This Week in Startups

Jason Calacanis

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.

  • 1 hour 26 minutes
    Will OpenAI Tank OpenClaw? | E2251

    Will OpenAI Tank OpenClaw? | E2251

    This Week In Startups is made possible by:

    Northwest Registered Agent - https://www.northwestregisteredagent.com/twist

    Lemon IO - https://lemon.io/twist

    LinkedIn Jobs - http://linkedin.com/HiringProOffer


    Today’s show:

    *OpenAI hired OpenClaw creater Peter Steinberger. What does this mean for the future of the AI virtual assistant platform, and what can the OpenClaw community do TODAY to help protect their favorite free, open-source resource?

    Jason and Alex consider the future of OpenClaw alongside guest experts and founders Hiten Shah and Jesse Genet. Plus we’re taking a look at all of their OpenClaw creations. Check out demos of Hiten’s “personal CRM” for busy investors and Jesse’s family media aggregator.

    PLUS we’ve got “AI Scott Adams” creator John Arrow to talk about why he was inspired to create an AI clone of the iconic podcaster and “Dilbert” creator, and why he thinks it has so many internet commenters up in arms.

    Hiten Shahhttps://x.com/hnshahhttps://crazyegg.com

    Jesse Genethttps://x.com/jessegenethttps://Lumi.com

    John Arrowhttps://x.com/johnarrowhttps://www.aiscottadams.com/


    Timestamps:

    (0:00) Introducing our guests Hiten Shah and Jesse Genet!
    (2:27) The panel’s biggest concerns about OpenAI hiring OpenClaw creator Peter Steinberger
    (6:03) Jason gives us his most optimistic and pessimistic OpenAI takes
    (7:58) Why Jason thinks OpenAI will give everyone their own closed-source assistant
    (10:45) Jesse’s Mac Minis now outnumber her children!
    (15:28) What the OpenClaw community can do right now
    (17:08)  Can companies “hijack” OpenClaw via hosting and skills?
    (20:12)  Hiten live-trains an OpenClaw skill based on Jason’s book “Angel”
    (22:37)  How much is everyone spending on tokens anyway?
    (25:56)  How Jesse vibe-coded an app to aggregate non-Slop videos for her family
    (34:19)  Why Jason thinks Jesse’s app is a great potential business
    (37:27)  Hiten built the “personal CRM” busy people have always dreamed of having
    (44:12)  “We’re in an appless world.”
    (45:19) Why markdown files (.md) are perfect for humans and their AI agents
    (52:36)  So why are founders so obsessed with OpenClaw?
    (58:47)  John Arrow, the creator of AI Scott Adams, joins the show
    (1:02:44) How does AI Scott Adams get more like Scott Adams over time?
    (1:04:37)  The legal and ethical considerations around posthumous AI Clones

    17 February 2026, 3:42 am
  • 1 hour 6 minutes
    OpenClaw is Our Friend Now | E2250

    This Week In Startups is made possible by:


    Sentry - http://sentry.io/twist


    Circle - http://Circle.so/twist


    Wispr Flow - https://wisprflow.ai/twist


    Today’s show: 


    What makes OpenClaw feel so much more ALIVE than other AI agents?


    On TWiST, we’re welcoming three amazing builders who are truly connecting with their OpenClaw bots, not just using them for productivity but getting to know them and their personalities on a deeper level.


    Serial entrepreneur Ryan Carson shows us Antfarm, which creates a team of agents with specialized roles, who work together to complete complex tasks.


    THEN David Im shows us Clawra, his AI virtual girlfriend that learns about you and your tastes, and even buys you presents!


    FINALLY, Alex Liteplo presents RentAHuman, a marketplace where bots can pay real people in stablecoins to complete IRL tasks.


    The future may not just be humans and AIs working side by side, but hanging out, being social, and learning from one another as well!


    Timestamps: 


    (0:00) It’s a Friday show with Lon and we’ve got THREE awesome OpenClaw builders


    (6:41) First up, Ryan Carson shows off his open source too, AntFarm


    (7:57) What is a “Ralph Wiggum Loop”?


    (10:54) Sentry - New users can get $240 in free credits when they go to http://sentry.io/twist and use the code TWIST


    (17:14) NOTI Q: What about security?!


    (18:13) David Im shows us his AI virtual girlfriend, Clawra


    (19:21) Circle.so -  the easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off the Circle Plus Plan by going to http://Circle.so/twist


    (20:33) Introducing your IRL girlfriend to your AI girlfriend


    (23:23) How to program an AI companion


    (28:26) Should Clawra be a best pal instead of a GF?


    (32:38) Wispr Flow: Stop typing. Dictate with Wispr Flow and send clean, final-draft writing in seconds. Visit https://wisprflow.ai/twist to get started for free today.


    (33:54) Jason’s Productivity Hack of the Month


    (36:17) Alex Liteplo shows us RentAHuman, where AI agents can hire real people


    (38:22) What are the bots hiring people to do, exactly?


    (50:02) Why robots might be better bosses than people…


    (50:51) Hiring 100 goth girls to hold signs in Times Square


    (55:25) OFF DUTY! Norwegian skier breaks down on live TV


    (58:01) Lon’s fav Best Picture nominees


    (59:08) Why Apple acquired “Severance.” 


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com/


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    Follow Lon:


    X: https://x.com/lons


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    Follow Alex:


    X: https://x.com/alex


    LinkedIn: https://www.linkedin.com/in/alexwilhelm/


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    X: https://twitter.com/Jason


    LinkedIn: https://www.linkedin.com/in/jasoncalacanis/


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    Thank you to our partners:


    (10:54) Sentry - New users can get $240 in free credits when they go to http://sentry.io/twist and use the code TWIST


    (19:21) Circle.so -  the easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off the Circle Plus Plan by going to http://Circle.so/twist


    (32:38) Wispr Flow: Stop typing. Dictate with Wispr Flow and send clean, final-draft writing in seconds. Visit https://wisprflow.ai/twist to get started for free today.


    Check out all our partner offers: https://partners.launch.co/

    14 February 2026, 2:52 am
  • 40 minutes 27 seconds
    Why J-Cal Invested to 200K in a former Employee | E2249

    This Week In Startups is made possible by:


    NetSuite - https://www.netsuite.com/twist


    Luma AI - https://lumalabs.ai/twist


    Squarespace - https://squarespace.com/twist


    Today’s show: 


    On today’s epsiode of TWiST, Jason gets pitched by two top founders, Presh Dineshkumar and Peter Cetale! 


    Presh used to work for Jason at Launch! When he left, Jason invested $200K into Presh’s new startup The Wellness Company. Presh pitches Jason on what he has been building, and Jason gives Presh advice for improving the product!


    Peter went through Andreesen Horowitz’s Speedrun accelerator program as CEO and co-founder of Sourcerer. Sourcerer uses AI agents to help US firms and distributors find the best prices for mass produced goods. 


    Check out how Jason digs in with these founders!


    Timestamps:


    (0:00) Presh was originally a TWiST fan who emailed Jason!


    (1:59) Why Jason invested in Presh’s startup


    (3:19) Checking out the Wellness Company’s hot new app, Tempo


    (4:03) How Tempo monitors your health and offers proactive advice with consistency


    (9:10) Why Jason recommends adding a group or family feature to make it stickier


    (9:51) Netsuite - Get the free business guide Demystifying AI at https://www.netsuite.com/twist


    (11:28) The end goal: bringing app advice and guidance into the real world


    (13:34) Presh shares where his apps are finding the most engagement


    (14:13) The key importance of Product Velocity and World-Class Design


    (17:27) Luma AI - Stop guessing and start directing with Ray3 Modify from Luma AI, the AI-powered post-production tool. Explore it at: https://lumalabs.ai/twist


    (18:38) Introducing Peter Cetale and Sourcerer!


    (19:32) How Sourcerer uses AI to help distributors and manufacturers automate their sourcing


    (22:48) How Sourcerer manages to actually bring costs down


    (25:02) Lining up REAL customers, not Letters of Intent (aka Letters of Nothing)


    (26:04) Peter’s experiences in a16z’s Speedrun accelerator


    (28:08) Working with agents on BOTH the supply and demand side


    (29:16) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://squarespace.com/twist


    (30:32) How has Tariff Mania impacted Peter’s business?


    (35:35) Why Peter thinks startups will keep getting leaner and compute will keep getting cheaper


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    Follow Lon:


    X: https://x.com/lons


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    Follow Alex:


    X: https://x.com/alex


    LinkedIn: https://www.linkedin.com/in/alexwilhelm/


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    Follow Jason:


    X: https://twitter.com/Jason


    LinkedIn: https://www.linkedin.com/in/jasoncalacanis/


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    Thank you to our partners:


    (9:51) Netsuite - Get the free business guide Demystifying AI at https://www.netsuite.com/twist


    (17:27) Luma AI - Stop guessing and start directing with Ray3 Modify from Luma AI, the AI-powered post-production tool. Explore it at: https://lumalabs.ai/twist


    (29:16) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://squarespace.com/twist


    Check out all our partner offers: https://partners.launch.co/

    12 February 2026, 11:50 pm
  • 45 minutes 4 seconds
    How These 3 Founders are building on Open Claw | E2248

    This Week In Startups is made possible by:


    Hubspot - http://clickhubspot.com/twist2


    Deel - http://deel.com/twist


    Iru - http://www.iru.com/


    Today’s show: 


    Today on TWiST we’re joined by 3 founders building on Open Claw,  Presh Dineshkumar, Vishnu, and Sean Liu!


    First, long time friend of the pod, Presh Dineshkumar, shows us how he’s using Open Claw to automate his work at The Wellness Company. His Open Claw agent, Eywa, lives in his email and in his product, able to compile user lists at his discretion.


    Then, we’re joined by Vishnu, who brings Open Claw to the masses. Non-technical folks, it’s your lucky day! Time to get Clawd-shotted! Last, Sean Liu joins the show to tell us about how he’s connecting Meta glasses to his Open Claw instance to interact with context that users can physically see!


    Timestamps:


    (0:00) We’re joined by Presh Dineshkumar of the Wellness Company, another OpenClaw fanatic


    (1:50) We meet Presh’s Replicant — Eywa — who spies on all of his emails


    (2:53) How Eywa is helping Presh keep track of his app’s most active users


    (4:35) LLMs have become very smart but they are trapped in the corner


    (6:10) How Presh gave Eywa its own email address and avoids prompt injections


    (8:56) Using Presh’s Replicant to do daily research dives


    (10:40) Hubspot: Check out the guide “Advanced ChatGPT Prompt Engineering: From Basic to Expert in 7 Days.” Download it for free at http://clickhubspot.com/twist2


    (13:21) Presh also has Eywa hunting down and fix bugs in his apps, all from email


    (16:16) Way more startups can be profitable now that they don’t need 10+ person teams


    (19:15) Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit http://deel.com/twist to learn more.


    (20:36) We’re joined by two more OpenClaw builders: Vishnu and Xiaoan (Sean) Liu


    (21:16) Sean hooked his Meta Ray Bans up to his OpenClaw!


    (29:53) Iru unifies identity, endpoint security, and compliance into one platform. Book a demo at http://iru.com/


    (31:05) Some dystopian thoughts on how to use VisionClaw technology


    (32:47) What kinds of startups will get the most value out of OpenClaw?


    (34:43) Why Vishnu made a product to simplify OpenClaw set-up and security


    (37:34) What inspires people to stop considering OpenClaw and go “all in” on the tech


    (40:17) Will Vishnu and Sean quit their jobs and take Jason’s investment $125K investment deal… YES


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com/


    Check out the TWIST500: https://twist500.com


    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


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    Follow Lon:


    X: https://x.com/lons


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    Follow Alex:


    X: https://x.com/alex


    LinkedIn: https://www.linkedin.com/in/alexwilhelm/


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    Follow Jason:


    X: https://twitter.com/Jason


    LinkedIn: https://www.linkedin.com/in/jasoncalacanis/


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    Thank you to our partners:


    (10:40) Hubspot: Check out the guide “Advanced ChatGPT Prompt Engineering: From Basic to Expert in 7 Days.” Download it for free at http://clickhubspot.com/twist2


    (19:15) Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit http://deel.com/twist to learn more.


    (29:53) Iru unifies identity, endpoint security, and compliance into one platform. Book a demo at http://iru.com/


    Check out all our partner offers: https://partners.launch.co/

    12 February 2026, 1:32 am
  • 1 hour 7 minutes
    Does Clawdbot (OpenClaw) Need Eyes? (feat. Alex Finn and Matt Van Horn) | E2247

    This Week In Startups is made possible by:


    LinkedIn - http://linkedin.com/twist


    Every.io - http://every.io/


    Northwest registered Agent - www.northwestregisteredagent.com/twist


    Today’s show: 


    Sean Liu gave his OpenClaw “eyes” by hooking the AI assistant up to his Meta Ray Bans. While Jason and Alex consider the implications… guest expert Alex Finn quickly loses interest…


    It’s another All-Clawdbot TWiST where we debate the most essential uses for the viral agent platform. For their part, Alex Finn and Matt Van Horn are building practical skills to help founders (esp. solo founders)… Alex has a brain trust of AI agents working round the clock to improve his organization and content, while Matt designed a skill for his agent to order sushi lunches (keeping them under $20).


    PLUS find out how Producer Oliver designed his “Model Council” based on Perplexity’s set-up, why running everything local is “illogical” for most people in 2026, AND why Jason’s next Founder U cohort will all be building with OpenClaw.


    Timestamps: 

    (00:00) Why Jason is STILL Claw-pilled! We can’t get enough!

    (03:17) “Mr. Clawdbot” Alex Finn of Creator Buddy joins us! He’s Claw-Pilled too!

    (04:50) Sean Liu (@_seanliu) added OpenClaw to his Meta Ray Bans… Here’s why Alex doesn’t care!

    (8:33) Lost your job to AI? Maybe AI can make you a founder!

    (12:35) LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at http://linkedin.com/twist Terms and conditions apply.

    (13:34) “Last 30 Days” skill creator Matt Van Horn (@mvanhorn) joins the show

    (14:54) Why Jason wants to invest in Matt’s new project.

    (15:53) Meeting Alex’s organization of AI agents who collaborate on his projects autonomously

    (22:28) Is Alex planning to turn his OpenClaw set-up into a company? Maybe…

    (23:10) Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit http://every.io/

    (25:16) Using OpenClaw to create a “lights out” startup

    (28:17) Deciding when to use local models vs. more powerful cloud-based models

    (29:52) Northwest Registered Agent. Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at www.northwestregisteredagent.com/twist

    (30:58) How Producer Oliver created a “Model Council” for LAUNCH based on Perplexity’s set-up

    (35:52) Why it’s so important to have an orchestrator that knows the right model for the right task

    (39:12) Why running everything local is “illogical” for most companies in 2026

    (41:15) Matt walks us through the latest and greatest incarnation of his “Last 30 Days” skill

    (45:57) Why Jason thinks recursive machine learning is the solution to human laziness

    (46:38) How Alex has supercharged his social media and his startup during OpenClaw Mania

    (50:15) Why Founder University is going ALL OPENCLAW next cohort

    (51:21) How big a jump over Opus 4.5 is Opus 4.6?

    (53:35) OpenClaw’s going to start scanning skills for malware… Will this help?

    (57:13) No one was SUPER impressed by the AI dot com Super Bowl ad… except JCal

    (1:01:11) Matt used his “Order Sushi” OpenClaw skill live on the show to get lunch

    (1:04:08) Polymarket’s sharps are wagering on Claude 5’s hotly anticipated release


    Thank you to our partners:

    (12:35) LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at http://linkedin.com/twist Terms and conditions apply.

    (23:10) Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit http://every.io/

    (29:52) Northwest Registered Agent. Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at www.northwestregisteredagent.com/twist


    Check out all our partner offers: https://partners.launch.co/

    10 February 2026, 12:24 am
  • 1 hour 10 minutes
    We built OpenClaw Ultron to replace 20 people at our company | E2246

    This Week In Startups is made possible by:


    Crusoe Cloud - https://crusoe.ai/savings


    Lemon IO - https://Lemon.io/twist


    Northwest Registered Agent - https://www.northwestregisteredagent.com/twist


    Thanks to our guests:


    Alex Cheema of ExoLabs http://exolabs.net


    Ryan Yanneli of NextVisit https://nextvisit.ai/


    Today’s show: 


    It’s the Age of Ultron at TWiST and LAUNCH. We’ve given our OpenClaw digital Replicants the keys to all of our systems and we’re seeing how much of our jobs they can really do when left to their own devices.


    Producer Oliver stops by the show to give us a peek behind the curtain, at the new control panel and dashboard OpenClaw built FOR ITSELF (with a bit of human assistance).


    PLUS we’re joined by Alex Cheema of ExoLabs. His company helps everyday consumers run powerful frontier LLMs on their own devices, essential to protect your data and personalize your AI experience.


    ALSO congratulations to Ryan Yanneli from NextVisit on winning our Gamma Pitch Deck Competition! He walks away with $25K from LAUNCH and our friends at Gamma.


    Timestamps:


    (00:00) Introducing Alex Cheema to the show


    (3:17) Why it is so important to run AI on local hardware


    (6:58) Using OpenClaw Producer to automate TWiST


    (8:59) How to Train your AI


    (11:58) What is a Chron Job? (Hint: chron means chronological)


    (13:24) Crusoe Cloud: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit https://crusoe.ai/savings to reserve your capacity for the latest GPUs today.


    (17:53) OpenClaw managing the LAUNCH/TWiST team


    (19:54)  Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist


    (20:58) Turning AI into Ultron, self optimization


    (27:21) The Future: frontier models: running on your Iphone!


    (28:37) Prompt injections: how people can hack your OpenClaw


    (30:25) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at https://www.northwestregisteredagent.com/twist


    (31:31) OpenClaw invites guests that join the show


    (40:29) Oliver shows off OpenClaw mission control dashboard


    (46:30) Stacking Apple Silicon vs. Running Kimi-K


    (50:18) How Exo Labs works — stringing together Mac Silicon


    (54:29) Ryan from Nextvisit wins Gamma Pitch Competition


    (59:10) Industry Season 4 reflects tech regulation


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    Check out the TWIST500: https://www.twist500.com


    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


    *


    Follow Lon:


    X: https://x.com/lons


    *


    Follow Alex:


    X: https://x.com/alex


    LinkedIn: https://www.linkedin.com/in/alexwilhelm/


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    Follow Jason:


    X: https://twitter.com/Jason


    LinkedIn: https://www.linkedin.com/in/jasoncalacanis/


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    Thank you to our partners:


    (13:24) Crusoe Cloud: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit https://crusoe.ai/savings to reserve your capacity for the latest GPUs today.


    (19:54)  Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist


    (30:25) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at https://www.northwestregisteredagent.com/twist


    Check out all our partner offers: https://partners.launch.co/

    7 February 2026, 12:22 am
  • 53 minutes 41 seconds
    Savvy is HQ Trivia + Wordle (feat. Scott Rogowsky) | E2245

    This Week In Startups is made possible by:


    Circle - http://Circle.so/twist


    Caldera Lab - http://calderalab.com/TWIST


    LinkedIn - http://linkedin.com/twist


    Today’s show: 


    There was a time, not long ago, when offices everywhere came to a standstill, and everyone became even more fixated on their phones than usual, each time HQ Trivia went live. The app-based game show was a massive viral hit… until suddenly, around a year later, it wasn’t.


    Now, HQ Trivia host Scott Rogowsky is back with a new concept: Savvy, another game show you play on your phone, this time inspired by the word puzzle hit Wordle. Is lightning about to strike twice? 


    PLUS, Alex chats with Trevor Bennett of space transportation outfit Starfish Space. This comes off two major successes for the team: the Remora mission that proved Stafish’s autonomous rendezvous capabilities and the $52.5 Million dollar contract to dispose of low Earth orbit satellites.


    Timestamps: 


    (00:00) How Scott first got involved with HQ Trivia


    (2:23) Why Scott thinks HQ Trivia struck such a chord with fans


    (4:12) Scott couldn’t get a job in late night, so he made his own show


    (5:31) Delving into the behind-the-scenes tensions at HQ Trivia


    (11:07) Circle -  the easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off the Circle Plus Plan by going to http://Circle.so/twist


    (13:53) The end of HQ Trivia and why Scott jumped ship


    (16:35) Savvy just had its series premiere: you play the game against the host


    (20:14) How to play Savvy and win cash


    (20:57) Why Jason thinks a subscription model is the future of Savvy


    (22:25) Whether you’re starting fresh or upgrading your routine, Caldera Lab makes skincare simple and effective. Head to http://calderalab.com/TWIST and use TWIST at checkout for 20% off your first order.


    (23:31) Introducing Dr. Trevor Bennet of Starfish Space


    (24:04) What the Otter Spacecraft does: de-orbiting to clean up space


    (26:46) Why space will need hundreds of Otters in space


    (29:24) LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at http://linkedin.com/twist Terms and conditions apply.


    (30:23) Starfish Space’s business model: operating a starfleet


    (33:17) The success of the Remora mission: autonomous rendezvous in space.


    (43:47) The rise of the space economy


    (48:18) Starfish’s $52.5 Million dollar contract and what it means for the space ecosystem


    *


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com/


    Check out the TWIST500: https://twist500.com


    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


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    Follow Lon:


    X: https://x.com/lons


    *


    Follow Alex:


    X: https://x.com/alex


    LinkedIn: https://www.linkedin.com/in/alexwilhelm/


    *


    Follow Jason:


    X: https://twitter.com/Jason


    LinkedIn: https://www.linkedin.com/in/jasoncalacanis/


    *


    Thank you to our partners:


    (11:07) Circle -  the easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off the Circle Plus Plan by going to http://Circle.so/twist


    (22:25) Whether you’re starting fresh or upgrading your routine, Caldera Lab makes skincare simple and effective. Head to http://calderalab.com/TWIST) and use TWIST at checkout for 20% off your first order.


    (29:24) LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at http://linkedin.com/twist Terms and conditions apply.


    Check out all our partner offers: https://partners.launch.com

    4 February 2026, 11:55 pm
  • 1 hour 7 minutes
    Where early-stage founders MUST focus to success | E2244

    This Week In Startups is made possible by:


    Quadratic - http://quadratic.ai/twist


    Today’s show: 


    Don’t get distracted! Here are the MOST CRUCIAL aspects of running a startup, where founders need to keep their full and uninterrupted focus.


    - Make sure you’re saving up your cash

    - Why you need to just get started and build SOMETHING

    - Trust and reliability is EVERYTHING for new products

    - Why distribution should be your top priority


    Download all this practical and tactical startup advice from seasoned veterans Jason Calacanis, Amanda Bradford, and William P. Barnes in this Tokyo edition of TWiST.


    Timestamps:


    (00:00) Amanda and Will’s big takeaways from Founder U in Saudi Arabia and now Tokyo


    (3:19) Why cash flow management is so important before you find PMF


    (5:57) Why first-time founders get the order of operations wrong


    (6:45) Just build SOMETHING, even if it’s taped together


    (11:19) “Focus is everything in the early stages”


    (14:17) From a wedge to a bridge


    (15:50) Quadratic - Bringing the productivity boost of AI into your spreadsheets. Visit http://quadratic.ai/twist to sign up and use the code TWIST to get one free month of their pro tier subscription.


    (18:45) What to put on your “Not Right Now” list


    (19:11) Embracing simplicity


    (22:00) The importance of trust and reliability (especially for Uber!)


    (28:12) Why innovation needs a constraining variable


    (33:40) To really drive word of mouth, you have to overdeliver


    (36:32) Distribution is the primary job of a founder/CEO


    (38:19) Some of the panel’s favorite distribution hacks


    (45:54) Why Jason respects Japan’s commitment to excellence and competency


    (49:38) Looking for “high slope” in early employees


    (53:11) Transitioning your team from early-stage startup to growth


    (57:45) Whoever writes it down gets credit for the idea


    (58:04) Q: Has the meaning of money changed for the panel now that they’ve had successful exits?


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    3 February 2026, 9:52 pm
  • 1 hour 2 minutes
    SpaceX + xAI deal gets us one step closer to Musk Industries | E2243

    This Week In Startups is made possible by:


    Uber - http://uber.com/twist


    Deel - http://deel.com/twist


    Northwest Registered Agent - https://www.northwestregisteredagent.com/twist


    Today’s show: 


    SpaceX is buying xAI, forming a mega-corp that plans to launch data centers into SPACE. Will Tesla also join up, fulfilling Elon’s destiny to become real-life Tony Stark, with his own Musk Industries? Jason and Alex break down the future of SpaceXAI in a breaking news report.


    THEN, we’re still celebrating OpenClaw (née Clawdbot) Mania! Oliver and Lukas return to TWiST to share their Almost Top 10 (okay it’s just a Top 6) favorite Skills so far. 


    Learn how they’re using Replicants to summarize TWiST episodes, surf Reddit, produce original Gamma decks, train agents to make themselves smarter, and take care of LAUNCH’s administrative and operations tasks.


    Timestamps:


    (00:00) BREAKING: SpaceX bought xAI!


     (1:56) Why it will be cheaper to generate compute in space than here on Earth


    (8:19) Will Tesla eventually join the club, forming “Musk Industries”?


    (11:36) Uber AI Solutions - Your trusted partner to get AI to work in the real world. Book a demo with them TODAY at http://uber.com/twist


    (12:37) ALSO BREAKING: We’re still obsessing about Clawdbot/OpenClaw


    (14:58) So is OpenClaw and all of its various skills secure yet? NO.


    (16:42) Today we’re looking at our picks for the Top 6 OpenClaw skills


    (17:13) Alex’s first pick: Reddit (read only), which makes it easier to track down what you want on the aggregator


    (19:35) Reddit hates bots! But maybe they’ll change their tune?


    (21:47) Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit http://deel.com/twist to learn more.


    (22:46) Our Replicant summarized the last few episodes of TWiST… but at what COST? (18 cents)


    (26:40) Lukas taught our Replicant to make Gamma decks for us


    (29:23) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at https://www.northwestregisteredagent.com/twist


    (30:21) Our Replicant has ALL the Polymarket data now! The power!


    (34:14) AI agents are also playing cards together on ClawPoker


    (35:07) Oliver tested out our pal Matt Van Horn’s (@mvanhorn) self-improving “Last 30 Days” skill


    (38:22) Why memory is so crucial for getting models to improve themselves over time


    (40:33) Yo dawg I know you like monitoring tasks so I built you a task monitor that monitors your tasks so you can task monitor your tasks


    (41:40) What makes OpenClaw so powerful is also what makes it dangerous!


    (49:12) If you want to really learn about OpenClaw, you need to make your own skills


    (50:03) Jason’s advice for OpenClaw’s suddenly famous creator: Peter Steinberger (@steipete)


    (56:31) What would be the best way(s) to monetize OpenClaw?


    (57:54) Will an OpenClaw agent sue a human in court?


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    (11:36) Uber AI Solutions - Your trusted partner to get AI to work in the real world. Book a demo with them TODAY at http://uber.com/twist


    (21:47) Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit http://deel.com/twist to learn more.


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    Check out all our partner offers: https://partners.launch.co/

    3 February 2026, 3:19 am
  • 1 hour 28 minutes
    How OpenClaw (Clawdbot) Is Rewriting the Way Our Team Works with Rahul Sood | E2242

    This Week In Startups is made possible by:

    Deel - http://deel.com/twist

    LinkedIn Jobs - http://linkedin.com/twist

    Northwest Registered Agent - https://www.northwestregisteredagent.com/twist


    Today’s show: 


    On Today’s action packed episode of This Week in Startups, our team is going full AI!


    Jason is joined by Oliver Korzen and Lukas Durand from the LAUNCH team, alongside Rahul Sood, founder/CEO of Irrevernt Labs and founder of Voodoo PC.


    With the rise of Clawdbot/Moltbot, the question on everyone’s mind is how fast, how much and how safe! Lukas and Oliver show off the ways that This Week in Startups are automating the hours of research and administrative tasks that take up our days and the what this means for running a podcast and venture firm.


    Timestamps:


    (00:00) Why we’re so obsessed with OpenClaw (Clawdbot)


    (00:47) LAUNCH’s own Lukas Durand has joined the pod for the first time… Here’s how he and Jason met…


    (02:26) Oliver is also here… check out his new series, This Week in AI


    (03:11)How LAUNCH has its OpenClaw bot set up (without all the details!!!)


    (06:03) The first few services that LAUNCH authenticated with our OpenClaw… And why!


    (6:59) How OpenClaw is helping Oliver to book the show


    (11:06) Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit http://deel.com/twist to learn more.


    (14:08) Why OpenClaw sometimes struggles with context and memory, and how to work around it


    (16:03) Understanding how to set up “cron jobs”


    (20:19) LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at http://linkedin.com/twist That’s http://linkedin.com/twist. Terms and conditions apply.


    (22:23) How OpenClaw works as our virtual podcast producer, and how much time we’ll save


    (24:40) Can OpenClaw also help us prep the podcast agenda (aka THE DOCKET)?


    (28:32) Lon chimes in to talk about how Claude helped him prep Jason’s Davos interviews


    (31:30) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at www.northwestregisteredagent.com/twist


    (32:28) How many “Replicants” or AI agents does one company really need?


    (36:09) Why Jason asked his OpenClaw bots to self-report on what they’re learning


    (37:14) What OpenClaw WON’T do… Where did these guardrails come from?


    (39:44)The hardware side… How much of this can you do from a Mac Studio?


    (43:29) Zombie Staffers: How OpenClaw can “revive” long-lost employees…


    (48:09) We’re putting OpenClaw in charge of the TWiST 500


    (51:18) Rahul Sood joins us to talk about the dangers of OpenClaw and how to stay protected


    (53:01) Why so many OpenClaw skills have major vulnerabilities


    (1:00:00) Moltbook: Where bots hang out with other bots and share info


    (1:06:44) Why powerful AI agents will make creative work by humans so much more important.


    (1:07:22) Rahul’s final recommendations for max possible OpenClaw security


    (1:14:00) Is OpenClaw going to bring hiring to a halt?


    (1:21:10) Why getting comfortable with AI tools will become essential for every employee


    Thank you to our partners:

    (11:06) Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit http://deel.com/twist to learn more.


    (20:19) LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at http://linkedin.com/twist That’s http://linkedin.com/twist. Terms and conditions apply.

    (31:30) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at www.northwestregisteredagent.com/twist

    Check out all our partner offers: https://partners.launch.co/

    31 January 2026, 2:18 am
  • 55 minutes 31 seconds
    How decriminalization led to an explosion in cannabis startups (Feat. Ford Smith, Andrew Duffy, and Socrates Rosenfeld) | E2241

    This Week In Startups is made possible by:


    Gusto - http://Gusto.com/twist


    Zite - http://zite.com/twist


    Circle.so - http://circle.so/twist


    Guest links: 


    Andrew Duffy, Founder and CEO, http://sparkplug.app — Retail incentives and brand partnerships platform


    Ford Smith, Founder of http://Ultranative.com — Investing in transformative startups


    Socrates Rosenfeld, Founder and CEO of http://iheartjane.com — One stop shop for cannabis products


    Today’s show: 


    On TWiST’s first Cannabis Roundtable, Jason is joined by three top Cannabis founders and investors: Ford Smith of Ultranative, Andrew Duffy of Sparkplug, and Socrates Rosenfeld of Jane.


    How will the regulatory environment and the move to Schedule III change the industry? Are those regulations shaping consumption? How are investors thinking about cannabis startups given the difficulty with exits? Most importantly, what’s the deal with the increasing potency of cannabis?


    Each guest has their own perspective, Andrew sees it as a natural reaction from CPG brands to power users, Ford points to “flyover” operators unconcerned with long-term health of the industry, while Socrates refers to moonshine drinking during the prohibition to say that regulations create these problems.


    Speaking of moonshine, alcohol consumption is dropping dramatically among Gen-Z, with many pointing to cannabis consumption as a substitute. Some perceive cannabis as healthier and lacking caloric nature of alcohol, which could explain why there are now more daily smokers than daily drinkers!


    Timestamps:


    (0:00) Guest Introductions for the Cannabis Roundtable!


    (2:50) Why Jason invested in Sparkplug


    (6:44) How Ford Smith got into Cannabis investing — is it Cannabis a good investment?


    (11:40) Gusto - Check out the online payroll and benefits experts with software built specifically for small business and startups. Try Gusto today and get three months FREE at http://Gusto.com/twist.


    (12:46) Socrates breaks down building a major cannabis marketplace


    (18:13) Canadian legalization and tailwinds for cannabis.


    (20:25) How Cannabis startups are pivoting to deal with high competition and regulatory pressure


    (21:47) Zite - Zite is the fastest way to build business software with AI. Go to http://zite.com/twist to get started.


    (27:07) Who benefits from legalization of cannabis? Healthcare? Retail? Banking?


    (28:03) How the alcohol industry is getting crushed by cannabis usage


    (31:27) Circle.so -  The easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off Circle’s Professional Plan by going to http://circle.so/twist.


    (32:47) Is new cannabis too potent? Is high potency cannabis a result of illegal rules.


    (42:05) Why heavy consumers are driving CPG startups to high doses


    (44:14) Cannabis psychosis and the problem with brands selling potency items.


    *


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    (11:40) Gusto - Check out the online payroll and benefits experts with software built specifically for small business and startups. Try Gusto today and get three months FREE at http://Gusto.com/twist.


    (21:47) Zite - Zite is the fastest way to build business software with AI. Go to http://zite.com/twist to get started.


    (31:27) Circle.so -  The easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off Circle’s Professional Plan by going to http://circle.so/twist.


    Check out all our partner offers: https://partners.launch.co/

    29 January 2026, 1:30 am
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