In this episode of Possible, Reid Hoffman and Aria Finger talk with Sean Neville, co-founder of Circle and architect of USDC, about building the financial infrastructure for an AI-driven economy. Now leading Catena Labs, Neville is working on what he calls the first AI-native bank—designed for autonomous agents that can transact, comply, and interact without humans in the loop. The conversation explores what breaks when AI tries to use today’s financial rails, why stablecoins may power machine-to-machine commerce, and why new concepts like “Know Your Agent” could become the foundation of trust in an AI financial system.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

Is SaaS actually dead or just evolving? Reid and Aria break down why the traditional seat-based software model is under pressure as AI reshapes how products are built, priced, and delivered. They discuss how these fundamental changes have started shifting SaaS software toward customization, token-based economics, and deeply integrated AI systems. The conversation digs into what this change means for engineers, why network effects and customer relationships still matter, and how new moats will emerge as software becomes faster, cheaper, and more dynamic than ever before.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

Reid and Aria unpack three emerging fault lines in the AI era: where real power sits in the AI stack, how AI is reshaping human creativity, and whether governments could ultimately treat AI as critical national infrastructure. Reid responds to Jensen Huang's "five-layer cake" framing of AI, arguing that while compute, infrastructure, and models carry geopolitical weight, the greatest economic value tends to emerge at the application layer. The episode then turns to a broader debate over a viral NYT experiment that pitted humans against AI writing. Reid and Aria close by examining Palantir CEO Alex Karp's warning about AI nationalization, weighing the tensions between innovation, national security, and democratic values as AI becomes foundational technology.

Reid and Aria unpack new research on AI decision-making in simulated nuclear crises—and what it reveals about the limits of machine reasoning. They explore why frontier models consistently escalated to nuclear conflict in war game scenarios, and what that says about the enduring importance of human judgment. Then Reid examines the rise of software agents that can be hired like employees, and the broader shift from hourly labor toward ownership and leverage in the AI economy. The episode closes with Reid and Aria debating AI-powered manufacturing—why automation may be the only viable path to rebuilding U.S. industrial capacity, and why embracing AI-amplified industries is essential for long-term competitiveness.

In this episode of Possible, Reid and Aria talk with Ivan Zhao, co-founder of Notion, about what happens when intelligence becomes abundant rather than scarce. Zhao shares his philosophy of treating computing as a material — like steel or steam — and why organizations must be built for human scale in an AI-driven world. From Renaissance cities to Xerox PARC, the conversation traces a shift from productivity software to cognitive infrastructure, and arrives at a clear conclusion: in an AI-powered future, human judgment, taste, and values matter most.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

In this episode, Reid and Aria are live from New York as they unpack why predictions about the “death” of San Francisco and New York keep missing the mark and how network effects continue to anchor these cities as the world’s leading tech and finance hubs. Reid also shares advice for young founders choosing where to build and explains how to align your startup with the right economic network by breaking down lessons from companies like Shopify and Spotify that scaled outside Silicon Valley. The conversation then shifts to the future of AI in biotech as Reid offers an update on Manas AI and why curing disease hinges on regulation as much as technological breakthroughs. The episode closes with a candid discussion on media, political pressure, and the dangers of “pre-obeying” authority. Reid reflects on free speech, institutional courage, and what a volatile post-midterm landscape could mean for American democracy.

In this episode, Reid and Aria examine a growing tension at the heart of the AI moment: whether these tools are actually saving time or simply accelerating the pace, volume, and expectations of work. The conversation touches on workflows across investing, engineering, legal, and management and why faster output rarely means less work. From there, Aria and Reid engage with competing essays about the AI moment, pushing back on both apocalyptic predictions of immediate white-collar collapse and dismissive claims that today’s AI are merely “tool-shaped objects.” The episode closes with a reframing of AI not as an inevitable force of gravity, but as a strategic capability that rewards those who are able to learn how to adapt more effectively as the landscape continues to shift.

In this episode, Reid and Aria unpack the growing panic around layoffs, the actual impact of AI on work, and why autonomous agents are reshaping productivity faster than most people realize. Reid points out that today’s layoffs are being erroneously blamed on AI, rather than on economic turbulence and post-COVID refactoring. The conversation then turns to the viral ClawdBot/Moltbot/OpenClaw moment and explores what it means for productivity, security, and trust when autonomous agents can not only act across email, calendars, files, and financial systems, but also interact and gather with each other. The episode closes with a pivot to politics, as Reid explains why Silicon Valley and business leaders can no longer claim neutrality in today's polarized political landscape, arguing that real leadership requires speaking up before it’s too late.

Before NFTs were a category and crypto was an industry, two artists released 10,000 characters into the world with no roadmap, no pitch, and no expectations. What started as an art experiment in code ended up flourishing into a movement about ownership and identity. In this episode of Possible, Reid sits down with Matt Hall and John Watkinson, co-founders of Larva Labs and creators of CryptoPunks, to trace how a small creative experiment became one of the most influential cultural phenomenons of the internet era. They reflect on what it means for art to live on-chain, why decentralization was a design choice rather than a slogan, and how digital identity became one of the most valuable real estates online. From museums and blockchains to profile pictures, permanence, the conversation explores how letting go of narrative control can allow culture and community to write the story themselves.

This episode is our third and final installment of a special, three-part Reid Riffs miniseries focused on what it actually means to become AI-native. In this episode, Parth shares how founders can rethink work by breaking problems into modular pieces, orchestrating AI agents in parallel, and collapsing timelines that once required entire teams days of iteration. Using real-world examples like coding agents that tackle week-long engineering challenges to reimagining how content can be localized across languages and regional markets, the conversation explores how AI enables small teams to operate with outsized leverage. Along the way, Reid and Parth discuss what separates real AI traction from “AI theater,” how founding teams are evolving, and why the most powerful AI often works best when it fades into the background, quietly amplifying human creativity and ambition.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

This episode is our second installment of a special, three-part Reid Riffs miniseries focused on what it actually means to become AI-native. Instead of a news or headline-driven conversation, Reid sits down one-on-one with AI engineer and strategist, Parth Patil, for a deeper exploration of how AI is changing the way people and organizations work. In this second episode, they discuss why most enterprises are still talking about AI without truly integrating it (“AI theater”), and how the real shift begins inside everyday workflows rather than strategy decks. Together, they explore how language models and agents can reduce friction in communication and coordination, reinvent meetings, and turn unstructured information into actionable insight (with examples). They also examine how AI-powered analysis, automation, and parallelized agents are accelerating decision-making, reshaping roles, and moving work from execution toward orchestration. Parth and Reid both highlight how an open mindset and experimentation are required to collaborate effectively with these systems as AI evolves from a productivity tool into a foundational layer for thinking and leadership.

Subscribe below to catch the third episode for startup founders and their early teams building AI-native companies. 

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/