Why do brains generate strange thoughts sometimes? And why do some brains refuse to let go of those thoughts? Today we'll talk about Obsessive Compulsive Disorder (OCD) with expert Jon Hershfield, getting a view from the inside and the outside. Why do some people lock the door but go back repeatedly to check it, and still have a feeling of uncertainty that it’s locked? Why do some people wash their hands over and over and never feel that they reach a point when it’s “done”. How, for some people, are intrusive thoughts like junkmail that the brain just cant help opening? We’ll see how obsessive thoughts can get caught in loops, and how those loops might therapeutically be broken.

What if your brain got stuck in sadness and never reset? What does it feel like when joy disappears completely? Can a person love their family deeply and still want to die? What do you do when treatment after treatment fails? What if the difference between despair and recovery is electrical? How can we better recognize invisible struggles in those around us? Join Eagleman with guest Jon Nelson, a man who suffered for years under the grip of depression, and finally found a science-fiction like treatment which gave him relief.

Week 2 of Mental Health Awareness month: Anxiety is close to everyone’s experience, either because you've had it or someone close to you has. Does your brain accidentally teach itself to stay anxious by looping on the same fears? Is anxiety helping you perform better, or does it make everything harder? Is it possible to unlearn worry the same way you learned it? Join Eagleman with Dr. Jud Brewer, who suffered with anxiety as a young man... and then became a psychiatrist and neuroscientist who studies anxiety and developed a very different approach to its treatment.

What do you do when your own mind stops feeling safe? How does a person sing on stage while panicking inside? How do you catch your thoughts before they catch you? Join Eagleman with singer/songwriter Jewel to talk about mental health: the battles she’s lived, the wisdom she’s earned, and the lives she’s helping shape. This episode kicks off Mental Health Awareness month, when we’re reminded to look directly at what is typically hidden. A troubled mind with stormy weather can often remain dark; join us this month to bring some light.

Why do we generally feel like the world is getting worse, when by almost all measures it’s getting better? How do ideas "have sex”, and why does that matter for innovation? Why do brains tend to systematically misread the future? What if optimism is a more rational stance than pessimism? If innovation isn’t primarily about lone geniuses, what’s it really about? Join Eagleman with scientist and author Matt Ridley to explore what it means to be, in Ridley’s phrasing, a "rational optimist".

Can you influence what you dream about tonight? Are you spending years of your life in a world you don’t recall? Can nightmares be manipulated as a therapy? Are dreams sometimes predictive of changes in your health before you become aware of them? Join Eagleman with Adam Haar Horowitz, a neuroscientist and dream engineer who spends his working days trying to help people during their night time.

How can a brain grow up in chaos but find its way to order? There are many ways to have a bad childhood, but why do some children break while others bend and keep going? How much of who you are is written in your genes & how much is sculpted by your environment? How many versions of you were possible & why did this one win out? Join Eagleman today with David Sussillo, who was abandoned as a child but grew up to become a neuroscientist & technologist. We’ll explore what his trajectory teaches about our genes, brains, and our own lives.

How can we improve political dialogue, and what does this have to do with the discovery that the universe behaves differently than expected? Why do we cling to beliefs even when evidence pushes against them? What if the biggest problem facing humanity could be solved with practice? Join Eagleman today with Saul Perlmutter, a Nobel-prize winning astrophysicist, but instead of the cosmos we talk about the inner cosmos: why polarization happens and how we might address it with a different kind of thinking.

Can the mind be captured with math? Modern AI seems to have burst out of the gate recently, but is it actually the latest chapter in a 300-year project to turn thought into something we can model? Why does current AI need petabytes of data, but a child can learn from just a few examples? Why does AI have 'jagged' intelligence – meaning it looks brilliant in one moment and then does something that seems nonsensical? In physics we have various laws (gravity, motion, etc), and today we’re joined by cognitive scientist Tom Griffiths to ask whether we're moving towards laws of thought.

When do you view another person like an object? This is what neuroscientists mean when they talk about de-humanization: your brain doesn't crank up its social circuitry to understand the other person as having a mind like you do. Is dehumanization a cause of violence, or the fuel that keeps it burning? Do people who view themselves as highly empathetic dehumanize more than others? And on the flip side, why do we sometimes think chatbots or robots are people with interior minds? Will kids raised with AI grow up to fight for AI rights? Today we dive deep into how your brain sees others with social neuroscientist Lasana Harris.

Do algorithms shape our lives? What did clickbait look like before the internet? Why do journalists start writing differently when metrics are introduced? What does any of this have to do with cooking pasta in the bathtub, the actress  Sarah Bernhardt, or Oxford English Dictionary’s word of the year? Join Eagleman with sociologist Angele Cristin to learn how algorithms invisibly sculpt our behavior.