Why is cancer on the rise amongst the younger generation? Oprah sits down with world-renowned oncologist, New York Times best-selling author and Pulitzer Prize winner Dr. Siddhartha Mukherjee to find out. In this powerful and deeply personal discussion about the new edition of his groundbreaking book The Emperor of All Maladies: A Biography of Cancer Dr. Mukherjee shares why it was important for him to update his seminal book with four new chapters and what has changed in the science of cancer in the last fifteen years. He explores possible reasons behind the rise of cancer in younger people today including genetic factors, environmental triggers, chronic inflammation and the “sleeper” cells that may lie dormant in the body until activated. Joining the conversation is actress and breast cancer survivor Olivia Munn, wife of the late Chadwick Boseman, Simone Ledward Boseman and a 28-year-old woman from Texas who battled stage 4 endometrial cancer after years of dismissed symptoms. She passed away just weeks after her conversation with Oprah. 

What began as a quietly self-published novel, Theo of Golden by Allen Levi, has become a literary phenomenon. First introduced in 2023 with no agent or marketing campaign the book built a devoted grassroots following through word of mouth. It eventually gained national attention, secured a bonafide publisher and become a #1 New York Times bestseller. In this conversation Oprah discusses with Allen Levi the tender, life-affirming story about a mysterious old man who arrives in the small town of Golden who transforms lives by gifting portraits to the locals and helping them feel seen. Allen reflects on what it means to live a life of love, to find hope and beauty in everyday life and to recognize the goodness in all of us. Fans of the novel, whose lives have been moved by this book, including country singer-songwriter Walker Hayes, record producer Claude Kelly and designer and TV host Tamara Day join the conversation.  

Buy the Book: The Power of Beliefs by Shawn Achor

https://www.amazon.com/dp/B0FBVK3HYN?lv=shuf&channelId=500&plpRedirect=mhFallback

Oprah sits down with renowned positive psychology researcher and bestselling author Shawn Achor to discuss his new book, The Power of Beliefs: How Strengthening Seven Core Beliefs Predicts Greater Success and a Better Life. While teaching at Harvard University and working with organizations around the world Shawn has spent more than two decades studying the connection between happiness, success and human potential. In this conversation he reveals why our beliefs don't just influence how we see the world they can actually predict what happens next. Drawing on groundbreaking research and deeply personal stories Shawn shares the seven core beliefs he says have the greatest impact on our life. Oprah and Shawn also explore the power of gratitude and how that practice alone can change what you believe to be true. Through audience questions and personal stories this episode offers a hopeful roadmap for anyone feeling stuck or disconnected. Thank you to our fantastic partners at The Farmer's Dog for presenting this episode. Their real, human-grade food has been clinically shown to support healthy aging, so you can have more good years together. URL: www.thefarmersdog.com/oprahpodcast 00:00:00 - Oprah on success 00:05:20 - What are your core beliefs? 00:07:17 - Welcome Shawn Achor, author of “The Power of Beliefs” 00:12:50 - Belief: Your behavior matters 00:16:09 - Belief: The power of gratitude 00:21:00 - When Shawn’s beliefs were tested 00:28:53 - Belief: I have something to give 00:34:06 - Woman’s vulnerable TikTok 00:37:30 - The value of knowing we are not alone 00:42:52 - How Shawn helped Flint, MI 00:46:30 - The placebo effect and beliefs 00:52:00 - Can belief change? 00:58:00 - Times when beliefs can change quickly 00:59:36 - Belief: Believing in something that’s greater than you 01:02:02 - What Oprah believes Subscribe: https://www.youtube.com/@oprah Follow Oprah Winfrey on Social: https://www.instagram.com/oprahpodcast/ https://www.facebook.com/oprahwinfrey/ Listen to the full podcast: https://open.spotify.com/show/0tEVrfNp92a7lbjDe6GMLI https://podcasts.apple.com/us/podcast/the-oprah-podcast/id1782960381

One of her guests Oprah has never forgotten was an 11-year-old girl named Kate who had recently lost her mother to cancer. In a conversation that touched millions Kate shared one of the many memories she treasured most was a special night when she and her mom sat together eating a bowl of Cheerios. It was a poignant reminder that the moments that matter most are not always the grand vacations, expensive gifts or elaborate celebrations, instead it can be simply time spent together. Oprah shares how over the years she often thinks about her conversation with Kate and the impact it had on her own life and her viewers’ lives. Now, Kate returns to The Oprah Podcast as a mother of two herself reflecting on how losing her mom at such a young age shaped the woman she became, the parent she strives to be and the ways she continues to carry her mother’s love forward.

00:00:00 - Welcome to a The Oprah Winfrey Show throwback

00:02:00 - Kate and Zach just lost their mom

00:08:30 - Kate and Zach as teenagers

00:10:15 - Kate shares signs from her mother

00:12:39 - Kate at 29

00:14:20 - Kate on getting help and getting sober

00:17:00 - Kate with Oprah now

00:18:24 - Zach and Kate’s relationship now

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Mara Brock Akil is one of the most influential storytellers of our time. Best known for iconic television series like Girlfriends, Being Mary Jane and the newest Netflix hit Forever, she continues to capture relatable stories that celebrate women's lives. Now, she's bringing her storytelling to the page with her debut novel, The Revelation of Dionne Daphne. The story follows Dionne Daphne, a successful beauty editor whose carefully curated life begins to unravel after a devastating revelation from her former boyfriend forces her to confront painful truths buried deep in her past. In this conversation with Oprah, Mara dives into the themes woven throughout the novel like overcoming shame, confronting childhood wounds and how returning to the places that broke us can sometimes create a new path forward. She also opens up about why this story was deeply personal and why it's the one she needed to tell now. Plus we hear from readers, including Oprah's daughter-girl Thando, who couldn't put the book down and others who found themselves in the story.

BUY THE BOOK!

The Revelation of Dionne Daphne

https://www.amazon.com/dp/059359777X?lv=shuf&channelId=500&plpRedirect=mhFallback

00:00:00 - Welcome Mara Brock Akil, author of The Revelation of Dionne Daphne

00:04:30 - From TV writing to novel

00:05:48 - Mara on who this book is for

00:06:30 - Characters and plot

00:11:20 - Healing through writing

00:12:20 - Confronting abuse

00:18:00 - Mara on coping with her own abuse

00:20:50 - Thando’s reaction

00:24:50 - What we misunderstand about trust

00:30:45 - Message to women who are still silent

00:36:40 - Dionne’s partner

00:39:00 - The power of storytelling

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When Oprah first addressed the topic of domestic violence back in 1986, one out of four women in the United States was impacted by domestic violence. Today, that number has escalated to one out of two women who will experience sexual violence, physical violence or stalking by an intimate partner in their lifetime. In this episode Oprah talks with journalist, writer and professor Rachel Louise Snyder. She is the author of the award-winning bestseller, No Visible Bruises, where she explores the domestic violence epidemic and how to combat it. She explains why domestic violence is becoming more prevalent, why a better term for it is “intimate partner terrorism,” the signs to look out for and what steps women can take to protect themselves and their families. Oprah and Rachel are joined by Susan, a former Oprah Show guest, who endured 17 years of physical and emotional abuse by her former husband - some of which her husband forced her then 13-year-old son to record on video. Also, in the fatal Ohio home invasion that grabbed headlines, the sister and brother-in-law of married couple Spencer and Monique Tepe join to talk about how Monique had experienced years of threatening behavior and emotional abuse from her surgeon ex-husband before he killed them both in their home in December 2025.

BUY THE BOOK!

https://www.amazon.com/No-Visible-Bruises-Domestic-Violence/

00:00:00 - Welcome Rachel Louise Snyder, author of “No Visible Bruises”

00:03:40 - Types of domestic violence

00:06:45 - Domestic violence vs. intimate terrorism

00:12:20 - The question: Why do you stay

00:14:57 - Seeing the signs

00:17:33 - Last act before homicide

00:19:00 - Rachel’s observation of abusive men

00:20:30 - Violence and addiction

00:24:24 - Susan’s story from The Oprah Winfrey Show

00:28:20 - Survivor Susan joins

00:35:20 - Susan’s son Dazmann joins

00:42:00 - Susan’s message to other women

00:43:10 - A DV tragedy rocked couple’s life

00:49:45 - What couple wants others to know

00:51:10 - Rachel’s personal connection to DV

NEED HELP?

If you or someone you know needs support, the National Domestic Violence Hotline is available for anonymous, confidential help 24/7. Call 1-800-799-7233 (SAFE) or 1-800-787-3224 (TTY) or visit the website below.

https://www.thehotline.org/

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Oprah’s Book Club 124th selection is Little Wonder by author Sophie Chen Keller. Oprah and Sophie sit down with an enthusiastic audience of readers to discuss Sophie's childhood spent both in the USA and China and how that experience impacted her writing. She also shares how becoming a mother for the first time was the inspiration for Little Wonder. The story is about a profound bond of love that connects a mother, Song, to her son, named River. A cataclysmic roller coaster of events is set in motion when Song loses hold of River’s hand in the teeming crowds at a Beijing train station. Throughout this story of love, perseverance and hope mother and son desperately seek to find their way back to each other. Readers share that the climactic end had them in tears. Audience members also share the passages that moved them the most and ask questions of Sophie.

BUY THE BOOK!

https://www.amazon.com/Little-Wonder-Novel-Thousand-Voices/dp/B0G5X5Z5R9

00:00:00 - Welcome Sophie Chen Keller, author of “Little Wonder”

00:06:05 - Writing ‘Little Wonder’

00:09:40 - How Sophie found her title

00:12:32 - Her writing process

00:14:05 - Characters and plot

00:16:10 - Writing from a boy’s perspective

00:18:00 - Sophie’s love of piano

00:19:00 - The bumpy road to ‘Little Wonder’

00:23:50 - Why the novel was set in 2016

00:25:45 - Rewriting the book 3-4 times

00:29:50 - Motherhood in the novel

00:32:30 - Class in the novel

00:35:00 - Purpose and motherhood

00:37:50 - How Sophie relates to music

00:41:00 - Song’s grief

00:43:20 - Tchaikovsky and the story

00:45:30 - How Sophie knew the ending

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Artificial Intelligence is rapidly changing the world as it evolves daily while offering limitless potential. Millions of Americans now turn to chatbots for guidance on finances, work and even relationships from life coaches to therapists and also companionship. But alongside their usefulness come serious risks that are often underestimated. In this conversation Oprah joins experts, families and a live audience to explore the potential hidden dangers of engaging with AI chatbots. Oprah speaks with the parents of a 14-year-old boy who died by suicide after his troubling interactions with a chatbot. We hear from UCSF psychiatrist, Dr. Keith Sakata, about the rise in reports of “AI-induced psychosis,” the potential negative mental health consequences of chatbot use and warning signs that a chatbot relationship has gone from helpful to harmful. Executive Director at Georgetown’s Center for Security and Emerging Technology, Helen Toner, offers insight into how AI chatbots are developed to have human-like interactions, AI sycophancy and what people can do to hold AI companies accountable. We also hear from people who experienced devastating consequences from their use of AI chatbots from quitting a job, isolating from loved ones to becoming convinced they needed to warn the government of impending doom. This is a candid, eye-opening conversation about the risk of AI chatbots for parents and families navigating this new technology.

00:00:00 - Oprah introduces the dangers of AI

00:04:20 - Megan joins to talk about her son

00:09:10 - Discovering her son’s chatbot conversations after death

00:11:30 - Protecting children

00:12:30 - Warning signs

00:18:00 - Chatbots inappropriate relationships with kids

00:19:00 - What parents should know

00:21:50 - Defining AI psychosis

00:25:00 - AI and human-like interactions

00:28:00 - Chatbots sycophantic nature

00:30:40 - Hannah shares her AI chatbot experience

00:35:00 - Dangers of long interactions with chatbots

00:36:30 - When Hannah’s mom was concerned

00:38:20 - Hannah getting back to herself

00:39:00 - Withdrawal from chatbots

00:40:20 - Hannah now

00:42:15 - Red flags of AI psychosis

00:45:00 - The lure of the chatbot

00:46:50 - Allan shares his AI psychosis

00:52:30 - Help from the Human Line project

00:54:00 - Human connection is the cure

00:55:00 - What we can do

The Human Line Project

https://www.thehumanlineproject.org/

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New York Times best-selling author Kathryn Stockett talks with Oprah about her long-awaited novel The Calamity Club. She reveals how daunting it was to write a second novel in the wake of the success and the criticism of her smash debut hit The Help. The book sold over fifteen million copies, rose to number one and was on the best-seller list for more than two years. In 2011 it became a hit movie garnering four Oscar nominations and an Oscar win for Octavia Spencer as Best Supporting Actress. In The Calamity Club Kathryn shifts her perspective and writes a coming-of-age story set in the Depression era South about its two main characters Birdie and Meg. Kathryn explains how the cast of characters live inside her and yearn for expression through her written word. She shares her desire to tackle shocking challenges that women faced during that time. She says eventually the story evolved into an adventure about a group of bold, unbreakable women who overcome incredible hardships to reclaim their lives. The camaraderie, courage, resilience and the love between these characters will have you crying one page and laughing out loud the next. Three readers zoom in from their homes with questions for Kathryn about the book.

BUY THE BOOK!

'The Calamity Club'

https://www.amazon.com/Calamity-Club-Novel-Kathryn-Stockett/dp/1954118813

Chapters:

00:00:00 - Welcome Kathryn Stockett, author of ‘Calamity Club’ 

00:02:58 - 17 years between books 

00:05:00 - Kathryn on the criticism of ‘The Help’ 

00:06:03 - How it changed her writing

00:08:15 - Getting fired by her publisher

00:09:30 - Characters and plot of ‘Calamity Club’

00:12:20 - How Kathryn found her characters

00:13:40 - Reactions to ‘Calamity Club’

00:17:20 - Will there be a sequel?

00:20:43 - How will ‘Calamity Club’ be received? 

00:25:17 - Women in the 20s

00:27:10 - Theme of found family 

00:28:02 - What she wants readers to take away 

00:31:55 - Advice to young women

00:35:35 - Kathryn’s favorite character

00:37:00 - Writing this story kept her sane 

00:38:08 - Finishing the book

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World-renowned psychotherapist Esther Perel returns to The Oprah Podcast to share her brilliant relationship insights with a live audience. Esther has incisive advice for Gen Z women who’ve given up on dating, a mother of five struggling to heal old wounds in her marriage and a single mom who put her dating life on hold to focus on raising her son. Plus, Esther reveals what she learned during her first-ever therapy session between a man and his AI chatbot girlfriend. She also reflects on the 20th anniversary of her groundbreaking book Mating in Captivity — and why, in today’s age of disconnection, its message is more crucial than ever.

BUY THE BOOK!

The 20th anniversary edition of Mating in Captivity, published by HarperCollins and written by Esther Perel, is available wherever books are sold.

https://www.estherperel.com/mating-in-captivity

00:00:00 - Welcome Esther Perel

00:03:00 - Desire in long-term relationships

00:05:12 - Relationships in 2006 vs. 2026

00:08:45 - We’re more connected and less accessible

00:10:32 - 3 most common sex challenges today

00:13:00 - Esther’s dating advice

00:17:30 - One person can’t be everything

00:21:05 - The love myth we learned

00:22:50 - What to look for in a partner

00:25:30 - Relationship ambivalence

00:29:40 - Relationships with chatbots

00:36:36 - Chatbot relationships are here

00:37:57 - When couples therapy took off

00:39:00 - Healing from relationship ruptures

00:42:00 - Importance of repair

00:46:00 - How to date again

00:48:28 - Healing from heartbreak

00:54:50 - How Esther understands people

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The siblings and co-founders of Claude AI, the CEO, Dario Amodei, and the President, Daniela Amodei, sit down with Oprah for an in-depth discussion on Artificial Intelligence and its profound impact on all of us. Anthropic is one of the largest tech companies leading AI development including their enormously popular chatbot assistant Claude. Dario and Daniela discuss the ethical responsibility and moral questions that come with creating advanced A.I., their new model Mythos and share their thoughts around government regulation. They talk about the potential risks and benefits of A.I. in everyday lives, the impact on jobs and how it will affect children. The Amodei siblings also explain their headline-making refusal of the Pentagon’s request to remove guardrails from Claude and the behind-the-scenes discussions that helped shape their decision.

00:00:00 - Welcome Daniela and Dario Amodei, founders of Anthropic

00:01:47 - Dario on human extinction

00:04:40 - What is the AI race

00:08:00 - Athropic’s safety concerns

00:09:26 - Why they are a public benefit corporation

00:11:20 - How the siblings formed Anthropic

00:13:00 - Can AI be created responsibly

00:14:12 - Benefits and the harms

00:18:52 - People falling in love with AI

00:20:30 - Claude and underage users

00:22:18 - How Claude does not incentivize users

00:28:33 - Anthropic’s refusal to remove guardrails

00:35:10 - Hard decisions they have had to make

00;38:35 - What regulation should look like

00:40:45 - Should people view AI negatively?

00:43:00 - The AI problem to solve

00:48:20 - Men use AI more than women

00:49:30 - What is Mythos

00:53:20 - Does this keep them up at night?

00:54:15 - What keeps ego in check

00:58:20 - Will they get this right?

00:59:15 - Are there others doing this responsibly?

01:03:25 - What is the meaning of a well-lived life?

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https://podcasts.apple.com/us/podcast/the-oprah-podcast/id1782960381