Should I try shrooms for science? In part two of three of our series investigating drugs for longevity, I’m putting psilocybin, LSD and DMT under the microscope - and revealing some pretty exciting research that connects psychedelics to longer lifespans. We’ll also talk about weed, and what the data says about marijuana for longevity.  

Study Links:

Psilocybin for Cancer Patients  

LSD: Longevity in Worms

Cannabis Use Disorder Increases Mortality Risk

Marijuana Increases Epigenetic Aging

Marijuana’s Impacts on Sleep 

Improving Sleep with Medical Cannabis

Hosts:

Bryan Johnson: Blueprint Founder

Kate Tolo: Blueprint Co-Founder

Dr. Mike Mallin: Lead Physician for Bryan Johnson

Connect: 

X: https://x.com/bryan_johnson

YouTube: https://www.youtube.com/@BryanJohnson

Instagram:  https://www.instagram.com/bryanjohnson  

TikTok:  https://www.tiktok.com/@_bryan_johnson_

Chapters: 

00:00 - Introduction 

01:52 - First Experiences With Drugs 

05:42 - Psychedelics in Society 

13:29 - Psilocybin, LSD & DMT 

34:35 - Marijuana 

50:53 - Longevity Rankings 

Can doing lines help you live longer? That depends on what you’re taking. In this three-part series, I’m ranking drugs based on their ties to longevity, starting with ketamine and cocaine. I tested ketamine on myself to study its impacts on the brain — here’s what we found.  

Study Links:

Ketamine’s Effects on Epigenetic Age 

Extending Ketamine’s Therapeutic Window

Ibogaine Therapy for PTSD 

Hosts:

Bryan Johnson: Blueprint Founder

Kate Tolo: Blueprint Co-Founder

Dr. Mike Mallin: Lead Physician for Bryan Johnson

Connect: 

X: https://x.com/bryan_johnson

YouTube: https://www.youtube.com/@BryanJohnson

Instagram:  https://www.instagram.com/bryanjohnson  

TikTok:  https://www.tiktok.com/@_bryan_johnson_

Chapters: 

00:00 - Introduction 

03:14 - Social Norms Around Drugs 

08:59 - Psychedelics as Therapy: Overview 

10:20 - Cocaine 

17:15 - Fentanyl Dangers 

23:27 - Ketamine: Brain Impacts + Longevity 

41:29 - Measuring The Impacts of Psychedelics  

47:51 - Longevity Rankings: Cocaine + Ketamine 

Fitness creator Jesse James West is a natural bodybuilder who makes some of the coolest videos on YouTube for over 7 million subscribers. We’re talking about his motto of “stay relentless,” and how he balances work, health and life now that he’s newly married. Plus, he shares about the time that he also had a breakdown in Target - and how it may have saved his life.

Connect with Bryan: 

X: https://x.com/bryan_johnson

YouTube: https://www.youtube.com/@BryanJohnson

Instagram:  https://www.instagram.com/bryanjohnson  

TikTok:  https://www.tiktok.com/@_bryan_johnson_

Connect with Jesse: 

YouTube: https://www.youtube.com/@JesseJamesWest

Instagram: https://www.instagram.com/jessejameswest

TikTok: https://www.tiktok.com/@jessejameswest

X: https://x.com/jessejameswestt

Chapters: 

00:00:00 - Introduction 

00:01:15 - Finding Work Life Balance

00:08:32 - Stay Relentless 

00:11:01 - Jesse’s Darkest Moment + What He Learned  

00:22:48 - What an AI Future Looks Like 

00:27:24 - Jesse’s Health Protocol 

00:34:26 - Longevity, Psychedelics, & Aliens 

00:44:58 - Married Life + Family Planning 

00:48:55 - Top Tips for Longevity 

00:54:02 - Bodybuilding, Steroids, & Healthy Eating 

00:57:23 - Jet Lag Protocol 

00:59:32 - Living For Tomorrow = Living Forever 

01:02:45 - Jesse’s Health Goals 

Between synthetic dyes, air pollution, and environmental toxins, kids have a lot of obstacles in the way of their health. I’m reviewing some top offenders (like synthetic dyes and added sugars) and discussing how to empower our kids to make informed choices. 

Study Links: 

Synthetic Dyes in Food & Beverages

HEPA Filters in LA Schools

US Kids Face Deadlier Odds

Peanut Allergies & Air Pollution

Hosts:

Bryan Johnson: Blueprint Founder

Kate Tolo: Blueprint Co-Founder

Dr. Mike Mallin: Lead Physician for Bryan Johnson

Connect: 

X: https://x.com/bryan_johnson

YouTube: https://www.youtube.com/@BryanJohnson

Instagram:  https://www.instagram.com/bryanjohnson  

TikTok:  https://www.tiktok.com/@_bryan_johnson_

Chapters: 

00:00 - Introduction 

02:20 - Synthetic Dyes + Added Sugars  

14:20 - Teaching Kids About Nutrition 

20:21 - Toxins, Food Allergies, & Air Quality 

22:42 - Kids Health Protocol 

24:24 - Screen Time, Social Media & Mental Health 

26:22 - U.S. Kids Are Dying at Higher Rates

29:44 - Societal Changes for Better Health

34:41 - Empowering Kids to Make Healthy Choices 

My team and I looked into the biological effects of eating a*s and choking during sex - here’s what we found. I’m also sharing why I monitor my erections - and why this metric is critical for good health and longevity. 

Study Links: 

Choking During Sex 

Overnight Erections

Female Erection Cycles 

Hosts:

Bryan Johnson: Blueprint Founder

Kate Tolo: Blueprint Co-Founder

Dr. Mike Mallin: Lead Physician for Bryan Johnson

Connect: 

X: https://x.com/bryan_johnson

YouTube: https://www.youtube.com/@BryanJohnson

Instagram:  https://www.instagram.com/bryanjohnson  

TikTok:  https://www.tiktok.com/@_bryan_johnson_

Chapters: 

00:00 - Introduction 

01:15 - Taboos Around Sex 

04:50 - Sex is Good For You 

08:33 - Choking During Sex 

15:06 - Anilingus (Rimming) 

22:20 - Sexual Preferences + Microbiome 

25:25 - Erection Cycles: Male and Female 

34:38 - We Need More Conversations About Sex

Had I protected my body and brain, I’d be wealthier and more successful today. Culture is lying to you — you do not need to martyr yourself to be successful. Here’s how you can avoid making the same mistake I did.

Study Links: 

Burnout + Heart Attack Risk 

Hours Worked + Heart Disease

Sleep Deprivation in CEOs

Sleep Deprivation in Judges

Hosts:

Bryan Johnson: Blueprint Founder

Kate Tolo: Blueprint Co-Founder

Dr. Mike Mallin: Lead Physician for Bryan Johnson

Connect: 

X: https://x.com/bryan_johnson

YouTube: https://www.youtube.com/@BryanJohnson

Instagram:  https://www.instagram.com/bryanjohnson  

TikTok:  https://www.tiktok.com/@_bryan_johnson_

Chapters: 

00:00 - Introduction 

03:11 - Martyring Yourself for Success 

15:50 - Study: ‘Overwork Will Kill You’ 

20:04 - Sleep + Decision Making (Studies) 

25:54 - Physical Fitness + Diet (Studies) 

28:24 - Treating Health Like Religion

33:30 - Tips for Balancing Work and Health 

43:58 - Resting Heart Rate Before Bed 

47:06 - Protecting Your Agency 

Society is bathing us in chemicals. From wildfires to 4th of July fireworks, toxins feel inescapable. Here’s what I’m doing to limit exposure and reduce my levels.

Show Links:  

Blueprint Food Guide: https://blueprint.bryanjohnson.com/pages/blueprint-protocol#food-guide

Further Listening: 

“How Sauna Detoxified My Body” - Bryan Johnson Podcast 

“We Need to Talk About Microplastics” - Bryan Johnson Podcast 

Hosts:

Bryan Johnson: Blueprint Founder

Kate Tolo: Blueprint Co-Founder

Dr. Mike Mallin: Lead Physician for Bryan Johnson

Connect: 

X: https://x.com/bryan_johnson

YouTube: https://www.youtube.com/@BryanJohnson

Instagram:  https://www.instagram.com/bryanjohnson  

TikTok:  https://www.tiktok.com/@_bryan_johnson_

Chapters: 

00:00 - Introduction 

01:20 - Fireworks + Toxic Celebrations 

12:27 - LA Wildfire Toxins 

16:57 - Truth About Air Quality

21:23 - PFAS 

31:49 - Reducing Toxins/PFAS

46:11 - Sauna, HBOT & Diet 

50:13 - Don’t Freak Out 

International travel is brutal on your mind, body, and sleep. We discuss the recent data and I share my current jet lag protocol (still evolving) to help minimize the damage after long flights.

Study Links: 

Olympic Athletes + Jet Lag: https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.998484/full

Connect: 

X: https://x.com/bryan_johnson

YouTube: https://www.youtube.com/@BryanJohnson

Instagram:  https://www.instagram.com/bryanjohnson  

TikTok:  https://www.tiktok.com/@_bryan_johnson_

Chapters: 

00:00 - Introduction

01:08 - Where’s Kate? 

02:00 - Bryan’s Travel Experiment  

03:44 - Debunking the ‘CEO Lifestyle’ 

06:28 - Why Jet Lag Happens  

08:00 - Jet Lag Recovery 

14:00 - Improving Sleep 

17:07 - Is Fighting Jet Lag Possible? 

21:44 - Olympic Athlete Study 

24:42 - Travel Rule of Thumb  

33:55 - Shifting Your Mindset  

35:10 - Setting Limits for Travel  

44:25 - Jet Lag Protocol  

50:41 - Stimulants During Travel

52:04 - Cryotherapy/Cold Therapy 

53:00 - Episode Takeaways

Microplastics are everywhere — even in glass bottles. Should you be worried? Kate, Mike, and I interpret the data to understand the risk. I’ll share how I reduced my own levels by 93% so you can too.  

Study Links: 

Glass Bottle Study: https://www.sciencedirect.com/science/article/pii/S0889157525005344

Impact on Children: https://www.nejm.org/doi/abs/10.1056/NEJMms2409092

Connect: 

X: https://x.com/bryan_johnson

YouTube: https://www.youtube.com/@BryanJohnson

Instagram:  https://www.instagram.com/bryanjohnson  

TikTok:  https://www.tiktok.com/@_bryan_johnson_

CHAPTERS 

00:00 - Introduction

01:27 - No Cause for Alarm (Yet) 

02:05 - Microplastics Nuance 

04:04 - What Are Microplastics? 

05:24 - Science Is Still Emerging 

07:39 - Microplastics in Our Bodies 

09:51 - Study: Microplastics in Glass Bottles 

11:42 - What Can We Trust? 

12:53 - Building a ‘Don’t Die’ Society

14:23 - Microplastics in IV Drips

17:11 - Impact on Kids 

18:47 - Microplastics in Washing Machines

19:31 - What is ‘Don’t Die’

21:05 - Bryan’s Microplastics Measurements

22:36 - Total Plasma Exchange / Blood Donation 

24:28 - The Water Bottle Dilemma 

27:50 - Water Systems / Reverse Osmosis 

28:36 - Reducing Microplastic Intake 

32:05 - An 80/20 Approach 

33:10 - Sauna and Microplastics 

35:38 - A Challenge for Humanity 

36:15 - Testing Microplastics at Home  

37:54 - Bryan’s Upcoming Microplastics Tests 

39:03 - Don’t Die Party 

39:31 -  Teaching Congress to Sleep

Quality sleep is the highest-return investment I’ve ever made. In this episode we walk you through my exact protocol, so you can cherry-pick what works, experiment, and track gains for yourself. 

Study Links: 

https://pmc.ncbi.nlm.nih.gov/articles/PMC3902870/

Connect: 

X: https://x.com/bryan_johnson

YouTube: https://www.youtube.com/@BryanJohnson

Instagram:  https://www.instagram.com/bryanjohnson  

TikTok:  https://www.tiktok.com/@_bryan_johnson_

Chapters

00:00 – What Ruins Your Sleep Most?

01:50 – Sleep in Vegas: A Cautionary Tale

03:45 – How Important Is Sleep?

05:30 – Sleep Deprivation

07:20 – Kernel Willpower Study

09:20 – The 80/20 Of Sleep

10:10 – Being a Professional Sleeper

13:00 – Resting Heart Rate

19:00 – Psychology of Tracking Sleep

22:30 – Heart Rate (Before vs. During Sleep)

25:00 – Wearables

30:00 – Food as the #1 Sleep Killer

33:40 – 10 Rules for Perfect Sleep

44:30 – Bonus Tips

49:00 – Sleep Alone?

51:20 – Sleep + Mental Health

52:40 – Bryan’s Final Plea: Learn to Sleep

At last, we tested sauna for longevity. I’m dropping my sauna protocol and explaining why they are definitely worth the hype. Plus, hear about my first time ever stepping into one, and why it was one of the most difficult — but rewarding — protocols I’ve ever done.

Connect: 

X: https://x.com/bryan_johnson

YouTube: https://www.youtube.com/@BryanJohnson

Instagram:  https://www.instagram.com/bryanjohnson  

TikTok:  https://www.tiktok.com/@_bryan_johnson_

Chapters

00:00 – First Impressions of Sauna

01:30 – Assessing the Sweat Response in Kate and Bryan

03:00 – Why Sauna? The Science Behind the Heat

05:20 – How Sauna Mimics Exercise

08:30 – Early Biomarker Changes with Sauna

12:00 – Protocol Design & Measurement Strategy

15:30 – Bryan’s Difficulties Starting the Sauna Protocol 

18:00 – Why Bryan Ices His Testicles in the Sauna

21:00 – Electrolyte Loss & Cramping

24:30 – Dry vs. Wet Sauna

27:00 – Practical Home Sauna Protocol

30:00 – Groups Who Shouldn’t Use Sauna

33:00 – Unexpected Effects of Sauna and Areas to Explore

38:00 – Skin Exposure & Sauna Material Safety

42:30 – Sauna Hygiene & Post-Sweat Protocol

45:00 – Measuring Sweat Toxins

47:30 – Kate and Bryan’s Personal Sauna Habits

49:00 – Sun Damage and Skin Aging with Teens

54:00 – Protocol as Part of a Broader Mission