- 1 hour 46 minutesHow Anthropic ships the #1 LLM in the World safely: Separating the Brain from the Hands
Katelyn Lesse and Angela Jiang join Latent Space to explain the engineering behind the Claude Platform: launching Opus 5.5, separating the model’s “brain” from the agent’s “hands,” scaling APIs, and building reliable managed agents. A new introduction ...
27 October 2026, 6:40 pm - 1 hour 16 minutesWhy Agents Love Supabase
AI agents are creating more software—and that changes what a backend needs to do. Supabase co-founders Paul Copplestone and Ant Wilson join swyx to discuss running long-lived workloads alongside the database, making schemas easier for agents to underst...
26 October 2026, 5:53 pm - 16 minutes 34 seconds⚡ An Eval for AI Scientists That Knows the Answer Key - Ian Quigley, Leash Bio
Watch the full show on YouTube: https://www.youtube.com/watch?v=vhPCo-8K78U
26 October 2026, 3:00 pm - 1 hour 25 minutesWhy AI Compute Comes in Rectangles — Erik Bernhardsson, Modal CEO
Warm welcome to Basil Chatha, our newest cohost from the Forward Deployed side of the AI Engineering world! We’ll be ramping up a new show with him and couldn’t pass up an interview with Modal’s CEO Eric on the occasion of their monster Series D! Two y...
22 October 2026, 5:40 pm - 26 minutes 40 secondsThe Recommendation Engine for Commodity Traders — Anekha Sokhal, Moshi
Anekha Sokhal, CEO of Moshi, joins swyx to discuss building a recommendation engine for commodity traders, turning market data into useful signals, and designing AI that fits users’ workflows. Watch: YouTube · Moshi · Anekha 0:00 AI Engineer New York a...
22 October 2026, 2:00 pm - 43 minutes 32 secondsAI for the Fortune 2000: How Tenex Builds an AI-Native SDLC — Alex Lieberman & CJ Hess
Alex Lieberman and CJ Hess join swyx at AI Engineer New York to discuss Tenex’s approach to AI-native engineering, paying for outcomes, MetaHarness, enterprise AI adoption and rebuilding SaaS. Show notes: Tenex: https://www.tenex.co/ Building an AI-nat...
21 October 2026, 5:01 am - 36 minutes 43 secondsThe Programmable Data Center — Evan Conrad, SF Compute
This was recorded on the sidelines of the new Compute Trading track at AIE NYC. Catch us next at AIE CODE, our last flagship for the top agentic engineers in the world. In the early days of cloud, former guest Martin Casado made something so disruptive...
20 October 2026, 7:31 pm - 1 hour 49 minutes🔬 Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio
A few years ago I stumbled upon Leash Bio’s Substack, and was hooked. Be it their Kaggle competition that showed that no, we really haven’t solved protein-ligand binding, or their crazy discovery that knowing a molecule’s author is perhaps all you need...
14 October 2026, 8:35 pm - 1 hour 11 minutesDyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics
Watch along AIE NYC and join us at AIE CODE in SF next month! This episode includes a live demo of the Taku robot that is best enjoyed on YouTube. Last month, Dyna made waves by announcing Dyna-2, a world-action model pre-trained on one million hours o...
13 October 2026, 10:25 pm - 31 minutes 55 seconds🔬 Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub
From the Bitter Lesson of AI scaling to the unsolved mysteries of protein folding, Google DeepMind’s Pushmeet Kohli and Biohub’s Sal Candido are rethinking what it takes to build AI that truly understands biology. In this special panel moderated by Bra...
10 October 2026, 12:31 am - 1 hour 23 minutes🔬 Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk
It’s hard to believe that Periodic was only launched last September: One year later, it is considered one of the pre-eminent AI scientist labs, with dizzying talent density and astonishing progress in the autonomous lab buildout: Most people are famili...
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