- 18 minutes 6 secondsIs Retatrutide the Most Powerful Weight-Loss Drug Yet? The Data So Far
A weight-loss injection with results on par with bariatric surgery? With retatrutide, that is not an exaggeration.
Although it’s not FDA approved yet, retatrutide is one of the most talked-about medications coming down the line. In this episode, I’m unpacking Eli Lilly’s new “triple agonist” medication, which targets three different pathways: GLP-1, GIP, and glucagon.
We’ll talk about how retatrutide may help curb appetite, support insulin sensitivity, increase energy expenditure, and accelerate fat metabolism.
I’ll also walk you through the standout clinical trial numbers behind the hype and take an honest look at tolerability, discontinuation rates, and side effects, including nausea, diarrhoea, and vomiting, so you can understand the full picture.
References
Harvard Study: Benefits of Micro Walks
Secure your spot for the September round of The 30/30 Program now (spaces limited).
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All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.
If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.comNot Sure Where to Start With the Podcast? I’ve Got You.
Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.
22 June 2026, 7:00 am - 18 minutes 16 secondsFoundayo (Orforglipron): Weight Loss Pill Benefits, Risks & Results
A new GLP-1 has entered the chat, and I'm already seeing a lot of confusion around it. Meet Foundayo (orforglipron), a needle-free tablet you take once a day with none of the usual restrictions around timing, food, or storage.
On paper, it sounds like the easier option. And for some people, it might be. But like most things in this space, the headline only tells part of the story.
In this episode, I’m breaking down what you really need to know before considering it, from cost and access to drug interactions and what the latest trial data shows about maintenance.
References
Ep. 156. Oral Wegovy: How to Take It, Who It's For, and What It Costs with Joseph Zucchi, PA
Secure your spot for the September round of The 30/30 Program now (spaces limited).
Get the free podcast roadmap for The Obesity Guide
Subscribe to my Youtube channel
All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.
If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.comNot Sure Where to Start With the Podcast? I’ve Got You.
Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.
15 June 2026, 7:00 am - 35 minutes 35 secondsHow to Hit Your Fiber Goal Without Overhauling Your Diet
The average American gets only about 10 to 15 grams of fiber a day, which is less than half the recommended 25 grams for women and 38 grams for men.
Most of us don’t realize we’re falling short until digestion starts to feel off: bloating, constipation, sluggishness, and that uncomfortable “never quite right” feeling. If you’re on a GLP-1 medication, low fiber intake can matter even more, since constipation is one of the most common and frustrating side effects.
So how do we close the gap without overhauling everything we eat?
In this episode, I walk you through simple, realistic ways to build more fiber into your day. I’m sharing the foods and products I personally rely on, what to know about magnesium and probiotics, and how to spot supplements that may be helping your digestion or working against it.
References
Secure your spot for the September round of The 30/30 Program now (spaces limited).
Get the free podcast roadmap for The Obesity Guide
Subscribe to my Youtube channel
Recommendations:
Folly Nutrition Hair Health Gummies (Use code MATTHEA)
The Only Bean dried edamame snacks
Recipes:
High-fiber blueberry dessert bowl
All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.
If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.comNot Sure Where to Start With the Podcast? I’ve Got You.
Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.
8 June 2026, 7:00 am - 46 minutes 18 secondsThe Hair Loss Conversation Your Doctor Should Be Having With You with Dr. Komal Patil-Sisodia
As women, so much of our identity is tied to our hair. And when it starts to fall out, the internet will sell you a thousand solutions before anyone stops to ask why.
In this episode, I'm joined by Dr. Komal Patil-Sisodia — triple board-certified endocrinologist, hormone expert, and someone who has lived this firsthand. Stress-related shedding in med school. Postpartum loss. Genetic thinning. She's been through every stage, and she's here to help you finally get some answers.
We get into the real hormonal and metabolic causes, the labs worth asking for, and why addressing the root cause will always matter more than the next serum, supplement, or device in your feed.
References
Folly Nutrition Hair Health Gummies (Use code MATTHEA)
Connect with Dr. Komal Patil-Sisodia:
Instagram/TikTok: @drpatilsisodia
Podcast: Clearly Hormonal
Practice: Eastside Menopause and Metabolism
Get the free podcast roadmap for The Obesity Guide
Subscribe to my Youtube channel
All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.
If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.comNot Sure Where to Start With the Podcast? I’ve Got You.
Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.
1 June 2026, 7:00 am - 17 minutes 19 secondsHow to Read Your Body Composition Data (And What to Do With It)
What if you've actually been making progress, but just didn't know how to see it?
So many people feel stuck because the scale isn't moving, or because progress feels painfully slow. But total weight is only one piece of the picture. You could be losing body fat, building muscle, and moving in exactly the right direction… without even realizing it.
In this episode, we look at how to use body composition data in a practical way, which numbers matter most, and how to avoid letting the data take over your life.
References
Folly Nutrition Hair Health Gummies (Use code MATTHEA)
Body composition scales:
Get the free podcast roadmap for The Obesity Guide
Subscribe to my Youtube channel
All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.
If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.comNot Sure Where to Start With the Podcast? I’ve Got You.
Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.
25 May 2026, 7:00 am - 17 minutes 22 secondsHow to Rebuild Your Routine When Life Has Wiped You Out
After pouring everything into my recent in-person retreat, coming home felt harder than I expected. I was sleeping in on weekends, struggling with my normal routine, and asking myself, "Why can't I just get it together?"
Turns out, even good things are exhausting, and pushing yourself to bounce back at full speed only makes it worse. In this episode, I'm sharing the four strategies that helped me rebuild my energy and momentum without forcing myself back to 100%. If you've ever crashed after a big season of life, I think this one will hit home.
References
Folly Nutrition Hair Health Gummies (Use code MATTHEA)
Ep. 170. Losing Weight and Losing Hair? Here's What to Do with Dr. Katherine Nolan
Get the free podcast roadmap for The Obesity Guide
Subscribe to my Youtube channel
Audio Stamps
00:30 – What Dr. Rentea’s recent retreats have taught her about energy management and rest.
03:21 – Dr. Rentea’s experience with hair loss and the two-pronged approach (prescription + supplements) that's finally making a difference.
09:40 – Ditching the "restart at 100%" mentality and rebuilding consistency before intensity.
11:07 – Finding your floor. What's the smallest habit you can stick to right now?
12:22 – Dropping the shame. When you're mentally exhausted, comfort-seeking is your brain doing its job.
13:13 – Ways to reduce friction and make it easy to show up, so you’re not relying on motivation when you're exhausted.
14:28 – Why it’s normal for your comeback to feel boring.
All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.
If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.comNot Sure Where to Start With the Podcast? I’ve Got You.
Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.
18 May 2026, 7:00 am - 34 minutes 31 secondsWhat GLP-1s Are Revealing About Addiction and the Brain with Dr. Nishant Kumar
“Doc, I just don't feel like drinking alcohol anymore."
Addiction psychiatrist Dr. Nishant Kumar kept hearing it. Patient after patient, unprompted. And nothing in their lives had changed… except one thing. They'd started a GLP-1.
What does that tell us about the brain, addiction, and our relationship with food?
In this episode, Dr. Kumar unpacks exactly that. We talk about what GLP-1s are revealing about cravings and the brain, how to recognize when your relationship with food has become a problem, how to find the right help, and the lifestyle factors that matter more than you might expect.
References
Get the free podcast roadmap for The Obesity Guide
Subscribe to my Youtube channel
All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.
If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.comNot Sure Where to Start With the Podcast? I’ve Got You.
Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.
11 May 2026, 7:00 am - 18 minutes 28 secondsSkin Removal Surgery After Weight Loss: What You Need to Know with Dr. Beckman
We talk a lot about losing weight… but rarely about what it actually feels like to live in that new body. And for a lot of people, that experience includes the physical and emotional impact of excess skin.
Excess skin isn’t just about appearance. It's the rashes, the infections, the discomfort that makes everyday movement harder than it should be. It's the frustration of working so hard to transform your body and still not feeling fully at home in it.
In this episode, I sit down with Dr. Beckman, a board-certified plastic surgeon based in Carmel, Indiana, who specializes in body contouring for post-weight loss patients. She breaks down exactly when to seek a consult, what procedures are most common, how to prepare your body for the best results, and what life can look like on the other side of surgery.
References
Connect with Dr. Beckman:
Practice Instagram: @myplasticsurgerygroup
Dr Beckman's Instagram: @dibeckmanmd
Website: https://myplasticsurgerygroup.com/
Get the free podcast roadmap for The Obesity Guide
Subscribe to my Youtube channel
All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.
If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.comNot Sure Where to Start With the Podcast? I’ve Got You.
Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.
4 May 2026, 7:00 am - 31 minutes 44 secondsLosing Weight and Losing Hair? Here's What to Do with Dr. Katherine Nolan
It’s one of the most distressing side effects people can experience during a weight loss journey, yet almost no one warns you about it.
At first, it’s easy to dismiss. Then it starts showing up everywhere: in the shower drain, on your pillow, and in your hands every time you run your fingers through your hair.
In this episode, I’m joined by board-certified dermatologist and hair loss specialist Dr. Katherine Nolan to break down why rapid weight loss can trigger shedding, how the hair growth cycle actually works, which labs to ask your doctor for, and when medication might make sense.
We’ll also talk through some of the biggest myths, including why expensive serums and biotin supplements are not usually the fix people hope they are.
References
Connect with Dr. Katherine Nolan:
Sign up for my Summer Reset series with Amanda Sabicer here.
A four-month guided recalibration for your metabolism, nervous system, and daily rhythm. Enrollment closes May 1st.
Get the free podcast roadmap for The Obesity Guide
Subscribe to my Youtube channel
All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.
If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.comNot Sure Where to Start With the Podcast? I’ve Got You.
Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.
27 April 2026, 7:00 am - 22 minutes 46 seconds8 Health Basics That Beat Every Supplement, Tracker and Program
I've been thinking a lot lately about how much we overcomplicate our health. Tracking 15 different metrics, obsessing over the perfect supplement, debating which programme is best — while the simple basics just... aren't happening. I catch myself doing it too.
So in this episode, we're rewinding right back to basics with the 8 things that actually matter for your health. Not all at once, not perfectly, just one small area at a time until it sticks.
If you feel like you've been doing all the things but still aren't making the progress you expected, consider this your reset. Simple, practical, and actually doable.
References
30/30 Program (Sept 2026 registration now open)
Ep 164. Jacqui Cook on GLP-1 Weight Loss, Maintenance Fears, and Letting Go of Diet Rules
Sign up for my Summer Reset series with Amanda Sabicer here.
A four-month guided recalibration for your metabolism, nervous system, and daily rhythm
Get the free podcast roadmap for The Obesity Guide
Subscribe to my Youtube channel
All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.
If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.comNot Sure Where to Start With the Podcast? I’ve Got You.
Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.
20 April 2026, 7:00 am - 32 minutes 36 secondsTired, Hungry, and Stuck? How Poor Sleep Affects Hormones, Cravings, and Weight Loss with Dr. Funke Afolabi-Brown
You might be blaming your hormones, your medication, or yourself... when the real problem could be your sleep.
Sleep is one of the most overlooked parts of metabolic health. And when it's off, everything feels harder. You feel hungrier. Your cravings get stronger. Your energy drops. Your blood sugar is harder to manage. Progress slows down, even when you feel like you're doing everything right.
In this episode, sleep medicine physician Dr. Funke Afolabi-Brown explains why sleep matters so much, what could be disrupting yours, and why waking up exhausted is not something you should just accept.
References
Connect with Dr. Funke Afolabi-Brown:
Sign up for my Summer Reset series with Amanda Sabicer here.
A four-month guided recalibration for your metabolism, nervous system, and daily rhythm
Get the free podcast roadmap for The Obesity Guide
Subscribe to my Youtube channel
All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.
If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.comNot Sure Where to Start With the Podcast? I’ve Got You.
Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.
13 April 2026, 7:00 am - More Episodes? Get the App