Chadi and guest Dr. Manmeet Ahluwalia, Deputy Director, Chief Scientific Officer, and Chief of Solid Tumor Medical Oncology at Miami Cancer Institute, delve into the latest breakthroughs in primary brain cancers. As a distinguished expert in brain metastases and primary brain tumors, Dr. Ahluwalia provides invaluable insights into clinical trial design, enrollment challenges, and the complexities of brain tumor development. Together, they explore the landscape of surgical and therapeutic interventions, uncovering advances in survival rates, quality-of-life enhancements, and promising therapeutic agents targeting specific mutations, as well as mechanisms of treatment resistance and the ongoing pursuit of effective solutions. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi delves into the realm of AI and its transformative impact on drug development with Adam Petrich, MD, Chief Medical Officer of QuantHealth, who unveils the AI solutions crafted by QuantHealth, aimed at simulating and predicting clinical trial outcomes to enhance the success rates of trials. Drawing from his expertise, Dr. Petrich sheds light on the integration of AI in the clinical trial creation process, offering insights into predicting investigational treatment efficacy against standard of care treatments. He also explores the delicate balance between sensitivity and specificity, and delves into the meticulous validation processes employed to ensure model accuracy. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Aaron Goodman, who started a petition that gathered over 20,000 signatures to end the MOC back in July 2023, found himself suddenly reported as NOT CERTIFIED by the ABIM in the specialty he practices and teaches (hematology). When he called the ABIM, he was told he needed to pay thousands of dollars in back fees for the Internal Medicine Board that he did not want to keep, as he is a specialist in bone marrow transplant and hematology. The ABIM advised that unless he pays these fees, he will be deemed “not certified,” which threatens his ability to see patients at his own institution. Aaron was shocked and so was Chadi. The entire story is here. Learn what happened, what is next, and what can be done. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Grace Cordovano, a distinguished Board Certified Patient Advocate and the visionary founder of Enlightening Results, as well as the co-Founder of Unblock Health, delves into her personal journey, recounting her own wrongful diagnosis of advanced lymphoma and how it propelled her into patient advocacy. Drawing from her extensive experience, she sheds light on the diverse array of individuals who seek her guidance and the multifaceted challenges they face, from navigating the complexities of tumor boards to grappling with insurance denials and prior authorizations. Dr. Cordovano also illuminates her innovative approach, harnessing the power of AI to provide patient-centric counsel and support. With a deep commitment to advocating for patients at every stage of their healthcare journey, she shares insights into her involvement in end-of-life care and offers invaluable perspectives on advocating for patients in the contemporary era. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi is joined by Simon Arkell, Co-Founder and CEO of Ryght, a pioneering company in the healthcare ecosystem that specializes in producing generative AI solutions that cater specifically to the needs of drug companies. Simon sheds light on the nuances between AI and traditional machine learning models, highlighting Ryght's innovative approach to making generative AI both accessible and secure. He expands on the intricacies of data synthesis, drawing from diverse sources to craft individualized models for each client. Simon further shares how customer feedback has been instrumental in refining Ryght's offerings, ultimately shaping the future of healthcare innovation. For more information about Ryght, visit their website. https://www.ryght.ai/about-us Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Paul Teirstein, President of NBPAS.org, joins Chadi to highlight and reveal how the National Board of Physicians and Surgeons (NBPAS) is challenging the status quo of board certification for all medical practitioners. With a mission to advocate for physicians and combat the monopoly of Maintenance of Certification, Dr. Teirstein explains how NBPAS provides a refreshing alternative for continuous board certification. Visit the NBPAS website. https://nbpas.org/ View Dr. Teirstein debating Dr. Lois Margaret Nora of the American Board of Medical Specialties. https://www.youtube.com/watch?v=_fc3BQ-9yMM View Dr. Teirstein’s MOC presentation. https://www.youtube.com/watch?v=h1vw2RPCd1s Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In this ASCO-GI research special, Dr. Bekaii-Saab of Mayo Clinic provides an insightful and comprehensive roundup of the most groundbreaking studies unveiled at the ASCO GI 2024 meeting. Delving into the realm of hepatocellular carcinoma, he dissects the pivotal previously-reported data from IMbrave050 and ASCO GI findings from EMERALD-1. Then, he sheds light on developments in colorectal cancer, exploring the impact of KEYNOTE-177 and CheckMate 8HW. Moreover, Dr. Bekaii-Saab explores the latest advancements in minimal residual disease assessment with a focus on studies like BESPOKE and GALAXY, as well as the prognostic value of ctDNA assessment showcased in COBRA. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Pedro Barata, Director of the Clinical Genitourinary Medical Oncology Research Program at UH Seidman Cancer Center, provides an exclusive round-up of the most groundbreaking and practice-changing research unveiled at the ASCO GU 2024 meeting. With expertise and insight, he delves into pivotal studies such as CheckMate 914 Part B and KEYNOTE-564, exploring their implications for kidney cancer. The episode further unravels the transformative findings from the AMBASSADOR study, shedding light on adjuvant immunotherapy in bladder cancer; genetic testing and FGFR advancements in bladder cancer; life-prolonging therapies and radioligand therapies in castration-resistant prostate cancer; and the latest in minimal residual disease research. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Joining host Chadi is the esteemed James LaBelle, MD, PhD, Associate Director of Pediatrics and Director of the Stem Cell and Cellular Therapy Program at the University of Chicago. Dr. LaBelle elucidates the complexities of sickle cell disease, unraveling the devastating impact it has on individuals. The episode delves into various treatments and approaches to combat this formidable disease, including bone marrow transplant and the groundbreaking use of CRISPR-Cas9 technology. LaBelle shares insights into the recent research breakthroughs, citing the remarkable research report published in the New England Journal of Medicine, showcasing the successful application of CRISPR-Cas9 for sickle cell disease. This episode serves as a gateway into the promising future of genetic therapies. Read Dr. LaBelle’s publication on CRISPR-Cas9 in NEJM. https://www.nejm.org/doi/full/10.1056/NEJMoa2215643 Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In a poignant episode, USA Today investigative journalist Emily Le Coz unravels the heart-wrenching narrative of Ashleigh Anderson, a CVS pharmacist whose tragic demise serves as a cautionary tale of overwhelming stress in the workplace. Emily shares her motivations behind delving into the pervasive issue of burnout in retail pharmacy and sheds light on the very real threat it poses. She recounts the details of the Ashleigh Anderson story, where the toxic culture within retail pharmacy played a pivotal role in a life lost to the pressures of the job. Together, Chadi and Emily Le Coz navigate the profound implications of burnout, exploring its dangers and the urgent need for systemic change within the retail pharmacy landscape. This episode serves as both a tribute to Ashleigh Anderson and a rallying cry for reform in an industry grappling with the devastating consequences of unchecked workplace stress. Read more about the Ashleigh Anderson story. https://www.usatoday.com/story/news/investigations/2024/02/08/cvs-pharmacist-ashleigh-anderson-death-rallying-cry/72406578007/ Read another piece by Emily Le Coz. https://www.usatoday.com/story/news/investigations/2023/10/26/pharmacy-chains-dangerous-conditions-medication-errors/71153960007/ Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Joining host Chadi is a trio of esteemed guests – Drs. Andy Evans, Matt Maurer, and Susan Parsons – of the HoLISTIC (Hodgkin Lymphoma International Study for Individual Care) Consortium. In this riveting conversation, they delve into the consortium's pioneering efforts, bringing together an international team of experts to scrutinize the multifaceted dimensions of Hodgkin lymphoma, spanning prognosis, epidemiology, treatment, survivorship, and health outcomes across all age groups. The discussion circles around consensus protocols for treatment, referral pathways, and clinical trials, probing the necessity of transplants in the era of novel therapeutics and the creation of predictive models tailored to individual patient needs. Tune in to hear about the meticulous efforts invested in building the HoLISTIC portal, automating data migration, and navigating the challenges and progress in predictive modeling for treatment selection, response, and failure. This episode offers a captivating exploration of how collaboration, technology, and data analysis converge to shape the future of Hodgkin lymphoma care. Find out more about the HoLISTIC Consortium. https://www.hodgkinconsortium.com/ Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA