Pancreatic Cancer Halted by Virus Injection 

Researchers injected an engineered virus directly into pancreatic tumors in three patients — the virus replicated inside malignant cells, triggered an immune response, and stopped tumor growth and spread at an intentionally low early dose. Host Dave Asprey breaks down why oncolytic viruses can do what chemotherapy can't, how the tumor's dense biological wall becomes less of an advantage when a virus can replicate inside it directly, and why a measurable response at a safety dose is the kind of early signal that changes how he's watching this field. 

Sources: 

https://www.newscientist.com 

AI Chatbots and Teen Mental Health 

A new survey shows roughly one in five adolescents and young adults are now going to AI chatbots when they feel sad, anxious, nervous, or stressed, with usage heaviest in the 18–21 range. Host Dave Asprey explains why general-purpose language models designed to be engaging are dangerous as a substitute for real mental health support, why false reassurance from a chatbot may make the pipeline to real care harder to reach, and why this is a health systems story masquerading as a tech adoption story — and what parents need to do about it. 

Sources: 

https://www.nbcnews.com 

GLP-1 Drugs Cut Breast Cancer Risk 

Penn Medicine published a retrospective analysis of over 111,000 women finding GLP-1 exposure associated with about 35% lower odds of breast cancer in the full cohort and around 30% lower in a matched comparison group. Host Dave Asprey breaks down why this isn't just a weight loss story — it's a metabolic dysfunction story — explains the insulin resistance, inflammation, and hormonal environment mechanisms that may be driving the signal, and makes the case that this finding should be reshaping how oncologists and OBGYNs think about high-risk patients right now. 

Sources: 

https://www.pennmedicine.org 

Putin's $26 Billion Longevity Program 

The Wall Street Journal reports that Russia has made anti-aging research a Kremlin-level national priority through a $26 billion program including gene therapy, organ bioprinting, and xenotransplantation, led by Putin's daughter Maria Vorontsova and physicist Mikhail Kovalchuk. Host Dave Asprey breaks down what's geopolitical theater, what's legitimately frontier science, and why the real question is whether any findings will make it out to the broader research community or get locked inside a state program. 

Sources: 

https://www.wsj.com https://www.france24.com 

Sauna vs. Cold Plunge 

A landmark Finnish study tracked over 2,300 men for nearly 21 years and found increasing sauna frequency associated with dramatically lower cardiovascular and all-cause mortality — strongest at four or more sessions per week. Host Dave Asprey settles the debate with the actual data, explains what heat shock proteins and cold shock proteins actually are and why the evidence base behind them is nowhere near equivalent, and calls out the wellness marketing presenting early-stage mouse model research as the cold water equivalent of two decades of human mortality outcomes. 

Sources: 

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2521522 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on cancer treatment breakthroughs, adolescent mental health and AI, metabolic drivers of disease, geopolitical longevity science, and the real evidence behind popular recovery modalities. Host Dave Asprey connects emerging clinical research, objective epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: oncolytic virus pancreatic cancer, engineered virus tumor treatment, AI chatbot teen mental health, adolescent AI emotional support, GLP-1 breast cancer risk, semaglutide cancer prevention, metabolic dysfunction root cause disease, Putin longevity program Russia, New Health Preservation Technologies, anti-aging biotech geopolitics, sauna longevity mortality data, cold plunge cold shock proteins, RBM3 heat shock proteins, sauna vs cold plunge evidence, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade 

Thank you to our sponsors!  

- Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today 

- Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. 

- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

Resources:   

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Intro 

00:42 – Pancreatic Cancer Halted by Virus Injection 

01:44 – Teens & AI Therapy Chatbots 

03:13 – GLP-1 Drugs Cut Breast Cancer Risk 

04:30 – Russia's $26B Longevity Program 

06:18 – Sauna vs. Cold Plunge 

09:10 – Closing 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Sulforaphane, Detox Pathways, and the Science of Microplastic Removal 

Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows actually moves microplastics, heavy metals, BPA, and benzene out of your body.. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. 

Host Dave Asprey sits down with Dr. John Gildea, a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time. 

They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that won't break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent use compounds the benefit over time. 

You'll Learn: 

• Why microplastics accumulate inside lysosomes and what sulforaphane does to release them 
• How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin 
• What an in-house study revealed about how and where microplastics actually leave the body 
• How toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them 
• Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch 
• How sulforaphane boosts BDNF and neuroplasticity at the cellular level 
• What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily 
• Why losing weight releases stored toxins and what to take to protect your brain and metabolism during fat loss 
• How sulforaphane activates the same AMPK longevity pathways triggered by fasting without restricting food 

Thank you to our sponsors!      

- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

- HeartMath | Go to https://www.heartmath.com/dave to save 15% off. 

- Timeline | Go to timeline.com/dave and you’ll get an additional 20% off your first month 

- Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Dr. John Gildea, David Roberts, Mara Labs, BrocElite, sulforaphane, microplastics, microplastic removal, lysosome, lysosomal surface translocation, detox pathways, glutathione, glucuronidation, sulfation, Nrf2 pathway, AMPK, TFEB1, BDNF, neuroplasticity, heavy metals, BPA, benzene, estrogen metabolism, toxic estrogen, xenoestrogens, berberine, BerbaLite, ResveraLite, c-Myc, cancer and estrogen, sleep optimization, ketosis, broccoli sprouts, isothiocyanates, PEITC, watercress, phase two detox, microplastic excretion, indoor air quality, HEPA filter, dryer lint microplastics, BPA receipts, endocrine disruptors, fat loss and toxins, autism and sulforaphane, ADHD and focus, vivid dreams and BDNF, fasting mimicry, anti-aging, biohacking, longevity, functional medicine, supplements, human performance, brain optimization, metabolism, cellular detox 

Resources:    

• For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   

• Danger Coffee: https://dangercoffee.com/discount/dave15    

• My Daily Supplements: SuppGrade Labs (15% Off)    

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    

• Dave Asprey’s BEYOND Conference: https://beyondconference.com    

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  

• Upgrade Labs: https://upgradelabs.com    

Timestamps:  

0:00 – Trailer 

1:55 – Intro & Context 

4:48 – Microplastics & Sulforaphane 

12:39 – Broccoli Sprouts Formulation 

15:20 – Lab Origin Story 

26:01 – Reducing Toxin Exposure 

37:06 – Estrogen, Hormones & Berberine 

52:46 – Autism, ADHD & Brain Health 

59:01 – Wrap-Up 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Patches, and How to Avoid Contaminated Peptides 

Peptides are one of the most powerful tools in biohacking and anti-aging medicine, and until now, most people couldn't access them safely, legally, or without a needle. This episode changes that. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days 

Host Dave Asprey sits down with Justin Kirkland, a longevity medicine expert with over 30 years in drug development and pharmaceutical innovation. Kirkland holds multiple drug synthesis and formulation patents, has founded multiple pharmaceutical companies, and is one of the few people in the world manufacturing peptides entirely on US soil, controlling every step of the synthesis process from raw amino acids to finished product. If you want to understand what is really inside your peptides and why it matters for your longevity and human performance, he is the person to listen to. 

Dave and Justin go deep on why most peptides on the gray market contain dangerous residual compounds that can spike liver enzymes and cause real harm, why Chinese-sourced APIs are not always what they claim to be, and how a new generation of needle-free delivery systems including microneedle patches and auto-injectors is making peptide therapy accessible to anyone serious about longevity and human performance. They also cover how AI and functional medicine are converging to make peptide protocols personalized based on genetics and microbiome status, why the thymus gland is one of the most overlooked anti-aging targets in the body, and what the suppression of peptide research reveals about who really controls your access to health tools. 

You Will Learn: 

• Why many gray market peptides contain toxic residual acids that damage the liver and how to identify clean products 
• How microneedle patches and auto-injectors are replacing traditional injections for peptide delivery 
• Which peptides are most effective for longevity, immune system repair, and human performance including BPC-157, Thymosin Alpha-1, and growth hormone secretagogues 
• Why your genetics and gut microbiome determine whether a peptide will work for you at all 
• How the thymus gland controls your immune system and why it disappears by your mid-20s 
• What the suppression of peptide research tells you about Big Pharma's control over your supplement and nootropics access 
• Why US-manufactured peptides represent a new standard for safety and quality in biohacking 
• How AI is transforming personalized peptide protocols in functional medicine 
• Which peptides are overhyped and which ones actually move the needle on anti-aging and recovery 
• How to store, mix, and dose peptides correctly to avoid the mistakes most people using them are making right now 

Thank you to our sponsors!      

- Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. 

- The One Device | Use code DAVE for $10 off at theonedevice.com/dave 

- Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout. 

- ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Justin Kirkland, peptides, needle-free peptides, microneedle patch, BPC-157, Thymosin Alpha-1, ipamorelin, CJC-1295, PT-141, KPV peptide, Dihexa, growth hormone secretagogue, peptide purity, TFA contamination, gray market peptides, US manufactured peptides, oral peptides, transdermal delivery, thymus gland, anti-aging, biohacking, longevity, functional medicine, peptide auto-injector, compounding pharmacy 

Resources:    

• Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   

• Danger Coffee: https://dangercoffee.com/discount/dave15    

• My Daily Supplements: SuppGrade Labs (15% Off)    

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    

• Dave Asprey’s BEYOND Conference: https://beyondconference.com    

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  

• Upgrade Labs: https://upgradelabs.com     

Timestamps:  

00:00 – Intro & Guest Welcome 

01:55 – Censorship & Platform Bans 

06:20 – Peptide Science & Bioavailability 

07:20 – Delivery Methods 

14:30 – Supply Chain & US Manufacturing 

17:01 – Manufacturing Risks & Contamination 

24:43 – Peptide Stacks 

28:41 – Immune Peptides & Thymus 

30:57 – Overhyped Peptides 

41:00 – Alternative Delivery (Patches, Nasal, Rectal) 

47:25 – Side Effects & Risk 

50:30 – Mixing & Storage Tips 

54:05 – Wrap-Up & Where to Buy 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily, and I spent a fortune trying to fix it from the top down...little worked until I realized the problem wasn't in my head—it was in my feet.

In this video, I break down the scientifically proven connection between your feet, your circulation, and your cognitive decline. We cover how your brain requires a massive 20% of your body's oxygen to function, and why sitting at a desk all day weakens the calf muscles that act as a "second heart" to pump that oxygenated blood back up to your skull. I also explain how modern cushioned shoes act as sensory deprivation chambers, muffling the critical signals your feet send to your brain. This sensory lack forces your nervous system into a constant, low-level survival state that completely kills your executive function. You don't need another brain supplement to get your mental edge back. You need to fix your foundation. I share the exact barefoot walking and foot-strengthening protocols I used to lift the fog and restore my cognitive sharpness.

Thank you to our sponsors!

• Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today
• Essentia | Go to https://myessentia.com/daveand use code DAVE for $100 off The Dave Asprey Upgrade.
• iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Timestamps:

00:00 – Personal Experience

00:47 – Root Cause: Not in Your Head

01:05 – Blood Flow and Brain Function

02:10 – The Calf Pump

03:52 – Foot Sensory Signals

04:26 – Nervous System Impact

06:22 – How to Fix It

07:51 – Personal Results

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey’s BEYOND Conference: https://beyondconference.com/

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Enhanced Games Debut in Las Vegas as the First Openly Drug-Enabled "Biohacker Olympics" 

The inaugural Enhanced Games took place in Las Vegas with more than 40 elite athletes competing openly while using performance-enhancing drugs, a $25 million prize pool, and a $1 million world record bonus on the table. Host Dave Asprey, who serves on the advisory board of the Enhanced Games, breaks down why this event is less a sports story than a cultural signal: enhancement has moved from underground to prime time, and the institutions that spent decades controlling that conversation through drug testing and bans watched it happen on a stage in Las Vegas. Dave explains why WADA has always existed to protect institutions rather than athletes, why bodily sovereignty is the real issue at the center of this debate, and what it means that even with full transparency about what every athlete was taking, the records didn't fall quite the way you'd expect. The Enhanced Games are the closest thing yet to a public beta test for extreme human enhancement, and the data it generates will matter far beyond sport. 

Sources: 

https://www.nytimes.com/athletic/7302319/2026/05/23/enhanced-games-athletes-world-records-doping-steroids/ 

https://www.npr.org/2026/05/24/nx-s1-5831252/enhanced-games-steroids-olympics-trump 

https://www.bbc.com/news/articles/cedpz1zqp8po 

https://www.wusf.org/2026-05-24/the-enhanced-games-are-sunday-heres-what-to-know-about-the-controversial-event 

Kyle Busch's Death Showed How Severe Pneumonia Can Rapidly Escalate Into Fatal Sepsis 

NASCAR driver Kyle Busch died after severe pneumonia progressed into sepsis, a condition most people hear about but few truly understand until it is too late. Host Dave Asprey breaks down the biology of what happens when the immune system stops containing an infection and starts attacking the body systemwide, why sepsis can escalate from manageable symptoms to a life-threatening emergency faster than most people expect, and why even someone with great biomarkers and a dialed-in health stack can be blindsided by an acute inflammatory crisis. The warning signs matter: worsening breathing, confusion, rapid decline, and a sense that something is badly wrong are emergency symptoms, not signals to wait and see. Longevity is not only about optimization rituals. It includes knowing when your biology is in crisis and acting before the window closes. 

Sources: 

https://www.cnn.com/2026/05/24/health/what-is-sepsis-kyle-busch-wellness 

https://www.cnn.com/2026/05/26/health/video/sepsis-kyle-busch-medical-care-lead-jake-tapper 

https://www.michiganmedicine.org/health-lab/nascar-stars-death-shows-how-sepsis-can-kill-anyone-if-not-caught 

https://www.huffpost.com/entry/what-is-sepsis-kyle-busch_l_6a15a9c1e4b0ddcc84641f34 

Menin Loss in the Hypothalamus May Be a Central Switch That Accelerates Aging 

New research in mice found that a protein called Menin in the hypothalamus may function as a central coordinator of biological aging across the whole body. When Menin declined, aging accelerated. When researchers restored it in older mice, memory improved and lifespan increased. Host Dave Asprey explains why this finding challenges the dominant wear-and-tear model of aging, what it means that the hypothalamus may be running a coordinated aging program rather than simply accumulating damage over time, and why a control-room model of aging points toward fundamentally different intervention strategies than chasing downstream symptoms like fatigue and memory loss. The research connects aging to neuroinflammation, which has direct implications for how biohackers think about hypothalamic health right now. It is still animal research, but the mechanistic case is strong and the implications for longevity science are significant. 

Sources: 

https://www.sciencedaily.com/releases/2026/05/260524012959.htm 

https://www.news-medical.net/news/20230323/Menin-protein-protects-against-aging-and-cognitive-decline.aspx 

https://www.eurekalert.org/news-releases/982100 

https://www.eurekalert.org/news-releases/1116021 

IL-6 Blockade With Tocilizumab Showed Early Promise for Treatment-Resistant Depression 

A small pilot randomized trial tested tocilizumab, an anti-inflammatory drug that blocks IL-6 signaling, in people with difficult-to-treat depression and found remission rates of 54% versus 31% with placebo. Host Dave Asprey breaks down why this result reframes depression as an immune biology problem for a meaningful subset of patients rather than a purely neurochemical one, and why the same inflammatory pathway that drives joint destruction in rheumatoid arthritis is showing up in the brains of people who don't respond to antidepressants. The practical implication is not to seek out a biologic drug off-label. It is to recognize that persistent low mood, fatigue, and low resilience may warrant a deeper biological workup than standard screening provides, starting with IL-6, CRP, and a full inflammatory panel. The brain is downstream of the immune system more than most psychiatry has been willing to admit, and this trial is the clearest evidence yet of why that matters. 

Sources: 

https://www.bristol.ac.uk/news/2026/may/pilot-trial-suggests-anti.html 

https://www.eurekalert.org/news-releases/1128678 

https://www.medicalxpress.com/news/2026-05-trial-anti-inflammatory-drug-difficult.html 

https://clinicaltrials.gov/ 

New Science Paper Says Intrinsic Human Lifespan May Be About 50% Heritable 

A paper published in Science argues that the genetic contribution to human lifespan is roughly 50% heritable, far higher than previous estimates, once researchers correct for deaths caused by accidents, infections, and external causes unrelated to aging biology. Host Dave Asprey explains why this finding is liberating rather than deterministic, what it means that genetics loads the dice on lifespan more than the mainstream has been willing to admit, and why personalized longevity strategy matters far more than generic population-level advice. Your genes load the dice but you still roll them. The study pushes the field toward genetic stratification and biomarker-based personalization, and it validates the core premise that the same intervention will not produce the same outcome in every person. Get your genetics tested and build your strategy from your own baseline, not from what worked for the average person in a study. 

Sources: 

https://www.science.org/doi/10.1126/science.adz1187 

https://pubmed.ncbi.nlm.nih.gov/41610249/ 

https://www.nature.com/articles/d41586-026-00300-w 

https://www.eurekalert.org/news-releases/1113892 

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on human enhancement, acute inflammatory risk, neuroendocrine aging, immune-driven depression, and the genetics of lifespan. Host Dave Asprey connects emerging clinical research, real-world performance culture, and actionable optimization frameworks into a clear picture of where biology actually drives outcomes and where most people are still managing symptoms instead of finding the mechanism. 

New episodes every Tuesday, Thursday, Friday, and Sunday. 

Keywords: Enhanced Games biohacking, performance enhancement bodily autonomy, WADA elite sport doping, Kyle Busch sepsis death, pneumonia sepsis escalation, sepsis warning signs, Menin hypothalamus aging, brain aging master switch, neuroendocrine aging longevity, tocilizumab depression IL-6, inflammation treatment-resistant depression, immune biology mental health, lifespan heritability genetics, longevity genetics personalization, genetic stratification healthspan, biohacking news 2026, longevity research 2026, healthspan optimization, inflammation testing CRP IL-6 

Thank you to our sponsors!  

- HeartMath | Go to https://www.heartmath.com/dave to save 15% off. 

- The One Device | Use code DAVE for $10 off at theonedevice.com/dave 

- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

Resources:   

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps: 

00:00 – Intro 

00:38 – Story 1: Enhanced Games 

01:49 – Story 2: Kyle Busch Death (Sepsis) 

03:09 – Story 3: Menin Protein and Brain Aging 

04:37 – Story 4: Inflammation and Depression 

06:20 – Story 5: Lifespan Heritability 

07:47 – Takeaway 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman 

Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Explore all of Wonderfeel’s products at: getwonderfeel.com/dave 

They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th.

Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide.  

Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most. 

You'll Learn: 

• Why NAD declines with age and which two enzymes are primarily responsible for draining it 
• How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy 
• Why creatine is one of the most underrated anti-aging and brain optimization supplements available 
• How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart 
• Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade 
• How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body 
• What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role 
• Why most creatine supplements fail to absorb properly and what to look for in a high-quality source 
• How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics 
• Why walking immediately after a meal may be doing more harm than good to your gut lining 

Thank you to our sponsors!      

- Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. 

- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off 

- Pique | Go to Piquelife.com/dave for 20% off. 

- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide 

Resources:   

• Explore all of Wonderfeel’s products at: getwonderfeel.com/dave 

• Order Youngr™: getwonderfeel.com/dave

• Order ChocoCreatin™: getwonderfeel.com/dave

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps:  

00:00 – Trailer 

01:12 – Introduction & BRCA Background 

02:19 – DNA Damage & PARP 

04:38 – Free Radicals & Oxidative Stress 

11:37 – NAD & Antioxidant Defense 

12:34 – CD38 & NAD Depletion 

23:31 – The Gut-Aging Hypothesis 

30:05 – ATP, Creatine & Energy Distribution 

36:41 – Creatine as Energy Shuttle 

51:09 – Microbiome & Gut Repair 

59:21 – TMAO & Nitric Oxide Interference 

1:03:52 – Flagellin & Gut Inflammation Research 

1:09:45 – FDA & Pharmaceutical Incentives 

1:16:05 – Closing 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Hidden Causes of Brain Fog, Anxiety, and Chronic Illness: Mold, Parasites, Histamine, and Low Cortisol 

If you're exhausted, inflamed, and can't figure out why, the answer might be hiding in your histamine, your hormones, your home, or something living inside you that your doctor will never test for. 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Jessica Peatross, a former hospitalist turned functional medicine powerhouse who walked away from a conventional medical career after discovering that 90% of disease traces back to lifestyle, environment, and the toxins most doctors ignore. After graduating magna cum laude and earning her medical degree from the University of Louisville, Dr. Jess pursued training in functional medicine, nutrigenomics, and alternative therapies, and now helps thousands of patients reverse chronic illness through her KillBindSweat method and WellnessPlus app. She is also the formulator and CMO of Aegis Formulas and a leading voice at international health conferences. If chronic illness, mold toxicity, or hormonal chaos is on your radar, she is the person you want in your corner. 

Together, Dave and Dr. Jess go deep into the hidden drivers of mystery symptoms that functional medicine is finally starting to crack open. They cover why low cortisol is more dangerous than high cortisol, how histamine and mast cell activation syndrome explain everything from anxiety and brain fog to endometriosis and POTS, and why most "Lyme disease" is actually undiagnosed mold toxicity. They also break down the parasite epidemic hiding in plain sight across the United States, the B vitamin mistake making millions of people sicker, and why your metabolism, mitochondria, and mental health are all downstream of things your standard lab panel will never catch. 

This episode also gets into the real story behind Dr. Jess surrendering her California medical license rather than comply with a system she believed was working against patient health. Her firsthand account of the medical board process is something every person who cares about medical freedom needs to hear. 

You'll Learn: 

• Why everyone who is chronically sick has a low cortisol awakening response and what to do about it 
• How histamine drives anxiety, racing thoughts, palpitations, bloating, skin issues, and hormonal chaos 
• Why 90% of people diagnosed with Lyme disease actually have toxic mold and how to test for both 
• The parasite epidemic in the U.S. and why standard testing misses most of it 
• How the spike protein reactivates dormant viruses and feeds the histamine loop behind long COVID 
• Why synthetic B6 causes the very neuropathy it is supposed to fix, and what to take instead 
• The cortisol, adrenaline, and blood pressure connection that explains "wired but tired" 
• How progesterone stabilizes mast cells and why estrogen dominance fuels inflammation and reactivity 
• Why Dave Asprey uses low-dose cortisol, dexamethasone, and modafinil as part of his daily performance stack 
• The mold binders that actually work, and which popular ones can harm hypermobile people 
• How nicotine at low doses blocks spike protein from ACE2 receptors and protects the brain 
• What the MTHFR gene, methylation, and folic acid have to do with breast cancer, depression, and estrogen detox 

Thank you to our sponsors!      

- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off 

- Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. 

- Cowboy Colostrum | Get your gut right by going to cowboycolostrum.com/asprey for 25% off of your entire order. 

-Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Dr. Jessica Peatross, functional medicine, mast cell activation syndrome, histamine intolerance, long COVID brain fog, mold toxicity, chronic Lyme disease, parasite testing, low cortisol, cortisol awakening response, MTHFR methylation, B6 toxicity, P5P, folinic acid, estrogen dominance, progesterone therapy, spike protein reactivation, Epstein-Barr reactivation, POTS, wired but tired, Kill Bind Sweat, WellnessPlus, vaccine exemptions, mold binders, nicotine ACE2, adrenal insufficiency, RCCX gene 

Resources:   

• Go to https://drjessmd.com/ and use code ‘DRJESS’ at checkout 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps:  

00:00 – Trailer 

00:33 – Releasing Medical License 

03:21 – Chronic Illness Root Causes 

05:00 – Hospital Nutrition 

08:11 – Dave's Health History 

10:22 – Parasites 

20:02 – Nicotine 

23:19 – Low Blood Pressure & Minerals 

28:09 – B Vitamins & Methylation 

33:45 – Autism & Genetics 

40:13 – Toxic Mold 

43:11 – ADHD Misdiagnosis 

48:27 – Histamine & Mast Cells 

50:56 – Long COVID & Spike Protein 

58:56 – Cortisol 

1:03:56 – Lyme Disease 

1:09:58 – Mold Testing & Binders 

1:16:37 – Closing 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this video, I break down the exact biological mechanisms keeping men in Okinawa, Japan, physically dominant and mentally sharp past 100. You don't need million-dollar lab work or intense weight training to reverse your biological age. Instead, these centenarians leverage five specific lifestyle protocols to naturally upgrade their biology. I explain the hard science behind how eating to 80% full shuts down the constant growth signaling that accelerates cellular aging. We'll also cover why the modern concept of retirement physically destroys your brain function within 2-3 years, and how specific social structures actually drop inflammatory chemicals in your body by up to 30%.

Thank you to our sponsors!

• TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off.
• Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.
• iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Timestamps:

00:00 – Intro

00:47 – Okinawa's Origins

01:28 – Hara Hachibu (80% Full)

02:36 – Ikigai (Purpose)

03:57 – Never Retire

05:19 – Social Bonds (Moai)

07:13 – Stress Resilience

08:54 – The 5 Habits

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey’s BEYOND Conference: https://beyondconference.com/

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Light Therapy, 40Hz Gamma & Brainwave Entrainment: How BrainTap Resets Sleep, Clears Brain Fog, and Boosts Productivity by 26% 

Your brain is being starved of the one nutrient it needs most, and it is not a supplement, not a nootropic, not a fasting protocol. It is light, and a 40 hertz flicker delivered at the right frequency can break up amyloid plaque, reset your nervous system, and get you 26 percent more productive in a single session. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Go to https://braintap.com/dave/ for an exclusive offer for The Human Upgrade listeners 

Host Dave Asprey sits down with Dr. Patrick Porter, PhD, award-winning author, educator, entrepreneur, and founder of BrainTap, who has spent over 35 years at the forefront of neurotechnology helping millions of people achieve mental and emotional resilience through cutting-edge brain entrainment tools. Backed by 72 peer-reviewed studies and research conducted alongside Google, Microsoft, universities in Brazil, and veteran treatment programs, Dr. Porter is one of the most experienced and validated practitioners in applied neuroscience and brain optimization working today. 

Together, Dave and Dr. Porter break down exactly how flickering light and binaural sound delivered through the BrainTap headset feeds the brain through the electron transport chain, triggers nitric oxide release, boosts mitochondrial energy, and drives neuroplasticity through frequency following response. They cover how 40 hertz gamma light breaks up amyloid plaque and why that same frequency is linked to reversing dementia, how BrainTap reset the circadian rhythms of coal miners in under three weeks, how 490,000 students in Brazil raised their GPA using brain wave entrainment, and how AI now builds personalized 21-day brain training protocols from 3,000 available sessions. If you are serious about biohacking your brain, upgrading sleep optimization, and doing smarter not harder work on your mind, this episode delivers the science and the tools. 

You'll Learn: 

• Why light is the most underrated nutrient for brain health and how BrainTap delivers it directly to every cell in your body 
• How 40 hertz gamma frequency breaks up amyloid plaque, restores blood flow, and may reverse dementia and Alzheimer's progression 
• Why binaural beats and isochronic tones trigger frequency following response and what that does to your focus, metabolism, and energy 
• How three 10-minute BrainTap sessions per day produces 26 percent more work output according to studies with Google and Microsoft 
• How BrainTap restored deep sleep and REM cycles in coal miners with destroyed circadian rhythms in under three weeks 
• Why 90 percent of autistic children in one study began speaking after six weeks of pulsed light therapy targeting alpha wave production 
• How AI inside BrainTap now generates personalized brain training protocols based on your specific stress, sleep, and performance goals 
• Why the vagus nerve is the hidden target of BrainTap's ear lights and how triggering it drives parasympathetic recovery 
• How SMR brain waves create the optimal state for focus and concentration and why elite athletes use this for both performance and academic results 
• What the NeuroCheck system measures across nine parameters of the nervous system in five minutes and how it validates your biohacking results 

Thank you to our sponsors!      

- AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers. 

- AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. 

- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Dr. Patrick Porter, BrainTap, brainwave entrainment, light therapy, sound therapy, binaural beats, isochronic tones, 40 hertz gamma, gamma frequency, amyloid plaque, Alzheimer's prevention, dementia reversal, neuroplasticity, brain optimization, neurotechnology, frequency following response, SMR brain waves, alpha waves, delta waves, theta waves, vagus nerve, vagal stimulation, parasympathetic nervous system, nitric oxide, mitochondria, electron transport chain, sleep optimization, circadian rhythm reset, deep sleep, REM sleep, Oura Ring, HRV, cognitive performance, focus and concentration, productivity, nootropics, brain entrainment, photobiomodulation, red light therapy, near infrared light, biohacking, human performance, anti-aging, longevity, neurohacking, mental resilience, stress reduction, anxiety relief, autism therapy, pulsed light therapy, AI personalization, personalized wellness, meditation technology, Dave Asprey, Beyond Biohacking Conference, NeuroCheck, nervous system assessment, brain health, mental performance 

Resources:   

• Go to https://braintap.com/dave/ for an exclusive offer for The Human Upgrade listeners 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps:  

00:00 – Trailer 

00:30 – Intro & Guest Welcome 

01:45 – BrainTap: Light & the Brain 

04:15 – 40Hz Gamma & Alzheimer's 

05:55 – Sound & Binaural Beats 

07:26 – Usage Protocol & Results 

08:37 – Sleep & Circadian Reset 

09:29 – AI-Personalized Sessions 

10:47 – Conference Preview 

12:19 – Vagus Nerve & Ear Lights 

13:33 – Closing & Offer 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The ancient fruit sitting in your grocery store right now outperforms rapamycin, rivals caloric restriction, and triggers a cellular cleanup process that most longevity scientists did not even know existed until a lab changed everything 18 years ago. 

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

-Go to timeline.com/Dave or just use code ‘Dave’ to get 20% off your next order. 

Host Dave Asprey sits down with Chris Rinsch, co-founder and President of Timeline Longevity and a PhD cell biologist who has spent nearly two decades doing pharmaceutical quality clinical research on one of the most underrated longevity molecules on earth. Before founding Timeline in 2007, Rinsch worked in venture capital investing in pioneering life sciences companies and in biotechnology developing cell-based therapies at Swiss biotech company ISOTIS SA. He has authored original publications in Nature Medicine, Nature Metabolism, JAMA Open, and Cell Reports Medicine, and holds internationally filed and granted patents on urolithin A. This is the first time a Timeline co-founder has appeared on the show. 

Together, Dave and Chris break down the full science of urolithin A, the postbiotic compound unlocked from pomegranate by gut bacteria, and why it triggers mitophagy to clear out damaged mitochondria and replace them with high-functioning ones. They cover why only 30 to 40 percent of people can produce urolithin A from food alone, how one month of supplementation measurably improved immune cell populations in people aged 50 to 70, and why Dave has stacked this into his daily longevity protocol alongside NAD precursors and nootropics for years. If you are serious about biohacking your mitochondria, extending healthspan, and doing smarter not harder longevity work, this episode delivers the deep science to back it up. 

You'll Learn: 

• Why urolithin A outperforms rapamycin in worm lifespan studies and rivals caloric restriction at 45 percent life extension 
• How mitophagy works, why it declines with age, and why it is one of the most important anti-aging mechanisms in the body 
• Why eating pomegranates or taking cheap pomegranate extract does not work for most people and what to take instead 
• How one month of MitoPure improved natural killer cells, CD8 T naive cells, and reduced inflammation in adults aged 50 to 70 
• Why mitochondria are central to metabolism, brain optimization, immune function, cardiovascular health, and skin aging 
• How Timeline's topical urolithin A produced statistically significant reductions in fine lines and wrinkles after eight weeks 
• Why Dave considers this one of the most clinically validated supplements in his longevity stack alongside NAD and fasting protocols 
• How L'Oreal became a Timeline investor after confirming the mitochondrial science was unlike anything in their existing ingredient library 
• What the XPRIZE Healthspan competition is targeting and why Timeline is competing to reverse biological aging by 10 to 20 years 
• Why the future of functional medicine will require a mitochondrial blood test and how close we are to having one 

Thank you to our sponsors!      

- EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE 

- Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. 

- Neuronic | Go to www.neuronic.online Code DAVE for $100 off 

- ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Chris Rinsch, Timeline Longevity, MitoPure, urolithin A, mitochondria, mitophagy, pomegranate, elagitannins, postbiotic, gut microbiome, longevity, anti-aging, healthspan, biohacking, supplements, human performance, metabolism, mitochondrial health, cellular health, autophagy, natural killer cells, immune health, inflammation, NAD, rapamycin, caloric restriction, muscle endurance, collagen, skin aging, fine lines, wrinkles, topical skincare, L'Oreal, XPRIZE Healthspan, Nature Aging, clinical trials, longevity stack, brain optimization, cardiovascular health, biological age, aging clock, fasting, nootropics, functional medicine, Dave Asprey, polyphenols, microbiome diversity 

Resources:   

• Go to timeline.com/Dave or just use code ‘Dave’ to get 20% off your next order. 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps:  

00:00 – Trailer 

00:37 – Intro  

03:57 – Pomegranates 

10:03 – Discovering Urolithin A & Mitophagy 

20:50 – Science vs. Pomegranate Supplements 

25:24 – Topical Skincare Science 

26:09 – L'Oreal Partnership & Skin Results 

33:38 – 15 Clinical Studies & XPRIZE 

43:50 – Nature Aging Immune Study 

49:22 – Dosing & Daily Routine 

51:29 – Future of Mitochondrial Health 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your relationships are reshaping your biology in ways that diet and exercise alone cannot fix, and the science behind it will change how you think about longevity, metabolism, and what it actually means to be healthy. 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Molly Maloof, a physician and one of the most innovative voices in personalized medicine, functional medicine, and human performance. Since 2012, she has advised or consulted for over 50 companies across digital health, consumer health, and biotechnology. She pioneered a course on healthspan at Stanford University and founded Adamo Bioscience, a company dedicated to unlocking the science of love as a pathway to healing and human connection. Dr. Maloof brings a rare combination of clinical depth, biohacking credibility, and entrepreneurial range to one of the most overlooked conversations in longevity. 

Together, Dave and Dr. Maloof dig into the neurobiology of love and attachment, the hormonal drivers of the sex drive and pair bonding, and how chronic isolation wrecks your metabolism at the cellular level. They explore the cell danger response and how toxic relationships, mold exposure, and trauma can lock your cells into a self-protection mode that blocks healing. They also cover psychedelics as hormetic tools, oxytocin as nature's medicine, the placebo response, peptide therapy for mitochondrial repair and anti-aging, and why regenerative medicine is about to rewrite the rules of human lifespan. If you are serious about biohacking your body from the inside out, this episode is essential. 

You'll Learn: 

• Why human connection is a biological necessity, not a lifestyle preference, and what isolation does to your mitochondria and metabolism 
• How the three neurobiological drives of sex, romantic love, and attachment are wired into your hormones and what happens when they go wrong 
• What the cell danger response is, why it gets stuck, and which peptides, supplements, and therapies help break the cycle 
• How oxytocin drives wound healing, immune function, and the placebo response 
• Why psychedelics work as hormetic love drugs and how they reproduce the neurobiology of romantic love 
• The top peptides for mitochondrial repair, brain optimization, and telomere biology 
• Why Dave and Dr. Maloof believe we have already reached longevity escape velocity 
• How AI is accelerating precision medicine, protein folding breakthroughs, and the future of anti-aging therapeutics 
• Why fasting, breathwork, neurofeedback, and somatic therapies all converge on the same biological reset mechanism 
• How to build the adaptive capacity and bioenergetic reserves to bounce back from anything 

Thank you to our sponsors!      

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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Dr. Molly Maloof, Adamo Bioscience, Stanford University, personalized medicine, functional medicine, healthspan, longevity, biohacking, human performance, anti-aging, regenerative medicine, longevity escape velocity, cell danger response, mitochondria, mitochondrial health, oxytocin, vasopressin, dopamine, serotonin, neurobiology of love, attachment theory, pair bonding, sex drive, hormone replacement therapy, testosterone, estrogen, menopause, andropause, libido, female sexual dysfunction, relationship biology, social health, isolation, community, co-regulation, trauma healing, psychedelics, MDMA, psilocybin, ibogaine, ayahuasca, hormetic stress, social hormesis, neurofeedback, 40 Years of Zen, breathwork, nervous system regulation, HPA axis, cortisol, mast cell activation, histamine, long COVID, mold exposure, phospholipid therapy, glutathione, vitamin C, BPC-157, TB500, SS31, epothilone, SELANK, SEMAX, BDNF, telomere biology, telomerase, peptides, GLP-1, placebo response, wound healing, metabolism, continuous glucose monitoring, gut health, AI, precision medicine, supplements, brain optimization, neuroplasticity 

Resources:   

• Grab Molly’s Book The Spark Factor: https://www.amazon.com/Spark-Factor-Supercharging-Optimizing-Feeling/dp/0063207206 

• Learn More About Dr. Molly’s Work: https://drmolly.co/ 

• Visit Your Healthspan Journey: https://yourhealthspanjourney.mystrikingly.com/ 

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ 

• Upgrade Labs: https://upgradelabs.com   

Timestamps:  

00:00 – Trailer 

00:28 – Intro 

01:39 – COVID Isolation & Its Effects 

03:11 – Science of Love & Hormones 

04:24 – Psychedelics & Love Chemistry 

09:22 – Cell Danger Response 

11:07 – AI, Tech & Human Connection 

13:20 – Social Connection as Medicine 

20:50 – Placebo, Care & Psychedelics 

24:49 – Altered States & Healing Modalities 

30:09 – Peptides & Longevity Drugs 

35:44 – Mast Cell & Personal Health Challenges 

43:46 – Regenerative Medicine & The Future 

46:17 – Longevity Escape Velocity 

50:05 – Outro 

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