I spent over $2 million hacking my own biology to reverse my age, but one of the most powerful discoveries didn’t come from a pharmaceutical lab. It came from NASA.

Try Danger Coffee: https://dangercoffee.com/dave (Discount Code DAVETUBE)

Try Energy Bits: https://energybits.com/discount/dave

Astronauts face the harshest environment known to science: space radiation. To keep them alive, NASA had to identify a nutrient dense enough to protect DNA and mitochondria from extreme oxidative stress. They found it in algae (spirulina and chlorella)—a superfood older than civilization that acts as "biological armor" for your cells.

In this episode, I break down why "aging" is actually just a buildup of oxidative stress (cellular rust) and how most antioxidants fail to fix it because they never reach the mitochondria. I reveal the exact science behind why algae works, the specific molecules (phycocyanin and chlorophyll) that protect your cellular walls, and the protocol I use to keep my liver young and my energy stable.

We also cover the critical lifestyle factors—from sleep to seed oils—that are throwing gasoline on the fire, and how to "clear the battlefield" so this superfood can actually do its job

Timestamps:

00:00 – Intro

01:03 – The Aging Myth

01:43 – How Aging Actually Starts

03:33 – Restoring Your Antioxidant Defense

04:56 – Why Most Supplements Fail

07:30 – NASA's Superfood Discovery

11:47 – How to Use Algae

13:24 – Lifestyle Factors That Undermine Algae

15:57 – Action Plan

Thank you to our sponsors!

• Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off.
• The One Device | Use code DAVE for $10 off at theonedevice.com/dave.

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey’s BEYOND Conference: https://beyondconference.com/

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your home could be quietly stealing your IQ, disrupting your hormones, destroying your mitochondria, and triggering chronic disease, and most people never connect the dots. This episode gives you the full picture on toxic mold, and exactly what to do about it 

Learn More About The Superstratum Products Dave Uses At: https://superstratumlabs.com/products/dave 

Host Dave Asprey sits down with Seth Jones, CEO of Superstratum and the creator of the first patent-pending process to remove mycotoxins from homes. Before founding Superstratum, Seth spent 15 years as an international songwriter, producer, and DJ until a personal experience with Building-Related Illness changed the entire direction of his life. Today he and his team are on a mission to heal the estimated 66 million homes in the U.S. that create toxic conditions for the 170 million people living inside them. If toxic mold has derailed your health, your relationships, or your ability to think clearly, this conversation will change how you see your home forever. 

Dave Asprey built his entire biohacking and longevity career trying to fix what mold did to his body. By his mid-twenties, he carried diagnoses of arthritis, chronic fatigue, fibromyalgia, and mold-induced brain damage that wiped out his prefrontal cortex activity. Functional medicine doctors couldn't help him. Specialists gave up. It took him years of self-directed research into mitochondria, metabolism, and environmental toxicology to understand that his home was the root cause. He lost 100 pounds, reversed brain damage confirmed by imaging, and recovered IQ points he thought were gone for good. 

In this episode, Dave and Seth break down the real science of how mycotoxins poison mitochondria, hijack hormones, crush sleep optimization, and block the neuroplasticity your brain needs to perform. They reveal why mold is additive with every other toxin in your environment, why most remediation fails, and how a systematic home detox protocol can do what no supplement, nootropic, or fasting protocol can fix on its own. 

You'll Learn: 

• Why mold toxins are direct mitochondrial poisons and what that means for your energy, willpower, and metabolism 
• How mycotoxins lower your IQ by up to 15 points and why removing them reverses the damage 
• The estrogen-mimicking mold toxin 10,000 times stronger than human estrogen that causes weight gain no diet can fix 
• Why your AC and HVAC system are the most dangerous mold delivery systems in your home 
• How mold disables detox pathways and makes every other environmental toxin worse 
• The connection between toxic mold, Lyme disease, Alzheimer's, cancer, and fertility loss 
• Why Danger Coffee and mold-free nutrition matter as much as fixing your home 
• The step-by-step Superstratum protocol for fogging, bombing, coating, and restoring a healthy home microbiome 
• How to salvage your belongings, treat your car, and avoid recontaminating a clean environment 

Thank you to our sponsors!     

- Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today 

- Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Seth Jones, Superstratum, toxic mold symptoms, mycotoxins in homes, Building-Related Illness, mold and IQ, mold brain damage, HVAC mold, home detox protocol, hypochlorous acid mold, environmental probiotics, HomeBiotic, mold and mitochondria, mold and hormones, zearalenone estrogen, mold weight gain, mold and fertility, mold and Alzheimer's, mold and Lyme disease, ochratoxin, mold and chronic fatigue, Dave Asprey, biohacking, longevity, functional medicine, human performance, anti-aging, Danger Coffee, mold detox, brain optimization, sleep optimization 

Resources:   

• Learn More About The Superstratum Products Dave Uses At: https://superstratumlabs.com/products/dave 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Trailer 

00:46 – Intro 

01:27 – Dave's Mold Origin Story 

02:37 – Health Decline & Recovery 

06:02 – Coffee, Bulletproof & Moldy Movie 

10:17 – Systemic Effects of Mold 

13:24 – Introducing SuperStratum 

18:04 – Weight, Hormones & Brain Damage 

19:53 – Brain Scans, Sleep & Symptoms 

26:09 – Fertility, Prevention & Costs 

31:03 – Treating the Home 

42:42 – Seth's Story 

48:45 – Resources & Car Detox 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Autism is reversible, and the science to prove it already exists. This episode delivers a master class on the biological roots of autism, what actually triggers it, and the protocols that have helped real families recover their children, including one mom who sold everything she owned to make it happen. 

Host Dave Asprey sits down with Tracy Slepcevic, bestselling author of Warrior Mom: A Mother's Journey in Healing Her Son with Autism, certified integrative health practitioner, Air Force veteran, and founder of Autism Health, a 501(c)(3) nonprofit organization dedicated to accelerating biomedical solutions for autism. Tracy has spent over 17 years researching treatments and therapies for autism and other neurological disorders, trained in complementary and alternative medicine, and built the Autism Health Summit into one of the most important annual gatherings for parents, physicians, and researchers in the autism recovery space. She is not a researcher observing from a distance. She is a mother who sold everything she owned, bartered for treatments, and traveled to Ukraine for stem cell therapy to recover her son Noah, who today lives a fully independent life, works full time, and travels the world alone. 

Together, Dave and Tracy tear apart the myth that autism is a fixed genetic condition and expose it for what it actually is: a biological cascade triggered by a recipe of environmental factors colliding with genetic susceptibility. They cover how mitochondrial dysfunction and chronic neuroinflammation combine to create the sensory overload and cognitive fog that defines autism, why healing the gut first is the non-negotiable foundation that determines whether every other treatment works, how glyphosate, toxic mold, heavy metals, volatile organic compounds, and vaccine injury each contribute to a compounding toxic load that crosses the threshold into autism, why plasmalogen supplements are producing results in non-speaking children that the medical establishment insists are impossible, and how AI is now accelerating the ability of parents and practitioners to identify personalized biological pathways and act on them in hours instead of months. Dave also shares his own journey reversing Asperger's syndrome over ten years through biology, mitochondrial repair, neuroplasticity retraining, and supplements, and explains why catching these conditions early and acting on them aggressively with functional medicine is the difference between a life of suffering and a life of superpowers. 

You'll Learn: 

• Why autism is biological, not purely genetic, and what environmental triggers pull the trigger on susceptible children 
• How mitochondrial collapse creates the energy deficit that drives sensory overload, social withdrawal, and cognitive dysfunction in autism 
• Why healing the gut first determines whether every other autism treatment works or fails 
• What plasmalogen supplements are doing for non-speaking children and adults with neurological disorders 
• How glyphosate, toxic mold, heavy metals, and volatile organic compounds compound into the recipe that causes autism 
• Why AI is transforming the ability of autism parents to identify personalized amino acid and supplement protocols overnight 
• How Dave reversed Asperger's syndrome through mitochondrial repair, neuroplasticity retraining, and targeted supplements 
• What stem cell therapy accomplished for Tracy's son Noah within 30 days of treatment 
• Why genetic testing before any vaccine or medication schedule should be mandatory for every child 
• How to clean your home environment of the VOCs, mold, and bacterial toxins that drive neuroinflammation in the whole family 
• Why the gifts that come with an autism diagnosis can become genuine superpowers once the biology gets fixed 

Thank you to our sponsors!     

- BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. 

- AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers. 

- Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18. 

- Timeline | Go to timeline.com/dave and you’ll get an additional 20% off your first month 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Tracy Slepcevic, Warrior Mom book, autism recovery, biomedical intervention autism, autism gut health, mitochondrial dysfunction autism, plasmalogen supplements, stem cell therapy autism, glyphosate autism, toxic mold neuroinflammation, vaccine injury autism, Autism Health Summit, heavy metals autism, neuroplasticity, biohacking, Dave Asprey, functional medicine, anti-aging, human performance, brain optimization 

 Resources:   

• Visit Tracy’s Website To Learn More: www.AutismHealth.com 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 – Trailer 

1:15 – Dave's Personal Autism Journey 

4:26 – What Causes Autism 

8:20 – Gut Health as the Foundation 

10:14 – Tylenol, Vaccines & Toxic Exposures 

12:21 – The Gifts & Superpowers of Autism 

15:42 – AI, Peptides & Plasmalogen 

22:06 – Mold, Lyme & Toxic Load 

27:57 – Top Autism Contributors 

31:04 – Cleaning Up Your Environment 

33:35 – Glial Cells & Neuroinflammation 

39:27 – Tracy's Story & Noah's Diagnosis 

51:55 – Warrior Mom: Sacrifice & Recovery 

54:08 – Vaccines & the Coverup 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people buying "clean" supplements are unknowingly loading their bodies with heavy metals, rancid fish oil, and glyphosate, even inside products labeled organic and healthy. This episode breaks down exactly what the supplement industry refuses to tell you and gives you the tools to stop poisoning yourself every morning. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Grab a discount on Puori Products by visiting: https://puori.com/pages/dave?dt_id=1750934 

Host Dave Asprey sits down with Oliver Amdrup-Chamby, founder and CEO of PUORI and a serial entrepreneur in the health and wellness space with over 16 years building what has become one of the most rigorously tested supplement brands in the world. Oliver opened the first CrossFit gym in Denmark in 2006, served as Regional Director of CrossFit HQ across Europe and the Middle East, holds an Executive Program credential from Stanford, and advises longevity projects including One Thirty Labs in Copenhagen. He founded PUORI in 2009 with a single obsession: creating the cleanest third-party tested fish oil on the market. That obsession grew into a full supplement line built on batch testing every finished consumer product for environmental toxins, a standard the industry has yet to catch up to. 

Together, Dave and Oliver expose the hidden contamination crisis inside the supplement industry, from oxidized fish oil that creates inflammation instead of fighting it, to plant-based protein powders carrying up to 10 times more heavy metals than whey. They break down why organic does not mean safe, how glyphosate embeds itself directly into your collagen infrastructure and disrupts the body's ability to build healthy connective tissue, and why the omega 3 index is one of the most powerful and measurable longevity biomarkers you are probably ignoring. They also dig into the surprising brain optimization and anti-aging benefits of creatine, including new research on concussion recovery and sleep deprivation, and how foundational supplements like vitamin D, magnesium, and high-quality fish oil remain the non-negotiables that no nootropic stack can replace. 

You'll Learn: 

• Why organic protein powder often contains more heavy metals than non-organic options 
• How glyphosate infiltrates collagen and gets rebuilt into your body's own tissue 
• What the omega 3 index is, why most Americans are dangerously low, and how raising it correlates with years of additional longevity 
• Why plant-based omega 3s fail to convert to DHA and what to take instead 
• How oxidized fish oil creates inflammation rather than reducing it, and what to look for on the label 
• Why vitamin D deficiency persists even with regular sun exposure and how genetics affect your required dose 
• The creatine research that has longevity doctors and neuroscientists paying attention for the first time 
• How foundational supplements support mitochondria, metabolism, and long-term resilience in ways that trendy biohacking stacks cannot replicate 
• What to look for in a clean supplement brand and why third-party batch testing of finished goods is the only standard that matters 

Thank you to our sponsors!      

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Oliver Amdrup-Chamby, PUORI supplements, fish oil oxidation, omega 3 index, heavy metals protein powder, glyphosate collagen, organic protein powder toxins, foundational supplements, creatine brain health, vitamin D deficiency, clean label testing, longevity supplements, biohacking, Dave Asprey, anti-aging, human performance, functional medicine, supplement transparency, plant-based protein heavy metals, whey protein 

Resources:   

• Grab a discount on Puori Products by visiting: https://puori.com/pages/dave?dt_id=1750934 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 – Trailer 

0:47 – Introduction 

2:19 – Foundational vs. Sexy Supplements 

4:33 – Omega-3 Index Explained 

5:45 – Vegan Omega-3s & DHA 

7:39 – Fish Oil Oxidation 

8:48 – Batch Testing & Industry Transparency 

16:03 – Storing Fish Oil Properly 

17:30 – Vitamin D, Magnesium & Fish Oil Stack 

19:11 – Vitamin D Dosing & Genetics 

21:34 – RDAs & Government Nutrition Advice 

23:06 – Glyphosate in the U.S. Food Supply 

26:40 – Heavy Metals in Fish Oil 

37:44 – Protein Powders & Heavy Metals 

45:52 – Creatine for Brain & Concussion 

48:48 – TrueDark & Brain Recovery 

51:24 – Brain Scanning 

53:58 – Toxins in Plant vs. Animal Protein 

56:30 – Collagen: Sourcing & Glyphosate Risk 

1:02:26 – Outro & PUORI Discount 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBE

I have spent 20 years and over $2 million testing my biology, and the biggest lesson I've learned is that sleep is a neurological system, not just a chemical one. Most people fail to get deep rest because they are stuck in Beta brainwaves—a state of hypervigilance fueled by stress and blue light. You can take all the melatonin in the world, but if your brain is electrically "awake," you will stay "tired but wired."

The "switch" I use to fix this is an amino acid called L-theanine. It crosses the blood-brain barrier to increase Alpha waves, which quiet the prefrontal cortex and stop overthinking. By boosting GABA and lowering glutamate, it prepares the brain for rest without the groggy "hangover" of traditional sedatives.

To make this work, I follow a strict protocol: taking 400mg–1000mg about 45 minutes before bed on an empty stomach. I also protect my "Alpha state" by blocking blue and green "junk light" with TrueDark glasses, which prevents cortisol spikes that ruin sleep architecture. When you combine the right compounds with a dark, low-stimulation environment and consistent timing, sleep stops being something you chase and becomes something your body does automatically.

Timestamps:

00:00 – Introduction

00:23 – How the Brain Enters Sleep

01:00 – Why Most Supplements Fail

02:15 – Beta Waves: The Sleep Blocker

03:29 – Alpha Waves: The Sleep Gateway

04:51 – The Amino Acid That Shifts Your Brain

06:11 – Introducing L-Theanine

06:48 – Common L-Theanine Mistakes

08:02 – The Right Protocol

09:34 – Light & Your Sleep Environment

11:13 – Fixing Your Light Environment

12:14 – The Full Sleep System

13:59 – Putting It All Together

Thank you to our sponsors!

• AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.
• LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser.

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey’s BEYOND Conference: https://beyondconference.com/

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your brain is hardware, and if the hardware is broken, no supplement stack, nootropic, or biohacking protocol in the world will get you to full capacity. This episode goes inside the most advanced stem cell and brain optimization clinic on the planet, where Host Dave Asprey undergoes a cutting-edge neurocognitive protocol that combines focused ultrasound, transcranial magnetic stimulation, and mesenchymal stem cells to target specific regions of the brain with millimeter precision.  

- Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

- Learn more about all the treatments at RMI by visiting: https://daveasprey.com/rmi/ 

Dr. Victor Urzola is a plastic and reconstructive surgeon with training from the University of Milan, microsurgery credentials from University Henri Poincare in France, and fellowship experience in facial aesthetic surgery and body contouring on both sides of the Atlantic. He is the former president of the Costa Rican Society of Plastic Surgery and holds membership in the Italian, European, and American societies of plastic and aesthetic surgery. As co-founder of RMI Clinic in Costa Rica, Dr. Urzola has spent years pushing the frontier of regenerative medicine, applying the rigor of academic surgical training to stem cell therapy, neurocognitive protocols, and longevity treatments that most clinics in the world are not yet attempting. 

Dave and Dr. Urzola break down how neuroinflammation silently degrades cognitive function the same way joint inflammation destroys athletic performance, and why treating the brain like a biological system you can upgrade changes everything. They cover the full RMI longevity protocol Dave completed in Costa Rica, including the neurocognitive brain upgrade, plasmapheresis for full-body anti-aging, orthopedic stem cell joint repair, and yes, the enhanced protocol Dave has become known for discussing without apology. 

This is next-level biohacking and regenerative medicine for anyone serious about brain optimization, longevity, and upgrading every system in the body before problems become permanent. 

You'll Learn: 

• How RMI uses functional MRI, neuronavigation, and focused ultrasound to target hypofunctioning brain regions with millimeter accuracy 
• Why neuroplasticity and cognitive recovery in dementia patients improved after just 15 days of treatment 
• How plasmapheresis removes pro-inflammatory mediators and toxins from your entire vascular system and why Dave does it annually 
• What shockwave therapy combined with stem cell injection accomplishes for both men and women in ways pharmacological treatment cannot 
• Why cell viability and placement matter more than raw cell count, and how RMI measures both 10 minutes before every injection 
• How orthopedic stem cell protocols achieve 82.5 percent improvement in joint function across 8,000 treated joints 
• Why Dave calls RMI the best hardware upgrade available and 40 Years of Zen the best software upgrade, and how the two work together 
• What the difference feels like between going from standard resolution to 4K inside your own brain 

Thank you to our sponsors!     

- HeartMath | Go to https://www.heartmath.com/dave to save 15% off. 

- EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Victor Urzola, RMI Clinic Costa Rica, stem cell therapy, brain optimization, neurocognitive protocol, focused ultrasound, transcranial magnetic stimulation, neuroinflammation, plasmapheresis, orthopedic stem cells, mesenchymal stem cells, blood brain barrier, regenerative medicine, anti-aging, longevity, biohacking, Dave Asprey, erectile dysfunction treatment, stem cell facelift, human performance 

Resources:   

• Learn More About All Of The Treatments at RMI by visiting: https://daveasprey.com/rmi/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Trailer 

01:02 – Introduction and RMI Overview 

03:02 – Cognitive Protocol Explained 

05:39 – Dave's Brain Treatment Experience 

13:08 – RMI Results & Patient Outcomes 

15:32 – Plasmapheresis (Blood Cleanse) 

17:10 – Orthopedic Stem Cell Treatments 

23:49 – Enhanced Protocol (Sexual Health – Men) 

25:29 – Sexual Health – Women 

27:40 – Facial Stem Cell Treatment 

30:05 – Closing & Resources 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the real reason you feel stuck, anxious, or unfulfilled has nothing to do with your biohacking stack and everything to do with which half of your brain you're actually using? In this episode, Host Dave Asprey sits down with Harvard professor and bestselling author Arthur Brooks to reveal the neuroscience of meaning, consciousness, and why your left brain's obsession with optimization is quietly destroying your happiness and human performance. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

- Buy Arthur’s new book “The Meaning Of Your Life” at: https://www.penguinrandomhouse.com/books/724315/the-meaning-of-your-life-by-arthur-c-brooks/ 

Arthur Brooks is a professor at both the Harvard Kennedy School and Harvard Business School, where he teaches leadership and happiness. He writes the wildly popular "How to Build a Life" column at The Atlantic, hosts the weekly podcast "Office Hours with Arthur Brooks," and has authored 15 books, including two number one New York Times bestsellers: Build the Life You Want with Oprah Winfrey, and From Strength to Strength. His new book, The Meaning of Your Life: Finding Purpose in an Age of Emptiness, releases March 31, 2026. Brooks is one of the world's foremost experts on the science of human happiness. 

Dave and Arthur go deep on hemispheric lateralization, the rediscovered neuroscience showing your right brain holds everything that makes life worth living: meaning, mystery, consciousness, and the ineffable experiences that no AI, no nootropic, and no amount of fasting or sleep optimization can manufacture for you. They break down why the depression and anxiety epidemic is really a right-brain deficiency crisis, and why all the supplements, ketosis protocols, and functional medicine hacks in the world won't fix it if you're living entirely in your left hemisphere. 

This is a rare episode that bridges hard neuroscience with the deepest questions of human existence. Whether you're deep into anti-aging, neuroplasticity training, or Smarter Not Harder living, this conversation will change how you think about what you're actually optimizing for. 

You'll Learn: 

• Why the mental health crisis is fundamentally a meaning crisis, and what your brain hemispheres have to do with it 
• How technology, AI, and screen culture are suppressing the right hemisphere and wiring you for anxiety 
• The six scientifically backed ways to open your right brain and unlock experiences of real meaning 
• Why self-improvement fails without first understanding the neuroscience of how ideas install in the brain 
• How suffering, handled correctly, is the single most powerful path to consciousness and purpose 
• Why romantic love, beauty, and deep conversation are forms of neurological medicine 
• What Dave's $2.5 million biohacking journey taught him about the limits of optimization 
• The Buddhist physics of suffering: pain times resistance, and how to lower the resistance instead of the pain 

Thank you to our sponsors!     

- Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off. 

- Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. 

- Join My Low-Oxalate 30-Day Challenge: daveasprey.com/2026-low-ox-reset 

- Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  

Keywords: Arthur Brooks, Harvard happiness research, meaning of life, hemispheric lateralization, right brain left brain, brain optimization, neuroplasticity, consciousness neuroscience, mental health crisis, depression anxiety solutions, human performance, self-improvement science, longevity mindset, biohacking happiness, Dave Asprey, functional medicine, suffering and purpose, AI limits, meaning and purpose, How to Build a Life 

Resources:   

• Buy Arthur’s new book “The Meaning Of Your Life” at: https://www.penguinrandomhouse.com/books/724315/the-meaning-of-your-life-by-arthur-c-brooks/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Trailer 

00:49 – Introduction 

02:09 – Teaching & Learning Science 

07:05 – Consciousness & Brain Hemispheres 

18:51 – Mental Health & Meaning Crisis 

20:08 – 6 Ways to Open the Right Brain 

21:44 – Deep Questions & Life's Purpose 

27:16 – Romantic Love & Relationships 

34:37 – Transcendence & Self 

41:18 – Finding Your Calling 

49:33 – Beauty 

53:41 – Suffering & Meaning 

57:20 – Closing 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is. 

• Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 
• Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at: https://omnibioticlife.com/ 

In this episode, Host Dave Asprey and microbiome expert Hannah Kleinfeld break down the hidden gut science behind GLP-1 drugs, ADHD, HRV, histamine intolerance, SIBO, and why most probiotics you're taking are probably dead before they even reach your intestines. 

Hannah Kleinfeld is the co-founder and COO of Omni-Biotic US, a Yale and Harvard graduate, and a certified health coach whose personal battle with Lyme disease drove her deep into functional medicine and microbiome science. Omni-Biotic is the number one probiotic brand in Europe, used in hospital systems alongside antibiotic treatment, and is now bringing that clinical-grade research to the US market. 

Dave and Hannah go deep on the gut-brain axis, the vagus nerve, and how dysbiosis drives everything from brain fog and poor sleep optimization to inflammation, metabolic dysfunction, and compromised mitochondria. They cover how GLP-1 drugs slow gut transit time and trigger secondary dysbiosis, why most capsule probiotics rehydrate in stomach acid and fail, how short-chain fatty acids like butyrate cross the blood-brain barrier to regulate neuroinflammation, and how your gut bacteria directly control your heart rate variability, hormones, libido, and skin. This is biohacking your biology from the inside out, and it goes far deeper than supplements and fasting. 

You'll Learn: 

• Why GLP-1 drugs like Ozempic create secondary dysbiosis and what to do about it 
• How gut inflammation suppresses HRV, disrupts sleep, and accelerates aging 
• Why most probiotics rehydrate in stomach acid and never make it to your intestines 
• The gut-brain connection behind ADHD, brain fog, anxiety, and mood disorders 
• How dysbiosis sabotages weight loss by skewing Firmicutes to Bacteroidetes ratios 
• What the vagus nerve has to do with stress resilience and mitochondria health 
• How to support your microbiome through antibiotics, travel, and SIBO recovery 
• The histamine problem hiding inside popular probiotic strains 
• Why the first 1,000 days of a baby's life shape lifelong immunity and HPA axis function 
• How targeted probiotic formulations are changing functional medicine 

Thank you to our sponsors!    

• Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today
• Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference 
• Fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE
• BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Hannah Kleinfeld, Omni-Biotic, gut microbiome, probiotics that work, GLP-1 gut damage, Ozempic side effects, secondary dysbiosis, gut brain axis, vagusnerve HRV, SIBO treatment, histamine intolerance probiotics, leaky gut inflammation, butyrate blood brain barrier, ADHD gut connection, probiotic capsules vs powder, antibiotic recovery, gut skin axis, microbiome sleep, Firmicutes Bacteroidetes weight loss, functional medicine gut health 

Resources:   

• Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at: https://omnibioticlife.com/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 - Trailer 

01:10 - Intro

03:12 - Kids & Gas: Gut Imbalance in Children 

06:42 - Pills vs. Powder Probiotics 

07:28 - Omnibiotic Overview & Dave's Story 

10:44 - Probiotics & Heart Rate Variability

14:14 - GLP-1 Drugs & the Microbiome 

17:24 - Gut & Sleep Quality 

19:13 - Probiotics & SIBO 

27:47 - Gut Bacteria & ADHD 

29:55 - Gut, Libido & Fertility 

36:04 - Gut & Unusual Microbiome Facts 

43:22 - Histamine Intolerance & Probiotics 

51:58 - Kids' Microbiome vs. Adults' 

56:10 - Outro 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBE

I transformed my vision from 20/80 to 20/15 by stopping the "management of decline" and starting the "restoration of tissue".

The retina is a metabolically hungry tissue that undergoes a nightly repair program, but modern habits like screen use and late-night blue light exposure suppress the melatonin and mitochondrial energy needed for this cleanup.

To reverse this, I use 7 specific daily habits to flip the self-healing switch:

- Mitochondrial Fuel: I use 670 nm red light to directly fuel retinal mitochondria and increase ATP production.

- Pigment Regeneration: I eat blueberries in the evening to accelerate night-vision pigment (rhodopsin) regeneration exactly when the eye needs it.

- Mechanical Rest: I practice "Eye Fasting"—looking at true distance—to release the mechanical tension of constant near-focus.

- Vascular Tone: I use a gentle cold rinse to improve vascular tone and blood flow around the eye.

- Oxidative Stress: I practice grounding to lower systemic oxidative stress and inflammation.

- Corneal Hydration: I use blink training to rehydrate the cornea and stabilize the protective tear film.

- Circadian Anchoring: Finally, I watch the sunset every day to anchor my circadian rhythm, ensuring my eye's repair enzymes activate on time.

Timestamps:

00:00 – Intro

01:05 – The Problem with Traditional Vision Care

02:48 – How Your Eyes Repair Themselves at Night

05:03 – How Modern Life Breaks the Repair Cycle

05:53 – The 7 Habits to Activate Your Eye's Self-Healing Switch

06:07 – Habit 1: Red Light Therapy

07:18 – Habit 2: Blueberries and Rhodopsin

09:22 – Habit 3: Cold Exposure for Blood Flow

11:10 – Habit 4: Grounding to Reduce Oxidative Stress

13:38 – Habit 5: Eye Fasting (Distance Viewing)

15:45 – Habit 6: Deliberate Blinking

17:53 – Habit 7: Sunset Light and Circadian Repair

Thank you to our sponsors!

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey’s BEYOND Conference: https://beyondconference.com/

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week's stories: 

*SNL Roasts the MAHA Movement 

Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker means staying precise about what you're actually skeptical of. 

Sources:  

-https://www.nbc.com/saturday-night-live  

-https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ 

*Pistachios Are a Stealth Longevity Stack 

New Cornell-linked research shows pistachios are significantly more bioactive than standard nutrition data suggested — hitting Nrf2, AMPK, and gut barrier pathways simultaneously. This is a whole-food hack hiding in plain sight. 

Sources:  

-https://www.reddit.com/r/Biohackers/comments/1rvcqiy/cornell_university_reveals_pistachios_are_far/ 

-https://www.instagram.com/p/DViqesBDOZQ/ 

*40 Million People Are Using ChatGPT as Their Doctor 

Industry estimates put daily ChatGPT health queries at roughly 40 million users — making AI the largest informal primary care interface on the planet. Dave lays out the only safe framework for using these tools without getting burned. 

Sources:  

-https://www.linkedin.com/pulse/month-healthcare-ai-march-2026-gary-monk-ermcf 

-https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ 

-https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/ 

*Your Microbiome Is a City — and Architecture Matters 

New biofilm research shows that how your gut microbes physically organize themselves may matter as much as which strains you have. The next frontier of microbiome hacking is infrastructure, not species. 

Sources: 

-https://phys.org/news/2026-01-hidden-microbial-communities-health-space.html 

-https://astrobiology.com/2026/03/rethinking-the-microbial-future-of-space-travel.html 

*Colon Cancer Is Now the Leading Cause of Cancer Death Under 50 

This is no longer a retirement problem. Dave breaks down the four drivers behind the spike — and why your gut health protocols are now frontline cancer prevention. 

Sources:  

-https://pubmed.ncbi.nlm.nih.gov/41754195/  

-https://www.washingtonpost.com/wellness/2026/03/03/muscle-strength-longevity-study/ 

*Measles Is Back — and the Math Is Unambiguous 

Over 1,300 confirmed cases across 31 states in 2026 alone, with the US at risk of losing its measles elimination status for the first time since 2000. Dave addresses the "natural immunity" argument directly — and doesn't pull punches. 

Sources:  

-https://www.cdc.gov/measles/cases-outbreaks.html  

-https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/ 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune resilience, gut health, microbiome optimization, cancer prevention, and how to use AI tools safely. Host Dave Asprey connects emerging science, cultural shifts, and real epidemiological data into practical frameworks you can use to build a resilient, adaptable health stack. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: MAHA movement biohacking, SNL vaccine sketch, RFK health satire, pistachios polyphenols longevity, pistachio Nrf2 AMPK, ChatGPT health advice AI, AI primary care risks, gut microbiome biofilm architecture, colon cancer under 50, colorectal cancer young adults, colon cancer prevention diet, measles outbreak 2026, measles elimination status, natural immunity measles risk, immune amnesia measles, biohacking news, longevity research 2026 

Thank you to our sponsors!  

-  Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap

-  The One Device | Use code DAVE for $10 off at theonedevice.com/dave

Resources:   

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Trailer 

00:41 – SNL Roasts the MAHA Movement 

03:20 – Pistachios and Longevity 

04:37 – AI as Your Health Advisor 

06:12 – Gut Biofilms and Microbiome Architecture 

07:44 – Colon Cancer in Young People 

09:23 – The Measles Comeback 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with McCall McPherson, a physician associate, TEDx speaker, and founder of Modern Thyroid Clinic, Modern Weight Loss, and the advocacy platform Thyroid Nation. McPherson has been honored on the 2024 and 2025 Inc. 5000 lists and named a 2025 Top 500 Inc. Female Founder. She hosts the Modern Thyroid and Wellness podcast and built her entire practice around thyroid care after being failed by conventional medicine while managing her own hypothyroidism. She treats patients nationwide via telemedicine and has become one of the most trusted voices in functional medicine thyroid care. 

Dave and McCall expose why standard TSH-only testing catches just 1 to 2 percent of actual thyroid variation, why the medication most doctors prescribe (Synthroid/levothyroxine) fails a massive percentage of patients, and why T3 is the active hormone that mainstream medicine has been trained to fear without good reason. They also get into how fluoride in tap water, bromine in American wheat, mold exposure, dairy, gluten, and oxalates directly suppress thyroid function and drive autoimmunity. If you want to optimize your metabolism, protect your mitochondria, support brain optimization, and stop leaving your longevity on the table, thyroid is the first domino. 

This is essential listening for anyone serious about biohacking, human performance, anti-aging, functional medicine, supplements, sleep optimization, and using smarter not harder strategies to take control of your biology. 

You'll Learn: 

• Why testing TSH alone misses thyroid dysfunction in the vast majority of people 
• What a full thyroid panel actually includes and the optimal ranges for T4, T3, and reverse T3 
• Why T4-only medications like Synthroid fail and what works better 
• How low thyroid directly tanks testosterone and libido in both men and women 
• The environmental triggers destroying your thyroid, including fluoride, bromine, mold, and inflammatory foods 
• How Hashimoto's connects to broader autoimmune risk and what drives it into remission 
• Why kids are being misdiagnosed with ADHD when the real issue is hypothyroidism 
• The supplements and cofactors (selenium, zinc, magnesium, ashwagandha, tyrosine) that support thyroid activation 
• How thyroid optimization connects to metabolism, dementia prevention, cardiovascular health, and economic outcomes 
• When to use T3 only vs. a T3/T4 combination, and how to know if your dose is off 

Thank you to our sponsors!    

• TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off. 
• BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com 
• Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide 
• Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: McCall McPherson, Modern Thyroid Clinic, thyroid testing wrong, full thyroid panel, free T3, reverse T3, Synthroid failure, T3 vs T4, Hashimoto's remission, fluoride suppresses thyroid, thyroid low testosterone, thyroid ADHD, thyroid depression, hypothyroidism misdiagnosis, thyroid and metabolism, thyroid hair loss, functional medicine thyroid 

Resources:   

• Learn More About McCall’s Work At: https://www.modernthyroidclinic.com/ 

• Get McCall's Thyroid Guide: https://gift.modernthyroidclinic.com/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Trailer 

01:05 – Intro & Guest Background 

02:26 – Dave & McCall's Thyroid Stories 

05:26 – How Thyroid Hormones Work 

12:51 – Why T4-Only Meds Fall Short 

23:05 – Why Thyroid Dysfunction Is So Common 

23:59 – Fluoride, Bromine & Environmental Triggers 

26:39 – Thyroid & Low Testosterone 

27:31 – Optimal Lab Ranges for TSH, T4 & T3 

36:58 – Mold, Hashimoto's & Autoimmunity 

44:44 – Thyroid, ADHD & Mental Performance 

49:38 – Supplements for Thyroid Support 

51:52 – Vitamin D & Circadian Rhythms 

56:30 – T3 Safety Myths & Medical Misinformation 

1:00:16 – Key Takeaways & Where to Get Help 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.