Professor Dame Pamela Shaw is a pioneering Neurologists and a leading figure in tackling motor neurone disease or MND. She is the founder and Director of SITran – the World leading Sheffield Institute for Translational Neuroscience, which is slowly but surely unlocking the secrets of MND and other devastating neurological conditions.

Pam was born in Rothbury, Northumberland, in 1955, and at three moved to Kuwait when her father took up the position of harbour master. She lived there until she was eleven, but with no suitable secondary school available locally, she was sent back to Northumberland to board at Our Lady's Convent High School in Alnwick.

She studied medicine at Newcastle University and began her clinical training in the North-east. Following her appointment as a consultant neurologist she developed an interest in Motor Neurone Disease.

A chance meeting with a recently dignosed MND patient led to Pam founding the Sheffield Institute for Translational Neuroscience in 2010. She was made a Dame in 2014.

Pam lives in Sheffield with her husband Paul. They have a grown-up daughter, Sophie.

DISC ONE: Messiah HWV 56, "Hallelujah Chorus". Composed by George Frideric Händel and performed by The London Philharmonic Orchestra, The London Philharmonic Chorus, conducted by Douglas Gamley DISC TWO: Somethin’ Stupid - Frank Sinatra / Nancy Sinatra DISC THREE: Both Sides Now - Joni Mitchell DISC FOUR: Clarinet Concerto in A Major, K.622: II. Adagio. Composed by Wolfgang Amadeus Mozart and performed by Thea King (clarinet), English Chamber Orchestra, conducted by Alun Francis DISC FIVE: Sweet and Dandy - Toots and the Maytals DISC SIX: The Marriage of Figaro / \"Duettino\" Sull 'Aria. Composed by Wolfgang Amadeus Mozart and performed by Edith Mathis, Gundula Janowitz (sopranos) The Orchestra of Deutsche Oper Berlin, conducted by Karl Böhm DISC SEVEN: Ashokan Farewell - The Band of H.M. Royal Marines DISC EIGHT: The Lucky One - Alison Krauss & Union Station

BOOK CHOICE: Kristin Hannah Collection LUXURY ITEM: Roses CASTAWAY'S FAVOURITE: Clarinet Concerto in A Major, K.622: II. Adagio. Composed by Wolfgang Amadeus Mozart and performed by Thea King (clarinet), English Chamber Orchestra, conducted by Alun Francis

Presenter: Lauren Laverne Producer: Tom Alban

Desert Island Discs has cast away many medical scientists over the years, including Stephen Westaby, Professor Dame Lesley Regan and David Nott. You can hear their programmes if you search through BBC Sounds or our own Desert Island Discs website.

Emma Grede is the businesswoman behind major fashion brands including Skims and Good American, which she co-founded with Kim Kardashian and Khloé Kardashian, respectively. Last year Forbes included her on their list of America's Richest Self-Made Women, with an estimated net worth of $405 million.

She grew up in Plaistow, East London, the eldest of four daughters. Her parents separated when she was five and she was raised by her mum, who worked long hours as a trader at an investment bank. Emma took on a lot of the responsibility at home caring for her sisters. Dyslexia meant she struggled at school, but she found satisfaction in a string of part-time jobs, from delivering newspapers to making sandwiches in a deli. She later dropped out of the London College of Fashion to pursue a career in the industry, and by her mid-twenties she had founded her first company.

She made her name brokering deals between celebrities and brands that included signing Natalie Portman as the face of Dior. In 2016 she founded an inclusive denim brand called Good American with Khloé Kardashian, and in 2019 she launched the shapewear brand Skims with Kim Kardashian.

Lately her success has led her out of the boardroom and into the spotlight with guest appearances on Dragon’s Den, and the US equivalent Shark Tank, as well as launching a podcast and writing a memoir.

Emma lives in Los Angeles with her husband and business partner Jens, and they have four children.

Presenter: Lauren Laverne Producer: Hannah Hufford and Christine Pawlowsky

Desert Island Discs has cast away many fashion leaders to the island over the years including Stella McCartney, Vivienne Westwood and Paul Smith. You can hear their programmes if you search through BBC Sounds or our own Desert Island Discs website.

Sir Roger Deakins is an acclaimed cinematographer who is known for his visual artistry on films including The Shawshank Redemption, 1917, Fargo, Skyfall and Blade Runner 2049. His talents have been acknowledged with a knighthood, five BAFTAs and two Oscars.

Roger was born in Torquay, Devon in 1949. In 1968 he attended the Bath Academy of Art where he was inspired by one of his tutors, the street photographer Roger Mayne, to go out with his camera and capture what he saw. Roger Deakins followed this advice and spent his weekends shooting people and places in British seaside towns.

In 1975 Roger graduated from the National Film School in Beaconsfield and started work as a cameraman – making documentaries and music videos. His first feature film was Cruel Passion which came out in 1977. In 1984 he worked on Michael Radford’s film adaptation of George Orwell’s novel 1984, starring Richard Burton and John Hurt.

The first of Roger’s collaborations with filmmakers Joel and Ethan Coen started in 1991 with the film Barton Fink. The three of them went on to make 12 films together including O Brother, Where Art Thou? Fargo and The Big Lebowski.

In 2018 Roger won his first Academy Award for Blade Runner 2049, directed by Denis Villeneuve. He was knighted for services to film in 2021.

Roger lives in California with his wife James. They also have a home in Devon.

DISC ONE: One of Us Cannot Be Wrong - Leonard Cohen DISC TWO: Aqaba - June Tabor DISC THREE: 21st Century Schizoid Man - King Crimson DISC FOUR: Soldier’s Song - Lucinda Williams DISC FIVE: Bat Out of Hell - Meat Loaf DISC SIX: The Island - Paul Brady DISC SEVEN: Sun Comes Up, It's Tuesday Morning - Cowboy Junkies DISC EIGHT: Isn’t it a Pity - Nina Simone

BOOK CHOICE: Moby Dick by Herman Melville LUXURY ITEM: Fishing tackle CASTAWAY'S FAVOURITE: Aqaba - June Tabor

Presenter: Lauren Laverne Producer: Paula McGinley

Shania Twain is a singer and songwriter and one of only two artists in history to have three consecutive diamond albums.

By the time she was eight years old, she had a repertoire of one hundred songs which she would sing in bars. She began to write her own songs at the age of ten. Her mother was convinced that she was going to be a star and took her to perform in smoky clubs.

Off stage, all was not well in the family home and Shania grew up in a turbulent household where there was much fighting. When she was thirteen years old, she persuaded her mother to drive Shania and her sisters to Toronto to a women’s shelter. Her parents eventually reunited and then were both killed in a car accident when Shania was twenty-two years old. She then became the guardian of her younger siblings and put her music dreams on hold to look after them.

Eventually she got a job in a golf resort singing and came to the attention of a Nashville music executive and was offered a recording contract when she was thirty.

She was enjoying a record-breaking global musical career when disaster struck. She was bitten by a tick and contracted Lyme disease which prevented her from singing for the best part of a decade. She announced her return in 2011 and returned to the stage in 2012.

Shania lives in Switzerland with her second husband.

DISC ONE: We’ve Only Just Begun - Carpenters DISC TWO: Goodbye Yellow Brick Road - Elton John DISC THREE: Dust in the Wind - Kansas DISC FOUR: El Paso - Marty Robbins DISC FIVE: Gabriel’s Oboe - Ennio Morricone DISC SIX: Gentle on my Mind - Glen Campbell DISC SEVEN: Sir Duke - Stevie Wonder DISC EIGHT: Ode to Billie Joe - Bobbie Gentry BOOK CHOICE: Life is Fair by Brian Hines LUXURY ITEM: Insect Repellent CASTAWAY'S FAVOURITE: Dust in the Wind - Kansas

Presenter Lauren Laverne Producer Sarah Taylor

Desert Island Discs has cast other musicians away over the years including Adele, Cher, Kylie Minogue and Cyndi Lauper. You can hear their programmes if you search through BBC Sounds or our own Desert Island Discs website.

Paul Farmer is a charity leader who has spent his life campaigning, fundraising and changing the national conversation around some of the most challenging issues in our society. Currently at the helm of Age UK, he previously spent 16 years as the CEO of Mind, the UK’s largest mental health charity.

Paul was born in Oxford, the son of a former Benedictine monk and a former nun. He read history at St Peter’s College, Oxford, where he met his future wife, Claire. After graduating, he found a role working for a heritage centre and fell in love with the charity sector, moving to the Samaritans. His experiences taking calls from those struggling with their mental health awakened a passion for working in the mental health sector.

In 2006 he moved Mind, where he became CEO. He led a fifteen-year campaign that helped to change legislation, and the national conversation around mental health. For the past few years, he has campaigned for older people as Chief Executive at Age UK, and encouraged the public to prepare and plan for a happier, healthier later life.

Paul lost his wife, Claire, to cancer in 2019. He lives in West London.

DISC ONE: Think - Aretha Franklin DISC TWO: Part of the Agnus Dei from the Mass for Five Voices, performed by The Sixteen with Harry Christophers conducting - William Byrd DISC THREE: Don’t Leave Me This Way - The Communards DISC FOUR: Rotterdam (Or Anywhere) - The Beautiful South DISC FIVE: Feeling Good - Nina Simone DISC SIX: Into My Arms - Nick Cave & The Bad Seeds DISC SEVEN: Drunk Surfer - Westside Cowboy DISC EIGHT: Sunshine on Leith - The Proclaimers

BOOK: A collection of Simon Armitage’s poetry LUXURY: A bowling machine with a combination of cricket and tennis balls CASTAWAY’S FAVOURITE: Sunshine on Leith - The Proclaimers

Presenter: Lauren Laverne Producer: Sarah Taylor and Hannah Hufford

Desert Island Discs has cast away many campaigners to the island over the years including Marjorie Wallace, Julia Cleverdon, and Sue Ryder, Baroness Ryder of Warsaw. You can hear their programmes if you search through BBC Sounds or our own Desert Island Discs website.

Professor Liz Morris is a glaciologist whose work in some of the earth’s most inhospitable environments has broadened humanity’s understanding of climate change and polar science. Her accolades include the prestigious Polar Medal and an OBE for services to Polar Science.

Liz was born in London in 1946 and family legend has it that she fell in love with snow and ice the following year during what was known as the Big Freeze - one of the most severe and punishing winters in British history.

She studied physics at Bristol University and applied for a role at the British Antarctic Survey in the early Seventies. At that time the institute did not have any female scientists working in the field and her application was rejected.

Liz bided her time and eventually did get to work at the BAS, becoming head of the Ice and Climate Division in 1986. The following year she became the first British woman to undertake tent-based research in Antarctica, arriving just as the ozone hole discovery was breaking.

Liz completed her last field trip in 2014. In 2020 the Antarctic Place-Names Committee named a glacier in her honour.

Liz divides her time between the Cotswolds and Scotland.

Presenter: Lauren Laverne Producer: Paula McGinley

Norman Cook is a musician and DJ also widely known as Fatboy Slim.

As a DJ, he has played everywhere from Bondi Beach and the Great Wall of China to the House of Commons and a fish and chip shop. His many accolades include a world record for the most number one singles by one musician in different acts. He has had a number of musical aliases including Pizzaman, Cheeky Boy and Beats International. He was also a member of the Housemartins.

He was christened Quentin by his parents and changed his name to Norman when he embarked on his musical career. His passion for music and collecting records led him down the path of becoming a DJ and his outdoor gigs, particularly in Brighton, saw him play to crowds of over a quarter of a million people.

He has been married twice, his second wife was the DJ and radio presenter, Zoe Ball. Norman lives in Brighton

DISC ONE: The Adventures of Grandmaster Flash on the Wheels of Steel - Grandmaster Flash and the Furious Five DISC TWO: Golden Slumbers / Carry That Weight - The Beatles DISC THREE: Rainbow Connection - The Muppets DISC FOUR: (White Man) in Hammersmith Palais - The Clash DISC FIVE: I Feel Love - Donna Summer DISC SIX: Satisfied ‘N’ Tickled Too - Taj Mahal DISC SEVEN: I Must Be In a Good Place Now - Bobby Charles DISC EIGHT: Born Slippy (Nuxx) - Underworld

BOOK CHOICE: The Ragged Trousered Philanthropists by Robert Tressell LUXURY ITEM: A label maker CASTAWAY'S FAVOURITE: I Feel Love - Donna Summer

Presenter Lauren Laverne Producer Sarah Taylor

Desert Island Discs has cast other musicians away over the years including Norman’s former neighbour Sir Paul McCartney and David Bryne. His former wife, Zoe Ball is in the Desert Island archive along with his former classmate, Prime Minister, Sir Keir Starmer. You can hear their programmes if you search through BBC Sounds or our own Desert Island Discs website.

Jo Nesbø is a writer, known as the king of 'Nordic Noir'. His internationally bestselling crime thrillers following the exploits of detective Harry Hole have been translated into fifty languages, sold over sixty million copies and have been adapted for film and TV.

Being a bestselling author was not his first job. As a teenager, he played football professionally before an injury put paid to his sporting career. He played guitar and wrote songs for a band which then became very successful in Norway and he combined his gigging nightlife with a day job on Norway’s stock market.

His relentless schedule led to him taking time off from both the band and the stock market and whilst he was travelling on a plane to Australia, he wrote his first draft of his debut Harry Hole novel. He has since gone on to write thirteen Harry Hole novels along with children’s stories and other standalone books.

Jo lives in Oslo.

DISC ONE: Perfect Skin - Lloyd Cole and the Commotions DISC TWO: Ticket To Ride - The Beatles DISC THREE: Make Me Smile (Come Up And See Me) - Steve Harley & Cockney Rebel DISC FOUR: I Can’t Be Satisfied – Muddy Waters DISC FIVE: Bus to Baton Rouge - Lucinda Williams DISC SIX: Hand of God - Nick Cave, Warren Ellis DISC SEVEN: Swamp - Talking Heads DISC EIGHT: Independence Day - Bruce Springsteen

BOOK CHOICE: Ham on Rye by Charles Bukowski LUXURY ITEM: A shoehorn CASTAWAY'S FAVOURITE: Independence Day - Bruce Springsteen

Presenter: Lauren Laverne Producer: Sarah Taylor

Desert Island Discs has cast other writers away over the years including Lee Child, Steven King and Martina Cole. You can hear their programmes if you search through BBC Sounds or our own Desert Island Discs website.

Anna Maxwell Martin is an award-winning actor whose versatility is evident from the breadth of parts she has played in popular television programmes including Motherland, Ludwig and Line of Duty.

Anna was born and brought up in Yorkshire and loved acting and performing from a young age putting on shows with her friends in the cul-de-sac where they all lived. She read history at Liverpool University and then won a place at LAMDA.

She made her professional debut in the Little Foxes at the Donmar Warehouse directed by Marianne Elliott. Her breakthrough came in 2003 playing Lyra Belacqua in the National Theatre’s landmark production of His Dark Materials.

In recent years she has become an advocate for vulnerable children and their families – especially those navigating the SEND – special educational needs and/or disabilities – system in schools. She was motivated to take on this role after struggling to get help for her daughters who were struggling with profound grief following the death of their father.

Anna lives in London with her daughters.

DISC ONE: I Love To Boogie – T. Rex DISC TWO: The Greatest Love of All - Whitney Houston DISC THREE: Together In Electric Dreams - Philip Oakey & Giorgio Moroder DISC FOUR: Gianni Schicchi: "O mio babbino caro" (Lauretta) Composed by Giacomo Puccini and performed by Maria Callas (soprano) and Philharmonia Orchestra, conducted by Tullio Serafin DISC FIVE: When A Knight Won His Spurs – The Choir of Salisbury Cathedral, directed by David Halls DISC SIX: Dry Your Eyes - The Streets DISC SEVEN: Ain't No Mountain High Enough - Marvin Gaye, Tammi Terrell DISC EIGHT: Tell Him - Lauryn Hill

BOOK CHOICE: Jackson Brodie Series by Kate Atkinson LUXURY ITEM: Anna’s lucky conker CASTAWAY'S FAVOURITE: The Greatest Love of All - Whitney Houston

Presenter: Lauren Laverne Producer: Paula McGinley

Desert Island Discs has cast away many actors to the island over the years including Julie Walters, Jessie Buckley and Adeel Aktar. You can hear their programmes if you search through BBC Sounds or our own Desert Island Discs website.

Peter Layton is a pioneering British glass artist and the founder of London Glassblowing, one of the most influential glass studios and galleries in the United Kingdom. He played a central role in the development of the studio glass movement, helping to establish glass as an artistic medium.

Born in Prague to Jewish parents, he and his family escaped in 1939 and settled in Bradford, where Peter counted the artist David Hockney among his friends. A trip to the United States in the 1960s to teach ceramics led him to his first encounter with glassblowing, and when he returned to the UK he set up a studio called London Glassblowing. Its ethos of collaboration and openness remains the same 50 years after its founding, and members of the public are welcome to see Peter and his colleagues create spectacular pieces of art out of glass.

Peter’s work is influenced by many things: early pieces tackled political issues, and he finds clouds, pebbles and other natural forms particularly inspiring. Peter lives in London with his wife Ann. He has three children and seven grandchildren.

DISC ONE: When I’m Cleaning Windows - George Formby DISC TWO: Kol Nidrei, Op. 4, composed by Max Bruch, performed by Jacqueline du Pré (cello) and Israel Philharmonic Orchestra, conducted by Daniel Barenboim DISC THREE: Take Five - Dave Brubeck DISC FOUR: Blowin’ in the Wind - Bob Dylan DISC FIVE: White Rabbit - Jefferson Airplane DISC SIX: Lute Concerto in D Major, RV 93: II. Largo, composed by Antonio Vivaldi, performed by Paul O'Dette (lute) The Parley of Instruments conducted by Peter Holman DISC SEVEN: Suzanne - Nina Simone DISC EIGHT: Elegy for the Arctic - Ludovico Einaudi

BOOK CHOICE: The Choice by Edith Eger LUXURY ITEM: A solar-powered digital picture frame CASTAWAY'S FAVOURITE: Suzanne - Nina Simone

Presenter: Lauren Laverne Producer: Tim Bano

Desert Island Discs has cast away many artists to the island over the years, including Peter’s friend David Hockney, as well as the sculptor Anthony Gormley and Cornelia Parker. You can hear their programmes if you search through BBC Sounds or our own Desert Island Discs website.

Guy Martin is a television presenter, mechanic and former motorcycle racer. During his career he achieved 17 podium finishes at the Isle of Man TT (Tourist Trophy) Races – one of the most prestigious and dangerous motorcycling events in the world. His television programmes often focus on his daredevil nature and combine two of his greatest loves - engineering and history.

Guy was brought up in the village of Kirmington in North Lincolnshire. When he was five his father, who raced bikes himself, bought him his first motorcycle which he promptly crashed into the rose garden. His father is a mechanic and Guy used to sit and watch him at work in the shed from a young age and at 12 he began working for him at weekends and during school holidays.

Guy’s first race meeting was at Cadwell Park in Lincolnshire when he was 19. Less than a minute into the race he crashed. He was not badly injured but the bike was destroyed in the process. In 2004 he made his debut at the biggest road race of them all – the Isle of Man TT, finishing seventh in the Senior race and winning the Newcomers Trophy.

Guy retired from racing in 2015 after a very bad crash at the Ulster Grand Prix. After that he turned to his bicycle and has taken part in several endurance cycling events, including the Tour Divide, to test his resolve and stamina and fill the adrenaline gap.

Guy lives in Lincolnshire with his wife Sharon, their daughter Dottie and three dogs.

DISC ONE: Bam Ba Lam (Here Comes Daddy) - Alabama 3 DISC TWO: Testify - Rage Against the Machine DISC THREE: Blinded by the Light - The Streets DISC FOUR: Getaway - The Music DISC FIVE: Me and my Monkey - Robbie Williams DISC SIX: Hurt – Johnny Cash DISC SEVEN: The Day is My Enemy - The Prodigy DISC EIGHT: With or Without You - U2

BOOK CHOICE: Stealing Speed by Mat Oxley LUXURY ITEM: The back catalogue of Race Engine Technology magazine CASTAWAY'S FAVOURITE: With or Without You - U2

Presenter: Lauren Laverne Producer: Paula McGinley