What if scientists could actually turn back the biological clock?

On this episode of In Conversation, Karl Stefanovic sits down with Dr Buck Parker, MD, FACS – a board-certified trauma and acute care surgeon and digital creator – to unpack one of the most extraordinary developments in modern medicine: the possibility of reprogramming ageing cells.

Dr Parker explains how scientists have discovered that cells are programmable, how four key proteins can reset the epigenetic ‘clock’ inside cells, and why researchers are now testing whether older cells can effectively be made younger.

Human trials are already underway, while experiments in mice have produced striking results – but Dr Parker explains why there are still major questions around dosage, delivery, cancer risk and the long-term effects.

Karl and Buck also dive into the explosion of peptides and wellness treatments, the growing influence of social media on medicine, patients using ‘Dr Google’ and ‘Dr AI’, and why he believes medicine is entering a completely new era.

So would Buck take the so-called fountain of youth himself? And how long could we have to wait before humans can actually slow or stop ageing?

His prediction: five to ten years.

Plus, Buck reveals what he actually takes, why he uses creatine, his experience with NAD and GLPs, and the simple things he recommends doing now to stay healthy.

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Labor is under fire – and Hollie Hughes and Gerard Rennick aren't holding back.

This week on The Panel, Karl Stefanovic is joined by former Liberal MP Hollie Hughes and Gerard Rennick for a fiery discussion about the Albanese Government, Jim Chalmers, the gun buyback, superannuation, energy and the growing political divide.

Hollie Hughes takes aim at Treasurer Jim Chalmers over his fundraising appeal, questioning why Australians struggling with the cost of living would be sending money to Labor.

The panel also tackles the Government’s gun buyback scheme, with Hughes arguing farmers are being punished for the actions of criminals and questioning the Government’s response to the Bondi terror attack.

Gerard Rennick takes aim at Australia’s superannuation system, arguing it is making it harder for younger and lower-income Australians to get into the housing market, while warning that the cost of superannuation tax concessions is already enormous.

Plus, the panel gets into Chris Bowen, Australia’s energy future, struggling infrastructure and the controversial Robert Irwin moment at the Logies – with Hollie Hughes delivering a particularly fiery response.

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Tonight on Karl Weekly, Dave Hughes explains why he’s hit the campaign trail with the Victorian Liberals – and why he says he’s had enough of Labor’s taxes, government waste and corruption.

Hughesy reveals what pushed him to become more politically outspoken, why he believes Australians are ‘over it’, and why he thinks Victoria desperately needs a change of government. He also takes aim at the Commonwealth Games blowout, government spending and the lack of accountability for decisions that have left Victoria billions in debt.

Karl also speaks to sixth-generation Victorian farmer Ben Duxson, who is fighting $814 fines issued to farmers for refusing access to their own properties as the government pushes ahead with the $11.4 billion VNI West transmission project, with Pauline Hanson joining the farmers’ campaign.

And former AFP Detective Superintendent Dr David Craig joins Karl to examine the government’s new gun buyback following the Bondi terror attack. Craig questions whether taking legal firearms off law-abiding Australians will actually make the country safer, and warns that the legislation will not stop the next terrorist attack.

He also reveals where he believes the real security failures occurred – from counterterrorism funding and intelligence sharing to the resources available to ASIO and the AFP – and warns that another Bondi attack could happen if those gaps aren't addressed.

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Dr Aseem Malhotra joins Karl for a wide-ranging conversation about vaccines, COVID, Big Pharma, medical research and the growing crisis of trust in the health system.

Malhotra discusses Donald Trump and RFK Jr’s approach to childhood vaccinations, why he believes every medical intervention should come with genuine informed consent, and why he says doctors need to be more transparent about the risks, benefits and uncertainties surrounding treatment.

He also takes aim at the pharmaceutical industry, questions the independence of medical regulators, and delivers a provocative challenge to conventional thinking around cholesterol and statins.

Malhotra reflects on the mistakes made during COVID, arguing that governments and medical authorities need to admit where they got things wrong if public trust is ever going to be restored.

He also weighs in on Anthony Fauci, the polarisation of left and right, the psychology behind the pandemic response, social media’s role in fuelling anger, and why he believes Australians and Britons need to find a way to debate without becoming trapped in opposing camps.

Plus, Malhotra explains why he changed his own position on COVID vaccines and why he believes changing your mind can be one of the hardest – but most important – things a person can do.

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The Fabian Society has influenced political thinking for more than 140 years – but how much influence does it really have over Australia?

Karl speaks with Topher Field about the origins of Fabianism, its strategy of gradual political change and the controversial idea of ‘permeation’, influencing institutions and government from within rather than seeking power directly.

Topher argues the Fabian approach has become deeply embedded in modern politics, warning that ‘if you accept that framework as the way that government should function, the Fabians have already won.’ He also reveals why he believes Fabian influence extends beyond Labor and into the Liberal Party.

They discuss the growth of bureaucracy, regulation and expert-led government – and why Topher believes ‘they’ve already got you without you even having to know their name.’

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Former Deputy Prime Minister John Anderson joins Karl Stefanovic for a wide-ranging and confronting conversation about Australia’s future - and why he believes the country is in “serious decline.”Anderson sounds the alarm on Australia’s fuel and food security, warning that the nation is dangerously reliant on overseas supply chains and questioning how prepared we are for another major global disruption.He also takes on Australia’s economic direction, housing affordability, falling living standards, energy policy and the decisions he believes are weakening the country’s ability to compete and prosper.Anderson and Karl discuss the Albanese Government, the growing frustration with Australia’s political leadership, why voters are abandoning the major parties, and whether the country has lost the ambition and leadership required to tackle the challenges ahead.From Australia’s economic future to national security and sovereignty, Anderson asks a fundamental question: “Where is the leadership?”John Anderson joins Karl Stefanovic for a frank conversation about where Australia is heading - and what needs to change.

Hollie Hughes and Isaac Butterfield join Karl Stefanovic for a fiery new episode of The Panel. 

The panel weighs in on Anthony Albanese’s controversial “melons’” gaffe, with Hughes declaring his comments “grotty and grubby” and Butterfield questioning whether Australians are seeing a different side of the Prime Minister.

Then, they take on Greens Senator Mehreen Faruqi’s support for students skipping school to protest One Nation, prompting Butterfield to declare: “This is what happens when schools brainwash kids” - while Karl calls students leaving school to protest “bad parenting”.

Karl also opens up about his concerns for Australian journalism, why he wants to hear from voices he believes have been overlooked, and why his approach to media is changing.

Plus: Australia’s housing pressures, the future of traditional media, political bias in journalism - and Karl’s mum makes an unexpected appearance.

Hollie Hughes and Isaac Butterfield join Karl Stefanovic on The Panel.

Australia has a growing drone problem, and the repeated breaches of restricted airspace over RAAF Base Williamtown have raised serious questions about how prepared we really are.

Karl speaks to Justin Olde, CEO of Canberra-based defence technology company Boresight, about the emerging threat posed by drones, the lessons Australia is learning from the war in Ukraine and why critical military and civilian infrastructure could be vulnerable.

Justin warns that drones over a military installation are unlikely to be harmless. They could be gathering intelligence, testing defences and identifying weaknesses in Australia's counter-drone capability.

His message is blunt: ‘if you're a modern military and you don't have an effective counter drone system in place, then you're not an effective military.’

So why were drones able to repeatedly enter restricted airspace over Williamtown? What other Australian assets could be vulnerable – from Sydney Harbour and Garden Island to critical infrastructure around the country? And why isn't Australia already fully equipped to deal with this threat?

Justin also explains how Boresight is building sophisticated target drones in Canberra to help militaries train against increasingly complex drone attacks, and why Australian technology companies such as Boresight, EOS and DroneShield are becoming increasingly important to the future of defence.

With drones transforming modern warfare, Justin argues Australia cannot afford to ignore the threat – or assume it won't happen here.

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Australia’s political landscape is shifting — and the major parties are under pressure.

On Karl Weekly, Karl Stefanovic is joined by One Nation leader Pauline Hanson, former Labor leader Mark Latham and economist Derek Francis for a wide-ranging look at the issues driving voter frustration across the country.

Pauline Hanson weighs in as One Nation surges and takes aim at the direction of the country, while Mark Latham argues Australians are looking for someone to “shake up the system” after two decades of major-party failure.

Economist Derek Francis breaks down where taxpayer money is going, why he believes government spending is holding back economic growth, and the enormous opportunity Australia could be missing by failing to capitalise on its uranium and mineral wealth.

Plus, Latham delivers his verdict on Anthony Albanese, the controversy surrounding the Prime Minister’s comedy appearance and whether Australia is witnessing the end of politics as a two-party contest.

Subscribe to The Karl Stefanovic Show for more interviews, debate and conversations on the biggest issues facing Australia.

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Is a divided right handing elections to the left?

Sir Jacob Rees-Mogg joins Karl Stefanovic for a wide-ranging conversation about the political and economic challenges facing Britain — and the striking parallels with Australia.

From Nigel Farage, Reform UK and Rupert Lowe to the future of the Conservative Party, Rees-Mogg argues Britain’s fractured right needs to find a way to work together if it wants to win again — pointing to Australia’s Liberal-National Coalition as a model worth considering.

He also weighs in on Britain’s migration crisis and why governments have failed to stop the boats, soaring energy prices, welfare dependency, government spending and taxation, and why he believes Britain needs fundamental economic reform.

Plus, does Britain need another Margaret Thatcher? And has bureaucracy gone too far when politicians are debating whether people should be allowed to drink standing up?

Could Australia learn from what’s happening in Britain?

Watch the full interview and tell us what you think.

Fred Brophy is the last of his kind.For decades, the legendary showman has travelled the country with Australia’s last surviving travelling boxing tent — preserving a piece of Australian history that has all but disappeared.In this special interview from Mount Isa, Fred sits down with Karl Stefanovic for an extraordinary conversation about his wild life on the road, being shot, going to jail, losing two fingers, the fighters whose lives he’s helped turn around and why he refuses to let one of Australia’s great traditions die.But Fred also has plenty to say about modern Australia.He gives Karl his unfiltered take on immigration, the housing crisis, Anthony Albanese and the government, reveals why Pauline Hanson is his favourite politician, and explains why he believes Australians are becoming increasingly fed up with the direction of the country.Plus, Fred reveals the story behind the world’s last travelling boxing tent — and gives Karl his very own fighting name.What do you make of Fred’s take on Australia today? Let us know in the comments.A big thanks to the legends at Ringers Western who we've partnered with to bring our Mount Isa Rodeo episodes to you. Get 20% off your first purchase with code Karl20 at https://ringerswestern.com