Harry Destecroix was studying for his PhD at Bristol University when he co-founded Ziylo. Based on 20 years of Bristol chemistry research, the spin-out company created a new technology that can be developed to treat diabetes more effectively. It's a breakthrough that led to its acquisition by pharmaceutical firm, Novo Nordisk, in a deal reportedly worth up to 600 million pounds. Harry has also founded the incubator, Science Creates and is the founding managing partner of SCVC, a venture capital firm. Harry tells Evan Davis why his own experience of spinning out a company has made him passionate to help other early-stage companies in the Bristol area – whether that’s providing lab space, finance or advice.

(Image: Harry Destecroix Credit: Peter Schiazza, Copyright: Science Creates)

Sophie Mirman was thrown in at the deep end when – at the age of 13 – she was in a car accident with her parents. They were both badly injured and, a few years later, Sophie felt she had to find a way to help the family finances.

She started as a very junior secretary in M&S, applied for jobs she says she wasn’t qualified for, and went on to hold the top jobs at Tie Rack, SockShop and Trotters.

She discusses the all-consuming nature of expanding outside the UK and how her more cautious approach these days is, ultimately, more enjoyable.

Producer: Sally Abrahams Editor: Matt Willis Sound: Jackie Margerum Production co-ordinator: Katie Morrison

(Image: Sophie Mirman. Credit: Pylewell)

When Jesper Brodin landed a job as IKEA’s purchase manager in Pakistan, he was only 26. And had no idea he was the only applicant. He’s now spent 30 years with the iconic Swedish brand - since 2017, as CEO of Ingka Group, which runs most IKEA stores. During that time, he’s led two major transformations - taking the company digital and making it more eco-friendly. Now, as he steps down from his role, he tells Evan Davis about the lessons he learned from IKEA’s legendary founder, Ingvar Kamprad. And why he’s planning to buy himself a new guitar.

(Image: Jesper Brodin. Credit: JOEL SAGET/AFP via Getty Images)

Heather Vernon never expected to become an entrepreneur. Her goal after university was to become a teacher, through the Teach First graduate programme - two years of intense learning on the job, schooling disadvantaged children in low income communities. It taught her resilience and prompted a move into politics, initially at a local level, then a job with the Labour party, advising members of the then shadow cabinet. She tells Evan Davis why working at Westminster was initially terrifying and what encouraged her to set up a PR business with a friend.

(Image: Heather Vernon Credit: Woburn Partners)

Three business leaders tackle fictional dilemmas that test their instincts, experience and nerves. To make it more realistic, none of the guests have any idea what the scenarios are in advance.

Guests: Ben Branson, Founder, Seedlip and Sylva Sophie Mermin, Founder, Trotters Childrenswear Margaret Heffernan, former CEO, entrepreneur, author and professor of practice at the university of Bath school of management

Production team: Presenter: Evan Davis Producer: Sally Abrahams Production co-ordinator: Katie Morrison Sound: Nathan Chamberlain and Gareth Jones Editor: Matt Willis

Productivity drives prosperity, yet the UK continues to lag behind countries like the US, France and Germany. We work harder, yet produce less than our peers. In this episode, Evan Davis and guests discuss what productivity really looks like in practice – from offices and factories to call centres and operating theatres. And ask whether AI could be the boost Britain's economy needs.

Guests: Katy Davies, Managing Director, Cap Air Systems Louise Stead, Group Chief Executive, Royal Surrey and Ashford and St Peter’s NHS Foundation Trusts Sameer Vuyyuru, Chief AI and Product Officer, Capita

Production team: Presenter: Evan Davis Producer: Sally Abrahams Production Co-ordinator: Katie Morrison Sound engineers: Dafydd Evans and Duncan Hannant Editor: Justine Lang

Do you ever feel the world is stacked in favour of the extrovert people – the most gregarious, the most outwardly confident, the perhaps sometimes sharp-elbowed, the loudest? What can natural introverts do to try and level the playing field and create a positive impression? Evan Davis asks Richard Etienne from the Introvert Space, Clare Farthing from South Somerset meet ups and Heather Vernon, co-founder of Woburn Partners. Produced by Bob Howard.

Once known as “personnel”, Human Resources seems to have become a real centre of power in modern business. No longer just handing out payslips or organising the Christmas party, HR now shapes company culture, influences major decisions and – some say – acts as a kind of corporate police force and judiciary. The profession has doubled in size over the past two decades and grown in authority. How did it rise so fast and what does its growing influence mean for the workplace? Evan Davis and guests discuss how HR seemingly took control of the corporate agenda and ask whether company bosses have delegated too much power to a profession that comes with its own code of values and priorities.

Guests: Neil Morrison, HR Director, Severn Trent Nicole Whittaker, Associate Director of HR Consultancy, Peninsula Pamela Dow, Co-founder and Chief Operating Officer, Civic Future

Production team: Presenter: Evan Davis Producer: Sally Abrahams Production Co-ordinator: Rosie Strawbridge Sound: Pat Sissons and Duncan Hannant Editor: Matt Willis

Can chaos ever be good for business? From Donald Trump’s unpredictable tariff policies to Elon Musk’s disruptive leadership style, some of the world’s most high-profile figures seem to thrive on disorder. But does chaos drive innovation – or just confusion? In a world where start-ups often celebrate mess and speed over tidy management, we ask if “getting things done” sometimes means throwing out the rulebook. Evan Davis and guests discuss whether the best results really come from a bit of chaos.

Guests: Jesper Brodin, CEO, IKEA (Ingka Group) Erin Meyer, Professor at INSEAD and co-author of ‘No Rules Rules’ Simon Dixon, CEO, Hatmill, supply chain and logistics consultancy

Production team: Presenter: Evan Davis Producers: Sally Abrahams, Phoebe Keane, Kirsteen Knight Production co-ordinator: Rosie Strawbridge Sound engineers: Kris Hansen and Neva Missirian Editor: Matt Willis

What happens when university research becomes a business? It’s called a spin-out and it’s built Silicon Valley, with Stanford University at the centre. In the UK, Oxford alone has launched more than 200 in the last 15 years.

Whether it’s a new drug, software or material, brilliant university research can create huge rewards – for founders, universities and the economy. But also battles over who really owns the idea and should get a share of the equity.

Does the spin-out system deliver or does it stall? Evan Davis and a panel of guests discuss.

Guests: Molly Allington, CEO of Albotherm Harry Destecroix, co-founder of Ziylo and also founder of incubator Science Creates in Bristol Amber Hill, founder of Research Grid

Production team: Presenter: Evan Davis Producers: Phoebe Keane and Sally Abrahams Production co-ordinator: Rosie Strawbridge Sound engineer: Rod Farquhar Editor: Matt Willis

It's easier than ever to create a website for your business and talk directly with customers, but what are the pitfalls to avoid? Three business leaders discuss the pros and cons of selling 'D2C' with Evan Davis.

Sellers no longer need to convince bigger retailers to carry their products or invest in inventory just to fill the shelves. Selling direct to consumers online also means businesses know exactly what their best sellers are, and who is buying what. These businesses can make improvements quickly and market only to those people most likely to buy.

But as online selling becomes more competitive and targeted advertising gets more expensive, how can 'direct to consumer' businesses grow? Does the answer lie in bricks and mortar?

Panel:

Alexandra Thurstan, co-founder Different Dog, fresh dog food company Lucas London, co-founder Lick, paint company Neil Campbell, Chief Growth Officer SMOL, eco cleaning product company