One Creatine Dose Kept Sleep-Deprived Brains 12% Sharper 

A randomized, double-blind crossover trial kept 29 healthy adults awake for 21 hours straight ... half the time on a single moderate dose of creatine (~14g), half the time on placebo ... and found the creatine group held on to up to 12% more cognitive performance across logic, reaction time, and language processing. Host Dave Asprey breaks down why sleep deprivation is just another form of brain energy stress, how creatine's phosphate-buffering mechanism stabilizes ATP in the prefrontal cortex under pressure, and why this changes how he thinks about red-eye flights and all-nighters. Vegetarians and women showed the largest effects ... your baseline diet sets your ceiling. 

Sources: 

• https://pubmed.ncbi.nlm.nih.gov/42075005/ 
• https://www.nutraingredients.com/Article/2026/04/21/single-dose-creatine-may-support-cognition-in-sleep-deprivation-study/ 
• https://pmc.ncbi.nlm.nih.gov/articles/PMC10902318/ 
• https://medicalxpress.com/news/2024-04-creatine-cognitive-deprivation.html 

Your Gum Is Dosing You With Thousands of Microplastics 

A pilot study tested 10 commercial gums ... five synthetic, five marketed as natural or plastic-free ... and found every single one shed hundreds to roughly 3,000 microplastic fragments per stick into saliva, with no meaningful difference between synthetic and "natural" varieties. Host Dave Asprey connects this to total toxic load management, explains why "natural" label claims mean nothing without polymer-free verification, and makes the case that even innocent daily habits contribute to the cumulative plastic burden most people aren't tracking. The takeaway isn't panic ... it's precision. 

Sources: 

• https://www.acs.org/pressroom/presspacs/2025/march/chewing-gum-can-shed-microplastics-into-saliva-pilot-study-finds.html 
• https://www.sciencedirect.com/science/article/pii/S2666911025000243 
• https://samueli.ucla.edu/bursting-your-bubble-chewing-gum-releases-microplastics-into-your-saliva-ucla-research-shows/ 
• https://www.food-safety.com/articles/10285-study-shows-chewing-gum-releases-thousands-of-microplastics-whether-gum-is-synthetic-or-natural 

Irregular Bedtimes in Your 40s May Double Heart Attack Risk 

Finnish researchers followed 3,231 people from age 46 using objective accelerometer data and tracked cardiovascular outcomes for a decade ... finding that people with highly irregular bedtimes, especially combined with short sleep, had roughly double the risk of major cardiovascular events compared to those with consistent sleep timing. Host Dave Asprey explains why your vascular biology runs on a precise circadian schedule, why ambitious, otherwise-healthy people are most at risk of ignoring this lever, and why a 90-minute bedtime window ... protected even on weekends ... may be one of the cheapest cardiovascular interventions available. It'snot just how much you sleep. It's when. 

Sources: 

• https://www.sciencedaily.com/releases/2026/05/260504154026.htm 
• https://hsph.harvard.edu/topic/aging/ 

Scientists Decode the Plant Molecule That Kills Cancer Cells in the Lab 

UBC researchers published a chromosome-level genome map of Mitragyna parvifolia ... a kratom relative ... and used it to decode the full biosynthetic pathway for mitraphylline, a rare alkaloid that has shown real anti-tumor activity in cell and animal models but has never been producible at clinical scale. Host Dave Asprey explains why this is the same early chapter that vincristine and paclitaxel were in before becoming mainstream chemotherapy, draws a hard line between this pipeline story and influencer narratives about kratom as a cancer treatment, and breaks down what it actually means when researchers crack a plant's genetic recipe for a bioactive compound. Nature has been solving cancer for millions of years... we're finally learning to read it. 

Sources: 

• https://academic.oup.com/plcell/article/37/9/koaf207/8237526 
• https://www.sciencedaily.com/releases/2026/05/260512213836.htm 
• https://news.ok.ubc.ca/2025/10/14/researchers-reveal-how-plants-make-anti-tumour-drugs/ 
• https://pmc.ncbi.nlm.nih.gov/articles/PMC12217235/ 

Scientists Built an On/Off Switch for Sperm Production — No Hormones 

Cornell researchers used a small-molecule inhibitor called JQ1 to pharmacologically shut down sperm production in male mice for the duration of treatment, then stopped the drug and watched full fertility restore... with healthy offspring and no detectable genomic damage. Host Dave Asprey breaks down the BRDT mechanism that makes this work without touching testosterone or hormones, explains why this is a proof-of-concept rather than a near-market drug, and outlines the questions that need answering before this moves to humans: long-term testicular health, epigenetic marks in recovered sperm, and mood and testosterone interaction over time. The era of precision male reproductive biology is just beginning. 

Sources: 

• https://pubmed.ncbi.nlm.nih.gov/41945432/ 
• https://www.sciencedaily.com/releases/2026/04/260407193844.htm 
• https://www.news-medical.net/news/20260407/Study-advances-safe-reversible-male-contraceptive-without-hormones.aspx 
• https://www.independent.co.uk/news/science/breakthrough-male-birth-control-sperm-b2972841.html 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on cognitive performance, toxic load management, circadian biology, plant-derived drug discovery, and the future of male reproductive medicine. Host Dave Asprey connects emerging clinical research, objective epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: creatine sleep deprivation cognition, brain energy ATP creatine, microplastics chewing gum, natural gum microplastics, toxic load biohacking, irregular bedtime heart attack risk, circadian rhythm cardiovascular, sleep timing heart health, mitraphylline cancer compound, kratom plant alkaloid drug discovery, oncolytic plant molecule, male birth control non-hormonal, sperm production reversible, BRDT JQ1 contraception, biohacking news 2026, longevity research, performance optimization, healthspanextension 

Thank you to our sponsors!  

- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off 

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- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

Resources:   

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Intro 

00:36 – Fluoride Correction 

01:14 – Story 1: Creatine & Sleep Deprivation 

03:21 – Story 2: Microplastics in Gum 

04:53 – Story 3: Irregular Bedtimes & Heart Risk 

06:31 – Story 4: Kratom Plant & Cancer Research 

08:18 – Story 5: Male Contraception On/Off Switch 

10:02 – Wrap-Up 

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If you're over 50 and still doing cardio to stay healthy, you're wasting your time and may actually be making things worse. This episode breaks down the exact movements, supplements, and anti-aging strategies that build real strength, protect your bones, and extend your longevity without spending hours in the gym. 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Will Harlow, a master's-level physiotherapist and founder of HT Physio, whose YouTube channel has amassed over 1.5 million subscribers by teaching people over 50 how to stay mobile, active, and independent without painkillers or surgery. Will graduated with a first-class degree from Brunel University, trained in both the NHS and professional sport, and has spent his career proving that what most doctors call "just aging" is actually optional. 

Together, Dave and Will dismantle the myths keeping older adults weak, injured, and overtrained. They get into why resistance training beats cardio for human performance and metabolism at every age, how anabolic resistance changes your protein needs after 50, which three compound movements deliver the biggest functional gains, and why your grip strength may be the most underrated biomarker you're ignoring. Dave also shares how he used biohacking, targeted supplements, and functional medicine principles to grow bones so dense his surgeon couldn't cut through them. They also dig into vestibular training, hydration, magnesium, Vitamin DAKE, and how tools like AI are now helping people identify movement problems before they become joint replacements. 

This is essential listening for anyone serious about longevity, anti-aging, biohacking, sleep optimization, supplements, smarter not harder training, human performance, and building a body that performs decades past its expiration date. 

You'll Learn: 

• Why chronic cardio decreases bone density and muscle mass in people over 50 
• The 3-2-1 resistance training method that delivers 80% of results in 40 minutes a week 
• How anabolic resistance changes protein requirements as you age and what to do about it 
• The three compound movements every person over 50 should master first 
• Why grip strength predicts overall health and how to train it 
• How vestibular disorders silently destroy balance and confidence, and how to reverse them 
• The supplement stack (Vitamin DAKE, magnesium glycinate, digestive enzymes) that supports bone, muscle, and metabolism 
• Why 7,000 steps beats 10,000, and where that number actually came from 
• How Dave used biohacking and functional medicine to grow bones that broke a surgeon's saw 
• Why AI tools can now spot gait problems that lead to hip replacements years later 

Thank you to our sponsors!      

- Active Skin Repair | Get 25% off your order until May 21, after that, it drops back to 20%, visit ActiveSkinRepair.com and use code DAVE. You can also find Active Skin Repair on Amazon and at your local CVS  

- Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off. 

- Neuronic | Go to www.neuronic.online Code DAVE for $100 off 

- Quantum Upgrade | Go to QuantumUpgrade.io/DAVE to claim your 15-day free trial 

- fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Will Harlow, HT Physio, Independence for Life, physiotherapy, physical therapy, over 50 fitness, resistance training, strength training, muscle mass, bone density, osteoporosis, goblet squat, Romanian deadlift, farmer's carry, compound movements, progressive overload, 3-2-1 method, exercise snacks, balance training, vestibular health, vestibular disorders, fall prevention, hip fracture, anabolic resistance, protein intake, muscle protein synthesis, grip strength, zone 2 cardio, overtraining, sarcopenia, frailty, mobility, functional movement, gait analysis, fascia, inflammaging, NLRP3, EGCG, green tea extract, luteolin, shockwave therapy, digestive enzymes, betaine HCL, stomach acid, magnesium glycinate, Vitamin K2, Vitamin DAKE, zinc, calcium, electrolytes, cortisol, testosterone, anti-aging, longevity, biohacking, supplements, human performance, metabolism, AI, Dave Asprey, 7000 steps, 10000 steps, pedometer, body weight training, resistance bands, home workout, senior fitness, healthy aging, biological age, heart rate variability, VO2 max, morning stiffness, hip pain, knee pain, back pain, fascia hydration, infant reflexes, vestibular training, eye tracking, sit to stand, bone density surgery, dense bones, UK healthcare, NHS, healthcare system 

Resources:   

• Preorder Will’s Upcoming Book Independence for Life (5/26) at: https://www.penguinrandomhouse.com/books/804636/independence-for-life-by-will-harlow/ 

• Learn More About Will’s Work: https://willharlow.com/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps:  

00:00 – Trailer 

00:36 – Intro 

02:59 – Why Resistance Training Matters 

03:38 – US vs. UK Health Culture 

06:15 – Getting Started with Resistance Training 

07:12 – Top 3 Movements Over 50 

10:30 – Hip Mobility & Inflammation 

12:19 – Hydration, Joints & Electrolytes 

14:11 – Balance, Falls & Exercise Snacks 

15:21 – Biological Age & Longevity 

16:41 – Biohacking vs. Optimization 

20:08 – Overtraining & the 3-2-1 Method 

29:42 – Protein & Anabolic Resistance 

33:57 – Energy, Fat & Cortisol 

37:49 – Vestibular Health & Balance 

50:07 – Gait & Movement Rehab 

56:56 – Steps, VO2 Max & Wearables 

57:25 – Book Promo 

01:02:14 – 7,000 Steps 

01:04:22 – Wrap-Up 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The person you love is either raising your hormones or destroying them, and most people have no idea which one is happening to them. John Gray, the author of one of the most beloved relationship books of all time, returns to reveal how your relational environment directly shapes your biology, and what you can do right now to hack it. 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

John Gray wrote Men Are from Mars, Women Are from Venus, the number one bestselling book of the entire decade and one of USA Today's top 10 most influential books of the last quarter century. His books have been translated into 45 languages across more than 100 countries. But what most people miss is that Gray is also a pioneer in the intersection of hormonal health, brain optimization, and human performance, a biohacker before the word existed. His newest book, Men Are from Mars for Women Only: Be Happy With or Without a Man, is the first in a six-part series packed with cutting-edge insights on relationships, biology, and longevity. 

Host Dave Asprey and John Gray go deep on the hormonal mechanics of desire, attraction, and emotional regulation, covering why societal testosterone collapse is driving relationship breakdown, how estrogen and testosterone function as a polarity system in both men and women, and why the relational environment you create every day is either building or destroying your biological potential. They also cover lithium orotate as a brain optimization supplement, the anti-aging power of semen retention, pre-digested protein as a nootropics-adjacent tool for brain healing, and how fasting and discipline directly boost testosterone. Gray even shares how he reversed early-stage Parkinson's using biohacking techniques and now maintains a testosterone level of 600 at age 74, with zero pharmaceutical support. 

This is essential listening for anyone serious about biohacking, longevity, anti-aging, supplements, human performance, brain optimization, functional medicine, metabolism, and hacking the biology of love and attraction. 

You'll Learn: 

• Why testosterone collapse is the hidden driver behind modern relationship failure 
• How your partner's emotional state directly affects your hormones in real time 
• The prolactin trap that kills sexual desire in long-term relationships and how to escape it 
• Why lithium orotate is one of the most underrated supplements for dopamine and serotonin balance 
• How mirror neurons open and close based on stress, and what that means for emotional connection 
• The five-finger ask technique that raises estrogen and testosterone simultaneously 
• How pre-digesting protein with enzymes achieves 93 percent assimilation and supports brain repair 
• Why fasting, discipline, and semen retention are among the most powerful testosterone-building tools available 

Thank you to our sponsors!      

- Active Skin Repair | Get 25% off your order until May 21, after that, it drops back to 20%, visit ActiveSkinRepair.com and use code DAVE. You can also find Active Skin Repair on Amazon and at your local CVS  

-  iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

- Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out

- Igniton | Try risk free at Igniton.com and use code DAVE at checkout for 15% off. Backed by a 30-day money back guarantee.

- Pique | Go to Piquelife.com/dave for 20% off

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: John Gray, Men Are from Mars Women Are from Venus, testosterone, estrogen, hormonal health, hormone optimization, prolactin, oxytocin, dopamine, serotonin, lithium orotate, mirror neurons, longevity, anti-aging, biohacking, supplements, fasting, semen retention, NoFap, multi-orgasmic men, sexual health, libido, foreplay, relationship advice, men and women, emotional regulation, stress hormones, cortisol, adrenaline, epigenetics, Parkinson's disease, protein assimilation, digestive enzymes, pre-digested protein, whey protein, casein protein, Mars Venus app, five finger ask, Venus talk, emotional processing, trauma, post traumatic stress, testosterone collapse, relationship breakdown, attraction, desire, masculine feminine polarity, Dave Asprey, 40 Years of Zen, hormones and behavior, relational biology, conscious relationships, mirror neurons and sex, luteinizing hormone, monk celibacy, meditation 

Resources:   

• Grab All Of John’s Books And Content At: https://www.marsvenus.com/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps:  

00:00 – Trailer 

00:45 – Intro 

02:23 – Testosterone & Relationship Collapse 

02:41 – Hormones & Stress 

08:37 – Attraction & Sexual Polarity 

10:36 – Communication & Conflict 

20:21 – Emotions & Trauma 

21:27 – Mirror Neurons 

31:03 – Masculine vs. Feminine Energy 

45:05 – Lithium Orotate 

49:52 – Protein & Longevity 

54:02 – Semen Retention 

59:46 – Prolactin & Long-Term Desire 

1:09:12 – Sex & Mirror Neurons 

1:12:45 – The Five Finger Ask 

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If you are constantly bloated, fatigued, and feeling heavy, your gut bacteria have taken over. The standard advice is to just stop eating and do a multi-day water fast. But if your gut is already inflamed, a strict zero-calorie fast will actually spike your cortisol, trigger adrenaline crashes, and blow open the tight junctions in your intestinal wall.

In this video, I break down the Italian fasting hack engineered by longevity researcher Valter Longo: The Fasting Mimicking Diet (FMD).

I explain exactly how to structure this 5-day protocol to trick your body into autophagy (cellular cleanup) while still eating 800 to 1100 calories of specific fats and complex carbs. You will learn how constant "grazing" paralyzes your Migrating Motor Complex, why hidden proteins in vegetables are secretly kicking you out of fasting mode, and the exact step-by-step protocol to re-feed your microbiome on Day 6 without causing a massive inflammatory storm.

Thank you to our sponsors!

-GOT MOLD? | Go to http://gotmold.com/shopand use DAVE10 to save 10% and see what’s in your air

-The One Device | Use code DAVE for $10 off at theonedevice.com/dave

-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Timestamps:

00:00 – Intro

00:40 – Gut Ecosystem

01:00 – Constant Snacking

02:57 – Gut-Brain Connection

03:40 – Why Standard Fasting Can Backfire

07:22 – The Fasting Sweet Spot

09:21 – Introducing the FMD

10:43 – Pre-Reset: Prep Days

13:24 – The 5-Day FMD Protocol

16:47 – Meal Timing & Circadian Rhythm

17:46 – Sleep, Stress & Recovery

18:22 – How Often to Do FMD

19:23 – Wrapup

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey’s BEYOND Conference: https://beyondconference.com/

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

*Testosterone Directly Suppresses Brain Tumor Growth in Males by 38% 

Cleveland Clinic research funded by NIH shows testosterone binds androgen receptors in glioblastoma stem cells — the root of tumor recurrence — and cuts growth by 38% when levels are restored. Dave breaks down why the mainstream framing of testosterone and cancer risk has it backwards, what androgen deprivation therapy may be doing to every other cancer pathway simultaneously, and why your hormone panel is now a cancer conversation, not just a performance one. 

Sources:  

-https://www.nih.gov/news-events/news-releases/nih-funded-study-suggests-testosterone-suppresses-brain-tumor-growth-males  

-https://bioengineer.org/nih-funded-research-indicates-testosterone-may-inhibit-brain-tumor-growth-in-males/ 

*CDC Halts Rabies Testing Nationwide  

A CDC staffing crisis has pushed rabies, mpox, and Epstein-Barr testing to overwhelmed state labs, creating one-to-two week diagnostic delays in a disease where post-exposure prophylaxis must begin within ten days of a bite — and where fatality is virtually 100% once symptoms appear. Dave explains exactly what to do if you or a pet is exposed, why outdoor biohackers are the most exposed population, and what pre-travel prevention looks like for anyone heading to endemic regions. 

Sources:  

-https://www.nbcnews.com/health/health-news/cdc-pauses-testing-rabies-monkeypox-epstein-barr-viruses-rcna266377  

-https://www.cidrap.umn.edu/rabies/state-public-health-labs-step-cdc-pauses-testing-various-pathogens-including-rabies-mpox 

*Mifepristone Mail Ban  

The Supreme Court issued a one-week stay blocking a 5th Circuit ruling that would have ended telehealth and mail access to mifepristone, used in over 63% of U.S. abortions. Dave sets aside the moral debate to focus on what this legal precedent means for FDA-approved compounded peptides, bioidentical hormones, and telehealth access to any treatment without full pharmaceutical backing — and why this case is one every biohacker should be tracking closely. 

Sources:  

-https://www.usnews.com/news/health-news/articles/2026-05-05/supreme-court-issues-stay-keeping-abortion-pill-mifepristone-available-by-mail-for-now  

-https://www.npr.org/2026/05/04/nx-s1-5810510/supreme-court-mifepristone-appeals-telehealth 

*Cow Flu and Dog Coronavirus  

University of Florida scientists are watching Influenza D — endemic in U.S. cattle herds — and canine coronavirus HuPn-2018, which already jumped to humans in China, as the two zoonotic threats most likely to achieve widespread human transmission. Dave covers why the conditions producing these jumps aren't going away, what the Influenza D finding means for the raw milk conversation right now, and the mucosal immunity stack that puts you in the strongest position regardless of which virus makes the leap next. 

Sources:  

-https://ufhealth.org/news/2026/scientists-say-these-two-viruses-may-become-the-next-public-health-threats 

-https://www.gavi.org/vaccineswork/six-major-health-threats-could-shape-2026-heres-what-experts-are-watching 

*Hantavirus Kills 3 on Cruise Ship  

Eight confirmed or suspected cases of Andes hantavirus aboard the MV Hondius off the Canary Islands have killed three and left two critical, with passengers from 23 countries already dispersed through global airports. Dave cuts through the pandemic panic to explain why American and South American hantavirus strains are categorically more lethal than European ones, why Andes is the only strain on earth that spreads human to human via respiratory droplets, and what early symptom recognition could mean for your survival window if exposure reaches your community. 

Sources: 

-https://www.cnn.com/2026/05/07/world/hantavirus-ship-tenerife-outbreak-intl 

-https://www.nbcnews.com/health/health-news/hantavirus-andes-virus-what-is-cruise-ship-outbreak-deadly-strain-rcna343901 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on hormonal optimization, infectious disease risk, immune resilience, and the legal infrastructure shaping medical autonomy. Host Dave Asprey connects emerging NIH research, Supreme Court developments, and live outbreak data into actionable frameworks for protecting your biology when institutions can't do it for you. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: testosterone brain cancer, testosterone glioblastoma, low testosterone tumor risk, androgen deprivation therapy cancer, CDC rabies testing paused, rabies post-exposure prophylaxis, rabies exposure protocol, mifepristone telehealth ban, SCOTUS mifepristone stay, telehealth medical autonomy, compounded hormones legal risk, influenza D cattle virus, canine coronavirus HuPn-2018, zoonotic virus 2026, raw milk bird flu risk, mucosal immunity biohacking, hantavirus cruise ship, Andes hantavirus outbreak, MV Hondius hantavirus, hantavirus human to human transmission, hantavirus vs coronavirus, biohacking news 2026, Dave Asprey weekly roundup, longevity research 2026 

Thank you to our sponsors!  

- Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap 

- Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. 

- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

Resources:   

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Intro 

00:35 – 1. Testosterone & Brain Cancer 

02:30 – 2. CDC Pauses Rabies Testing 

04:09 – 3. Mifepristone & Telehealth Access 

05:42 – 4. Influenza D & Canine Coronavirus 

07:15 – 5. Hantavirus Cruise Ship Outbreak 

09:36 – Takeaways 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if an invisible field could protect your brain from EMF damage, improve your HRV, accelerate recovery, and optimize your biology without pills, devices, or a single lifestyle change? Host Dave Asprey sits down with Philippe Samor von Holtzendorff-Fehling, founder of Leela Quantum Tech and Quantum Upgrade, to explore one of the most controversial and compelling frontiers in biohacking today: quantum energy fields delivered remotely, in real time, to your body, your pets, your home, and even your business. 

-Try Quantum Upgrade Free for 15 days, no credit card required: quantumupgrade.io/dave 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  

Philippe Samor von Holtzendorff-Fehling is a coach, conscious entrepreneur, and energy healer who built a parallel path alongside a high-level international business career, working through his own blockages to fully connect with his true self. He served as Vice President at both T-Mobile International and T-Mobile US, and is now the founder and CEO of Leela Quantum Tech and Quantum Upgrade. He is also a kundalini yoga teacher, a passionate bio and bio-energy hacker, a father of two, a dog lover, and the number one ranked tennis player in the US in the Men 50+ category. His work sits at the intersection of functional medicine, quantum biology, and human performance, and the science behind his technology is harder to dismiss than most people expect. 

Dave and Philippe go deep on how chronic EMF exposure from 5G towers, Starlink satellites, electric vehicles, and everyday Wi-Fi actively disrupts your brain waves, blood cells, heart rate variability, and mitochondria function. They also break down how Quantum Upgrade works as a remote, customizable field that can harmonize these frequencies in real time, and why it may be one of the most underrated tools for sleep optimization, brain optimization, recovery, anti-aging, and longevity. 

This episode also covers the groundbreaking work Philippe is doing with autistic children, including a clinical study showing measurable reductions in autism spectrum scores, and a remarkable collaboration with Susie Miller of the Telepathy Tapes. 

This is essential listening for anyone serious about biohacking, human performance, anti-aging, longevity, brain optimization, sleep optimization, functional medicine, mitochondria health, and hacking every system in your body with smarter not harder solutions. 

You'll Learn: 

• Why EMF from 5G, Starlink, and electric vehicles is more biologically dangerous than most people realize 
• How a 256-channel EEG captured real-time brain changes triggered by Quantum Upgrade 
• What "quantum coherence" actually means for your biology and why it matters for human performance and longevity 
• How remote quantum fields affect HRV, blood clarity, ATP production, and mitochondria function 
• Why autistic children showed measurable spectrum score reductions in a clinical trial using this technology 
• How to customize your own quantum field for sleep optimization, recovery, energy, and brain optimization 
• What Dave uses Quantum Upgrade for at his 40 Years of Zen facility in Austin 

Thank you to our sponsors!      

- Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave 

- Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today 

- Timeline | Go to timeline.com/dave and you’ll get an additional 20% off your first month 

- Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Philippe Samor von Holtzendorff-Fehling, Quantum Upgrade, Leela Quantum Tech, quantum energy, EMF protection, electromagnetic fields, 5G health effects, Starlink radiation, biohacking, human performance, longevity, anti-aging, brain optimization, sleep optimization, mitochondria, functional medicine, HRV, heart rate variability, dark field microscopy, EEG, ATP production, quantum coherence, biofield, energy healing, autism spectrum, telepathy tapes, Susie Miller, kundalini yoga, electric vehicle EMF, Wi-Fi health effects, smarter not harder, Dave Asprey, 40 Years of Zen, wound healing, placebo controlled trials, quantum biology, coherent field, EMF harmonization, remote quantum field, energy frequency, conscious entrepreneurship 

Resources:   

• Try Quantum Upgrade Free for 15 days, no credit card required: quantumupgrade.io/dave 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps:  

00:00 – Trailer 

01:15 – What Science Can't Explain 

04:05 – What Is Quantum Upgrade? 

06:04 – The Research 

07:47 – Origin Story 

12:20 – EEG Testing & Brain Effects 

12:53 – EMFs, Electric Cars & 5G 

17:57 – Measuring Results 

21:25 – Autism Study & Telepathy Tapes 

26:16 – Frequencies & Settings 

29:09 – Starlink & Global EMF 

30:54 – Skeptics & Proof 

33:08 – Kids & Pets 

37:10 – Wrap-Up & Free Trial 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your biological age can drop by over three years in just eight weeks, and the tools to do it are already in your kitchen. This episode breaks down the cutting-edge science of methylation, polyphenols, Yamanaka mimetics, and epigenetic reprogramming that is rewriting what we know about anti-aging, longevity, and human performance. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Kara Fitzgerald, ND, IFMCP, a leading voice in functional medicine and epigenetic aging research. Her award-winning clinical studies published in Aging (2021, 2023, and 2025) proved that targeted diet and lifestyle interventions can measurably reverse biological age on validated epigenetic clocks. She is the author of Younger You, an IFM faculty member and Certified Practitioner, and one of the most rigorously credentialed researchers working at the intersection of functional medicine, nutrition, and longevity science today. 

Together, they go deep on Yamanaka factors, the Nobel Prize-winning discovery that can wind back a 90-year-old cell to its 20s, and the emerging class of compounds called Yamanaka mimetics, polyphenol-based supplements that may replicate some of those same cellular rejuvenation effects without the risks. They cover why polyphenols do the heavy lifting in biological age reversal, how AI is accelerating longevity research, and why the dark matter of nutrition may matter more than macros, carnivore protocols, or ketosis for long-term health. They also get into oxalates, mitochondria, fibroids, ovarian rejuvenation, and why the original Horvath clock may be more relevant than scientists thought. 

This is essential listening for anyone serious about biohacking, longevity, supplements, functional medicine, anti-aging, brain optimization, human performance, and using smarter not harder strategies to take control of your biology. 

You'll Learn: 

• How diet, supplements, and meditation reversed biological age by over three years in eight weeks in a randomized controlled trial 
• What Yamanaka factors are and why scientists are calling partial cellular reprogramming the future of anti-aging 
• Which polyphenols do the heaviest lifting for epigenetic rejuvenation, including EGCG, urolithin A, rosemary, marjoram, and yarrow 
• Why the Horvath epigenetic clock may actually be touching on programmatic aging rather than just exposomic wear and tear 
• How AI is unlocking patterns in longevity data that no human researcher could find alone 
• The problem with high-oxalate superfoods and how to get polyphenol benefits without the inflammatory downside 
• Why ovarian rejuvenation may be the highest-leverage Yamanaka application for women's longevity and brain health 
• How compounds like AKG, sodium butyrate, and forskolin may act as Yamanaka mimetics already available today 
• What the PRC2 polycomb clock reveals about programmatic aging and why it matters more than second-generation clocks 
• Why perimenopause does not have to be painful, and how functional medicine addresses it at the root 

Thank you to our sponsors!      

- Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. 

- Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body. 

- STEMREGEN | Go to stemregen.co/dave30 Use code DAVE30 for 30% OFF your next order. 

- Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Kara Fitzgerald, biological age reversal, epigenetics, DNA methylation, Yamanaka factors, polyphenols, EGCG, urolithin A, anti-aging, longevity, biohacking, functional medicine, supplements, mitochondria, epigenetic clock, cellular reprogramming, AKG, sodium butyrate, methylation, Steve Horvath, Vittoria Sebastiano, coleus, perimenopause, ovarian rejuvenation, pluripotent stem cells, PRC2, dark matter of nutrition, TRIM study, dihydroxyflavone, BDNF, Prenuvo, chemical cellular rejuvenation 

Resources:   

• Learn more about all of Dr. Fitzgerald’s work at: https://www.drkarafitzgerald.com/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps:  

0:00 – Trailer 

1:28 – Explaining Study 

3:45 – What Is The Diet 

6:49 – Age Reversal 

8:17 – Polyphenols vs. Supplements 

9:27 – Food vs. Supplement Dosing 

12:41 – Oxalate & Polyphenol Trade-offs 

18:41 – Yamanaka Factors Explained 

28:59 – Chemical Cocktails 

32:15 – PRC2 Clocks & Programmatic Aging 

40:28 – Seasonal Eating 

43:40 – Carnivore Diet: Short vs. Long Term 

45:31 – Inuit Diet 

46:39 – Flavones & Brain-Crossing Compounds 

48:50 – Why Only Men in the Study? 

51:05 – Women, Perimenopause & the Protocol 

53:20 – Fibroids & Gaps in Women's Research 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I spent fifteen years living with brain fog until I realized the problem wasn’t in my brain, but in a nervous system stuck in a survival mode that pulls energy away from focus and memory.

In this video, I explain why "trying harder" or popping supplements rarely works, and instead, I show you the 9,000-year-old ritual of heat and cold that pulls your body out of stress mode so clarity can actually return.

I break down the specific science of how I use infrared wavelengths and contrast therapy to retrain the brain to stay calm under pressure, moving beyond temporary fixes to target the root cause of mental fatigue.

Follow this protocol to finally complete your body's stress cycles, reset your biological default settings, and reclaim the lasting mental performance you’ve been missing.

00:00 – Introduction

01:02 – What Brain Fog Really Is

03:00 – Why Trying Harder Doesn't Work

04:51 – Supplements: Useful But Not Enough

06:14 – Why Sauna Works

07:32 – Infrared vs Traditional Sauna

08:02 – Sunlighten Sauna Overview

09:28 – Sauna Routine & Protocol

10:34 – Why Home Access Matters

11:41 – Post-Session Recovery

12:11 – Contrast Therapy

13:11 – How to Do Contrast Therapy

13:54 – Closing & Takeaways

Thank you to our sponsors!

-TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off.

-Neuronic | Go to www.neuronic.online Code DAVE for $100 off

-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey’s BEYOND Conference: https://beyondconference.com/

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week's stories: 

*Mud Playgrounds Double Kids' Bacterial Diversity and Spike Immune Genes 30% 

Finland swapped rubber playground surfaces for natural soil and mud across eight kindergartens — and after just one month, kids in dirt had twice the bacterial species diversity on their skin and a 30% increase in expression of ten immune-related genes. Dave breaks down why your immune system requires microbial exposure to calibrate properly, what the hygiene hypothesis actually means for adults, and the dead-simple weekly habit that primes your innate immunity the same way. Sources: 

• https://creators.yahoo.com/lifestyle/story/finland-replaced-artificial-playground-surfaces-with-natural-elements-like-mud-and-soil--and-the-results-surprised-even-researchers-184318556.html 
• https://www.sciencedaily.com/releases/2026/04/mud-playground-immunity.htm 

*Mixing Exercise Types Cuts All-Cause Mortality Up to 40% in 170,000-Person Study 

A 30-year BMJ Medicine cohort study found that people who rotate at least three different types of exercise weekly see 19 to 40% lower all-cause mortality — and that benefit held independent of total training volume. Dave explains why variety is a distinct biological signal, not a motivation trick, and why grinding more of the same thing is leaving longevity gains on the table. Sources: 

• https://bmjmedicine.bmj.com/content/early/2026/04/26/bmjmed-2025-001513 
• https://www.sciencedaily.com/releases/2026/04/260426012305.htm 
• https://www.theguardian.com/society/2026/apr/26/exercise-diversity-mortality 

*Facial Aging Rate from Photos Predicts Cancer Survival Better Than Blood Biomarkers 

AI analysis of serial facial photos in 1,000+ cancer patients found that computed facial aging rate independently predicted five-year survival with a hazard ratio of 2.1 — outperforming CRP and other standard blood markers. Dave covers what the AI is actually reading in those photos, why your face is a more accurate biological ledger than most labs your doctor orders, and the free monthly habit that turns this into an early warning system. Sources: 

• https://medicalxpress.com/news/2026-04-photos-reveal-faster-biological-aging.html 
• https://www.nature.com/articles/s43587-026-00123-4 

*Vibration Vest OsteoBoost Mimics Weight-Bearing Exercise to Rebuild Bone Density 

OsteoBoost raised $8M for a wearable vest delivering 30–50Hz vibrations to the spine and hips, triggering the same Wnt/β-catenin osteoblast pathway activated by mechanical loading — with early trials showing 2–5% bone mineral density gains in six months. Dave makes the case forwhy bone loss is one of the most underrated aging crises in the biohacking community, and who should be watching this category closely. Sources: 

• https://longevity.technology/news/osteoboost-raises-8m-to-scale-bone-wearable/ 
• https://www.crunchbase.com/organization/osteoboost 

*10+ States Advance Raw Milk Bills as H5N1 Hits 100+ Dairy Herds 

Legislation expanding raw milk access is moving in Arizona, Iowa, New Hampshire, and elsewhere — while the CDC flags H5N1 in over a hundred dairy herds with documented aerosol transmission concerns. Dave gives an honest read on where the freedom argument, the microbiome argument, and the current risk calculus actually stand in April 2026, and what more rigorous sourcing looks like right now. Sources: 

• https://www.yahoo.com/news/articles/us-med--raw-milk-legislation-120124275.html 
• https://www.cdc.gov/flu/avianflu/dairy.htm 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune priming, exercise science, biological age tracking, bone health, and real food risk assessment. Host Dave Asprey connects emerging clinical research, large-scale cohort data, and real-world protocols into actionable frameworks for extending healthspan and sharpening performance. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: mud playground immune system microbiome, soil bacteria skin diversity, hygiene hypothesis biohacking, exercise variety longevity, BMJ exercise mortality study, mixed training lifespan, facial aging rate cancer survival, biological age face AI, facial photo biomarker longevity, OsteoBoost vibration vest bone density, whole body vibration osteoporosis, bone mineral density wearable, raw milk H5N1 bird flu, raw milk legislation 2026, raw dairy safety biohacking, biohacking news, longevity research 2026, Dave Asprey weekly roundup  

Thank you to our sponsors!  

- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off 

- Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18. 

- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

Resources:   

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Intro 

00:20 – Dirt & Immune Training 

02:22 – Exercise Variety & Longevity 

04:16 – Facial Aging as a Health Biomarker 

05:47 – Bone Loss & Vibration Tech 

07:31 – Raw Milk & H5N1 Risk 

09:20 – The Wrapup 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your cells are starving for oxygen, and it's silently driving inflammation, fatigue, brain fog, and accelerated aging. This episode reveals how pairing Exercise with Oxygen Therapy (EWOT) and red light therapy supercharges your mitochondria, reverses pseudo-hypoxia, and unlocks a level of human performance most people never experience. 

-Save up to $500 (through 5/17) at One Thousand Roads: https://www.onethousandroads.com/Dave 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Brad Pitzele, founder of One Thousand Roads and one of the most credible voices in oxygen therapy and red light therapy. Brad didn't come to this work through a lab. He came to it through desperation. After battling autoimmune arthritis, melanoma, and Lyme disease, he rebuilt his health from the ground up starting in 2016 by targeting mitochondrial function when he could barely walk. Eighteen months later, he founded One Thousand Roads to bring these tools to everyone still searching for a way out. 

Together, Dave and Brad break down the unified theory behind oxygen therapy and red light therapy, two of the most powerful and underrated tools in biohacking. They go deep on pseudo-hypoxia, the condition where your blood oxygen looks fine but your tissues are starving, and explain why this hidden dysfunction sits at the root of chronic fatigue, inflammaging, fibromyalgia, long COVID, and poor sleep optimization. They also cover the endothelium, nitric oxide, arterial stiffness, pulse wave velocity, and why your morning biology might be the most honest readout of your metabolic health. 

This is essential listening for anyone serious about longevity, anti-aging, brain optimization, functional medicine, mitochondria, metabolism, and smarter not harder approaches to human performance. 

You'll Learn: 

• What EWOT is and why elite athletes and biohackers use it to flood tissues with oxygen in 15 minutes 
• How pseudo-hypoxia silently blocks energy production and drives chronic illness 
• Why stacking red light therapy immediately after EWOT multiplies results for both 
• How mitochondrial dysfunction connects to endothelial aging, microcirculation failure, and systemic inflammation 
• The role of nitric oxide in arterial flexibility, vasodilation, and real anti-aging markers like pulse wave velocity 
• Why your lungs are your biggest detox organ and how oxygen therapy supports that process 
• How ketosis, fasting, and cellular energy interact with EWOT and red light for maximum benefit 
• What LED lighting is doing to your mitochondria every single day and how to fix it 
• How to build an affordable at-home EWOT setup for around $2,500 

Thank you to our sponsors!      

- Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. 

- ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. 

- Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today 

- Cowboy Colostrum | Get your gut right by going to cowboycolostrum.com/asprey for 25% off of your entire order. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Brad Pitzele, One Thousand Roads, EWOT, exercise with oxygen therapy, oxygen therapy, red light therapy, infrared light therapy, pseudo-hypoxia, mitochondria, mitochondrial dysfunction, biohacking, longevity, anti-aging, human performance, inflammation, inflammaging, microcirculation, endothelium, glycocalyx, nitric oxide, arterial stiffness, pulse wave velocity, capillary health, cellular energy, ATP production, aerobic respiration, anaerobic respiration, VO2 max, chronic fatigue, fibromyalgia, brain fog, autoimmune disease, Lyme disease, Bartonella, long COVID, mast cell activation, detoxification, lung health, sleep optimization, metabolism, functional medicine, ketosis, fasting, red light bulbs, LED lighting, light therapy, wavelengths, near infrared, oxygen concentrator 

Resources:   

• Save up to $500 (through 5/17) at One Thousand Roads: https://www.onethousandroads.com/Dave 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Trailer 

01:41 – Welcome Brad 

03:01 – What Is EWOT? 

05:27 – EWOT vs. Hospital Oxygen 

06:51 – Longevity & Inflammaging 

11:42 – Pseudo-Hypoxia 

12:57 – Red Light Therapy 

15:47 – EWOT + Red Light Unified Theory 

18:00 – Nutrition, Ketosis & VO2 Max 

19:56 – Stacking EWOT & Red Light 

22:01 – Equipment & Cost 

26:00 – Junk Light & LED Problems 

30:51 – Sunlight & Nitric Oxide 

32:36 – Endothelium & Microcirculation 

38:49 – Arterial Stiffness & Pulse Wave Velocity 

43:29 – Lungs as a Detox Organ 

45:04 – EWOT for Long COVID 

47:58 – Wrap-Up 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If you're a woman in your 30s, 40s, or 50s feeling like your body is betraying you, this episode reveals the hormonal, gut, and environmental triggers behind perimenopause that most doctors never address, and exactly what you can do about it. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Cynthia Thurlow, a nurse practitioner, CEO and founder of the Everyday Wellness Project, and a globally recognized expert in intermittent fasting and women's hormonal health. Her TEDx talk on intermittent fasting has surpassed 10 million views, and she brings over 20 years of functional medicine clinical experience to one of the most underserved conversations in longevity and human performance. 

Together, they tear apart the outdated medical narrative around perimenopause and menopause, exposing how a lack of knowledge, not biology, is destroying relationships, careers, and quality of life for millions of women. Dave and Cynthia dig into the gut microbiome's role in every symptom women experience in midlife, the mold toxin that is 10,000 times more potent than human estrogen and directly linked to hormonal chaos, and why biohacking your hormones as early as 35 could be the most important longevity move a woman makes. They also cover why statins are wrecking women's metabolism, how trauma accelerates ovarian aging and mitochondrial decline, the surprising connection between histamine reactions and hot flashes, and why GLP-1 micro-dosing alongside hormone replacement therapy is a game-changer for body composition and anti-aging. 

This episode is essential for listening for anyone serious about biohacking, sleep optimization, functional medicine, longevity, brain optimization, supplements, metabolism, human performance, and smarter not harder approaches to women's health. 

You'll Learn: 

• Why perimenopause actually begins around age 35 and what to do about it before symptoms hit 
• How a mold-derived xenoestrogen found in conventional beef disrupts hormones at 10,000 times the potency of human estrogen 
• The gut microbiome changes that drive hot flashes, brain fog, weight gain, and mood disorders in perimenopause 
• Why oral micronized progesterone beats topical for sleep optimization and hormonal stability 
• How testosterone drives executive function, motivation, and brain optimization in women 
• The lab tests every woman in perimenopause should run, including fasting insulin, ApoB, ferritin, and a full thyroid panel 
• Why adverse childhood events and unresolved trauma age the ovaries and tank mitochondria 
• How mold toxicity and Lyme disease create a hormonal perfect storm that no amount of supplements will fix 
• The real reason 70 percent of divorces are initiated by women, and what hormones have to do with it 

Thank you to our sponsors!      

- Neuronic | Go to www.neuronic.online Code DAVE for $100 off 

- Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave 

- Joymode | Go to tryjoymode.com/DAVE Or enter DAVE at checkout for 20% off. 

- Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Cynthia Thurlow, The Menopause Gut, perimenopause, menopause, hormones, hormone replacement therapy, HRT, bioidentical hormones, progesterone, estrogen, testosterone, thyroid health, gut microbiome, women's health, functional medicine, biohacking, longevity, anti-aging, human performance, mitochondria, sleep optimization, metabolism, supplements, mold toxicity, zearalenone, xenoestrogen, hot flashes, brain fog, body composition, GLP-1, intermittent fasting, trauma, cortisol, adrenal health, leaky gut, histamine intolerance, mast cell activation, insulin resistance, fasting insulin, ApoB, ferritin, statins, ovarian aging, Dave Asprey, smarter not harder 

Resources:   

• Learn More From Cynthia And Get Her New Book The Menopause Gut at: https://www.cynthiathurlow.com/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Intro 

04:35 – Root Causes of Perimenopause 

07:50 – When Perimenopause Starts 

09:47 – Progesterone: When & How 

12:16 – Testosterone for Women 

14:14 – Thyroid & Energy 

18:41 – FDA's HRT Policy Change 

20:15 – Hormones & Divorce

21:53 – GLP-1s & Body Composition 

27:17 – Key Lab Tests 

31:13 – AI & Budget Labs 

39:44 – Gut Microbiome & Menopause 

42:57 – Histamine, Mast Cells & Hot Flashes 

47:55 – Toxic Mold & Xenoestrogens 

50:31 – Dairy, Raw Milk & Leaky Gut 

59:27 – Healing Trauma 

1:03:00 – Book Recommendations 

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