Designing proteins that have never existed in nature is no longer sci-fi — it’s becoming a real drug discovery strategy. In this episode, Kashif Sadiq, Founder & CEO of DenovAI Biotech, explains how AI is powering a shift from searching for biologic binders to intentionally designing new proteins from scratch.
Kashif shares his journey from studying physics at University of Cambridge into computational biophysics, and how breakthroughs like AlphaFold from DeepMind helped unlock the next frontier: de novo protein design. Instead of hoping evolution has already produced a usable molecule, Kashif describes how modern AI can engineer bespoke proteins for specific functions, including challenging targets where traditional approaches come up short.
The conversation dives into the sheer scale of “protein space” and why evolution has only explored a tiny fraction of what’s possible. Kashif outlines how this opens the door to targeting diseases and biological mechanisms that have historically been considered undruggable, especially where flat protein interfaces or complex signalling pathways have made small molecules ineffective.
Finally, Kashif explains why combining generative AI with physics-based methods is essential to reduce false positives, improve real-world binding performance, and enable “one-shot design” — where discovery and optimisation become a single integrated process. He also shares what keeps him up at night: clinical trial attrition — and why designing better earlier may be the key to improving success later.
Topics Covered
De novo protein design vs traditional biologics discovery
Why evolution explored only a tiny fraction of protein space
“Programmable biologics” and intentional molecular design
Alpha Design and designing proteins from the inverse problem
Antibodies, nanobodies, and therapeutic protein engineering
Combining generative AI with physics-based validation
Reducing false positives in protein binding predictions
“One-shot design” and compressing discovery timelines
Undruggable targets, flat interfaces, and intracellular signalling
Clinical trial attrition and what’s missing at the preclinical stage
When the first de novo-designed therapeutic could enter trials
About the Podcast
AI for Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr Andree Bates, created to help pharma, biotech and healthcare organisations understand how AI-based technologies can save time, grow brands, and improve company results.
This show blends deep sector experience with practical, no-fluff conversations that demystify AI for biopharma execs — from start-up biotech right through to Big Pharma. Each episode features experts building AI-powered tools that are driving real-world results across discovery, R&D, clinical trials, market access, medical affairs, regulatory, insights, sales, marketing, and more.
Dr. Andree Bates LinkedIn | Facebook | X
Large Language Models (LLMs) are moving far beyond text generation—and into the heart of scientific discovery and pharmaceutical research. In this episode, Javier Tordable, founder and CEO of Pauling.ai and former Google technologist, explains how agentic AI systems are transforming early-stage drug discovery.
Javier shares how modern LLMs differ from earlier generations, highlighting their ability to perform autonomous, multi-step scientific workflows rather than isolated tasks. These AI agents can read and synthesize massive volumes of scientific literature, generate novel hypotheses, validate ideas against published research, and accelerate computational chemistry simulations that once took months or years.
The discussion dives into how LLMs are being used today to identify drug targets, design molecules, optimize clinical trials, and reduce manual scientific labor, while still preserving the critical role of human creativity and experimental validation. Javier also addresses the real risks—hallucinations, data quality, reproducibility—and why hybrid AI + physics-based approaches are essential for trustworthy results.
This episode is a must-listen for researchers, founders, and operators exploring LLMs in biotech, pharma AI, scientific automation, and computational drug discovery.
About the Podcast
AI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.
This show brings together leading experts and changemakers to demystify AI and show how it’s being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI’s role in social good, this podcast offers valuable insights.
AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget.
As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses.
This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so much more.
Artificial intelligence is rapidly reshaping the pharmaceutical industry—and nowhere is that more evident than in small-molecule drug discovery. In this episode, we sit down with Tom Shani, CEO and co-founder of ProPhet, an AI-driven biotech company focused on discovering drugs for hard-to-target proteins.
Tom explains how machine learning models, transformers, and AI-driven molecular representations are overcoming the biggest limitations of traditional drug discovery: slow timelines, high failure rates, missing data, and billion-dollar R&D costs. Rather than relying solely on physics-based simulations and trial-and-error lab work, AI systems learn patterns directly from noisy biological data—making them uniquely suited for real-world biology.
The conversation explores how AI can compress drug discovery timelines from decades to years, reduce failed trials, and dramatically lower costs by improving early-stage target and molecule selection. Tom also breaks down why small molecules remain the backbone of modern medicine, how AI enables scalable exploration of vast chemical space, and why trust, regulation, and validation remain the biggest hurdles to adoption.
This episode is essential listening for anyone working in pharma R&D, biotech, AI-driven drug discovery, computational biology, or life sciences innovation.
About the Podcast
AI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.
This show brings together leading experts and changemakers to demystify AI and show how it’s being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI’s role in social good, this podcast offers valuable insights.
AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget.
As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses.
This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so much more.
In this episode, Dr. Andre Bates, Founder & CEO of Eularis, joins Cures and Capital hosts Martin and Simona to explore how artificial intelligence is transforming drug discovery, R&D productivity, and enterprise strategy across the biopharma industry.
Dr. Andre Bates shares a pragmatic view on AI in the biopharma industry, cutting through the hype to explore where AI is already delivering value and where companies need to focus for real impact. From regulatory document preparation to AI-driven drug discovery, Andre explains how AI is transforming the industry—and why human adoption is just as critical as the technology itself.
What You’ll Learn from This Episode:
About the Podcast
AI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.
This show brings together leading experts and changemakers to demystify AI and show how it’s being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI’s role in social good, this podcast offers valuable insights.
AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget.
As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses.
This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so much more.
In this episode, Dr. Andre Bates, Founder & CEO of Eularis, joins Cures and Capital hosts Martin and Simona to explore how artificial intelligence is transforming drug discovery, R&D productivity, and enterprise strategy across the biopharma industry.
Dr. Bates shares actionable insights into the real-world potential of AI to reduce time-to-market, cut development costs, and create competitive advantage. From AI strategy alignment with business goals to executive board responsibilities and data governance, this episode dives deep into what it takes to implement AI successfully across the pharmaceutical value chain.
What You’ll Learn in This Episode:
Whether you’re a pharma executive, AI strategist, or R&D professional, this episode provides a comprehensive roadmap to harness AI for sustainable innovation and measurable ROI in biopharma.
About the Podcast
AI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.
This show brings together leading experts and changemakers to demystify AI and show how it’s being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI’s role in social good, this podcast offers valuable insights.
AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget.
As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses.
This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so much more.
In this episode, Dr. Andre Bates, Founder & CEO of Eularis, joins Cures and Capital hosts Martin and Simon for a deep dive into how AI is transforming the biopharma industry. With over two decades of experience applying AI across R&D, clinical development, regulatory, medical affairs, and commercial teams, Dr. Bates explains how the field has evolved from early digitisation to the current generative AI era.
She discusses the post-ChatGPT shift in executive decision-making, why many organisations are stuck in endless piloting, and how companies can build a strategic, business-aligned AI roadmap that delivers real-world value. Dr. Bates also breaks down a practical framework for calculating ROI on AI initiatives and highlights where pharma teams are seeing the strongest impact today—from drug discovery and clinical trials to regulatory workflows and personalised commercial engagement.
About the Podcast
AI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.
This show brings together leading experts and changemakers to demystify AI and show how it’s being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI’s role in social good, this podcast offers valuable insights.
AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget.
As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses.
This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so much more.
Dr. Andree Bates LinkedIn | Facebook | Twitter
In this episode, we take you inside the AI factory — the place where companies are transforming real business operations using AI workflows, not just experimenting with flashy demos or proofs of concept.
AI strategist Dustin Jensen breaks down what differentiates AI systems that scale from those that become expensive experiments. He explains why companies waste money when they “throw AI at a workflow” without truly understanding the process, the data, and the human-in-the-loop requirements.
You’ll hear how to build AI workflows that integrate with existing infrastructure, collaborate with people, and close the loop on real tasks — not copilots that need constant oversight.
About the Podcast
AI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.
This show brings together leading experts and changemakers to demystify AI and show how it’s being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI’s role in social good, this podcast offers valuable insights.
AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget.
As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses.
This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so much more.
Dr. Andree Bates LinkedIn | Facebook | Twitter
In today’s episode, we explore the Simplify to Scale approach — how companies can use AI, intelligent automation, and design thinking to remove operational friction, improve workflows, and unlock sustainable growth.
Our guest, Anthony Franco, is a serial entrepreneur, AI strategist, and co-author of AI First Principles and The Wiser Method. He has launched and successfully exited six companies, and now advises enterprise leaders on how to operationalize AI safely and strategically.
You'll learn how to identify the difference between necessary complexity (the kind that creates competitive advantage) and unnecessary complexity (the kind that wastes time, budget, and energy). Anthony also reveals why most companies fail with AI implementation — and how the right simplification process prevents wasted effort.
If you're a founder, CEO, COO, or operator who wants to grow without adding more tools, processes, or people, this episode shows how to scale smarter, not bigger.
About the Podcast
AI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.
This show brings together leading experts and changemakers to demystify AI and show how it’s being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI’s role in social good, this podcast offers valuable insights.
AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget.
As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses.
This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so much more.
Dr. Andree Bates LinkedIn | Facebook | Twitter
What if drug testing didn’t need animals — or risky early-stage human trials?
In today’s episode, we explore organ-on-a-chip technology, a breakthrough innovation that is transforming how drugs are developed, tested, and brought to market. These micro-sized devices — containing real living human cells — can accurately replicate the function of organs like the liver, lungs, brain, kidney, and intestine.
Our guest, Daniel Levner, Chief Technology Officer and co-founder of Emulate, breaks down how this technology works, why the FDA is recognizing it as an alternative to animal testing, and how it’s already being used by leading pharma companies to predict toxicity, reduce failures in clinical trials, and accelerate drug development.
About the Podcast
AI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.
This show brings together leading experts and changemakers to demystify AI and show how it’s being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI’s role in social good, this podcast offers valuable insights.
AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget.
As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses.
This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so much more.
In this episode, we explore one of the most disruptive advancements currently reshaping the pharmaceutical and biotech industry: AI-powered digital twins for clinical trials.
Our guest, Aaron Smith, PhD — Founder and Head of Machine Learning at Unlearn.AI — breaks down how digital twins and generative AI are transforming drug development by enabling faster, smaller, and more efficient clinical trials.
Unlearn.AI builds digital twin models: virtual patient replicas created using clinical trial data, registry data, and real-world data. These digital twins allow researchers to simulate how a patient’s disease will progress under standard care, long before a clinical trial is completed. When combined with randomized controlled trials, this technology reduces data variability, increases trial power, and can dramatically shrink sample sizes and timelines.
Some pharma companies are already estimating a six-month reduction in time-to-market, with millions saved in development and operational costs.
About the Podcast
AI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.
This show brings together leading experts and changemakers to demystify AI and show how it’s being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI’s role in social good, this podcast offers valuable insights.
AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget.
As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses.
This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so much more.
What if artificial intelligence could detect throat cancer instantly — in real time — during a routine exam?
In this groundbreaking episode, we speak with Marius Wellenstein, Founder and CEO of WSK Medical, the company behind the world’s first AI-powered endoscopic solution for real-time detection and classification of throat and head & neck cancers.
Marius shares how his team developed a plug-and-play AI system that integrates seamlessly into existing endoscopy equipment to identify both benign and malignant lesions within seconds — helping ENT surgeons catch cancers earlier, reduce diagnostic delays, and save lives.
He also discusses how AI is redefining clinical workflows, accelerating cancer diagnostics, and bringing expert-level accuracy to every outpatient clinic, no matter its size.
If you’re interested in the future of AI in medicine, oncology innovation, or digital health entrepreneurship, this episode is a must-listen.
About the Podcast
AI for Pharma Growth is a podcast focused on exploring how artificial intelligence can revolutionise healthcare by addressing disparities and creating equitable systems. Join us as we unpack groundbreaking technologies, real-world applications, and expert insights to inspire a healthier, more equitable future.
This show brings together leading experts and changemakers to demystify AI and show how it’s being used to transform healthcare. Whether you're in the medical field, technology sector, or just curious about AI’s role in social good, this podcast offers valuable insights.
AI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr. Andree Bates created to help organisations understand how the use of AI based technologies can easily save them time and grow their brands and business. This show blends deep experience in the sector with demystifying AI for all pharma people, from start up biotech right through to Big Pharma. In this podcast Dr Andree will teach you the tried and true secrets to building a pharma company using AI that anyone can use, at any budget.
As the author of many peer-reviewed journals and having addressed over 500 industry conferences across the globe, Dr Andree Bates uses her obsession with all things AI and futuretech to help you to navigate through the, sometimes confusing but, magical world of AI powered tools to grow pharma businesses.
This podcast features many experts who have developed powerful AI powered tools that are the secret behind some time saving and supercharged revenue generating business results. Those who share their stories and expertise show how AI can be applied to sales, marketing, production, social media, psychology, customer insights and so much more.