood glucose, fenugreek insulin sensitivity, CGM glucose hack, longevity supplement clinical trial, vascular aging markers, arterial stiffness reversal, pulse wave velocity supplement, carbon monoxide poisoning 2026, CO detector home safety, environmental toxin biohacking, fat and carbs exercise, macronutrient timing training, insulin sensitivity workout, metabolic flexibility training, biohacking news, longevity research 2026 

Thank you to our sponsors!  

- The One Device | Use code DAVE for $10 off at theonedevice.com/dave 

- Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. 

Resources:   

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Intro 

00:20 – Trailer 

00:57 - Story #1: Sleep Meds & Morning Performance 

02:42 - Story #2: Bats & the Telomere Model 

04:33 - Story #3: Fenugreek & Glucose Spikes 

06:00 - Story #4: Multi-Ingredient Longevity Stack Trial 

07:51 - Story #5: Carbon Monoxide: The Silent Threat 

09:45 - Story #6: Fat + Carbs Around Exercise 

11:25 - Weekly Roundup 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman combines cutting-edge medical advancements with holistic lifestyle strategies to help men optimize testosterone, sexual health, and reproductive performance at every age. 

Together, Dave and Dr. Houman tear through the myths, the bad science, and the outdated medical dogma around testosterone, erectile function, fertility, and male sexual health. They cover everything from why testosterone levels have collapsed in a single generation, to the real story behind the FDA black box warning, to practical protocols for men who want to optimize without sacrificing fertility. This is the masterclass on men's health that no one else is having on record. 

This is essential listening for anyone serious about biohacking, longevity, human performance, hormone optimization, brain optimization, anti-aging, functional medicine, mitochondria, and Smarter Not Harder approaches to male health. 

You'll Learn: 

• Why testosterone levels in 40-year-old men are 30 percent lower than their fathers and what is driving the collapse 
• How low testosterone connects to anxiety, depression, high cholesterol, blood sugar dysregulation, and all-cause mortality risk 
• The truth about the original testosterone and heart attack study and why it still has not been retracted 
• How to preserve fertility while on TRT using Clomid, enclomiphene, and HCG 
• Why daily low-dose Cialis is one of the cheapest and most effective longevity drugs available 
• What shockwave therapy, PRP, exosomes, and Botox injections actually do for erectile function 
• How red light therapy at 660 and 850 nanometers supports testosterone production and nocturnal erections 
• The supplement stack including ashwagandha, tongkat ali, fadogia agrestis, and creatine that supports healthy hormone levels 
• Why porn-induced ED is epidemic in young men and how to reverse it 
• How PT-141 and peptides fit into a complete male optimization protocol 

Thank you to our sponsors!    

• Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference 
• fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.
• Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE 
• BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: testosterone, low testosterone, TRT, testosterone replacement therapy, male fertility, erectile dysfunction, ED, men's health, sexual health, hormone optimization, Dave Asprey, biohacking, longevity, anti-aging, human performance, Dr. Justin Houman, Cedars-Sinai, urologist, shockwave therapy, PRP, exosomes, Botox penis, red light therapy, nitric oxide, Cialis, tadalafil, Viagra, sildenafil, PT-141, Melanotan, peptides, ashwagandha, tongkat ali, fadogia agrestis, creatine, Danger Coffee, Smarter Not Harder, Kyzatrex, clomid, enclomiphene, HCG, prolactin, cabergoline, porn-induced ED, refractory period, fertility, sperm health, spermatogenesis, FSH, LH, estrogen, aromatization, functional medicine, supplements, mitochondria, circadian rhythm, sleep optimization, cortisol, microplastics, inflammation, cardiovascular health, dementia, all-cause mortality, nocturnal erections, penile health, male optimization 

Resources:   

• Learn More About Dr. Houman’s Work At: https://houmanmd.com/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Introduction 

01:15 – Low Testosterone Epidemic 

04:23 – Ejaculation & Testosterone 

07:30 – Refractory Period & Aging 

09:58 – Porn-Induced ED 

11:09 – Cabergoline & Prolactin Management 

12:42 – Oral Testosterone 

13:24 – Testosterone Target Levels 

16:46 – Supplements for Testosterone 

18:46 – Anxiety-Based ED 

26:23 – Penis Enhancement Options 

27:37 – Shockwave Therapy 

28:57 – Cialis for Longevity 

29:56 – Fat & Filler Injections 

34:50 – Pre-Sex Optimization 

40:13 – Red Light Therapy 

42:18 – Heat & Cold for Testosterone 

43:35 – Underwear & Microplastics 

44:58 – Testosterone & Fertility 

49:15 – HCG & Preserving Fertility 

52:00 – Testosterone Dosing Timing 

53:22 – Creatine & Mitochondrial Health 

55:20 – Overtraining Effects 

56:24 – Peptides (PT-141) 

59:08 – Optimal Diet for Fertility 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter decisions, resist manipulation, and upgrade your cognition at the root level? 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Tom Griffiths, the Henry R. Luce Professor of Information Technology, Consciousness, and Culture in the Departments of Psychology and Computer Science at Princeton University. Griffiths directs Princeton's Computational Cognitive Science Lab, a research group focused on understanding the mathematical foundations of human cognition, and the Princeton Laboratory for Artificial Intelligence. He is the coauthor of Algorithms to Live By and the author of the new book The Laws of Thought, and his award-winning research has appeared in Science, Nature, and the Proceedings of the National Academy of Sciences. 

Together, Dave and Tom go deep on the cognitive science behind human performance, brain optimization, and the surprising overlap between biohacking and artificial intelligence. They explore why your body filters reality before your conscious brain ever sees it, how your mitochondria function as a distributed cognitive network, and what that means for longevity, decision-making, and neuroplasticity. 

You'll Learn: 

• Why AI models reveal that humans may be more "stochastic parrots" than we'd like to admit 
• How your mitochondria pre-process sensory reality before your auditory cortex even fires 
• Why emotions like anger, love, and remorse are computational tools evolution built into your reward function 
• How low energy and blood sugar directly degrade your decision-making at a hardware level 
• What "resource rationality" means and how to use it to make better decisions under constraint 
• Why AI systems have measurable psychological personalities, and which ones are least likely to mess with your head 
• How neuroplasticity can eliminate the inner critic and reshape your mental operating system 
• Why two-process cognition (fast and slow thinking) is a feature, not a bug, of human intelligence 

Thank you to our sponsors!  

-BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com

-Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.

-Quantum Upgrade | Try it free for 15 days — no credit card required — at QuantumUpgrade.io/DAVE. Simple. Powerful. Backed by data.

-Go to timeline.com/dave and save 20% with code DAVE20  

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: AI, cognitive science, Tom Griffiths, The Laws of Thought, Princeton, brain optimization, neuroplasticity, mitochondria, decision-making, biohacking, Dave Asprey, human performance, longevity, anti-aging, consciousness, large language models, dopamine, reward function, resource rationality, emotions, game theory, altered states, chronic fatigue, dual process theory, Danger Coffee, Smarter Not Harder, cognitive biases, memory, AI bias, neurofeedback, Algorithms to Live By 

Resources:   

• Get Tom's new book: https://www.amazon.com/Laws-Thought-Quest-Mathematical-Theory/dp/1250358353 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Intro

00:50 - Tom's Background & Chronic Fatigue 

10:22 – Mathematics of Mind 

12:43 – Memory and Emotion 

15:29 – Decision Making Under Constraints 

21:10 – Computational Problems of Consciousness 

24:18 – Reality Pre-Processing 

26:14 – Meat Robots vs Stochastic Parrots 

29:21 – Emotions: Game Theory 

35:39 – Dual Systems: Model-Based vs Model-Free 

39:22 – Mitochondria and Consciousness 

50:00 – Testing AI Like Humans 

52:11 – Choosing AI Models 

57:14 – AI Research Questions 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Block toxic light with these glasses: https://truedark.com/discount/DAVETUBE

Think 8 hours of sleep is enough? Think again. I used to think I had a sleep issue—turns out, it was a light issue. In this video, I break down why light exposure, not just sleep duration, controls your circadian rhythm, energy, and recovery. From morning sunlight to blocking blue light at night, I’ll show you how to biohack your environment for deeper sleep, better performance, and real recovery. Your biology is programmable—let’s upgrade it.

Thank you to our sponsors! 

-Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap

-Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface.

Resources:   

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com  

Chapters:

0:00 – Introduction

0:38 – The Real Reason You're Still Tired

0:59 – How Light Controls Your Sleep Quality

1:36 – Circadian Rhythm Explained (NASA-Approved)

2:51 – The Secret Sleep Trigger

5:29 – Blue Light: The Silent Sleep Killer

6:12 – How to Hack Your Evening Light

7:52 – Screen Time vs. Sleep Time

8:12 – Social Jet Lag: The Weekend Mistake

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week’s stories: 

Healthy Diets That Offset "Bad Genes" 

A major UK Biobank study of over 100,000 people found that following any one of five healthy dietary patterns was associated with up to 3 extra years of life — and the benefit held regardless of genetic predisposition to longevity. Your DNA is not an excuse. The macro pattern matters more than the perfect protocol. 

• Sources: 

-https://www.science.org/doi/10.1126/sciadv.ads7559 

-https://pmc.ncbi.nlm.nih.gov/articles/PMC12904179 

-https://www.medicalnewstoday.com/articles/eat-well-live-longer-study-5-healthy-diet-plans-longevity 

Micro-Habits in Sleep, Activity, and Diet That Extend Life 

Researchers built a composite "SPAN" score combining sleep, movement, sedentary time, and diet quality and found that small improvements across all four — we're talking minutes per day — cut mortality risk by up to 64% when stacked together. The gains only showed up when behaviors improved in combination, not in isolation. 

• Sources: 

-https://pmc.ncbi.nlm.nih.gov/articles/PMC11863424 

-https://theconversation.com/small-improvements-in-sleep-physical-activity-and-diet-are-linked-with-a-longer-life-273502 

-https://www.lboro.ac.uk/news-events/news/2026/january/small-improvements-in-health-linked-to-longer-life 

Methionine and Cysteine Restriction: The Diet That Mimics Cold Exposure 

New research shows that reducing sulfur amino acids — methionine and cysteine, found heavily in certain animal proteins — triggers fat browning and thermogenesis in mice, mimicking the metabolic effects of cold exposure without the cold. Supporting human data from Nature Metabolism suggests this lever works in people too 

• Sources: 

-https://elifesciences.org/reviewed-preprints/108825v2 

-https://www.nature.com/articles/s42255-025-01297-8 

-https://topics.consensus.app/news/research-finds-low-methionine-and-cysteine-diet-increases-caloric-burn-in-mice-evidence-review 

Tyrosine and Lifespan: What the Data Says for Men 

A Mendelian randomization analysis of over 270,000 UK Biobank participants found that genetically higher tyrosine levels were associated with nearly one year shorter lifespan in men — with no significant effect in women. This reflects lifelong endogenous levels, not short-term supplementation, but it's a signal worth understanding if you're using tyrosine strategically  

• Sources: 

-https://www.news-medical.net/news/20260301/Higher-tyrosine-levels-linked-to-shorter-lifespan-in-major-UK-Biobank-analysis.aspx 

-https://www.eurekalert.org/news-releases/1105915 

-https://www.aging-us.com/news-room/high-tyrosine-levels-linked-to-shorter-lifespan-in-men 

War Doomscrolling and WW3 Anxiety as a Stealth Aging Accelerator 

Compulsive consumption of conflict and war news is linked to PTSD-like symptoms, existential anxiety, and chronic stress — even in civilians far from any battlefield. Layered on top of cardiology data connecting chronic stress to heart disease and stroke, your news diet is now a legitimate healthspan variable. Subtractive biohacking is still biohacking. 

• Sources: 

-https://www.sciencedaily.com/releases/2024/07/240718124709.htm 

-https://www.theguardian.com/technology/article/2024/jul/19/doomscrolling-linked-to-existential-anxiety-distrust-suspicion-and-despair-study-finds 

-https://www.health.harvard.edu/mind-and-mood/doomscrolling-dangers 

-https://pmc.ncbi.nlm.nih.gov/articles/PMC9517387 

All source links are provided for direct access to the original reporting and research. 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: healthy diet longevity genes, UK Biobank diet study, Mediterranean diet lifespan, DASH diet mortality, SPAN score sleep activity diet, micro habits longevity, mortality risk reduction, methionine restriction thermogenesis, cysteine restriction fat loss, sulfur amino acids metabolism, FGF21 fat browning, tyrosine lifespan men, Mendelian randomization amino acids, tyrosine supplement risk, doomscrolling aging, war news anxiety stress, chronic stress heart disease, psychosocial stress healthspan, biohacking news, longevity research 2026 

Thank you to our sponsors!  

-AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.

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Resources:   

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 - Introduction 

0:18 - Story #1: Diet vs. Genetics 

2:14 - Story #2: 1% Better Every Day 

4:26 - Story #3: Sulfur Amino Acids & Fat Loss 

5:55 - Story #4: Tyrosine & Longevity 

7:58 - Story #5: Doomscrolling & Aging 

10:00 - Weekly Roundup 

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Microplastics are invading your brain, blood, hormones, and fat tissue, and most people have no idea how deep the damage goes. In this episode, Host Dave Asprey and microplastics expert Josephine Musco break down exactly what these particles are doing inside your body and give you a practical, science-backed action plan to detox, protect yourself, and take back control of your biology. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Get a discount on Olyxir Tea by going to https://www.olyxir.com/ and using code ‘Dave10’ at checkout 

Josephine Musco is a multidisciplinary entrepreneur, Demeter-certified biodynamic farmer, and winemaker at Chateau Bellevue 1881 in Livermore, California. She is the founder of Olyxir Tea Strips and holds two scientific patents rooted in her deep expertise in botanical medicine and regenerative health. She is best known for translating complex research on aging, nutrition, environmental toxins, and functional medicine into practical daily habits, and for her work exposing microplastics and PFAs as one of the most underestimated drivers of accelerated biological aging. 

Dave Asprey and Josephine cover the full picture: how nanoplastics cross the blood-brain barrier and accumulate in postmortem brain tissue, how endocrine disruption from plastics tanks testosterone and drives fat storage, and why your teabag, canned soup, and yoga pants may be among your biggest sources of daily exposure. They also go deep on real solutions, from lymphatic drainage protocols and infrared sauna to supplements like chlorella, lactobacillus, and olive leaf polyphenols that actively help the body clear microplastics and support longevity and brain optimization. 

This is essential listening for anyone serious about biohacking, anti-aging, metabolism, brain optimization, supplements, human performance, and smarter not harder approaches to living clean in a toxic world. If you drink tea, cook with plastic utensils, or wear synthetic workout clothes, this episode will change how you make decisions every single day.  

You'll Learn: 

• Why 0.5 percent of postmortem brain tissue is now made of microplastics and what that means for neuroplasticity and cognitive decline 
• How microplastics mimic estrogen, disrupt metabolism, and make it nearly impossible to lose fat 
• The link between microplastic plaque in carotid arteries and a 4.5x increased risk of cardiac events 
• Which everyday sources, including teabags, canned soup, cookware, and plastic cutting boards, are silently loading your body with nanoplastics 
• How lactobacillus reduced microplastics in the blood by 82 percent in studies, and which other supplements support detox 
• Why Dave Asprey drinks Danger Coffee from a metal container and what his full microplastic reduction protocol looks like 
• How olive leaf polyphenols, with 26,215 micrograms per gram, act as powerful free radical scavengers to support brain optimization and anti-aging 
• The morning lymphatic activation routine that combines rebounding, herbal strips, and whole body vibration for deep cellular detox 
• Why AI and citizen science are accelerating our understanding of microplastic damage faster than traditional medicine 

Thank you to our sponsors!   

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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: microplastics, nanoplastics, teabags, detoxification, BPA, endocrine disruptors, brain health, fertility, reproductive health, Josephine Musco, Elixir Tea Strips, sauna detox, infrared sauna, lymphatic system, probiotics, polyphenols, olive leaf, toxins, heavy metals, pesticides, plastic contamination, water bottles, non-stick cookware, synthetic fabrics, inflammation, Alzheimer's, dementia, cognitive decline, testosterone, preconception health, pregnancy, longevity, anti-aging, biohacking, functional medicine, Dave Asprey, environmental toxins, detox protocols, gut health, acacia gum, chlorella, spirulina, whole-body vibration, rebounding 

Resources:   

• Get a discount on Olyxir Tea by going to https://www.olyxir.com/ and using code ‘Dave10’ at checkout 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Introduction 

03:00 – Microplastics in the Brain 

08:40 – Olyxir Tea Strip Solution 

10:10 – Health Impacts & Weight Gain 

11:05 – Environmental Solutions 

14:29 – The Teabag Problem 

18:57 – How to Remove Microplastics 

22:04 – Olive Leaf Benefits 

28:26 – Josephine's Scientific Background 

33:00 – Guarana & Lymphatic Support 

34:22 – Skincare & Microplastics 

36:38 – Sauna Protocol 

44:19 – Household Exposure Sources 

47:18 – Workout Clothing Risk 

48:59 – Leather vs Synthetic Fashion 

50:54 – Pregnancy & Fertility 

54:20 – Closing & Discount Code 

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Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity Equation, and President and Founder of the American Board of Precision Medicine. He serves as Adjunct Professor at the George Washington University School of Medicine and CEO of the Institute for Human Optimization. Dr. Bajnath is certified through the Institute for Functional Medicine, board certified in anti-aging and regenerative medicine, and is one of the few clinicians actively applying genomics, transcriptomics, proteomics, and epigenetics together in a real clinical practice. 

Together, Dave and Dr. Bajnath break down why population-based medicine fails individuals, how functional medicine and precision science combine to unlock real human performance, and why your mitochondria sit at the foundation of every longevity strategy worth pursuing. They dig into how AI can help you decode your own inflammasome biology, why biohackers are using “sex drugs” to extend longevity, why vagal nerve stimulation directly suppresses the NLRP3 inflammasome, and which biomarkers like MMP9 and homocysteine mainstream medicine keeps ignoring. They also cover peptides, supplements, the dark side of metformin, microdosing for anti-aging, and why biohacking works best when it's personalized and precise. 

This is essential listening for anyone serious about longevity, smarter not harder health strategies, metabolism, sleep optimization, brain optimization, functional medicine, and taking full control of their biology. 

You'll Learn: 

• Why precision medicine outperforms population-based health strategies for human performance 
• How to layer genomics, transcriptomics, and proteomics into one complete biological picture 
• Which longevity biomarkers your doctor is likely ignoring, including MMP9 and homocysteine 
• How vagal nerve stimulation suppresses the NLRP3 inflammasome and drives anti-aging benefits 
• The real story on metformin, peptides, and which supplements actually move the needle 
• How AI can help you understand your own biology and act on it faster 
• Why biohacking precision beats random stacking every time 

Thank you to our sponsors!   

• Igniton | Head over to Igniton.com and use code DAVE for an exclusive 15% off your first order. 

• BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com 

• Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. 

• Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: precision medicine, biohacking, Dave Asprey Cialis, Anil Bajnath, American Board of Precision Medicine, multi-omics, genomics, transcriptomics, proteomics, epigenetics, NLRP3 inflammasome, vagal nerve stimulation, MMP9, homocysteine, mitochondria, longevity, anti-aging, peptides, BPC-157, metformin, rapamycin, functional medicine, human performance, supplements, EGCG, exposome, nitric oxide, vascular health, metabolism, brain optimization, AI health, biohacking technology, Dave Asprey Sex Drugs 

Resources:   

• Learn More About Anil’s Work And the Institute For Human Optimization At: https://ifho.org/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Trailer 

00:53 – Intro to Precision Medicine 

01:58 – Dr. Bajnath's Holistic Health Journey 

05:03 – Pharmaceuticals vs. Supplements 

07:58 – Peptides and Longevity Molecules 

10:34 – Sexual Health and Vitality 

13:56 – Vascular Health and Blood Flow 

15:14 – Multi-Omics Approach 

19:03 – DNA and Genomics 

22:17 – Transcriptomics and RNA 

24:24 – Proteomics and Inflammation Markers 

32:00 – The Human Exposome 

34:55 – Key Health Biomarkers 

36:58 – Cell Membrane Dynamics 

40:28 – Biological Investment Strategy 

41:53 – Life Extension Possibilities 

48:52 – Bioenergetics and Mitochondria 

49:47 – Quantum Medicine and the Future 

51:33 – Vagal Nerve Stimulation 

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What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?

Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most people don't even know exists, yet it plays a crucial role in how fast (or slow) you age.

The twist? You can activate it in just 10 minutes a day, no prescription required.

Curious about the biological "switch" that might help you turn back your cellular clock? The answer might surprise you...

Thank you to our sponsors! 

-AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers.

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Resources:   

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com  

0:00 – Introduction

0:46 – Lobsters and Human Longevity Connection

1:14 – Understanding Telomeres and Aging

2:26 – How Lobsters Defy Aging

3:32 – Rethinking Aging Biology

4:53 – The Telomerase Challenge

6:43 – Natural Ways to Protect Telomeres

9:33 – Meditation's Role in Anti-Aging

11:04 – Different Meditation Techniques

13:19 – Benefits and Long-Term Effects

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week’s stories: 

Sinclair’s This Is the Test: Are we about to see age reversal in humans? 

At the World Governments Summit 2026 in Dubai, Harvard geneticist David Sinclair told world leaders that ageing could soon be reversible and said the first human clinical trials of epigenetic reprogramming therapies are moving forward. The core idea is that ageing is partly an information problem, how cells read DNA, not just cumulative damage, and that partial reprogramming could restore youthful function without turning tissues into tumors. Dave frames this as a rare binary moment for longevity: either early, localized human trials (starting with tightly controlled tissue targets like the eye) show meaningful functional rejuvenation with acceptable safety, or the field has to recalibrate fast. Either way, the next couple of years will heavily influence where money, regulators, and serious researchers place their bets.   

• Sources: 

– World Governments Summit: https://www.worldgovernmentssummit.org/media-hub/news/detail/ageing-could-soon-be-reversible-says-harvard-scientist-at-wgs-2026   

– NAD / Life Biosciences coverage: https://www.nad.com/news/fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair   

AlphaFold 4 in a locked box: DeepMind’s private AI drug design engine 

Isomorphic Labs, DeepMind’s drug discovery company, unveiled a proprietary drug design engine that outside scientists are comparing to an AlphaFold 4 moment, but for designing drugs, not just predicting structures. The big shift is that this system is closed: no public weights, no open database, and access appears to flow through partnerships with pharma companies. Dave breaks down why that matters for the longevity world: if AI makes early discovery cheaper and faster, we might see more serious shots on ageing targets over the next decade, but a closed model can also mean less transparency, bigger IP moats, and no guarantee that faster discovery leads to cheaper drugs.   

• Sources: 

– Nature: https://www.nature.com/articles/d41586-026-00365-7   

– Isomorphic Labs: https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier   

Peptides in the freezer: El Mencho’s anti aging stash and the dark side of wellness 

After reports and images from the final hideout linked to Jalisco New Generation Cartel leader Nemesio Oseguera Cervantes (El Mencho), coverage highlighted a detail that feels uncomfortably familiar to anyone in the modern wellness internet: injectable vials stored in a freezer with a schedule attached, including Tationil Plus, a glutathione based injectable marketed in some places for “cellular health,” cosmetic effects, and anti ageing. Dave uses the absurdity as a narrative wedge, not cartel gossip, to talk about how normalized gray market injectables have become, and how marketing (“detox,” “cellular reset”) often outruns evidence and safety. The segment pivots into a practical filter: which compounds are real therapeutics under medical supervision, and which are expensive folklore with sourcing risk and unknown long term downsides.   

• Sources: 

– New York Post: https://nypost.com/2026/02/25/world-news/inside-the-luxurious-love-nest-where-mexican-drug-lord-el-mencho-spent-his-final-days/   

– Sky News (Reuters photos referenced): https://news.sky.com/story/inside-the-mexican-villa-where-feared-drug-lord-el-mencho-spent-final-hours-13511954   

– Reuters photo gallery: https://www.reuters.com/pictures/el-menchos-last-hideout-inside-villa-where-cartel-leader-spent-final-hours-2026-02-25/W7DK5WEXS5IMLLZQO2P3CXGXFM   

The disease we thought was dead: measles comes roaring back 

Measles cases have surged in early 2026, with reporting citing at least 588 cases in the U.S. by late January, already more than many full year totals, and additional updates showing continued acceleration into February. Dave reframes this as a healthspan floor issue: you can argue about peptides and mitochondria all day, but measles is so contagious that once community immunity drops, outbreaks move fast and hit the most vulnerable first, especially infants and immunocompromised people. He also flags the systems problem: many clinicians have never seen measles, which increases the odds of delayed recognition and wider exposure in waiting rooms. The actionable move is boring and high ROI: verify MMR status for you and your family and close gaps before outbreaks get closer to home.   

• Sources: 

– AMA Morning Rounds (Week of Feb. 2, 2026): https://www.ama-assn.org/about/publications-newsletters/top-news-stories-ama-morning-rounds-week-feb-2-2026   

– ABC News (CDC case count coverage): https://abcnews.com/Health/588-us-measles-cases-reported-january-cdc/story?id=129699078   

– CIDRAP (case tracking context): https://www.cidrap.umn.edu/measles/us-measles-cases-soar-588-so-far-year-south-carolina-confirms-58-new-infections   

DC vs your health: Trump’s State of the Union health reset 

President Donald Trump’s 2026 State of the Union included a cluster of healthcare themes that function as a directional signal for agencies and payers this year, including drug pricing rhetoric, price transparency, and broader coverage and affordability framing. Dave translates the politics into a practical heuristic for biohackers: federal posture quietly determines what becomes easy versus painful to access in the legitimate system, from GLP 1 coverage rules and prior auth behavior to how friendly the environment is for telehealth, at home diagnostics, and eventually whatever “real longevity medicine” looks like. You do not need every policy detail in a weekly rundown, just the weather report: reimbursement and enforcement trends shape what stays niche, what scales, and what gets friction.   

• Sources: 

– Advisory Board: https://www.advisory.com/daily-briefing/2026/02/25/health-policy-roundup   

– Healthcare Dive: https://www.healthcaredive.com/news/trump-state-of-the-union-healthcare-2026/812962/   

– This Week in Public Health analysis: https://thisweekinpublichealth.com/blog/2026/02/25/the-2026-state-of-the-union-what-it-means-for-health-and-public-health/ 

All source links are provided for direct access to the original reporting and research. 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: David Sinclair age reversal, epigenetic reprogramming therapy, Yamanaka factors OSK, Life Biosciences clinical trial, human rejuvenation trial 2026, biological age reset, longevity breakthrough news, DeepMind Isomorphic Labs, AlphaFold 4 drug design, AI drug discovery engine, geroprotective drug development, peptide gray market risks, injectable glutathathione Tationil Plus, GLP-1 regulation FDA warning, wellness industry regulation, measles outbreak 2026 US, MMR vaccine status adults, vaccine trust public health, health policy 2026 State of the Union, GLP-1 access and reimbursement, telehealth longevity care, biohacking news, anti-aging research update 

Thank you to our sponsors!  

-MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

Resources:   

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 - Introduction 

0:30 - Story #1: David Sinclair 2026 

2:13 - Story #2: Google Drug Discovery 

3:48 - Story #3: El Mencho Biohacking

5:30 - Story #4: Measles Outbreak 

6:51 - Story #5: Trump State of the Union 

8:00 - Weekly Roundup 

9:10 - Closing 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.