At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to [email protected].
Today’s arms race looks a little different from those of the past. Under the Trump administration, the US Department of War (DoW) is deploying generative AI to millions of employees in order to maintain a strategic edge over our global adversaries. Sarah Guo and Elad Gil sit down with Emil Michael, the Under Secretary of War for Research and Engineering of the United States, to discuss the radical technological transformation of the US military. Emil outlines the architecture and launch of GenAI.mil, a DoW internal AI platform powered by Gemini and Grok that reached over one million unique users in its first 30 days. He also highlights critical technology priorities for national security, including hypersonics, direct energy, and autonomous drone swarms. Together, they also explore the urgent need to rebuild the American defense industrial base and end dependency on foreign supply chains for critical materials, as well as how Emil is recruiting the next generation of “fixer-builder” workers to serve their country in government.
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Chapters:
00:00 – Cold Open
00:00 – Emil Michael Introduction
00:58 – Emil’s Role at the Department of War
05:22 – Innovation Priorities for the DoW
08:27 – Shift Toward Autonomous Defense Technologies
10:41 – Identifying Common Needs Across the DoW
12:02 – Architecting GenAI.mil
13:48 – Applied AI Initiatives at the DoW
15:57 – The Future of Warfare
17:55 – Recruiting for DoW
19:33 – Arsenal of Freedom Tour
22:25 – Opportunities for Entrepreneurs at DoW
25:49 – Speeding Up and Scaling DoW Initiatives
28:37 – Innovation in Defense Tech
30:00 – Change Management in Government
32:09 – Rebuilding the Defense Industrial Base
37:27 – Initiatives and Opportunities at the Office of Strategic Capital
41:41 – Lessons from Emil’s Government Experience
44:30 – Conclusion
Even if ChatGPT never existed, the tech giant NVIDIA would still be winning. The end of Moore’s Law—says NVIDIA President, Founder, and CEO Jensen Huang—makes the shift to accelerated computing inevitable, regardless of any talk of an AI “bubble.” Sarah Guo and Elad Gil are joined by Jensen Huang for a wide-ranging discussion on the state of artificial intelligence as we begin 2026. Jensen reflects on the biggest surprises of 2025, including the rapid improvements in reasoning, as well as the profitability of inference tokens. He also talks about why AI will increase productivity without necessarily taking away jobs, and how physical AI and robotics can help to solve labor shortages. Finally, Jensen shares his 2026 outlook, including why he’s optimistic about US-China relations, why open source remains essential for keeping the US competitive, and which sectors are due for their “ChatGPT moment.”
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Chapters:
00:00 – Jensen Huang Introduction
00:17 – Biggest AI Surprises of 2025
04:12 – AI and Jobs: New Infrastructure and Demand for Skilled Labor
09:03 – Task vs. Purpose Framework in Labor
12:31 – Solving Labor Shortages with Robotics
15:14 – The Layer Cake of AI Technology
18:39 – The Importance of Open Source
21:52 – The Myth of “God AI” and Monolithic Models
23:54 – Addressing the “Doomer” Narrative and Regulation
29:25 – The Plummeting Cost of Compute and Tokenomics
35:09 – The Return to Research
37:49 – Future of Coding and Software Engineering
43:20 – The Industries Due For Their “ChatGPT” Moments
46:00 – The Evolution of Self-Driving Cars and Robotics
54:06 – Energy Demand and Growth for AI
58:49 – 2026 Outlook: US-China Relations and Geopolitics
1:04:43 – Is There An AI Bubble?
1:16:20 – Conclusion
Pundits are screaming about the so-called “AI bubble.” But historically slow-to-adopt industries like medicine and law are actually embracing AI at an unprecedented speed. Sarah Guo and Elad Gil look ahead to 2026, breaking down the major trends that will define the next era of AI technologies. They explore the future of AI foundational models, predicting breakthroughs in solving complex scientific problems. They share competing views on the timeline for robotics and self-driving cars, debating whether startups have a chance for survival or if incumbents will dominate. Elad and Sarah also discuss the return of tech IPOs and M&As, forecast a new wave of AI consumer agent software, and explore why consumer product innovation has been slower than expected. Finally, the two offer bold non-AI predictions for the new year, including the acceleration of defense tech startups and the second-order underrated impacts of GLP-1 drugs on biohacking.
Plus, stick around to hear predictions on what’s next for AI in 2026 from some of tech’s biggest names and industry leaders. We hear from Jensen Huang (Founder/CEO NVIDIA), Arvind Jain (Founder/CEO, Glean), Winston Weinberg (Founder/CEO, Harvey), Scott Wu (Founder/CEO, Cognition), Raiza Martin (Founder/CEO Huxe), Zach Ziegler (Founder/CTO, Open Evidence), Aaron Levie (Founder/CEO, Box), Misha Laskin (Founder/CEO, ReflectionAI), Noam Brown (Research Scientist, OpenAI), Joshua Meier (Founder/CEO Chai Discovery), Bryan Johnson (Living Man, Don't Die), Sholto Douglas (Member of the Technical Staff, Anthropic), Ben & Asher Spector (Stanford PhDs) and Dylan Patel (Founder/CEO SemiAnalysis).
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Chapters:
00:00 – Introduction
02:43 – AI Predictions for 2026
04:40 – Adoption of AI in Professional Fields
07:17 – Robotics and Self-Driving Cars
08:25 – Robotics: Incumbents vs. Startups
13:59 – Future of IPOs and M&A in AI
16:42 – Challenges in Consumer AI Innovation
21:08 – Funding of Neo Labs, RL Research
26:28 – Predictions for 2026 Beyond AI
26:44 – The Future of Defense and Technology
28:23 – Biohacking and Peptide Therapies
30:37 – 2026 Prediction from AI Industry Leaders
40:46 – Conclusion
Imagine learning chess from a grand master, or negotiating tactics from an expert FBI hostage negotiator. ElevenLabs’ voice AI technology is making that unlock possible. Sarah Guo sits down with Mati Staniszewski, co-founder of ElevenLabs, to explore how the three-year old company is transforming how humans interact with technology through voice. Mati talks about the technical challenges of building foundational audio models, the strategic thinking between conducting research and deploying products in tandem, and why voice is the ultimate interface for everything from computers to robots to immersive media. They also discuss how the coming revolution of AI personal tutors will shift agentic AI from reactive to proactive support, break down language barriers globally, and even provide the framework for agentic government services.
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Chapters:
00:00 – Mati Staniszewski Introduction
00:46 – 11 Labs: Growth and Scale
02:46 – Voice Technology and Applications
06:52 – Research and Product Development
12:36 – Voice Quality and Customer Preferences
17:54 – Agent Platform and Use Cases
23:21 – Choosing the Right Technology Partner
26:43 – The Role of Foundation Models
29:58 – Open Source Models and Future Trends
32:37 – Research and Development Focus
36:53 – Future of AI Companions and Education
41:37 – Conclusion
In just over three years, Harvey has not only scaled to nearly one thousand customers, including Walmart, PwC, and other giants of the Fortune 500, but fundamentally transformed how legal work is delivered. Sarah Guo and Elad Gil are joined by Harvey’s co-founder and president Gabe Pereyra to discuss why the future of legal AI isn’t only about individual productivity, but also about putting together complex client matters to make law firms more profitable. They also talk about how Harvey analyzes complex tasks like fund formation or M&A and deploys agents to handle research and drafting, the strategic reasoning behind enabling law firms rather than competing with them, and why AI won’t replace partners but will change law firm leverage models and training for associates.
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Chapters:
00:00 – Gabe Pereyra Introduction
00:09 – Introduction to Harvey
02:04 – Expanding Harvey’s Reach
03:22 – Understanding Legal Workflows
06:20 – Agentic AI Applications in Law
09:06 – The Future Evolution of Law Firms
13:36 – RL in Law
19:46 – Deploying Harvey and Customization
23:46 – Adoption and Customer Success
25:28– Why Harvey Isn’t Building a Law Firm
27:25 – Challenges and Opportunities in Legal Tech
29:26 – Building a Company During the Rise of Gen AI
37:24 – Hiring at Harvey
40:19 – Future Predictions
44:17 – Conclusion
The robotics industry is on the cusp of its own “GPT” moment, catalyzed by transformative research advances. Enter Memo, the first general-intelligence personal robot, focused on taking on your chores to give back your time. Sarah Guo sits down with Tony Zhao and Cheng Chi, co-founders of Sunday Robotics, to discuss the state of AI robotics. Tony and Cheng speak to the challenges they faced while developing their technology, the innovative glove system employed to scale real-world data collection, and the impact of diffusion policy and imitation learning. Plus, they talk about their 2026 in-home beta program and why personal robots are only a handful of years away from mass deployment.
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Chapters:
00:00 – Tony Zhao and Cheng Chi Introduction
00:56 – State of AI Robotics
02:11 – Deploying a Robot Pre-AI
03:13 – Impact of Diffusion Policy
04:29 – Role of ACT and ALOHA
07:02 – Imitation Learning - Enter UMI
10:38 – Introducing Sunday
11:57 – Sunday’s Robot Design Philosophy
15:05 – Sunday’s Shipping Timeline
19:02 – Scale of Sunday’s Training Data
23:58 – Importance of Data Quality at Scale
24:56 – Technical Challenges
27:59 – When Will People Have Home Robots?
30:48 – Failures of Past Demos
32:34 – Sunday’s Demos
36:53 – What Sunday’s Hiring For
39:10 – Conclusion
Bringing new drugs to market is a costly, time-consuming endeavor. On top of that, most medicines fail at some point in the research and development phase. Sarah Guo is joined by Sajith Wickramasekara, co-founder and CEO of Benchling, a company that has not only become the central system of record for biotech R&D, but uses AI agents to assist scientists to help fix this broken system. Sajith details the roadblocks that impede drug development and approval, the “dot com” bust occurring in biotech, and how AI agents and simulation can help scientists experiment faster. Plus, they talk about China’s competitive rise in the pharma space, and the unique challenges of building an interdisciplinary culture that merges the worlds of science and software.
Rebuild biotech for the AI era - Sajith Wickramasekara
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Chapters:
00:00 – Sajith Wickramasekara Introduction
00:38 – Origin and Mission of Benchling
02:08 – The Drug Development Process
03:49 – Current State of the Biotech industry
08:46 – AI’s Role in Biotech
16:14 – Benchling AI and Its Impact
18:36 – The Future of AI in Biotech
26:28 – Debunking AI Drug Discovery Myths
28:50 – Data’s Role in Biotech
29:35 – The Importance of Tools in Pharma
31:28 – AI’s Impact on Scientific Research
34:55 – Building a Biotech Company
40:18 – Interdisciplinary Collaboration in Biotech
43:06 – Tech and Biotech: Learning from Each Other
48:16 – Conclusion
Snowflake is moving beyond the data warehouse. Its new Snowflake Intelligence is an agentic platform for every employee, not just data teams. Sarah Guo sits down with Snowflake CEO Sridhar Ramaswamy to discuss his first 18 months at the helm, as well as the massive pivot to make the data giant AI-first. Sridhar talks about Snowflake Intelligence, the company's new AI agent platform, and its implications for enterprise data management. They also explore how Sridhar navigates partnerships with major tech companies, how he fosters a culture of continuous improvement within the organization, and how he envisions Snowflake’s future as an integral data-driven enterprise solution.
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Chapters:
00:00 – Sridhar Ramaswamy Introduction
00:42 – Snowflake’s Market Adaptation
03:14 – Snowflake’s Evolution and AI Integration
05:44 – Introducing Snowflake Intelligence
09:01 – Snowflake Intelligence User Experience
11:55 – Drawing the Line Between Data, Agent System, and App
13:30 – Leadership and Organizational Changes
16:19 – How Being an Investor, Entrepreneur Informed Sridhar’s Leadership
18:50 – Importance of Product-Market Fit
22:46 – Snowflake’s Strategic Positioning
27:10 – Snowflake’s Partnership Strategy
30:20 – How Sridhar Sees the ROI of AI
35:09 – How AI Changes the Ad Model
38:15 – Why LLMs Still Need Search
42:11 – Conclusion
2025 has thus far been a year of great leaps and advances in AI technology. And Sarah and Elad have spoken with some of the most enterprising founders and scientific minds in the field of AI today. So we’re revisiting a few of our favorite conversations on No Priors so far in 2025 – Winston Weinberg (Harvey), Dr. Fei-Fei Li (World Labs), Brendan Foody (Mercor), Dan Hendrycks (Center for AI Safety), Noubar Afeyan (Flagship Pioneering), Brandon McKinzie and Eric Mitchell (OpenAI o3), Isa Fulford (OpenAI), Arvind Jain (Glen), and Dr. Shiv Rao (Abridge).
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Chapters:
00:00 – Episode Introduction
0:21 – Winston Weinberg on Leaning into New Capabilities
02:01 – Dr. Fei-Fei Li on Spatial Intelligence
04:13 – Brendan Foody on AI Disruption in the Workforce
06:10 – Dan Hendrycks on the Geopolitics of Superintelligence
08:06 – Noubar Afeyan on Entrepreneurship
10:38 – Brandon McKinzie and Eric Mitchell on Reasoning Models
12:41 – Isa Fulford on Training Deep Research
13:49 – Arvind Jain on Innovating Enterprise Search
16:21 – Dr. Shiv Rao on AI’s Human Impact
18:58 – Conclusion
For decades, the developer terminal has remained largely unchanged. But for Warp CEO and co-founder Zach Lloyd, reinventing this core tool is the key to unlocking AI agents for coding, debugging, and automating the entire development process. Zach joins Elad Gil to discuss how seeing this opportunity for innovation led to Warp’s agentic terminal for developers. Zach talks about the phases of software development, from coding by hand to the current "develop by prompt" era, and the coming age of fully automated development. Plus, Zach and Elad explore the deep philosophical questions around intelligence versus consciousness in AI models, and what it would take to believe a computer program is truly aware.
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Chapters:
00:00 – Zach Lloyd Introduction
00:32 – AI, Intelligence, and Consciousness
06:55 – What Warp Does
07:38 – Benefits of the Terminal as a Launchpoint
08:27 – Features Driving Warp’s Adoption
09:12 – Zach’s View of the Coding Market
10:27 – Evolution of Coding Development
12:45 – Importance of Senior Engineer Expertise
14:11 – Future of Security and Other Dev Tools
22:22 – Why Zach Focused on the Terminal
23:52 – The Future of the Model Layer
25:36 – What Zach’s Excited About in the AI Dev World
27:18 – Conclusion
With demand from AI for energy already exploding, our electric grid is facing a crisis. Base Power CEO and co-founder Zach Dell is ready to re-architect its future from the ground up. Zach sits down with Elad Gil to talk about Base Power’s recent $1 billion fundraise from major investors. Zach discusses the role of energy across industries, as well as Base Power's mission to lower electricity costs through vertical integration. Zach and Elad also explore the future of energy, the role of batteries in transforming the grid, and the regulatory challenges facing the energy industry. Plus, Zach pitches why top talent should make their careers in energy generation.
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Chapters:
00:00 – Zach Dell Introduction
00:50 – Base Power’s Vision
02:15 – Base Power’s Products and Services
04:00 – What Drew Zach to Working on Power
05:12 – Base Power’s Founding Team
06:58 – Base Power’s Hiring Needs
08:02 – How Zach Hired an Awesome Founding Team
09:51 – How Do We Meet Energy Demands?
12:58 – How Viable is Nuclear Energy?
17:04 – Global Energy Cost Dynamics
17:41 – Future of AI Training Centers
18:32 – What Will Drive Energy Buildout
20:38 – Drivers of Energy Transmission Cost
22:30 – Regulation and the Energy Industry
23:52 – What Zach is Optimistic About in Energy
24:42 – Cultivating Base Power’s Culture
27:26 – Zach’s Philosophy on Capitalization
30:00 – How Base Power Uses Scale
31:57 – Conclusion