- 25 minutes 24 secondsOctober 2026: The RECOVER Trial of Vagus Nerve Stimulation in Markedly Treatment-Resistant Depression: Critical Findings, Lessons Learned, and Future Directions
Dr. Charles Conway (Washington University School of Medicine, St. Louis) joins the podcast to discuss the RECOVER trial, a RCT that looked at vagus nerve stimulation and its effects on profoundly treatment resistant depression. Following that, AJP Editor-in-Chief Dr. Ned Kalin is joined by the October issue guest editor, Dr. William McDonald (Emory University, Atlanta) to discuss the rest of the October issue, which focuses on neuromodulation and precision therapeutics.
- 00:42 Conway interview
- 02:34 Quality of life
- 05:13 Ethical considerations of a sham arm in this population
- 07:00 Timing and VNS treatment
- 08:03 Clinical implications
- 09:02 Limitations
- 10:12 Further research
- 11:30 McDonald and Kalin interview
- 13:50 Song et al.
- 14:08 Li et al.
- 15:44 Donnery et al.
- 16:38 Valiengo et al.
- 17:28 Rush
- 20:03 Mahmoudi
- 22:37 Conway et al.
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1 October 2026, 9:00 am - 29 minutes 57 secondsSeptember 2026: Circadian Rhythm Stabilization App to Prevent Mood Episode Recurrence in Patients With Mood Disorders: A Multicenter, Double-Blind, Sham-Controlled, Randomized Clinical Trial
Dr. Heon-Jeong Lee (Korea University, Seoul) joins AJP Audio to discuss an app-based intervention designed to help individuals with mood disorders regulate their circadian rhythms to prevent recurrence of mood episodes. Afterwards, Dr. Ned Kalin will join us again to discuss the rest of the September issue of the Journal, which takes a close look at clinical treatment.
- 00:44 Findings
- 01:42 How the app works
- 03:05 Differences between the app and traditional lifestyle advice
- 04:14 Ethics surrounding shame treatment arms
- 05:43 Broader applicability of the intervention
- 06:50 Limitations
- 08:19 Immediate clinical implications
- 09:33 Further research
- 10:08 Kalin interview
- 10:27 Yeom et al.
- 16:02 Schacht et al.
- 20:31 Khosravani et al.
- 24:52 Peterson et al.
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1 September 2026, 9:00 am - 33 minutes 59 secondsAugust 2026: Cognitive, Electrophysiological, and Behavioral Presentation of First-Episode Psychosis With or Without Cannabis Exposure
Dr. Deepak Cyril D'Souza (Yale University School of Medicine) joins the podcast to discuss a study looking at two cohorts of patients hospitalized with first instances of psychosis, one with cannabis exposure and one without. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the August issue of the Journal, which takes a look at issues surrounding schizophrenia spectrum disorder, from the clinical to basic science.
- 00:40 D'Souza interview
- 02:38 Subtyping and schizophrenia spectrum disorder
- 04:19 Relapse and long-term implications for cannabis induced psychosis
- 05:43 Improvements in cognition
- 08:03 Differences between the groups
- 09:26 Greater access and greater potency of cannabis products
- 11:29 Further research
- 13:45 Kalin interview
- 13:59 D'Souza et al.
- 21:34 Forsyth et al.
- 27:36 Enwright et al.
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1 August 2026, 9:00 am - 37 minutes 41 secondsJuly 2026: Social Determinants of Health in Psychiatric Disorders: Exciting Opportunities for Biopsychosocial Research and Clinical Care
Dr. Dilip Jeste (Social Determinants of Health Network, La Jolla, CA) joins the podcast to discuss how social determinants of health interact with treatment for psychiatric disorders. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin once again puts the rest of the July issue into context.
- 00:31 Impacts of social determinants of health on psychiatric disorders, research, and clinical care
- 04:43 Health related social needs versus social determinants of health
- 08:47 Loneliness as a risk factor
- 12:36 A clinician's role in societal factors
- 14:47 Mechanistic understandings social determinants and the exposome
- 18:17 Further research
- 22:25 Kalin interview
- 22:30 Jeste and Gyan
- 23:33 Blundell et al.
- 28:03 Yang et al.
- 32:20 Van der Meer et al.
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1 July 2026, 8:00 am - 29 minutes 15 secondsJune 2026: Low-Dose Buprenorphine Following Ketamine Treatment for Suicidal Ideation in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
Dr. Jason Tucciarone and Dr. Alan Schatzberg (Stanford University, Stanford, CA) join AJP Audio to discuss the use of low-dose buprenorphine as an adjunctive therapy to extend the anti-suicidal effects of ketamine treatment in patients with major depressive disorder and suicidal ideation. AJP Editor-in-Chief Dr. Ned Kalin joins to discuss the rest of the June issue of the Journal, which takes a close look at issues surrounding suicide and severe depression.
- 01:20 Tucciarone and Schatzberg interview
- 03:36 Disparity between effects on suicidal ideation and antidepressant ratings
- 05:36 Ethics of placebo and ketamine in patients with suicidal ideation
- 08:28 Immediate clinical implications
- 11:40 Limitations
- 14:10 Further research
- 16:19 Kalin interview
- 16:24 Tucciarone et al.
- 20:39 Rovers et al.
- 24:30 Jelen et al.
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1 June 2026, 7:00 am - 22 minutes 58 secondsSpecial Episode: The Future of DSM
In this special episode of AJP Audio, AJP Editor-in-Chief Dr. Ned Kalin is joined by Dr. María Oquendo (Perelman School of Medicine at the University of Pennsylvania, Philadelphia), chair of APA's Future DSM Strategic Committee to discuss a series of commentaries published in the May issue of the Journal discussing the strategic vision for the future of DSM.
- 00:39 Oquendo interview
- 03:07 Size of the response
- 04:18 Feedback
- 06:04 Incorporating the feedback
- 07:57 Emphasizing science with a title change for DSM
- 10:18 A living document
- 12:35 Changes from previous versions of DSM
- 16:08 Changes in documentation and coding
- 18:51 Lived experience
- 20:02 Working with AJP
Links to the commentaries:
- Initial Strategy for the Future of DSMMaría A. Oquendo, M.D., Ph.D., et al.
- The Future of DSM: A Report From the Structure and Dimensions SubcommitteeDost Öngür, M.D., Ph.D., et al.
- The Future of DSM: Are Functioning and Quality of Life Essential Elements of a Complete Psychiatric Diagnosis?Karen Drexler, M.D., et al.
- The Future of DSM: Role of Candidate Biomarkers and Biological FactorsBruce Cuthbert, Ph.D., et al.
- The Future of DSM: A Strategic Vision for Incorporating Socioeconomic, Cultural, and Environmental Determinants and IntersectionalityMilton L. Wainberg, M.D., et al.
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15 May 2026, 7:16 am - 30 minutes 15 secondsMay 2026: Psychiatric Comorbidities in Substance Use Disorders: Sex-Based Differences in a National Real-World Clinical Sample
Dr. Eduardo Butelman (Icahn School of Medicine at Mount Sinai, New York) joins AJP Audio to discuss the varying incidence of psychiatric comorbidities across patients diagnosed with substance use disorders. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to discuss the rest of the May issue, which includes a discussion on the future of the DSM.
- 00:53 Butelman interview
- 02:23 Mechanisms of difference between males and females
- 04:04 Patterns of response between males and females in substance use disorders
- 05:54 Implications for research into sex-based differences
- 07:33 Racial and ethnic variations in findings
- 09:30 Limitations
- 10:46 Immediate clinical implications?
- 12:09 Further research
- 13:18 Kalin interview
- 13:38 Butelman et al.
- 17:11 Hinojosa et al.
- 22:49 van Rooij et al.
- 26:06 The future of DSM
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1 May 2026, 9:08 am - 35 minutes 58 secondsApril 2026: Mobile Health for Alcohol Use Assessment: Longitudinal Effects of Breathalyzer Self-Monitoring in Everyday Contexts
Yang Lu, M.S., and Catharine E. Fairbairn, Ph.D. (University of Illinois, Urbana-Champaign) join AJP Audio to discuss the longitudinal effects of the use of personal alcohol breathalyzers in a natural setting on alcohol usage. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to discuss the rest of the April issue, which focuses on subjects related to substance use disorders.
- 00:57 What did you discover about the long term effects of using a personal blood alcohol monitor?
- 03:12 Do health monitoring devices actually change behaviors?
- 04:10 What did your cohort look like?
- 08:49 Disparate impact of monitoring on heavy drinkers and light drinkers
- 11:36 Clinical implications
- 14:34 Limitations
- 15:46 Avenues for further research
- 18:39 Kalin interview
- 18:46 Lu et al.
- 24:00 Wittekind et al.
- 29:50 Nicholson et al.
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1 April 2026, 8:52 am - 33 minutes 17 secondsMarch 2026: Primary Prevention of PTSD Symptoms in Combat-Deploying Soldiers Using Attention Bias Modification: A Randomized Controlled Trial
Chelsea Dyan Gober Dykan, M.A. (Tel Aviv University, Israel), joins AJP Audio to discuss a study looking at two versions of attention bias modification with an eye towards a prophylactic impact on developing PTSD in a cohort of combat-bound soldiers. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the March issue into context.
- 00:57 Attention bias modifications
- 03:54 Response-time and gaze-contingent paradigms
- 05:05 Differences in efficacy between the two arms
- 08:06 Ethical considerations in investigating combat-bound soldiers
- 10:44 Controlling for combat experiences in studying PTSD
- 12:24 Duration of the effect
- 13:44 Limitations
- 15:03 Immediate clinical implications
- 16:22 Further research
- 17:05 Kalin interview
- 17:22 Dykan et al.
- 21:03 Kaul et al.
- 26:19 Kantrowitz et al.
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1 March 2026, 10:00 am - 29 minutes 58 secondsFebruary 2026: Doxycycline Use in Adolescent Psychiatric Patients and Risk of Schizophrenia: An Emulated Target Trial
Dr. Ian Kelleher (University of Edinburgh, Scotland) joins AJP Audio to discuss an emulated target trial looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk to develop schizophrenia spectrum disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context.
- 00:53 Doxycycline and the risk of developing schizophrenia
- 04:03 Emulated target trials versus randomized control trials
- 06:43 Methods of action
- 09:24 Dosage and exposure levels for doxycycline
- 10:15 Immediate clinical applications
- 10:56 Limitations of the study
- 11:33 Future research
- 12:43 Kalin interview
- 13:00 Lång et al.
- 19:43 Zhao et al.
- 25:20 Metrik et al.
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1 February 2026, 10:00 am - 33 minutes 12 secondsSpecial Episode: 2025 Articles of Import and Impact
This special episode of AJP Audio brings together the editors of the American Journal Psychiatry and the AJP Residents' Journal to discuss important and impactful articles published in 2025.
- 00:39 Ned H. Kalin, M.D., discusses "Transcriptomic Analysis of the Human Habenula in Schizophrenia" by Ege A. Yalcinbas, Ph.D., et al.
- 06:23 Elisabeth Binder, M.D., Ph.D., discusses "Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study" by Zhiqiang Sha, Ph.D., et al.
- 11:17 Kathleen T. Brady, M.D., Ph.D., discusses "High-Potency Cannabis Use and Health: A Systematic Review of Observational and Experimental Studies" by Stephanie Lake, Ph.D., et al.
- 15:35 David A. Lewis, M.D., discusses "20 Years of Aberrant Salience in Psychosis: What Have We Learned?" by Philip R. Corlett, Ph.D., and Kurt M. Fraser, Ph.D.
- 17:27 William M. McDonald, M.D., discusses "Psychedelics for the Treatment of Psychiatric Disorders: Interpreting and Translating Available Evidence and Guidance for Future Research" by Roger S. McIntyre, M.D., F.R.C.P.C., et al.
- 24:04 Daniel S. Pine, M.D., discusses "Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial" by Carlos M. Grilo, Ph.D., et al.
- 26:06 Carolyn Rodriguez, M.D., Ph.D., discusses "Randomized Controlled Trial of the Effects of High-Dose Ondansetron on Clinical Symptoms and Brain Connectivity in Obsessive-Compulsive and Tic Disorders" by Emily R. Stern, Ph.D., et al.
- 30:26 Sean T. Lynch, M.D., discusses "From Medical Practice to Mass Incarceration: A Historical Analysis of Racial and Ethnic Targeting in U.S. Drug Policy" by Rathisha Pathmathasan, D.O., et al.
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