STOP intermittent fasting if you think it automatically keeps you young. In this episode, you’ll learn why short-term fasting results can mislead long-term aging outcomes, and how duration, frequency, refeeding, and protein intake determine whether fasting supports longevity or quietly accelerates decline.  

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Valter Longo, one of the world’s leading longevity researchers with over 30 years of experience studying aging, nutrition, and disease prevention. Dr. Longo is the Director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology and the Director of the Longevity and Cancer Program at IFOM, the Italian Foundation for Cancer Research Institute of Molecular Oncology in Milan. He is the author of the bestselling book The Longevity Diet and was named one of TIME Magazine’s 50 most influential people in health care for his research on fasting-mimicking diets. 

Together, Dave Asprey and Dr. Longo explain why many people focus too heavily on short-term effects and extrapolate them incorrectly across a lifetime. They break down how intermittent fasting differs biologically from multi-day fasting, why five-day fasting cycles trigger deeper cellular changes, and how insulin, IGF-1, mTOR, and growth hormone shape aging, regeneration, and disease risk over time. 

The conversation covers protein and amino acid intake, muscle preservation, frailty risk, and the tradeoffs between strength, function, and longevity. They explore ketosis, fasting-mimicking diets, stem cell activation, mitochondrial function, neuroplasticity, and why equilibrium and cycling matter more than constant restriction. Dave and Valter also discuss supplements, nootropics, creatine, carnivore-style eating, metabolism, sleep optimization, and how AI may eventually personalize fasting and nutrition based on individual biology rather than population averages. 

You’ll learn: 

• Why short-term fasting benefits do not predict long-term longevity 

• How fasting duration changes gene expression and cellular regeneration 

• The difference between intermittent fasting and multi-day fasting 

• How protein and amino acids influence mTOR, IGF-1, and aging 

• Why muscle, strength, and longevity must be balanced, not maximized 

• When ketosis overlaps with fasting and when it does not 

• Why supplements can disrupt biological equilibrium 

• How AI could support future personalization in fasting and nutrition 

Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Thank you to our sponsors! 

• BEYOND Conference 2026 | Register now with code DAVE300 for $300 off at https://beyondconference.com/

• AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.

• Caldera + Lab | A small habit with big results. Go to https://CalderaLab.com/DAVE and use code DAVE for 20% off your first order.

• Timeline | Go to https://timeline.com/Dave for 20% off.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: intermittent fasting longevity, fasting mimicking diet, fasting and aging science, biohacking fasting podcast, longevity fasting research, protein restriction longevity, amino acids aging, mTOR IGF-1 longevity, mitochondria aging science, neuroplasticity fasting, ketosis fasting science, metabolism longevity podcast, anti-aging fasting, functional medicine longevity, supplements fasting debate, nootropics brain optimization, muscle frailty aging, sleep optimization longevity, AI personalized nutrition, carnivore diet longevity debate, Dave Asprey fasting, Valter Longo longevity, longevity diet podcast, human performance aging 

Resources:   

• Learn More About Valter’s Work At: https://valterlongo.com/ 

• Join My Fasting Challenge: https://daveasprey.com/#14-day 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Upgrade Collective: https://www.ourupgradecollective.com   

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 Introduction & Aging Fundamentals 

4:36 Fasting Mimicking Diet Overview 

7:03 Insulin, IGF-1 & mTOR 

11:03 Body Fat & Fasting Frequency 

17:08 The Protein Debate 

20:22 Blue Zones & Centenarian Evidence 

23:10 Amino Acids & Leucine 

30:30 Growth Hormone & Longevity 

34:01 Five-Day Fasting Benefits 

40:55 Personalization & AI 

42:29 Plant-Based Concerns 

49:07 Fasting Risks & Limits 

53:05 Supplements & Equilibrium 

1:03:05 Ranking Longevity Pathways 

1:05:05 Modern Environmental Challenges 

1:16:21 Final Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people think aging starts with wrinkles, gray hair, or memory loss. It doesn’t.

Aging starts when your legs begin to weaken, long before you notice it.

In this video, you’ll learn why your leg muscles age faster than the rest of your body, how damaged mitochondria silently drain your strength, and why traditional solutions like exercise and protein stop working after 40.

You’ll also discover the one cellular process that controls muscle aging, why it shuts down with age, and how targeted support can turn it back on.

Chapters

00:00 – Why weakness is the first real sign of aging

01:28 - Mitophagy and why it shuts down with age

02:30 - Why exercise and protein won't help

03:55 - The real problem doctors and trainers miss

04:28 - The compound that turns mitophagy back on

05:22 - Why most people can’t produce it enough naturally

05:40 - The gut bacteria problem explained

06:09 - How researchers solved the bottleneck

06:56 - Human studies and muscle strength

Thank you to our sponsors!

-IGNITON | Head over to Igniton.com and use code DAVE for an exclusive 15% off your first order.

-AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers.

Resources:  

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

• Danger Coffee: https://dangercoffee.com/discount/dave15  

• My Daily Supplements: SuppGrade Labs (15% Off)  

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)  

• Dave Asprey’s BEYOND Conference: https://beyondconference.com  

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com  

• Upgrade Labs: https://upgradelabs.com  

• 40 Years of Zen: https://40yearsofzen.com 

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: 

Instagram: https://www.instagram.com/TheHumanUpgradePodcast/ 

Facebook: https://m.facebook.com/Thehumanupgrade/

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In the late 1990s, a strange carbon molecule quietly delivered the single longest lifespan extension ever recorded in mammals. The rats lived about 90% longer, and almost no one was paying attention. This episode breaks down what that molecule is, why it works, and how it may upgrade mitochondria, sleep, and human performance when used correctly. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Chris Burres, founder and chief scientist of MyVitalC and the original long-term manufacturer of carbon 60. Chris has produced this Nobel Prize–winning molecule since the early 1990s, supplying research institutions around the world years before it ever entered the biohacking space. He explains how carbon 60 behaves differently from traditional antioxidants, why stability and concentration used to be major problems, and how modern manufacturing finally made real-world use possible. Chris is also a published author, longevity summit host, patent holder, and longtime science communicator who brings rare clarity and humor to complex biology. 

Dave and Chris explore how carbon 60 interacts with mitochondria, oxidative stress, metabolism, and electrical signaling in the body, and where it fits alongside ketosis, nootropics, supplements, and functional medicine strategies. They also unpack why improving mitochondrial function often shows up first as better energy and sleep optimization, and how that foundation supports longevity, brain optimization, and Smarter Not Harder performance. Along the way, Dave shares his own early experience with C60, how he uses it today, and why it now shows up even in his Danger Coffee stack. 

You’ll Learn: 

• Why carbon 60 produced the longest longevity result ever recorded in mammal studies 

• How mitochondrial efficiency shapes energy, sleep, and human performance 

• What makes C60 a selective antioxidant instead of a blunt one 

• Why purity, concentration, and stability determine whether a supplement works 

• How carbon 60 fits into biohacking stacks built around ketosis and metabolism 

• What users report first, from focus and resilience to deeper sleep 

• Why mitochondrial health underpins long-term anti-aging strategies 

• How to think about supplements through a Smarter Not Harder lens 

Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Affiliates: 

• Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. 
• ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: carbon 60 podcast, C60 longevity science, biohacking mitochondria, mitochondrial optimization podcast, anti-aging supplements science, human performance longevity, selective antioxidant mitochondria, sleep optimization biohacking, brain optimization supplements, nootropics longevity stack, ketosis metabolism longevity, functional medicine mitochondria, oxidative stress longevity, carbon 60 supplement science, MyVitalC podcast, Chris Burres interview, Dave Asprey biohacking, Danger Coffee stack, Smarter Not Harder longevity, Nobel Prize molecule longevity, mitochondrial health podcast 

Resources:   

• Get a 30% discount on your next purchase of ESS60 at: https://www.myvitalc.com/pages/humanupgradeod?ref=humanupgrade 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Upgrade Collective: https://www.ourupgradecollective.com   

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 – Introduction & C60 Discovery 

4:04 – The Molecule & Nobel Prize 

8:27 – Quantum Properties & Superconductivity 

11:16 – Rat Longevity Study Results 

14:33 – Selective Antioxidant Properties 

15:51 – User Experience & Timeline 

18:15 – Biological Age Testing 

21:33 – Why Oil & Product Development 

23:32 – Mechanism of Action 

28:13 – Biohacker Discovery Story 

30:03 – FDA & Supplement Regulation 

33:50 – Migraines & Clinical Observations 

37:53 – Athletic Performance 

40:43 – Stacking & Contraindications 

45:57 – Skincare Product 

50:43 – Who Benefits Most 

1:00:37 – Mitochondria & Consciousness 

1:02:03 – Where to Buy & Closing 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Aging is not something Zoltan Istvan plans to accept quietly. He wants to treat death like a technical bug, rewrite the rules of biology, and turn California into the global test bed for radical human upgrades. From cyborg implants to AI driven longevity science, this episode explores what happens when a candidate for governor openly argues that humans should evolve beyond their biological limits and take control of how long and how well they live. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Zoltan Istvan, a leading transhumanist, futurist, longevity advocate, and current candidate for Governor of California. Zoltan has spoken at Parliaments and Senates around the world, appeared on The Joe Rogan Experience, consulted for the US Armed Forces, and served as a correspondent for The New York Times. He has addressed the World Bank, the World Economic Forum, and the UK Parliament, and his work has influenced world leaders while shaping global conversations on AI, liberty, and human enhancement. Trained in philosophy and ethics at Columbia University and the University of Oxford, Zoltan brings rare depth to the intersection of technology, biology, and governance. 

Together, they explore whether aging should be classified as a disease, why regulation is slowing breakthroughs in longevity science, and how California could become ground zero for anti-aging innovation. They debate biology versus machine integration, open source technology versus centralized control, and what morphological freedom really means when enhancement technologies move faster than policy. The discussion spans mitochondria, neuroplasticity, brain optimization, stem cells, organ printing, implants, and the ethical risks of surveillance, algorithmic persuasion, and unchecked AI. 

This episode is essential listening for anyone serious about biohacking, hacking human performance, longevity, metabolism, functional medicine, anti-aging strategies, supplements, nootropics, ketosis, fasting, carnivore frameworks, sleep optimization, and living Smarter Not Harder in a world increasingly shaped by AI and technology, ideally with a cup of Danger Coffee in hand. 

You’ll Learn: 

• Why aging may be a solvable problem rather than an unavoidable fate 

• How politics and regulation influence access to longevity and anti-aging therapies 

• The real tradeoffs between biological upgrades and machine integration 

• Why mitochondria, neuroplasticity, and brain optimization matter in human enhancement 

• How AI and surveillance technology threaten cognitive and biological autonomy 

• What morphological freedom means for the future of medicine and personal choice 

• Why open source approaches to biohacking could protect liberty and innovation 

• How Smarter Not Harder strategies support longevity in a rapidly evolving world 

Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Thank you to our sponsors! 

• BEYOND Conference 2026 | Register now with code DAVE300 for $300 off at https://beyondconference.com/ 
• MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. 
• GOT MOLD? | See what’s in your air and save 10% with code DAVE10 at http://gotmold.com/shop 
• EMR-Tek | Get 40% off EMF protection with code DAVE at https://www.emr-tek.com/DAVE 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: transhumanism podcast, human cyborg future, biohacking transhumanism, longevity technology podcast, anti-aging technology, human enhancement podcast, cyborg implants future, AI human evolution, aging as a disease, radical longevity science, human performance future, brain optimization technology, mitochondria longevity science, neuroplasticity enhancement, biohacking longevity politics, California longevity policy, morphological freedom body, human augmentation debate, AI risk humanity, surveillance technology health, open source biohacking, stem cell longevity future, organ printing technology, functional medicine future, metabolism longevity science, ketosis fasting longevity, nootropics brain optimization, supplements longevity science, carnivore diet longevity, sleep optimization performance, Dave Asprey transhumanism, Zoltan Istvan podcast, futurist longevity interview, governor cyborg policy, technology immortality debate 

Resources:   

• Learn More About Zoltan’s Work At: https://zoltanistvan.com/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Upgrade Collective: https://www.ourupgradecollective.com   

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 – Introduction 

3:51 – What Is Transhumanism 

8:15 – Biology vs Technology 

12:53 – Government & Regulation 

20:43 – Running for Governor 

26:13 – Social Media & Kids 

30:18 – Life Extension & Upgrades 

38:59 – Defining Humanity 

46:12 – Consciousness & Uploading 

49:27 – Religion & Society 

58:02 – AI Existential Risk 

1:02:57 – Space & Future Enhancement 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your butt is not about aesthetics. It is a longevity organ that directly impacts metabolism, brain optimization, resilience, and how long you stay strong as you age. In this episode, you’ll learn why strength training and protein intake matter more than body fat percentage, how mitochondria drive human performance and recovery, and why building muscle protects your brain, stabilizes mood, and supports long-term longevity. This conversation reframes biohacking, anti-aging, and health from weight loss to muscle span, the length of time you live with strong, functional skeletal muscle. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Gabrielle Lyon, an accomplished physician and New York Times bestselling author of Forever Strong: A New, Science-Based Strategy for Aging Well, and author of the upcoming The Forever Strong Playbook, releasing January 27, 2026. Dr. Lyon pioneered the Muscle-Centric Medicine® approach, which places muscle at the center of disease prevention, metabolic health, and true vitality. She has trained elite athletes, military operatives, and public figures, while also living this philosophy at home as a mother of two with her husband, a retired Navy SEAL. 

Together, they break down why intermuscular fat may matter more than body fat percentage, how skeletal muscle drives insulin sensitivity and lowers inflammation, and why becoming physically stronger improves brain function and neuroplasticity. They explore protein needs across the lifespan, fasting, ketosis, carnivore-style nutrition, supplements, sleep optimization, and the real tradeoffs of GLP-1 drugs, including the risk of accelerated muscle loss if strength and protein are neglected. The conversation also covers mindset, hormesis, and why physical resilience creates emotional regulation and clearer decision-making in a world increasingly shaped by AI and convenience. 

This episode is essential listening for anyone serious about biohacking, hacking human performance, longevity, mitochondria, neuroplasticity, nootropics, metabolism, functional medicine, anti-aging strategies, supplements, and living Smarter Not Harder, ideally with a cup of Danger Coffee in hand. 

You’ll Learn: 

• Why your glutes and skeletal muscle are critical drivers of longevity and brain health 

• Why intermuscular fat can matter more than body fat percentage for metabolic dysfunction 

• How strength training improves neuroplasticity, cognition, and emotional resilience 

• Why protein needs increase with age and why outdated limits can hold you back 

• What GLP-1 drugs get right, where they fail, and how to protect muscle span 

• Why progressive stimulus beats lifting heavy for long-term strength and injury prevention 

• How sleep optimization and recovery support mitochondria and human performance 

• How building muscle creates clarity, resilience, and better decision-making 

Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Thank you to our sponsors! 

• Quantum Upgrade | Support your brain, energy, focus, sleep, and recovery with Quantum Upgrade, a 24/7 streaming quantum energy service designed to work continuously in the background. Try it free for 15 days with no credit card required: https://quantumupgrade.io/DAVE 
• Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave 
• BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. 
• KillSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com and use code DAVE for 20% off. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: muscle longevity organ, glutes brain health, strength training longevity podcast, muscle span aging, intermuscular fat metabolism, IMAT insulin resistance, skeletal muscle brain function, neuroplasticity strength training, protein intake aging, high protein diet longevity, metabolism muscle health, mitochondria muscle brain, muscle centric medicine podcast, gabrielle lyon podcast, forever strong playbook, women strength training longevity, GLP-1 muscle loss, sarcopenia aging prevention, resistance training brain health, sleep optimization muscle recovery, fasting ketosis muscle health, carnivore diet muscle metabolism, functional medicine muscle health, biohacking strength longevity, human performance muscle, anti-aging strength training, supplements muscle recovery, progressive stimulus training, blood flow restriction training, muscle resilience mindset 

Resources:   

• Get Gabrielle’s NEW book The Forever Strong Playbook: https://drgabriellelyon.com/playbook/

• Gabrielle’s Website: https://drgabriellelyon.com/ 

• Follow Gabrielle’s Instagram: https://www.instagram.com/drgabriellelyon/ 

• Gabrielles Youtube: https://www.youtube.com/@DrGabrielleLyon 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Upgrade Collective: https://www.ourupgradecollective.com   

• Upgrade Labs: https://upgradelabs.com    

Timestamps: 

0:00 – Introduction 

1:01 – The Playbook vs Workbook 

3:47 – Protein & Metabolic Health 

6:21 – Mindset & Negativity 

7:20 – Histamines & Hot Flashes 

10:49 – Women & Strength Training 

13:40 – Connective Tissue & EDS 

16:15 – Muscle Span & Aging 

19:41 – Training for Kids 

21:55 – Pain Cave & Discomfort 

25:25 – Emotional Regulation 

29:46 – Resilience & Dating 

32:11 – Building Friction & Discernment 

35:47 – Self-Denial vs Awareness 

41:03 – Mitochondria & Energy 

42:46 – Bigger Booty, Bigger Brain 

44:52 – Body Fat vs IMAT 

49:01 – Measuring Muscle Health 

52:08 – GLP-1s & Muscle Loss 

56:12 – Protein Absorption Myths 

59:30 – mTOR & Protein 

1:01:29 – Closing Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your gut already has its own version of Ozempic, and it’s been doing this job long before injections existed.

In this video, I explain how appetite is actually regulated, why synthetic shortcuts often create new problems over time, and what has quietly shut down the body’s natural satiety signals for so many people.

Once you understand the pathway drugs are trying to imitate, the question stops being “how do I eat less?” and becomes “why was my body blocked from doing this in the first place?”

This is about restoring a system, not overpowering it.

Chapters

0:00 - Introduction: Your Body’s Natural Ozempic

0:53 - Hunger Is a Hormone Problem

5:08 - How to Fix Your Hormone Signals

7:28 - Why Ozempic Often Backfires

10:54 - The Resistant Starch Solution

15:03 - How to Use Resistant Starch

18:12 - Rebuilding Your Gut Environment

19:31 - Lifestyle Support for Gut Health

Resources:  

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. 

• Danger Coffee: https://dangercoffee.com/discount/dave15  

• My Daily Supplements: SuppGrade Labs (15% Off)  

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)  

• Dave Asprey’s BEYOND Conference: https://beyondconference.com  

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com  

• Upgrade Labs: https://upgradelabs.com  

• 40 Years of Zen: https://40yearsofzen.com 

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

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This episode covers: 

• Real Food Reset in U.S. Dietary Policy 

The new Dietary Guidelines for Americans 2025–2030 put real food back at the center of U.S. nutrition policy and take a direct swing at ultra processed foods, added sugar, and sugary drinks. Dave breaks down why this matters beyond personal dieting: these guidelines influence school meals, SNAP and WIC, federal feeding programs, and they shape what eventually shows up on labels and in public institutions. He also shares how biohackers can use this shift as leverage to push for better food environments in schools, workplaces, and hospitals. 

-Source: https://www.usda.gov/about-usda/news/press-releases/2026/01/07/kennedy-rollins-unveil-historic-reset-us-nutrition-policy-put-real-food-back-center-health 

• Drug Combo Extends Lifespan of Frail Old Mice by 73% 

A new aging study found that combining oxytocin with a compound called A5i extended the remaining lifespan of frail elderly male mice by 73%, while also improving function and tissue health. Dave explains why this is a big signal for the future of longevity medicine: stacking targeted interventions can outperform single compounds, especially when you start late in life. He also explains what to do with the idea right now: stop building random “everything stacks” and start thinking in phases, tracking outcomes, and waiting for real human combo data. 

-Source: https://www.futura-sciences.com/en/study-finds-drug-combo-could-slow-aging-and-increase-lifespan-by-73_23229/  

• ChatGPT Health Turns Your Data Into a Health OS 

OpenAI launched ChatGPT Health, a dedicated health experience that lets you securely connect medical records and wellness apps like Apple Health and MyFitnessPal, so you can summarize visits, interpret labs, and prepare better questions for your doctor. Dave explains why this is a turning point for quantified self and protocol building: it reduces the friction of pulling data from five different places, and it makes pattern-finding accessible to nontechnical people. He also shares how to use it like a pro: clean inputs, smarter questions, and better doctor conversations. 

-Source: https://openai.com/index/introducing-chatgpt-health/ 

• Whole Milk Is Back in Schools 

The Whole Milk for Healthy Kids Act restores whole and reduced-fat milk options in schools, aligning school nutrition rules with the updated dietary guidelines that no longer treat full-fat dairy like a default villain. Dave breaks down why this matters for child healthspan: satiety and nutrient density drive behavior, learning, and metabolic stability. He also explains why this is a real-world policy experiment worth watching across school districts, and how it can open the door for bigger institutional upgrades like better protein and fewer ultra processed items. 

-Source: https://www.usda.gov/about-usda/news/press-releases/2026/01/14/whole-milk-back-president-trump-signs-whole-milk-healthy-kids-act 

• Tirzepatide Trial Targets Biological Age With Aging Clocks 

A registered clinical trial titled Tirzepatide to Slow Biological Aging is using multiple DNA methylation aging clocks as primary endpoints, along with functional metrics like grip strength and a 6-minute walk test. Dave explains why this is a big maturity step for longevity science: instead of assuming metabolic improvement equals slower aging, this study is measuring biological age directly, across multiple clocks, with performance outcomes. He also shares the practical lesson for biohackers: stop relying on one favorite metric and start thinking in panels, function, and durability of results. 

-Source: https://clinicaltrials.gov/study/NCT07220473 

All source links provided for direct access to the original research and reporting. 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want practical strategies rooted in cutting-edge science. Host Dave Asprey translates emerging research into actionable upgrades for your biology, from metabolism and food policy to AI-driven tracking, institutional nutrition, and biological aging measurement. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: Dietary Guidelines for Americans 2025-2030, real food policy reset, ultra processed foods policy, added sugar limits, sugary drinks guidelines, school lunch nutrition policy, SNAP WIC nutrition impact, USDA HHS dietary guidelines 2026, whole food protein guidelines, full fat dairy guidelines, oxytocin aging study, A5i lifespan extension, frail elderly mice lifespan 73 percent, combination longevity therapies, aging intervention synergy, staged longevity protocols, functional aging biomarkers, ChatGPT Health launch, OpenAI health records AI, Apple Health ChatGPT integration, MyFitnessPal ChatGPT integration, AI lab interpretation, AI doctor visit summary, quantified self AI tools, Whole Milk for Healthy Kids Act, whole milk back in schools, school dairy policy change, child satiety nutrition, school meal regulations USDA, tirzepatide biological aging trial, GLP-1 GIP longevity, epigenetic aging clocks trial, DNAmAge PhenoAge GrimAge DunedinPACE, grip strength aging endpoint, 6 minute walk aging endpoint, biological age measurement, longevity clinical trial endpoints, biohacking news update, longevity policy shifts, metabolic health upgrades  

Thank you to our sponsors!  

-BEYOND Conference 2026 | Register now at https://beyondconference.com/ 

-EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off 

Resources:  

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome 

• Danger Coffee: https://dangercoffee.com/discount/dave15  

• My Daily Supplements: SuppGrade Labs (15% Off)  

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)  

• Dave Asprey’s BEYOND Conference: https://beyondconference.com  

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com  

• Upgrade Labs: https://upgradelabs.com  

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps:

0:00 - Intro

0:19 - New Dietary Guidelines

2:09 - Longevity Research Breakthrough

3:41 - ChatGPT Health Launch

5:10 - Whole Milk Returns to Schools

6:29 - GLP-1 Aging Trial

7:34 - Weekly Upgrade Protocol

9:09 - Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain’s immune cells produce and use energy. This episode shows how mitochondrial health inside microglia influences cognition, emotion, and long-term brain resilience, and how everyday inputs quietly push those systems toward damage or repair. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey is joined by Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, metabolism, and brain health. A Fellow of the American College of Nutrition and member of the Editorial Board of the Journal of Alzheimer’s Disease, Dr. Perlmutter brings decades of clinical and research experience to this conversation on how inflammation and mitochondrial function shape the brain across the lifespan. 

Together, they explore how microglial cells shift their behavior based on metabolic conditions, and how those shifts influence neurodegeneration, emotional regulation, impulse control, and cognitive performance. The discussion covers real-world inputs that shape these systems, including sleep optimization, fasting, ketosis, glucose regulation, gut signaling, environmental toxins, and tools referenced in the episode such as red and infrared light, 40 Hz light and sound, hyperbaric oxygen, lithium, nicotine, supplements, nootropics, GLP-1 agonists, and dietary approaches like carnivore and ketosis. The conversation connects brain biology to lived experience, showing how metabolism influences behavior, decision making, and long-term human performance through a Smarter Not Harder lens. 

You’ll Learn: 

• How microglia shift between supportive and destructive states and why metabolism drives that change 

• How mitochondrial function inside immune cells influences inflammation and brain resilience 

• How inflammation affects the prefrontal cortex, impulse control, and reward-driven behavior 

• What the episode says about GLP-1 agonists and behavior changes like reduced cravings and gambling 

• How gut-derived signaling and short-chain fatty acid balance (butyrate vs propionate) relates to brain function 

• How tools like red and infrared light, hyperbaric oxygen, and 40 Hz light and sound connect to microglia 

• The lifestyle levers discussed in the episode: sleep optimization, fasting, ketosis, glucose control, and toxin reduction 

• The compounds mentioned, including lithium, nicotine, urolithin A, CoQ10, rosmarinic acid, and dihydromyricetin 

Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Thank you to our sponsors! 

• KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. 
• BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. 
• Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide 
• Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE 

 Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: microglia brain health, brain immune system mitochondria, neuroinflammation podcast, mitochondrial dysfunction brain, david perlmutter podcast, dr david perlmutterneurologist, grain brain author podcast, alzheimers brain metabolism, parkinsons microglia, autism brain inflammation, gut brain immune signaling, short chain fatty acids brain, butyrate propionate brain, glp-1 brain behavior, glp-1 addiction research, red light therapy brain, infrared light mitochondria brain, 40 hz light sound brain, hyperbaric oxygen brain health, lithium microglia brain 

Resources:   

•  Learn More About Dr. Perlmutter at: https://drperlmutter.com/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Upgrade Collective: https://www.ourupgradecollective.com   

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 - Introduction 

1:45 - Autism Spectrum 

4:38 - Alzheimer’s & Beta Amyloid 

7:02 - Brain Immune Cells 

8:06 - GLP-1 & Parkinson’s 

10:44 - M1 vs M2 Microglia 

13:08 - Pharmaceutical Microdosing 

15:51 - Gene Therapy 

19:09 - Mold & Toxins 

21:58 - Environmental Pollution 

26:05 - MPTP Discovery 

29:07 - Healing Interventions 

31:39 - Light & Sound Therapy 

36:35 - Mitochondrial Function 

44:57 - Inflammation & Prefrontal Cortex 

48:00 - GLP-1 Global Impact 

52:11 - Mitochondrial Community 

56:05 - Consciousness & The Field 

1:00:00 - Psychedelics 

1:01:59 - Love & Judgment 

1:06:35 - Death & Knowing 

1:09:06 - Heart-Brain Connection 

1:11:06 - Closing Thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your body does not fail all at once. Aging starts when cells quietly shift into survival mode and never come back out. In this episode, you go inside the thinking of a true medical outlier to understand how stress, travel, toxins, and metabolic overload reprogram cells, shut down energy, and accelerate aging, and how restoring mitochondrial function can reverse that trajectory from the inside out. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Theodore Achacoso and Boomer Anderson, leaders in Health Optimization Medicine and Practice. Dr. Achacoso is a physician-scientist and the founding pioneer of Health Optimization Medicine, known for his work on cellular networks, metabolomics, and mitochondrial function. Boomer Anderson is the CEO of Smarter Not Harder and Troscriptions, where he focuses on translating complex biology into practical tools for human performance and longevity.  

Together, they unpack how cells respond to perceived threats through the Cell Danger Response, why mitochondria control energy, inflammation, and repair, and why chasing disease labels misses the real drivers of aging. The discussion covers methylene blue as an electron recycler, why LDL cholesterol plays a role in detoxification and immune signaling, how fasting and ketosis shift metabolism between repair and growth, and why sleep optimization, circadian rhythm, and light exposure matter even more when you travel. They also explore neuroplasticity, consciousness, nootropics, supplements, and why health optimization works best when you restore balance instead of forcing outcomes. 

You’ll Learn: 

• What the Cell Danger Response is and how it reshapes aging and performance 

• How mitochondria sense stress before symptoms appear 

• Why cellular energy controls resilience, sleep, and longevity 

• How methylene blue supports mitochondrial electron flow 

• Why fasting and ketosis shift metabolism between repair and growth 

• How travel, light, and circadian disruption affect aging 

• Why very low LDL can impair detoxification and immune signaling 

• Why real anti-aging starts at the cellular level, not with disease labels 

Thank you to our sponsors! 

• AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. 
• Screenfit | Get your at-home eye training program for 40% off using code DAVE at www.screenfit.com/dave. 
• Puori | Use code DAVE at puori.com/DAVE to get 32% off your Puori Fish Oil when you start a subscription. You save more than $18. 
• fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: cell danger response podcast, mitochondria aging, mitochondrial dysfunction aging, health optimization medicine, dr ted achacoso, boomer anderson, troscriptions, troscriptions methylene blue, methylene blue mitochondria, methylene blue biohacking, cellular aging podcast, anti aging mitochondria, metabolic stress aging, fasting ketosis metabolism, mitochondrial energy production, neuroplasticity mitochondria, sleep optimization aging, functional medicine mitochondria, smarter not harder biohacking, dave asprey mitochondria 

Resources:   

•  Get A Discount On All Troscription Products with code ‘dave’ at: https://troscriptions.com/ 

•  Learn More About Methylene Blue From My Full Masterclass Covering The Topic: https://daveasprey.com/mb/ 

• Discover More About The ‘Health Optimization Medicine and Practice’ From Our Guests: https://homehope.org/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Upgrade Collective: https://www.ourupgradecollective.com   

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 – Trailer 

1:25 – Introduction & Guest Background 

3:11 – Health Optimization Medicine Origins 

4:26 – Root Causes of Health vs Disease 

6:15 – Biohacking & Self-Experimentation 

8:19 – Medicinal Plants & Nootropics 

11:25 – Travel & Jet Lag Solutions 

13:42 – Cell Danger Response 

17:38 – Metabolites & Cellular Health 

18:57 – LDL & Lipopolysaccharides 

20:42 – Cellular Model & First Principles 

22:55 – Consciousness & Mitochondria 

25:46 – Nanotechnology Research 

28:55 – Giving Back & Service 

31:17 – Blue Cannatine Development 

34:48 – Methylene Blue Products 

36:22 – Metformin Discussion 

38:00 – Dosing & Cordycepin 

41:25 – Closing & Discount Code 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

One freezing sip on a Tibetan mountain rewired his hunger, silenced cravings, and unlocked a kind of fat-burning “switch” no doctor ever mentioned. What happened next—Silicon Valley obsession, a global butter shortage, and a new theory of weight loss—might change how you see food forever.

The only coffee I drink: Danger Coffee: https://dangercoffee.com/DAVE15

Thank you to our sponsors! 

- GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your air.

- EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.

Resources:   

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Upgrade Collective: https://www.ourupgradecollective.com   

• Upgrade Labs: https://upgradelabs.com   

• 40 Years of Zen: https://40yearsofzen.com  

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: 

Instagram: https://www.instagram.com/TheHumanUpgradePodcast/ 

Facebook: https://m.facebook.com/Thehumanupgrade/

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This drug has been misunderstood for decades, and that confusion is costing people focus, learning speed, and cognitive performance. In this episode, you’ll learn why nicotine itself is not the problem, why delivery method and dose change EVERYTHING, and how oral nicotine can be used strategically for biohacking brain optimization, neuroplasticity, and human performance in a healthy and safe way. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with David Renteln, Co Founder and CEO of LUCY Nicotine, a company pioneering science led alternatives for adult nicotine users who want better options. Before launching LUCY, David was also a co founder of Soylent, where he helped pioneer new approaches to functional nutrition and metabolism. 

Together, Dave and David break down how nicotine works in the brain through acetylcholine and dopamine, why speed of absorption determines addiction risk, and how nicotine affects learning, memory, motivation, and mood. The conversation also covers sleep optimization, mitochondrial signaling, tolerance, cycling strategies, and why modern regulation often slows innovation in functional medicine, anti aging science, and human performance.

You’ll Learn: 

• Why nicotine itself is not the same as smoking or vaping 

• How delivery speed changes addiction risk and brain response 

• How nicotine supports learning, focus, and neuroplasticity 

• Why acetylcholine matters for memory and brain optimization 

• How to think about dosing, cycling, and tolerance safely 

• How nicotine stacks with caffeine, nootropics, and Danger Coffee 

• The relationship between nicotine, sleep architecture, and REM 

• Why harm reduction matters for longevity and mitochondrial health 

• How nicotine fits into a Smarter Not Harder biohacking strategy 

Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Thank you to our sponsors! 

-Lucy! Get a 20% discount by using code ‘Dave’ at www.lucy.co/dave

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: nicotine podcast, nicotine nootropic, oral nicotine benefits, nicotine brain optimization, nicotine acetylcholine dopamine, nicotine learning memory, nicotine addiction risk, nicotine pouches vs smoking, LUCY nicotine, david renteln lucy, david renteln nicotine, lucy nicotine pouches, harm reduction nicotine, nicotine biohacking, nicotine human performance, nicotine longevity, nicotine neuroplasticity, nicotine sleep optimization, nicotine tolerance cycling, caffeine nicotine stack, danger coffee nicotine, dave asprey nicotine, dave asprey lucy, nootropics nicotine, functional medicine nicotine 

Resources:   

•  HeartMath | Go to https://www.heartmath.com/dave to save 15% off. 

•  LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Upgrade Collective: https://www.ourupgradecollective.com   

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

0:00 – Trailer 

1:10 – Origin Story 

2:20 – Product Forms & Usage 

3:52 – Effects & Mechanisms 

9:21 – Dosing & Addiction 

15:33 – Memory & Cognitive Benefits 

18:57 – Personality & Stacking 

21:41 – Quitting Smoking 

24:39 – Government Regulation 

32:00 – Addiction Philosophy 

35:30 – Behavior Change & Routines 

39:08 – Final Recommendations 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.