Erythritol, a popular sweetener found in countless sugar-free and keto products, has long been considered a safe alternative to sugar. This episode of Revolution Health Radio examines emerging research that challenges that assumption. Chris explains how erythritol promotes blood clotting, impairs blood vessel function, increases oxidative stress, and interferes with the body’s ability to dissolve clots. You’ll learn why erythritol accumulates in the bloodstream, how regulatory loopholes allowed it to be widely adopted without long-term safety data, and why people with diabetes, obesity, and heart disease may be especially vulnerable. Chris also discusses similar concerns with xylitol, explores gut health side effects of sugar alcohols, and outlines safer alternatives like allulose, pure stevia extract, and monk fruit.

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In this episode of Revolution Health Radio, Chris Kresser is joined by neuroscientist and physician Dr. Tommy Wood to explore how cognitive function can be preserved—and even enhanced—as we age. Dr. Wood challenges outdated ideas about inevitable cognitive decline and reframes dementia as a largely preventable, multifactorial condition. The conversation covers the historical roots of Alzheimer’s disease, why “one-size-fits-all” drug approaches have failed, and how lifestyle, environment, and brain use interact to shape long-term brain health. Dr. Wood introduces his 3S model of brain health, explains why retirement may be a mismatch for brain biology, and breaks down the roles of exercise, nutrition, sleep, and cognitively demanding activities in building lifelong cognitive resilience.

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In this episode of Revolution Health Radio, Chris breaks down a new large-scale study challenging the popular belief that plant-based diets promote longevity. The findings reveal that vegetarians—especially vegans—were significantly less likely to reach age 100 compared to omnivores. Chris explores the biological reasons behind these findings, emphasizing the importance of high-quality protein and nutrient bioavailability, as well as why certain nutrients may be harder to obtain from plant-only diets. He also discusses the powerful nutritional synergy that occurs when plant and animal foods are consumed together, arguing against rigid dietary dogma and advocating for a balanced, omnivorous approach to support healthy aging and longevity.

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In this episode of Revolution Health Radio, Chris sits down with gastroenterologist and microbiome researcher Dr. Zain Kassam to explore the rapidly evolving science of the microbiome and its profound impact on sleep, circadian rhythm, cognitive performance, stress resilience, immune balance, and longevity. From groundbreaking research on microbiome diversity and sleep quality to emerging innovations like cobiotics, Dr. Kassam explains how our microbial partners regulate core biological systems far beyond the gut. They discuss the connection between the gut and the brain, eyes, skin, and even ears—along with practical strategies for supporting microbial health in a modern world that constantly disrupts it.

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Depression and anxiety are often treated as chemical imbalances in the brain—but what if the real problem starts in the gut? In this episode of Revolution Health Radio, we dive deep into the gut–brain connection and the growing body of research linking gut inflammation, microbiome imbalance, and mood disorders. You’ll learn how inflammatory cytokines contribute to depression, why butyrate is emerging as a powerful antidepressant compound, and how specific probiotic strains can improve mental health outcomes. Chris also shares practical, evidence-based strategies—including diet, supplementation, and functional testing—to address root causes and support lasting emotional well-being.

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In this episode of Revolution Health Radio, Chris Kresser explains why vitamin D supplementation should never be one-size-fits-all. Drawing on new research—including a groundbreaking study on magnesium’s regulatory role—Chris explores how genetics, ethnicity, body weight, age, health status, sun exposure, and nutrient cofactors all shape an individual’s vitamin D needs. He outlines optimal testing strategies, safe and effective target ranges, and the critical roles of magnesium, vitamin K2, and vitamin A in vitamin D metabolism. The episode reframes vitamin D optimization as a personalized, systems-based approach that prioritizes balance, testing, and real-world physiology over generic dosing guidelines.

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Cold plunges and ice baths dominate social media, but do they really deliver the best metabolic benefits? In this episode of Revolution Health Radio, Chris Kresser challenges the “colder is better” narrative and explores what the science actually shows about cold exposure. Drawing on clinical research, he explains how brown adipose tissue works, why sustained mild cold exposure activates it more effectively than brief extreme cold, and how this can improve insulin sensitivity, glucose metabolism, and overall metabolic health.

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In this episode of Revolution Health Radio, Chris challenges the conventional focus on sleep duration and makes the case that sleep timing and circadian alignment matter just as much—if not more—than total hours slept. Drawing on new research, he explains how circadian disruption underlies poor sleep quality, chronic fatigue, and a wide range of mental health conditions, even in people who appear to be doing everything “right.” He explains why light exposure, sleep-wake consistency, and meal timing are the primary drivers of restorative sleep, why adolescents are uniquely vulnerable to sleep-related mental health risks, and shares practical strategies to improve sleep naturally and when supplements may be helpful.

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In this episode of Revolution Health Radio, Chris examines research confirming that menopause-related brain fog is real, measurable, and reversible. He explains how gray and white matter changes, blood-flow disruption, inflammation, and declining estrogen impact cognitive function during perimenopause and menopause. He also highlights the critical role of the gut microbiome in regulating estrogen metabolism and influencing brain health, and provides listeners with a comprehensive, root-cause approach to improving memory, focus, and clarity through diet, exercise, stress management, sleep, targeted nutrients, and gut-supportive strategies.

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Seed oils have become one of the most controversial topics in nutrition, especially after a 2024 University of South Florida study linked high omega-6 levels with inflammation in colon tumors. In this episode of Revolution Health Radio, Chris takes a deep, evidence-based look at what the study actually means — and what it doesn’t. You’ll learn the crucial difference between naturally occurring omega-6 fats in whole foods like nuts, chicken, and avocados and oxidized omega-6 fats found in ultra-processed foods and industrial seed oils. He explains why awareness of the omega-6 to omega-3 ratio and the issues of the modern Western diet are far more important than demonizing individual oils and offers practical advice on which cooking oils to use, which to limit, how to improve omega-3 intake, and how to adopt a balanced approach to dietary fats without fear or obsession.

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In this episode, Chris explains why obsession with anti-aging hacks may actually undermine our long-term health. He examines the common longevity traps people fall into, which foundational habits truly extend lifespan and health span, and outlines a simple framework for prioritizing what really works. If you’re overwhelmed by conflicting longevity advice, this episode brings clarity, realism, and a grounded path forward.

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