Dr. Julia Linke (University of Mainz, Germany) joins AJP Audio to discuss the use of neural efficiency, a measure of brain activity, as a potential biomarker in the treatment of children with anxiety disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context.

• 00:31 Linke interview
• 02:15 State or a trait?
• 04:15 Neural efficiency and CBT
• 05:22 Potential as a biomarker
• 07:08 Patient-rated and parent-rated measures of anxiety
• 08:16 Immediate clinical implications
• 09:50 Limitations
• 10:43 Future directions of research
• 11:44 Kalin interview
• 11:50 Linke et al.
• 15:16 Mallard et al.
• 18:11 Naples et al.
• 21:44 Mac Giollabhui et al.

Transcript

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Dr. Suresh Durgam (Intra-Cellular Therapies, a Johnson & Johnson Company, Bedminster, NJ) joins AJP Audio to discuss a phase 3 randomized controlled trial looking at the use of the antipsychotic medication lumateperone as adjunctive to antidepressant therapy in the treatment of patients with major depressive disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue of the Journal.

• 00:48 Durgam interview
• 03:09 Mechanism of action
• 04:44 Patient-reported outcomes
• 06:31 Immediate clinical implications
• 07:32 Limitations
• 08:08 Further research
• 09:25 Kalin interview
• 09:38 Durgam et al.
• 13:09 Lin et al.
• 17:22 Brodsky et al.

Transcript

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Dr. Lara Coughlin (University of Michigan, Ann Arbor) joins AJP Audio to discuss a study looking the impact of contingency management on all cause mortality in patients with stimulant use disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the November issue of the Journal.

• 01:09 Coughlin interview
• 02:05 Stimulant use disorder and contingency management
• 04:37 Mortality
• 05:12 Contingency management and "moral hazard"
• 08:30 Clinical uptake of contingency management
• 09:28 Broader applicability to psychiatric conditions
• 10:31 Limitations
• 11:39 Further research
• 12:32 Kalin interview
• 12:49 Coughlin et al.
• 16:41 Yalcinbas et al.
• 22:22 Na et al.

Transcript

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Dr. Shau-Ming Wei (National Institute of Mental Health, Bethesda, MD) joins AJP Audio to discuss a replication study looking at impact of hormone addback to a hormone suppression regimen for the treatment of premenstrual dysphoric disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the October issue of the Journal.

• 00:34 Wei interview
• 02:59 PMDD
• 04:22 Up and downsides of hormone suppression
• 05:52 Hormone addback
• 07:15 Limitations of the current study
• 08:38 Further research
• 10:42 Kalin interview
• 10:58 Wei et al.
• 15:25 Sanacora et al.
• 20:07 Whittle et al.
• 23:06 Cooper et al.

Transcript

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Dr. Deidre Anglin (City College, CUNY, New York) joins AJP Audio to discuss the disparate impact of schizophrenia spectrum disorder diagnosis on racial and ethnic minorities in the United States based on localized neighborhood data. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the September issue of the Journal.

• 00:31 Anglin interview
• 04:40 Zip code sizes
• 05:18 The long legacy of redlining
• 07:17 Socially vulnerable neighborhoods
• 09:43 Structural racism, clinicians, and working with individuals
• 13:45 Limitations
• 15:56 Further research
• 18:08 Kalin interview
• 18:13 Anglin et al.
• 25:19 Vano et al.
• 29:40 Moussa-Tooks et al.
• 33:34 Zhang et al.

Transcript

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Dr. Vinod Rao (Massachusetts General Hospital, Boston) join AJP Audio to discuss predicting the relative risk of patients with an ADHD diagnosis developing a later stimulant or substance use disorder based on the method of prescription, in person or via telehealth. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the August issue of the Journal.

• 00:07 Rao interview
• 01:53 Stimulant use disorder versus substance use disorder
• 02:59 Cohort size and incidence of SUDs
• 04:28 Length of clinician engagement in non-profit versus for profit hospital systems
• 05:18 Patient cohort
• 06:20 Potential difference in mechanism between prescribing practices
• 07:35 Continued use of telehealth
• 08:43 Limitations
• 10:03 Further research
• 11:17 Kalin interview
• 11:24 Rao et al.
• 15:41 Mahjani et al.
• 19:59 Zhang et al.
• 25:11 Sha et al.
• 29:33 Gao and Olfson

Transcript

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Dr. Tanner Bommersbach (University of Wisconsin School of Medicine and Public Health) and Dr. Greg Rhee (University of Connecticut and Yale University School of Medicine) join AJP Audio to discuss estimating national trends in suicidal ideation and attempts in high school students with and without accompanying high-risk behaviors. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the July issue of the Journal.

• 00:07 Bommersbach and Rhee interview
• 00:36 Trends in suicide among high school students in the US
• 02:49 Variation in rates based on gender, racial identity, and sexuality
• 03:50 Did the rates increase during the COVID-19 pandemic?
• 04:14 Lessons to be learned from COVID?
• 05:23 Behavior risk factors
• 06:33 Clinical implications
• 08:19 Inflections in risk factors due to the pandemic?
• 08:52 Limitations
• 09:32 Future research
• 10:16 Kalin interview
• 10:31 Bommersbach et al.
• 14:20 Müller et al.
• 18:54 Ahn et al.
• 21:47 McCabe et al.

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Dr. Roy Perlis (Mass General Bringham, Boston) joins AJP Audio to discuss a machine learning model to examine electronic health records in individuals who had recently given birth designed to detect those who might develop postpartum depression. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the June issue into context.

• 00:31 Perlis interview
• 02:56 Lack of validation in screening methods
• 04:03 Stumbling blocks on the road to validation
• 05:10 Synergy between screening scores and machine learning models
• 06:36 Issues with clinician adoption?
• 08:44 Administrative burden for running these models
• 10:38 Current clinical application
• 12:37 Screening without those with a history of depression
• 13:48 Limitations
• 15:30 Future research
• 17:26 Kalin interview
• 17:41 Clapp et al.
• 21:41 Kępińska et al.
• 25:19 Savitz et al.
• 25:25 Miller
• 28:38 Wall et al.

Transcript

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Dr. Kenneth Ruggiero (Medical University of South Carolina, Charleston) joins AJP Audio to discuss the the effectiveness of an app-based intervention at reducing the symptoms of sleeplessness and posttraumatic stress in a broad cohort in the wake of a natural disaster. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the May issue into context.

• 00:38 Ruggiero interview
• 03:13 Bounce Back Now app
• 05:03 Natural disasters and other sources of trauma
• 07:31 Low cost and broad-based intervention
• 08:49 Limitations
• 10:19 Changes in how the intervention was designed
• 11:17 Uptake and interactions with the app
• 13:15 Future directions
• 14:36 Kalin interview
• 14:50 Ruggiero et al.
• 19:26 Norman et al.
• 23:29 Conrod et al.
• 27:53 Olfson et al.
• 31:44 Olfson et al.

Transcript

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Dr. Valentina Mancini (Oxford University) joins AJP Audio to discuss the impact of anticholinergic burden on cognition in patients with schizophrenia. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context.

• 00:32 Mancini interview
• 02:26 Anticholinergic burden method of action
• 02:58 Balancing the impact of side effects in schizophrenia treatment
• 04:52 Limitations
• 05:34 The need for further studies
• 05:59 Clinical implications
• 06:32 Further research
• 07:01 Trials needed
• 07:54 Kalin interview
• 08:03 Mancini et al.
• 11:23 Tiihonen et al.
• 13:43 Zhou et al.
• 16:28 Omlor et al.
• 18:51 Orhan et al.

Transcript

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Dr. William Horan (Bristol Myers Squibb) joins AJP Audio to discuss a newly approved, novel treatment for schizophrenia spectrum disorder, which has potential impacts for cognition in patients. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context.

• 00:45 Horan interview
• 03:15 Novel mechanism of action in the treatment of schizophrenia
• 05:39 Side effect profiles
• 07:20 Clinical impacts
• 08:31 The need for further investigation
• 09:58 Limitations
• 11:05 Further research
• 13:08 Kalin interview
• 13:21 Horan et al.
• 17:34 Levenstein et al.
• 19:00 Fountoulakis et al.
• 20:57 Couture et al.
• 23:18 Stern et al.
• 27:35 McGirr et al.

Transcript

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