Most men think erectile dysfunction is a bedroom problem. It's actually one of the earliest warning signs of cardiovascular disease, capable of showing up three to five years before a heart attack.

In this episode, Dr. Gabrielle Lyon sits down with Dr. Amy Pearlman, a urologist trained in men's sexual health, to discuss:

• Why ED is a symptom of vascular health, not a standalone disease and how the artery feeding the heart is roughly double the size of the one feeding the penis, so problems show up "down there" first
• Why "normal" testosterone can be meaningless, and the questions to ask before accepting a lab result that didn't flag
• How daily erections preserve penile tissue the way water keeps a sponge supple and why disuse can cost noticeable size over just a few months
• That cardiovascular exercise can rival ED medication for improving erectile function, making your heart health the real fix
• How to track erectile fitness before there's a problem, instead of waiting until something breaks

By the end, you'll understand the single signal your body uses to flag heart and metabolic risk early and the simple, mostly drug-free steps that protect both your cardiovascular health and your sexual function for life.

Thank you to our sponsors:

• Manukora - Go to https://bit.ly/3RCMrKx to save 31% plus $25 worth of free gifts.
• Timeline - Get 20% off your Mitopure order at https://bit.ly/4dW6BGN
• Bon Charge - Save 15% at https://bit.ly/433Xi2B with code DRLYON

Explore More from Dr. Gabrielle Lyon

• Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com
• Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/
• Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/

Listen to "Pearls of Wisdom" on all your favorite platforms!

Spotify: https://open.spotify.com/show/4uOhWn5DeVXO7D2ppa0RoV

Apple Podcasts: https://podcasts.apple.com/us/podcast/pearls-of-wisdom/id1617916659

Find Dr. Amy Pearlman at:

Website: https://www.primeinstitute.us/

YouTube: https://youtube.com/@docamyurology?si=oJ2LZ_sxMPYTaK41

Instagram: https://www.instagram.com/amypearlmanmd/

X: https://x.com/AmyPearlman1

LinkedIn: https://www.linkedin.com/in/amy-pearlman-54a2b0208

Connect with Dr. Gabrielle Lyon:

• Instagram: https://www.instagram.com/drgabriellelyon/
• TikTok: @drgabriellelyon
• X (Twitter): https://x.com/drgabriellelyon
• Facebook: https://www.facebook.com/doctorgabriellelyon

Timestamps

00:00 - Introduction

01:25 - Erections predict cardiac events

01:41 - The pen and artery analogy

03:40 - No health milestones for men

07:52 - Normal structure and function

11:45 - The five S's of men's health

21:24 - Why "normal" testosterone misleads

25:00 - Testosterone and fertility risk

31:05 - Steroids versus FDA-approved agents

41:13 - The untreated 25-year-old

43:56 - Sperm health and home testing

52:02 - Peyronie's disease and injury

1:01:34 - Protein, nutrition, supplements

1:05:09 - Daily Cialis as a pre-workout

1:13:32 - The sponge analogy

1:15:31 - Erectile fitness tracking

1:23:05 - The penis pump, used right

1:27:24 - Restoring lost size

1:35:00 - Traction and girth enhancement

1:46:00 - Women's anatomy and pleasure

If you found this episode valuable, share it with someone who would benefit from it.

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Most people think the cholesterol number on their lab report tells them whether their heart is at risk. But former National Lipid Association President Dr. Kevin Maki explains that LDL is just one piece of a much bigger picture and focusing on it alone can mean missing the markers that matter most.

In this episode, Dr. Gabrielle Lyon sits down with Dr. Kevin Maki, former President of the National Lipid Association and co-editor-in-chief of the Journal of Clinical Lipidology, to discuss:

• Why ApoB and Lp(a) are better predictors of heart risk than LDL and why only about 2% of people ever get Lp(a) tested
• What a beef-vs-chicken feeding study revealed about red meat and cholesterol (the LDL results came back identical at 112 mg/dL)
• The evidence behind the seed oil debate, including why higher linoleic acid levels tracked with lower inflammation markers across a 2,000-person dataset
• Why the balance of cholesterol-raising and cholesterol-lowering foods matters more than saturated fat alone
• The simple "ABCs" framework: A1c, blood pressure, cholesterol - for actually lowering long-term cardiovascular risk

By the end, you'll know which numbers actually predict heart risk, which tests to ask your doctor for, and how to cut through the conflicting noise around fat so you can make evidence-based decisions for the long haul.

Thank you to our sponsors:

• OneSkin - Get 15% off at https://bit.ly/4tZnOpk with code DRLYON
• BodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/48SJ7AC
• Amp - Visit https://bit.ly/3RcmqBz to get your AI-powered at-home gym for smarter, personalized training.

Explore More from Dr. Gabrielle Lyon

• Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com
• Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/
• Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/

Find Dr. Kevin Maki at:

• Midwest Biomedical Research: https://www.mbclinicalresearch.com/
• LinkedIn: / kevin-c-maki-phd-497ba34

Connect with Dr. Gabrielle Lyon:

• Instagram: https://www.instagram.com/drgabriellelyon/
• TikTok: @drgabriellelyon
• X (Twitter): https://x.com/drgabriellelyon
• Facebook: https://www.facebook.com/doctorgabriellelyon

Chapters

00:00 - Introduction

00:31 - Dr. Kevin Maki and the National Lipid Association

01:04 - New dietary guidelines and the LDL confusion

02:04 - What raises and lowers LDL cholesterol

03:51 - Cholesterol levels from birth through puberty

05:11 - The lipid panel kids should get before age 11

06:42 - Lp(a): the test only 2% of people get

08:18 - ApoB and the three risky particle types

11:35 - Do we have evidence for "lower is better"?

14:09 - The FLASH-GLICK risk factor framework

17:10 - The 10% saturated fat guideline explained

19:36 - Many dietary patterns can be healthy

24:50 - Beef vs. chicken: identical LDL results

27:10 - The balance of fatty acids that matters

29:24 - Olive oil vs. corn oil feeding study

31:00 - Lower for longer: 40-year risk reduction

34:15 - Genetic cholesterol disorders and risk

40:33 - The omega-3 index and why it matters

49:10 - Are seed oils really driving inflammation?

53:11 - How seed oils are processed and refined

1:07:48 - Inherited beliefs and outdated nutrition science

1:08:54 - Butter vs. cheese and high-fat dairy surprises

1:14:48 - Exercise effects on HDL and triglycerides

1:21:20 - The ABCs of reducing cardiovascular risk

If you found this episode valuable, share it with someone who would benefit from it.

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Colorectal cancer is now the leading cancer killer in adults under 50, and patients in their 20s are presenting with metastatic disease that has nothing to do with family history. Most physicians are still telling young patients with rectal bleeding that it's probably just hemorrhoids and that's costing lives.

In this episode, Dr. Gabrielle Lyon sits down with Dr. Michelle Pearlman, a board-certified gastroenterologist and founder of a Miami-based gastro-metabolic clinic, to discuss:

• The specific warning signs every adult under 50 should never ignore, regardless of age including rectal bleeding, unintentional weight loss, and persistent abdominal pain
• Why GLP-1 medications like Ozempic and Zepbound are being miscategorized as weight loss drugs when they're actually metabolic reprogrammers with applications in fatty liver, sleep apnea, and inflammation
• The protein, fiber, and resistance training protocol Dr. Pearlman uses to protect muscle mass in patients on GLP-1 therapy
• How hormone replacement therapy combined with GLP-1s is changing body composition outcomes for perimenopausal women and why current guidelines are still 20 years behind the data
• Dr. Pearlman's personal osteoporosis diagnosis at 39, despite being a lifelong bodybuilder, and what it revealed about the diagnostic gaps in standard medicine

This conversation gives you the framework to recognize the warning signs most physicians are still missing, and the foundational habits; nutrition, resistance training, and hormone optimization that protect your gut, bones, and muscle through midlife and beyond.

Thank you to our sponsors:

Cozy Earth - Go to https://bit.ly/4teXQhz for up to 20% off!

Timeline - Get 20% off your Mitopure order at https://bit.ly/4eLBWhB

Lucy - Get 20% off your next order with code DRLYON at https://bit.ly/42HiUlc, or find yours in store at https://bit.ly/3RfGnYa

Amp - Visit https://bit.ly/3RcmqBz to get your AI-powered at-home gym for smarter, personalized training.

Explore More from Dr. Gabrielle Lyon

Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com

Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/

Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/

Find Dr. Michelle Pearlman at:

Instagram: https://www.instagram.com/michellepearlmanmd/

Website: https://www.primeinstitute.us/

Connect with Dr. Gabrielle Lyon

Instagram: https://www.instagram.com/drgabriellelyon/

TikTok: https://www.tiktok.com/@drgabriellelyon

X (Twitter): https://x.com/drgabriellelyon

Facebook: https://www.facebook.com/doctorgabriellelyon

Chapters

00:00 - Introduction: Colorectal cancer under 50

01:15 - The gastro-metabolic approach explained

03:30 - Why nutrition isn't taught in GI fellowship

05:45 - When the colonoscopy is normal but patients suffer

07:00 - Weight, reflux, and visceral fat

09:15 - PPIs, bone density, and long-term risk

11:30 - Three things to never do for gut health

14:00 - Ultra-processed food and early-onset cancer

16:45 - Rectal bleeding, warning signs, and age

19:00 - Screening guidelines and the obesity gap

22:30 - GLP-1 medications: history and mechanism

27:15 - Hunger, cravings, and food noise

30:00 - The stigma around metabolic medications

33:45 - Side effects: nausea, reflux, constipation

38:30 - Compounded formulations and pharmacy safety

42:00 - Hair loss, protein, and supplementation

45:15 - Pill versus injection delivery systems

49:30 - Fiber, the microbiome, and short-chain fatty acids

54:00 - GLP-1s plus hormone replacement therapy

58:45 - Testosterone, Kyzatrex, and women's bone health

1:03:00 - Pearlman's osteoporosis diagnosis at 39

1:09:30 - The diagnostic gap in standard medicine

1:14:00 - Building Bite MD and the future of nutrition tech

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Most parents are quietly paving the road their kids were supposed to learn to walk on by themselves and Jocko Willink has spent 20 years watching what happens when that road is too smooth.

In this episode, Dr. Gabrielle Lyon sits down with Jocko Willink, retired Navy SEAL commander, founder of Echelon Front, and bestselling author of Extreme Ownership and Discipline Equals Freedom, to discuss:

• Why the "apex parent / apex kid" mindset is a quiet trap, and what to do instead of paving the road
• How nature vs nurture actually plays out and what you can and cannot shape in your child
• The one trait Jocko wants his kids to inherit (and why every virtue becomes a vice when pushed to the extreme)
• The lie that successful, high-functioning people tell themselves about wanting more
• The single most important trait of a great leader and the one habit Jocko says will make every other part of your life better starting tomorrow

You'll walk away with a clearer operating system for the kind of parent, leader, and person you actually want to be and the one habit Jocko swears is the highest-ROI move any human can make.

Thank you to our sponsors:

• BodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/48SJ7AC
• Our Place - Visit https://bit.ly/4c8OrAB and use code DRLYON for 10% off sitewide.
• Branch Basics - Get 15% off the Premium Starter Kit at https://bit.ly/4eu4Mm8 with the code DRLYON.
• Amp - Visit https://bit.ly/41BvjXj to get your AI-powered at-home gym for smarter, personalized training.

Watch on Spotify. If you’re subscribed to Spotify Premium, you don’t get any Spotify ads on my video.

Explore More from Dr. Gabrielle Lyon

• Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com
• Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/
• Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/

Find JOCKO WILLINK at:

Instagram: https://www.instagram.com/jockowillink/?hl=en

Facebook: https://www.facebook.com/jkowillink/

Tiktok: https://www.tiktok.com/@jocko_willink

X: https://x.com/jockowillink

YouTube: https://www.youtube.com/@JockoPodcastOfficial

Linkedin: https://www.linkedin.com/in/jocko-willink-260b289/

Get Jocko Willink’s books: https://jocko.com/books/

Connect with Dr. Gabrielle Lyon

Instagram: https://www.instagram.com/drgabriellelyon/

TikTok: @drgabriellelyon

X (Twitter): https://x.com/drgabriellelyon

Facebook: https://www.facebook.com/doctorgabriellelyon

Chapters

00:00 - Introduction: Leadership and parenting are the same skill

03:24 - Nature vs nurture and the kids who won't compete

06:56 - The guardrails of failure

07:48 - Dharma and the path kids are meant to walk

09:17 - The one trait Jocko wants his kids to inherit

11:33 - What daughters should learn about men from their fathers

13:32 - How men and women experience fear differently

14:24 - Rebuilding trust after good people do bad things

18:34 - Letting your daughter do cheerleading

21:22 - Hiring people by putting them in the real environment

24:22 - The lie successful people tell themselves

29:16 - Strategic thinking vs the donut decision

35:18 - What failure teaches that success cannot

38:25 - Why Jocko stopped being about himself

44:09 - Aging, losing movements, and rage against the dying of the light

46:49 - Why a leader has to be in physical shape

50:41 - The single most important trait of a leader

54:09 - The one habit that changes everything

If you found this episode valuable, share it with someone who would benefit from it.

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Most men don't know they have a pelvic floor, and most doctors aren't trained to look for dysfunction in it. The result: testicles are being surgically removed for pain that's actually neuropathic, at double the rate of a far more effective nerve-sparing procedure.

In this episode, Dr. Gabrielle Lyon sits down with Dr. Susan Macdonald, a board-certified urologist, surgical program director at Penn State, and one of only ~30 U.S. specialists treating chronic pelvic pain in men, to discuss:

• Why "prostatitis" is often the wrong diagnosis, and how rounds of antibiotics mask the real problem
• The male pelvic floor anatomy almost no medical school teaches, and how to recognize dysfunction in yourself or a patient
• Off-label medications (Cymbalta, gabapentin, amitriptyline) that are quietly transforming chronic pelvic pain treatment
• Why erectile dysfunction is rising sharply in teenagers, and the role pornography plays in rewiring young brains
• Who actually qualifies for a penile implant, and what the surgery really involves

If you've been told your pain is "all in your head," or you're a clinician seeing patients fall through the cracks, this conversation gives you the framework, the language, and the next steps to find real answers.

Thank you to our sponsors:

• Manukora - Go to https://www.MANUKORA.com/DRLYON to save 31% plus $25 worth of free gifts.
• Timeline - Get 20% off your Mitopure order at https://www.timeline.com/lyon
• BONCHARGE - Save 15% at https://boncharge.com/ with code DRLYON

Explore More from Dr. Gabrielle Lyon

• Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com
• Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/
• Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/

Find Dr. Susan Macdonald at:

Instagram: https://www.instagram.com/drsusanmacdonald/

X (Twitter): https://x.com/smacdonald_md

LinkedIn: https://www.linkedin.com/in/susan-macdonald-506324191/

Connect with Dr. Gabrielle Lyon

Instagram: https://www.instagram.com/drgabriellelyon/

TikTok: @drgabriellelyon

X (Twitter): https://x.com/drgabriellelyon

Facebook: https://www.facebook.com/doctorgabriellelyon

Chapters

00:00 - Introduction

01:42 - Meet Dr. Susan Macdonald

03:00 - The high-powered lawyer nobody could help

05:01 - Why testicle pain is 5% of urology visits

07:49 - Men have a pelvic floor (and what it does)

12:46 - How a man knows he has pelvic floor dysfunction

21:30 - Why these muscles are "too tight" in men

26:33 - Chronic pain rewires the brain

29:21 - Stress, trauma, and the mind-body connection

33:29 - Stretching, breathing, and self-treatment at home

36:21 - The medications that actually work (Cymbalta, gabapentin)

44:34 - Muscle relaxers, acupuncture, and the guidelines panel

55:09 - Sexual trauma and chronic pelvic pain

01:00:08 - The "pain plus" diagnostic framework

01:05:23 - The micro-surgical denervation surgery

01:08:36 - Erectile dysfunction in 17-year-olds

01:11:00 - How porn rewires young men's brains

01:18:27 - 40% of men by 40, 50% by 50

01:23:39 - Penile implants: who qualifies, how they work

01:28:10 - Stage 4 cancer at 42 and the pivot to teaching

01:34:17 - Living big with finite time

01:39:00 - Closing message to chronic pain patients

If you found this episode valuable, share it with someone who would benefit from it.

This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Most people are chasing the wrong version of strength and paying for it with pain, poor movement, and a body that breaks down faster than it should. In this episode, Dr. Gabrielle Lyon sits down with Mark Bell, elite powerlifter, entrepreneur, and founder of Slingshot, to discuss:

• Why strength training is essential at every age but most people are defining "strength" too narrowly
• How modern life has created an "exercise deficiency," and why artificial exercise is the only fix
• The truth about fat, protein, and the biggest nutrition mistakes holding people back from lasting weight loss
• The emerging peptide and drug landscape, and what it means for the future of health optimization
• Why forcing your kids to move isn't cruelty, it's one of the most protective things you can do as a parent

Whether you're 25 or 75, this episode will challenge how you think about movement, muscle, and what it actually means to be strong physically and mentally.

Thank you to our sponsors:

• OneSkin - Get 15% off with code DRLYON — https://bit.ly/4tZnOpk
• Amp - Get your AI-powered at-home gym for smarter personalized training — https://bit.ly/41BvjXj
• Branch Basics - Get 15% off the Premium Starter Kit with the code DRLYON — https://bit.ly/4eu4Mm8
• BodyHealth - Get 20% off your first order with the code LYON 20 — https://bit.ly/4etWlr5

Explore More from Dr. Gabrielle Lyon

• Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content — https://foreverstrong.supercast.com
• Weekly newsletter: Recipes, podcast updates, and practical weekly insights — https://drgabriellelyon.com/sign-up/
• Apply to become a patient: Personalized care with Dr. Lyon's clinical team — https://drgabriellelyon.com/new-patient-inquiry/

Find Mark Bell at:

• https://www.instagram.com/marksmellybell/
• https://www.youtube.com/@MarkBellSuperTraining
• Slingshot: https://originmaine.com/

Connect with Dr. Gabrielle Lyon

• Instagram: https://www.instagram.com/drgabriellelyon/
• TikTok: @drgabriellelyon
• X (Twitter): https://x.com/drgabriellelyon
• Facebook: https://www.facebook.com/doctorgabriellelyon

Chapters

00:00 – Introduction

02:48 – Mark Bell's Motto

07:00 – Mind-Body Strength Connection

10:45 – Wrestling > Powerlifting > Entrepreneurship Journey

17:37 – Rationale of Goals

22:04 – Effects of Consistency and Efficiency in Training

32:55 – Recommended Training and Lifestyle Modalities

37:32 – Artificial Exercise vs. Exercise Deficiency

37:47 – "Artificial Exercise" and "Exercise Deficiency"

39:36 – Impact of Physical Activity in Children

44:57 – Biggest Mistake in Weight Loss

50:46 – Overconsumption is a Problem

53:17 – Era of GLP-1, Peptides, and Steroids

1:02:28 – Training to Decrease Mortality

1:03:33 – Cancer Research Updates

1:04:36 – Collective Research on Supplementation

1:16:50 – Influencing Children to Engage in Physical Activities

Share This Episode If you found this episode valuable, share it with someone who would benefit from it.

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

We are living through one of the most significant shifts in medicine in generations, and most people don’t fully understand what it means. Dr. Christle Guevarra joins me to zoom out on the entire GLP-1 landscape; from the drug’s origins as a modest diabetes treatment in 2005 to today’s third-generation medications still moving through clinical trials, and what all of it means for the future of obesity, performance, and longevity.

🙌Thank you to our sponsors:

🌍 Cozy Earth - Go to https://bit.ly/4teXQhz for up to 20% off!

🤍 Timeline - Get 20% off your Mitopure order at https://www.timeline.com/lyon

🚲 Carol Bike - Visit https://bit.ly/4tg4cxa and use code LYON for $100 off your CAROL Bike

Explore More from Dr. Gabrielle Lyon:

Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com

Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/

Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/

Connect with Dr. Christle Guevarra

YouTube: https://bit.ly/4vDMVQa

Instagram: https://bit.ly/4mxnfAc

Get Dr. Christle Guevarra’s book, “Bodybuilding Anatomy”: https://bit.ly/3ODIDYd

📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:

YouTube: https://bit.ly/4boCFC3

Spotify: https://bit.ly/4cWTbLG

📱Connect with Dr. Gabrielle Lyon:

Instagram: https://bit.ly/4uk9adc

TikTok: https://bit.ly/3OFK3kJ

X.com: https://bit.ly/4l3YlaX

Facebook: https://bit.ly/3MBrJso

⏰Timestamps:

00:00 Intro of Show

06:48 Changes in the Fat Loss Landscape

06:54 Engagement in Competitive Powerlifting

11:29 Perspectives on GLP-1 Medication

26:10 Perimenopause Journey

27:13 Topamax

28:03 Urosepsis

30:23 Weight Loss Programming

31:43 Patients' Decision to Take GLP-1

37:44 Risks and Effects on Taking GLP-1

38:10 Pancreatitis

41:40 Fen-Phen (Fenfluramine/phentermine) / Ephedra

45:59 Who Should Not Take GLP-1?

49:24 Proper Nutrition to Support Taking GLP-1

52:14 Recommendation for the New Dietary Guidelines

59:01 Residency and Sports Medicine Fellowship

1:02:38 Are Athletes Recommended to Take GLP-1?

1:08:49 Lack of Randomized, Controlled Trials for Peptides

1:10:38 Key Take-away's from Dr. Christle

1:13:24 Should Women Weigh Themselves?

1:21:02 Should Women Lift Weights?

1:21:55 What's Next for Dr. Christle?

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

This episode includes paid sponsorships.

The moment you decide to show up publicly, you open the door to opinions from people who would never say those things to your face. Dominique Sachse, journalist, author, and content creator who has lived her life on camera for over three decades, gets honest about what it costs to put yourself out there, why online cruelty is a psychology problem more than a content problem, and how “Teflon Dom” developed the thick skin to let none of it redirect her.

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📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:

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⏰Timestamps:

00:00 ​Intro of Show

02:10 Dominique’s Mission

05:13 Women’s Reinvention with Aging

12:07 Handling People’s Opinions in the Media

18:03 Why Dominique Wrote “Life Makeover”

26:08 Activating One’s Faith through Life’s Challenges

29:16 Decision to Leave the News Business

34:12 Traditional Media Transitioning to Online Media

37:09 How to Curate Information

38:42 Effectively Communicating with Journalism and Research Skills

43:17 Managing Conflicts On-and-Off Air

45:28 The Aging Process

49:53 Personal Training with Body Builders

52:33 Changes in Training and Nutrition

54:49 Importance of Discipline

1:00:28 How Dominique Makes Decisions

1:04:03 Dominique’s Goal and Message

1:08:46 Midlife Wellness Protocols

1:14:29 What’s Next for Dominique?

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

This episode includes paid sponsorships.

Only nine scientists were asked to advise on the 2025 Dietary Guidelines for Americans, and Dr. Tom Brenna was one of them. In this conversation, he pulls back the curtain on how dietary guidelines are actually made, why the process has never been the same twice, and what it was like to watch a decades-old saturated fat recommendation get carried forward despite a lack of evidence supporting it at the level of total mortality. This is the dietary guidelines conversation the internet has been missing: straight from someone who was actually in the room.

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References:

https://nutrition.org/american-society-for-nutrition-calls-for-strong-science-in-national-nutrition-guidance/

https://ajcn.nutrition.org/article/S0002-9165(24)00527-6/fulltext

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📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:

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⏰Timestamps:

00:00 ​Intro of Show

00:14 Dr. Tom Brenna’s Background

05:19 Working with IBM

08:46 Family Life

10:38 2015 vs. 2025 Dietary Guidelines for Americans

28:06 American Society for Nutrition: Behind-the-Scenes of Dietary Guidelines

32:10 History of Saturated Fat

42:17 Different Types of Fat

45:23 How Are People Eating during World War II

51:09 The Whole Milk for Healthy Kids Act of 2025

53:58 What is Saturated Fat?

57:57 Link between Saturated Fat and Cardiovascular Diseases

1:05:53 Saturated Fat vs. Total Mortality

1:13:13 Best Studies on Saturated Fat

1:14:42 Reduction of Saturated Fat = Lowered LDL Cholesterol

1:22:35 Pregnancy and Fish Consumption Myths

1:37:55 Recommended Nutrition

1:39:59 Different Types of Oil and Effects on Health

1:42:04 Omega 3’s and 6’s Recommendation

1:50:02 Omega 3 Fatty Acids and ADHD

1:50:54 What’s Next: Precision Nutrition and Genetics

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

This episode includes paid sponsorships.

In a world flooded with conflicting health advice, how do you actually figure out what’s true? Dr. David Allison, one of the most rigorous scientific minds in obesity and nutrition research, shared the exact framework he uses to evaluate evidence, from peer-reviewed trials to podcast recommendations to AI-generated summaries. He explains the difference between trusting science as a process and trusting individual studies, why most nutrition epidemiology functions more like advertising than research, and how ordinary people can build a reliable filter for health claims without a PhD.

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📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:

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⏰Timestamps:

00:00 ​Intro of Show

03:55 Dr. David Allison’s Background

09:50 Principles vs. Scientific Data

14:48 What is Doubly-Labeled Water?

16:42 Misconceptions on Diet

21:08 Concept of Human Discomfort

24:18 Childhood Obesity

28:49 Research: What Really is the Purpose?

31:14 Can We Trust Science?

40:54 INSERT LINK: NEWSLETTER ON OBESITY AND ENERGETICS

40:54 Obesity: Causes and Treatments

50:29 Different Outcomes from Weight Loss Drugs

57:21 Safety is a Social Judgment

1:00:18 Making Decisions in a Noisy Landscape

1:08:29 Podcasts as a Good Source of Information

1:16:09 Stance on Ultra-Processed Foods and Seed Oils

1:22:50 Dr. David’s New Projects

1:29:40 How to Make Good Decisions

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

This episode includes paid sponsorships.

Up to 70% of dementia may be preventable, so why aren’t more people talking about what actually drives cognitive decline? In this episode, I’m with Dr. Tommy Wood, neuroscientist and author of “The Stimulated Mind,” to explore the lifestyle levers that protect your brain across a lifetime. Learn how white matter hyperintensities develop and whether they can reverse, what MCTs and ketones actually do for a glucose-starved brain, and why social connection may be the most underrated variable in cognitive aging. What is the one change you could make today that would most protect your brain tomorrow?

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📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:

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Website: https://bit.ly/3NdV2kT

Books: https://bit.ly/4r6ugZK

Newsletter: https://bit.ly/402QCAj

⏰Timestamps:

00:00 ​Intro of Show

01:52 Elite Athlete’s Brain and Emotional Regulation

06:51 How to Regulate Emotions

11:30 Mindset Impacting Hormonal Responses

15:39 Future-Proofing the Brain

19:42 Brain Development vs. Shrinkage

26:11 Dementia Types, Causes, and Prevention

39:29 Social Isolation Influencing Cognitive Function

50:00 Social Stress’ Drivers

52:34 Non-Negotiable’s to Avoid Dementia Risks

57:42 Seafood Consumption Beneficial for Brain Function

1:03:35 Alcohol and Sleep Impacting the Brain

1:10:16 Is Brain Function Recovery Possible?

1:18:43 Use of Ketones and Glucose for Cognitive Recovery

1:23:09 Power of Mindfulness

1:27:06 Get Dr. Wood’s Book

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

This episode includes paid sponsorships.