have been wanting to sit down with Dr. Darshan Shah for three years. We finally made it happen at South by Southwest in Austin and it did not disappoint.Dr. Shah is the founder of Next Health, one of the most advanced longevity and functional medicine clinics in the world with over 30 locations. He is also a surgeon who performed over 20,000 procedures and then had a personal health crisis in his early 40s that changed everything. He was 50 pounds overweight, had high blood pressure, cardiovascular disease, diabetes and an autoimmune condition, and was on 10 different medications at the same time.He fixed all of it in 8 months through functional medicine. And he has never gone back.In this episode we talk about the hidden causes of inflammation that show up even in people who think they have a clean lifestyle. Why your toothpaste and Listerine are sabotaging your health. The biomarkers every person should be testing and what optimal actually looks like versus disease state. Why 80 to 90 percent of the surgeries he performed over his career could have been avoided. How AI is now reading thousands of your health data points and finding connections that even experienced doctors miss. What Therapeutic Plasma Exchange actually does to your blood and why it is being used to reverse biological age. The truth about peptides and why buying them without a prescription from online sources is genuinely dangerous. What the NVIDIA founder said about the future of human biology that stopped Dr. Shah in his tracks. And the one functional lab test he would take to a desert island.This is one of the most information dense episodes we have done on Biohack-it. You will want to take notes.Sponsors:Try Branch Basics:20% off Premium Starter Kit https://branchbasics.com/BIOHACKIT20 Code:Biohackit20Rho Nutrition:Check out Rho's Liposomal NAD+ at rhonutrition.com and Use code BIOHACKIT for 20% off sitewide.

Sleep is the one thing I know I need to be better about. And when I found Dr. Chris Winter, I knew he was the person I wanted sitting across from me for this conversation.

Dr. Winter is a neurologist and one of the leading sleep experts in the country. He has spent his career working with everyone from elite athletes to everyday people who just cannot get their sleep right. And in this episode, he told me a lot of things I did not expect to hear.

We talk about why your Oura ring score is probably making your sleep worse, not better. Why sleeping longer is not the same as sleeping better. What your brain is actually doing while you sleep and what happens when it stops doing it. The link between poor sleep and dementia, and why the research says you can change that outcome even if you carry the gene. How alcohol destroys your sleep even if it helps you fall asleep fast. What a proper melatonin dose actually looks like and why most people are doing it wrong. Why waking up at night is completely normal and not what your tracker is making you think it is. The one supplement combination Dr. Winters says is backed by real research. And why falling asleep in under two minutes is a red flag, not a flex.

This episode completely changed the way I think about sleep. I hope it does the same for you.

Sponsor:

Shop Natrol Ultra Sleep here: https://www.natrol.com/collections/ultra-sleep

Try Branch Basics:

20% off Premium Starter Kit

https://branchbasics.com/BIOHACKIT20

Code:Biohackit20

I have been wanting to have this conversation on Biohack-it for a long time. And I can personally vouch for everything Maria says in this episode.

Maria Marlowe is a world renowned nutritionist who specializes in clearing skin from the inside out. She had severe acne for almost five years, tried every prescription, and was about to take Accutane when she saw the side effects on the label. Instead she changed her diet. Her skin cleared in three months. She went back to school, became a nutritionist, and has spent her career teaching people what their dermatologist never told them.

In this episode we break down why everything the skincare industry tells you is backwards. Your skin is not a surface problem. It is a gut problem. We talk about the gut-skin connection, why all acne starts in the gut whether it is hormonal or not, the healthy foods that are secretly driving breakouts (whey protein and biotin are two you need to know about), Chinese face mapping and what where you break out reveals about your hormones and organs, how to choose a probiotic that actually works for your skin, how to read the label so you know you are not wasting your money, and Maria's three day skin reset that people use for emergency clear skin results.

This is the episode to send to anyone who has tried every product and is still breaking out. The answer is in the gut. It always has been.
Follow Maria: @mariamarlowe | mariamarlowe.com

Clear Skin Starter Kit: mariamarlowe.com

Sponsor:
Try Branch Basics:
20% off Premium Starter Kit 
https://branchbasics.com/BIOHACKIT20 
Code:Biohackit20

🔔 Hit that subscribe button for exclusive access to thought-provoking podcasts, self-growth tips, inspiring guidance, empowerment for bold spirits, and more!
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🔗 Stay Connected With Us.

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🎬 Recommended Playlist

👉 Season One 
https://www.youtube.com/playlist?list=PLQWTIuStNqibK2-K-T3GfnIxdLlK_KXMD 

🎬 WATCH OUR OTHER VIDEOS:

👉 Revolutionize Your Health with Dr. Vincent Pedre: The Transformative Power of Plant Medicine 
https://www.youtube.com/watch?v=rcvHjUFT0-w 

👉 Why Modern Relationships Fail: Expert Insights from Jillian Turecki 
https://www.youtube.com/watch?v=qseduflV5oo 

👉 Carolina Reis, PhD on Reversing Aging and Keeping Skin Healthy 
https://www.youtube.com/watch?v=DOf9SqMYtqg 

👉 Dr. John Kim on Debunking Detoxification Myths | Biohack-it 
https://www.youtube.com/watch?v=_kuQtZ4A_Ao 

👉 Inside the Operating Room with New York's Hottest Plastic Surgeons 
https://www.youtube.com/watch?v=Sku8y9y-AuM 

=============================

✅ About Biohack-it.

Welcome to Biohack-it! Immerse yourself in a world of authenticity, empowerment, and innovation. Biohack-it, led by Iman Hasan, is a transformational journey of personal development and self-discovery. Join us to nurture bold spirits, ignite meaningful conversations, and celebrate your true self. We're not just storytellers; we're architects for change.

Biohack-it isn't your typical wellness podcast. It's a beacon for the bold and curious, craving authenticity. Discover conversations that challenge the status quo and empower your deepest self. With Iman Hasan's guidance, each episode becomes a chapter in your self-discovery journey.

🔔 Subscribe & stay tuned for exclusive content on captivating podcasts, self-discovery tips, nurturing bold spirits, insightful guidance, and more!
https://www.youtube.com/@Biohack-it/?sub_confirmation=1 

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⚠️ DISCLAIMER: The content shared on Biohack-it is for informational purposes only. It's not intended as medical advice, diagnosis, or treatment. Always consult with a professional for health-related inquiries. 

Copyright Notice: This video and our YouTube channel contain dialogue, music, and images that are the property of Biohack-it. You are authorized to share the video link and channel and embed this video in your website or others as long as a link back to our YouTube channel is provided. 

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Keywords: Maria Marlowe, acne nutritionist, clear skin from inside out, gut skin connection, how to clear acne naturally, face mapping acne, hormonal acne gut, healthy foods causing acne, whey protein acne, biotin acne breakouts, probiotic for acne, best probiotic for skin, acne diet, Biohack-it podcast, how to get clear skin fast, 3 day skin reset, acne without Accutane, dermatologist diet acne, skin gut inflammation, leaky gut acne

I have waited two and a half years to bring you this conversation. Today, I am joined by the world-renowned OBGYN and women’s health expert, Dr. Jessica Shepherd from HERS.

We live in a culture that promises "salvation" through a single shot, a specific pill, or one hormone replacement. But as Dr. Shepherd reveals, the truth about total body optimization is far more complex. This episode is an urgent call for women to reclaim sovereignty over their own bodies and nervous systems.

In this masterclass, we discuss:

The HRT Lie: Why an entire generation of women was taught to fear hormones and the devastating impact of that misinformation.

The GLP-1 Reality: Why your health transformation requires more than just a shot to reach the "best version of you".

Total Body Levers: The specific, alternative points of view on medicine that allow you to optimize your health from a cellular level.

Personal Expansion: How to bridge the gap between "getting by" and achieving true longevity.

If you feel like you’ve been looking for answers in all the wrong places, this conversation will give you the tools to finally pull the right levers for your health.

Follow Dr. Jessica Shepherd: Instagram: @jessicashepherdmd

Sponsors:
Try Branch Basics:
20% off Premium Starter Kit 
https://branchbasics.com/BIOHACKIT20 
Code:Biohackit20

Rho Nutrition:
Check out Rho's Liposomal NAD+ at rhonutrition.com and 
Use code BIOHACKIT for 20% off sitewide.

I've been using Branch Basics for five years. It changed my health before I even fully understood why.

In this episode I sit down with Allison Love, co-founder of Branch Basics, to break down something most people never think about: the toxic load hiding in your cleaning products, laundry detergent, personal care items and yes, the air inside your own home. We talk about how Allison's co-founder reversed her PCOS not through medication but by changing what she was washing her clothes with. We talk about Marylee, their mentor, whose son went from a healthy, coordinated child to barely being able to lift his head off a pillow after pesticide exposure, and how stripping their home one product at a time brought him back.

We also get into why the word "natural" on a label means nothing, how fragrance hides hundreds of toxic chemicals in a single word, why your sanitizers and disinfectants may actually be making you more vulnerable to getting sick, and what the word "fragrance" is legally allowed to conceal.

I share my own story too. Ovarian cysts since 15. One ovary reconstructed. Migraines. Inflammation. And how switching my environment, not just my diet, changed everything.
If you have kids, pets, or a body, this episode is for you.

Follow Branch Basics: @branchbasics
Follow me: @imanhasan

Sponsors:
Try Branch Basics:
20% off Premium Starter Kit 
https://branchbasics.com/BIOHACKIT20 
Code:Biohackit20

Rho Nutrition:
Check out Rho's Liposomal NAD+ at rhonutrition.com and 
Use code BIOHACKIT for 20% off sitewide.

What does it actually take to walk away from a successful career and build something that genuinely fulfills you?

Erika De Pellegrin did exactly that. Corporate lawyer in Australia. New continent. New career. New baby. All of it — on her own terms.

We talked about the moment she realized her job title wasn't her identity, why who you marry is the most important decision you'll make, how she balanced motherhood with building a podcast that blew up, and why women evolve in ways most people never fully account for.

This one is for every woman who has ever asked herself: is this it?

Try Branch Basics:
20% off Premium Starter Kit 
https://branchbasics.com/BIOHACKIT20 
Code:Biohackit20

Chapters:
00:00 — Intro
01:20 — Meet Erika De Pellegrin — corporate lawyer to content creator
03:00 — The moment she asked herself: is this it?
05:00 — Why she didn't need a dramatic pivot — just a gap to fill
06:30 — January 1st, 2020, a Gary V clip, and a husband who said "start a podcast"
09:00 — Running a podcast while working full-time — how she balanced it
12:00 — Moving from Australia to Dubai: the why behind the leap
20:30 — Raising a baby away from family — guilt, sacrifice, and presence
23:30 — The most important decision a woman makes: who she marries
24:45 — Why women evolve so differently than men over a lifetime
26:30 — How to attract the right people when you're still figuring yourself out
32:00 — Your niche is YOU — why the market is never too saturated for authenticity
35:00 — People-pleasing, projection, and learning to stop letting others define you
42:00 — AI, content creation, and why a machine will never have your why
47:00 — Final advice: how you think and feel about yourself will be reflected in your opportunities
49:00 — Closing: what's the one thing YOU'VE been putting off?

I have been obsessed with frequency medicine since last year, but after sitting down with Henry and Laura from Soaak Technologies, I realized we are only scratching the surface of what’s possible. This isn't "woo-woo"—this is clinical-grade technology currently being used by the U.S. Air Force to optimize pilot performance and mission readiness.

In this episode, we dive into the science of Sympathetic Resonance and how sound frequency compositions can literally turn your "square tires" into round ones. Henry and Laura share the incredible journey of taking these modalities from a high-end clinic in Oklahoma to a global app that is now changing lives in 190 countries.

Try Soaak for yourself:

Go to https://www.soaak.com/biohack-it

(Use code BIOHACKIT for 30 days free!)

Try Branch Basics: 20% off Premium Starter Kit https://branchbasics.com/BIOHACKIT20 Code:Biohackit20

I’ve always been fascinated by the strength of Saudi women, but my conversation with Nada Baeshen went deeper than I ever expected. In this episode of Biohack It, we’re pulling back the curtain on what marriage, divorce, and financial independence really look like in the Middle East—and I’m sharing a massive personal update about my own life.Nada, one of the biggest TV presenters in the Kingdom, opens up about why she preaches financial freedom as the only way for women to truly "take their power back." We discuss the cultural pressure to get married, the fear of "being old" at 32, and the heartbreaking reason she shifted her entire life toward wellness after her father’s dementia diagnosis.Plus, I’m being completely transparent with you guys for the first time: I am going through a conscious uncoupling at 42. We dive into why choosing yourself is sometimes the hardest—and healthiest—biohack you can perform. If you’ve ever felt stuck in a relationship or a career that no longer aligns with your frequency, this masterclass on resilience and starting over is for you.

I finally sat down with the incredible Dr. Natalia Spierings, and she is exactly the kind of pattern-interrupt this industry needs. Natalia isn’t just a UK-trained consultant dermatologist and surgeon—she is also a professional IFBB bodybuilder. Today, we are cutting through the multi-billion dollar marketing hype to get to the "no bullshit" truth about your skin and your body.

In this episode, Natalia exposes why most skincare products are essentially useless and why she believes Vaseline is closer to magic than any luxury serum. We dive deep into the science of Tretinoin, the dangers of long-term fillers (and the "alien" looks they can create), and why fat transfer might be a better surgical alternative for under-eye rejuvenation.

We also discuss the bodybuilding mindset: why most women fail to change their body composition despite lifting weights, and the power of DEXA scanning to keep you accountable. If you’re tired of "hope in a bottle" and want a straightforward, evidence-based approach to longevity and anti-aging, this masterclass is for you.

Connect with Dr. Natalia Spierings:

Instagram: @drnataliaspierings

Sponsors:

Vibrant Wellness: Get the Hormone Zumra test to understand your body’s unique needs. Visit http://vibrant-wellness.com/imanhasan

Chapters:

00:00:00 – Intro

00:01:37 – The Bodybuilding Pivot: From Cycling Accident to the UK Arnold

00:03:55 – The Bodybuilding Mindset in Medicine: Stick to the Basics

00:05:00 – Tretinoin: The Real Gold Standard for Anti-Aging

00:06:48 – The Biggest Skincare Lie: Why Drinking Water Doesn’t Hydrate Skin

00:09:28 – The Danger of Injectables: FDA Approval vs. Efficacy

00:11:00 – Under-Eye Tragedies: Why Fillers Can Block Your Lymphatic System

00:13:38 – Fat Transfer vs. Fillers: A Surgeon’s Take on Volume Loss

00:16:50 – Skincare Scams: Why Peptides and Exosomes are Marketing Gimmicks

00:23:13 – Debunking "Clean" Scams: The Truth About Hydroquinone and Minoxidil

00:25:20 – HRT and Skin: Why Doctors Should Stay in Their Lane

00:30:05 – Botox Myths and the Rise of "Alien" Aesthetic Faces

00:33:32 – Body Composition: Why You’re Not Gaining Muscle

00:35:36 – Knowledge is Power: The Role of DEXA Scanning in Longevity

I have followed Dr. Natalie Crawford for years, and having her on the show is a true full-circle moment for me. As a board-certified reproductive endocrinologist, Natalie is a beacon of knowledge for anyone navigating a fertility journey. In this episode, she gets incredibly raw about her own struggle with infertility and how being gaslit by the medical system led her to discover the "big dirty secret" of reproductive health: inflammation.

We dive deep into the science of ovarian aging and why your "biological clock" is about more than just your age. Natalie explains how mitochondrial health and insulin resistance are the real drivers of egg quality and how you can proactively lower your inflammatory burden through sleep, nutrition, and nervous system regulation. Whether you are considering IVF, egg freezing, or just want to understand your hormones better, this masterclass in preventive care is for you.

In this episode, we discuss:

The connection between chronic stress, cortisol, and fertility loss.

Why building skeletal muscle is the key to fighting insulin resistance.

The truth about forever chemicals (PFCs) in your kitchen and water.

The latest research on Rapamycin and PRP for ovarian longevity.

A step-by-step guide to cycle tracking and identifying ovulation signs.

I have been trying to get Dr. Amy Shah on Biohack-it for 18 months, and we finally made it happen while filming in Riyadh, Saudi Arabia. As two South Asian women, we dive straight into a conversation that hits close to home: why our race is built so petite yet remains at a significantly higher risk for type 2 diabetes, Alzheimer’s, and heart disease than other populations.In this episode, Dr. Amy Shah breaks down the fascinating science of "thrifty genes"—the biological survival mechanism from ancestral famines that makes our bodies hold onto sugar differently. We discuss the "skinny-fat" phenomenon and how modern lifestyle choices, like processed seed oils and a lack of protein, are creating a metabolic crisis. Dr. Shah shares her proprietary 30-3-3 rule for gut health and her signature "cortisol reset" to help you regulate your nervous system and reclaim your energy.Sponsors: Vibrant Wellness: Get the Hormone Zumra test to understand your body’s unique needs. Visit http://vibrant-wellness.com/imanhasan