Today, I'm sitting down with Dr. Gus Vickery, a good friend and one of my favorite collaborators when it comes to cutting-edge insights in personalized health and longevity. In this episode, I put myself under the microscope as we walk through my own metabolomics testing after a period of heavy travel, stress, and—yes—a break from my usual supplement routine. If you've ever wondered whether skipping your foundational health habits "just for a little while" really matters, you're about to find out. If you are a clinician and would like to offer the Aristotle test to your patients please use this link to learn more about the Theriome test: therio.me/niddam

If you are a patient and would like to run the Theriome Aristotle test and get a full interpretation and protocol based on your results from Dr Vickery & his team please use this link: https://authentichealth.com/precision-health-evaluation/

Episode Timestamps:

Introduction to Longevity Podcast and episode overview ... 00:00:00

Metabolomics and interpreting health data – practitioner guidance needed ... 00:05:05

Combining metabolomics, gut, and blood data for whole-system insights ... 00:06:02

Nutrient depletion and oxidative stress: critical findings ... 00:18:57

Supplementation essentials for aging well ... 00:27:05

Metabolomics comparison by age group and optimization goals ... 00:29:03

Stacking interventions: why less is more with diagnostics ... 00:31:05

Functional health markers and the value of context ... 00:34:47

Sympathetic dominance, mindset, and impact on longevity ... 00:35:26

Restoring nervous system balance – inner work and tech tools ... 00:42:38

Toxins, heavy metals, and practical detox strategies ... 00:49:11

Clean environment, resiliency, and realistic lifestyle shifts ... 00:55:29

Key nutrient deficiencies revealed by metabolomics ... 01:09:15

Genetic and metabolomic tests: what's actionable? ... 01:15:07

Hope for the future: human resilience and expanding technology ... 01:22:24

Weekly actionable: walk outside for mitochondria and stress relief ... 01:26:55

Our Amazing Sponsors:

Cozy Earth – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at cozyearth.com with code LONGEVITY for up to 20% off, and don't forget to mention this podcast in the post-purchase survey.

Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order.

Blue Peptide Spray from Young Goose brings the message back loud and clear. With NAD+ APEX to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, "Hey, start making that collagen again!" It's longevity science, not cosmetic hype. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.

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Today, I'm joined by the remarkable Dr. Gabrielle Lyon, a pioneer in redefining the longevity conversation by making muscle health—not weight—the centerpiece of aging well. With a background in geriatrics and nutritional sciences, she illuminates why the quality of your muscle tissue is a far more powerful predictor of health than any number on the scale. Her perspective challenges the notion of a "healthy sedentary person" and reveals the major role of intramuscular fat in metabolic dysfunction. Check out her book The Forever Strong Playbook.

Episode Timestamps:

Introduction, podcast focus, and welcoming Dr. Gabrielle Lyon ... 00:00:00

Muscle's impact on brain health, inflammation, and healthy aging ... 00:01:03

Dr. Lyon's childhood, grit, and self-discipline ... 00:04:33

Mentorship and protein science under Dr. Donald Lehman ... 00:07:05

Muscle as the overlooked metabolic organ ... 00:08:45

Why intramuscular fat matters more than body weight ... 00:10:06

Plant vs. animal protein for muscle health ... 00:13:29

Muscle as an endocrine organ and cognition ... 00:16:21

Future of muscle science: anabolics, imaging, and technology ... 00:18:22

GLP-1s, sarcopenic obesity, and muscle-first protocol ... 00:46:45

Sarcopenia, aging, and the importance of early training ... 01:04:35

Building lifelong resilience—mental and physical ... 01:08:31

Predictions: anabolics, muscle testing, and assessment ... 01:12:17

"Strength is a responsibility, not a luxury" ... 01:13:53

Our Amazing Sponsors:

Cozy Earth – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at cozyearth.com with code LONGEVITY for up to 20% off, and don't forget to mention this podcast in the post-purchase survey.

Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off.

Tranq Dart by Wizard Sciences - a multi-pathway sleep support from Wizard Sciences. It's not a knockout pill; it's a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit wizardsciences.com and use code NAT15 for 15% off. Sleep smarter, not harder.

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Today, I'm joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators.

Use code NAT10 for 10% off products at https://alchemiqlabs.com/

Episode Timestamps:

Welcome and episode introduction ... 00:00:00

Anthony Castore's path from strength coaching to cellular medicine ... 00:05:55

Connecting strength training with cellular pathways (AMPK, mTOR) ... 00:12:27

Explaining and balancing AMPK and mTOR for performance ... 00:13:03

Training strategies: Metabolic, hypertrophy, and neural approaches ... 00:18:18

Building a solid foundation: Lifestyle, training, nutrition, peptides ... 00:23:04

Assessing recovery capacity and individualizing protocols ... 00:26:02

Mitochondrial fission, fusion, and targeted adaptation ... 00:29:57

Optimizing muscle gain and fat loss through calories and recovery ... 00:31:00

Differentiating bodybuilder vs. longevity approaches ... 00:34:44

Integrating peptides and support molecules into routines ... 00:40:44

Ketone esters and mitochondrial peptide interventions ... 00:41:20

Cautions on stacking and combining interventions ... 00:54:04

Lessons learned from overdoing interventions ... 01:05:02

Our Amazing Sponsors:

Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off.

BEAM Minerals - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at beamminerals.com with code NAT20.

Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off.

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Today, I'm joined by the deeply thoughtful and refreshingly honest Dr. Sanjay Bhojraj, a self-described "curious cardiologist" who spent decades treating heart attacks in the cath lab — before stepping away to ask a bigger question: Why are we waiting for the crisis instead of preventing it?

Episode Timestamps:

Welcome to Longevity & episode setup … 00:00:00

Dr. Bhojraj's shift from ER cardiology to prevention … 00:06:30

Why most heart attacks aren't caused by big blockages … 00:09:15

Stress, nervous system load & heart attack risk … 00:13:10

CIMT explained: what it measures (and what it misses) … 00:26:40

Calcium scores vs CT angiograms … 00:35:45

CLEERLY scan: seeing dangerous soft plaque … 00:38:45

Can plaque actually regress? … 00:41:55

When heart scans make patients less afraid … 00:44:05

When should you test — even without symptoms? … 00:45:50

Why age 45 is a major cardiovascular inflection point … 00:47:10

Hormones, estrogen loss & women's heart risk … 00:50:10

Why cardiology still misunderstands women … 00:54:30

Small dense LDL, ApoB & oxidized cholesterol … 01:02:00

Why fixing inflammation matters more than numbers … 01:05:50

Our Amazing Sponsors:

Regenerive - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it's not just "healthy aging" in theory. Go to regenerive.co and use code NAT25 to save 25%

Mitopure® Longevity Gummies are the only clinically proven Urolithin A gummies supporting mitochondrial health — one of the key hallmarks of aging. Get 35% off a one-month subscription at Timeline.com/Nat2026 *Special deal through January 2026.

PW1 by Puori — A clean, high-quality whey protein that's third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to puori.com/NAT and use code NAT for 32% off your first subscription or 20% off anything on the site.

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Today, I'm joined by Charles Bohdy, a true innovator in water purification technology, and Victor Sagalovsky, a passionate advocate for bringing the science of water quality into our daily lives. Together, we take a deep dive into the unseen world of the water running through our homes—exploring not just its purity, but its hidden potential to support our biology in ways most of us have never considered.

Whole HOME Water System - Use code NAT100

Episode Timestamps:

Intro to Longevity Podcast and today's water focus ... 00:00:00

Water system's health benefits and testing ... 00:01:33

Why water quality is overlooked yet critical ... 00:07:20

Common water issues and municipal limitations ... 00:09:10

Filtration methods: carbon blocks and pathogens ... 00:15:26

Charles's nano-ceramic multilayer filters ... 00:20:14

Concerns with chlorine and fluoride in water ... 00:23:44

Retaining healthy minerals: charge-based filtration ... 00:35:18

Reverse osmosis: pros, cons, and fungal risks ... 00:50:49

Structured water's role in biological health ... 00:56:53

Water structuring: agricultural validation ... 01:00:21

Whole-home filtration: installation and costs ... 01:11:02

Closing thoughts: bringing nature's water home ... 01:25:00

Our Amazing Sponsors:

Regenerive - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it's not just "healthy aging" in theory. Go to regenerive.co and use code NAT25 to save 25%

Primeadine by Oxford Healthspan: Primeadine supports autophagy — your cells' natural renewal and cleanup process — using food-derived spermidine, no fasting required. If you want to support resilience from the inside out, head to https://www.oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout (one-time purchases only).

Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off.

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Today, I'm joined by Ben Katz—better known online as Mr. Mass Spec —an academic analytical chemist from UC Irvine whose mission is to uncover what's really in our everyday foods, drinks, and products. Ben reverse engineers everything from Taco Bell meat to Doritos, and sometimes even entire industries, using cutting-edge mass spectrometry. His curiosity and expertise have made him a go-to source for those wanting to know what's hiding behind vague ingredient labels and "natural flavors."

Episode Timestamps:

Welcome and podcast introduction ... 00:00:00

What is mass spectrometry? ... 00:05:00

Viral "what's in it?" projects and public interest ... 00:07:27

Synthetic vs. plant-derived nicotine and toxins in plant extracts ... 00:09:53

Food label transparency and loopholes (natural flavors, FEMA, GRAS) ... 00:20:11

Sweeteners & artificial additives: sucralose, stevia, cost motivations ... 00:23:07

Ultra pasteurization of milk and added flavors ... 00:29:48

Chocolate, caffeine content, and labeling challenges ... 00:33:12

Industrial food processes, GMOs, and food security insights ... 00:38:36

Microplastics: occurrence, regulation, and PEG in food ... 00:50:15

Supplements under development for microplastic removal ... 00:58:43

Adulteration in olive oil, maple syrup, and honey ... 01:04:08

Hidden sweeteners, and processed food pitfalls ... 01:10:14

Avoid artificial sweeteners, problematic plastics, and hidden flavors ... 01:14:36

Our Amazing Sponsors:

Manukora Honey - rich, creamy Manuka honey packed with powerful bioactives, all in just one heaped teaspoon a day. Go to MANUKORA.com/NAT to save up to 31% plus $25 in free gifts with the Starter Kit.

Magnesium Breakthrough - uses seven absorbable forms of magnesium to support deeper sleep, calmer nerves, and real recovery. Get up to 35% off at bioptimizers.com/bionat with code BIONAT.

Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order.

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Today, I'm kicking off the new year with a back-to-basics deep dive into one of the most pivotal yet overlooked foundations of longevity: gut health. Over the past episodes, we've explored everything from gene therapy to advanced tech, but it all comes back to the habits and systems we rely on every single day—and the gut is right at the center of that equation.

Episode Timestamps:

Gut health as the cornerstone of longevity ... 00:00:00

Why disease and wellness begin in the gut ... 00:03:46

Symptoms and signs of gut imbalance ... 00:08:53

Normalizing digestive discomfort ... 00:09:33

Key stressors for gut health: stress, poor food choices ... 00:12:03

How chronic stress disrupts digestion ... 00:12:59

Processed foods, toxins, and nutrient deficiencies ... 00:13:14

The importance of whole foods, healthy fats, and cooked veggies ... 00:14:27

Testing and understanding your own food tolerances ... 00:16:31

Risks of dehydration, overtraining, and PPIs ... 00:19:24

Structure of a healthy gut: digestion, gut barrier, organ support ... 00:23:19

Pre-meal rituals for better digestion ... 00:25:33

Choosing and introducing probiotics and fiber ... 00:37:44

Tracking your food and gut motility ... 00:42:12

Lifestyle habits: exercise, sleep, stress, meal timing ... 00:45:00

Avoiding snacking and late meals ... 00:49:05

Remove offenders, restore with enzymes, replenish with probiotics ... 00:50:12

Bone broth, anti-inflammatory foods, and gut repair ... 00:54:19

Peptides and bioregulators for organ optimization ... 00:57:03

Our Amazing Sponsors:

Tranq Dart by Wizard Sciences - a multi-pathway sleep support from Wizard Sciences. It's not a knockout pill; it's a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit wizardsciences.com and use code NAT15 for 15% off. Sleep smarter, not harder.

Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off.

Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off.

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Today, I'm joined by the insightful Ashley Koff, renowned registered dietitian and fierce advocate for personalized, realistic nutrition that actually works in the real world. In this episode, Ashley Koff opens up about her personal and professional journey—from her early days in big brand marketing (think sugared cereals and infobesity) to her pivotal "aha" moments that led her to champion true weight health, not just weight loss.

Episode Timestamps:

Welcome and introduction to the Longevity Podcast ... 00:00:00

Personal experiences shaping nutrition philosophy ... 00:05:59

Influence of marketing on nutrition decisions ... 00:09:01

Big revelations: digestion, GLP-1, and health ... 00:16:43

The power of personalization in nutrition ... 00:19:59

The "Mr. Pizza Pop" case and behavioral change ... 00:23:03

Digestion as the foundation before diet quality ... 00:27:05

Dangers of generic "healthy diet" advice ... 00:36:01

GLP-1 medications: promise, risks, and prerequisites ... 00:40:10

Who truly needs GLP-1 versus lifestyle change alone ... 00:43:09

Muscle, bone, and shifting focus to building health ... 00:51:30

Nutrient intake, fiber, and supplement personalization ... 00:55:11

Digestive enzymes and optimizing digestion ... 01:03:10

Food noise, satiety, and psychological freedom ... 01:07:29

Ongoing assessment: tracking weight, fat, muscle ... 01:15:19

Weaning off GLP-1 and the importance of professional support ... 01:18:32

Our Amazing Sponsors:

Primeadine by Oxford Healthspan: Primeadine supports autophagy — your cells' natural renewal and cleanup process — using food-derived spermidine, no fasting required. If you want to support resilience from the inside out, head to https://www.oxfordhealthspan.com/BIONAT15 and use code BIONAT15 at checkout (one-time purchases only).

Magnesium Breakthrough by BiOptimizers: Better sleep isn't about willpower — it's about absorption. Magnesium Breakthrough uses seven real forms of magnesium that help you rest deeper and recover faster. Get up to 35% off at bioptimizers.com/bionat with code BIONAT.

Just Thrive Gut Essentials Bundle: pairs a probiotic proven to arrive 100% alive with digestive bitters that support digestion and curb cravings, so you actually feel the difference fast. Save 20% on your first Gut Essentials Bundle at justthrivehealth.com/NAT20 with code NAT20 — 100% money-back guarantee.

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Today, I'm excited to bring back the always thought-provoking Joel Greene, author of "The Immunity Code" and "The Way," for a fresh conversation on why true longevity is about so much more than how much muscle you have or the latest diet trend you're following. Joel Greene opens up about the hard lessons he's learned from decades of self-experimentation and reveals why chasing that ideal gym physique might actually backfire as you age.

Episode Timestamps:

Welcome & episode introduction ... 00:00:00

The evolving nature of health and homeostasis ... 00:08:29

Beware rigid diet tribes—find nutritional flexibility ... 00:21:41

Biomarkers people miss: fasting insulin and acyl carnitines ... 00:23:11

Chronic ketosis, ATP, and metabolic slowdowns ... 00:25:16

Myth-busting muscle and the limits of bodybuilding for aging ... 00:27:17

Functional movement, flexibility, and big toe strength ... 00:34:29

Simple foundation: daily jumps or hops ... 00:47:41

Sensible protocols for muscle gain after 50 ... 01:00:07

Balance in diet as the true key to insulin sensitivity ... 01:08:06

Rules of thumb: meal timing for insulin ... 01:15:56

Stillness, faith, and feeding your spirit ... 01:21:56

Most abused supplement: Antioxidants ... 01:27:54

Body fat percentage as top longevity marker ... 01:29:12

Our Amazing Sponsors:

Quantum Upgrade - Supports nervous system balance without wearables or apps—just effortless, 24/7 quantum energy streaming. With 21+ studies showing measurable improvements in stress and cellular function, it's easy to try for yourself. Visit quantumupgrade.io/NAT and use code NAT10 to start the free trial.

Blue Peptide Spray from Young Goose - Brings the message back loud and clear. With NAD+ APEX™️ to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, "Hey, start making that collagen again!" It's longevity science, not cosmetic hype. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.

Mitopure® Longevity Gummies are the only clinically proven Urolithin A gummies supporting mitochondrial health — one of the key hallmarks of aging. Get 35% off a one-month subscription at Timeline.com/Nat2026 *Special deal through January 2026.

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Today, I'm joined by a lineup of trailblazers in the science of longevity: Ben Azadi, Dr. Teo Soleymani, Dr. Carrie Jones, Ian White, Dr. Robert Lufkin, and Dr. Jenn Simmons . Together we dig into some of the most persistent myths and cutting-edge research shaping how we age—including why "eat less, move more" misses the mark, what really causes skin cancers, breast cancer screening risks, and the often-overlooked ripple effects of perimenopause.

Links to full episodes:

• #333: Keto Myths, Carb Days, and Why Calories Don't Count | Ben Azadi on Breaking the Weight Loss Cycle
• Episode 338: How the Sun ACTUALLY Impacts Skin Aging and Cancer Risk: Skin Cancer Controversies, Sun Safety Secrets, and Anti-Aging Breakthroughs With Teo Soleymani, MD
• Episode 376: Survival Tips for Perimenopause, NEW At-Home Hormone Testing & Bioidentical Myths With Dr. Carrie Jones
• Episode 350: Nature's Longevity CODE Revealed: Exosomes, Plasma HACKS & the Real Science of Aging | With Dr. Ian White
• Episode 318: Lies He Taught In Medical School: The METABOLIC Secret To Reversing Chronic Disease with Dr. Robert Lufkin
• Episode 300: Breast Cancer Overdiagnosis, Mammogram Myths, The REAL Risks For Women And Bold NEW Alternatives With Dr. Jenn Simmons

Episode Timestamps:

Welcome & podcast overview ... 00:00:00

Longevity habits handout & sponsor plug ... 00:00:48

Clean protein choices & contamination risks ... 00:01:25

Calorie focus vs. hormones in weight loss ... 00:02:42

Why calories in/calories out fails ... 00:03:27

Cellular inflammation & gut microbiome in weight ... 00:04:43

Healthy, flexible metabolism over fast metabolism ... 00:07:51

Sun exposure, genetics & skin cancer ... 00:08:02

Sunscreen myths & ingredient safety ... 00:11:47

Perimenopause symptoms beyond hot flashes ... 00:12:27

Hormone replenishment: lifestyle + medical strategies ... 00:15:35

Breaking menopause myths & self-education ... 00:19:05

Blood factors & parabiosis in aging ... 00:21:37

Plasma exchange — practical and scientific updates ... 00:26:01

Western medicine vs. chronic disease reality ... 00:28:07

Breast cancer screening & over-treatment concerns ... 00:33:16

Hormone therapy after menopause—timing & benefits ... 00:37:07

Our Amazing Sponsors:

PW1 protein powder is third-party tested for more than 200 contaminants, and Puori was the only brand that earned the Clean Label Project Transparency Certificate. That level of disclosure is rare. And refreshing. If you want protein that supports your goals — without the guesswork — go to Puori.com/NAT and use code NAT for 32% off your first subscription or 20% off anything on the site.

Manukora - Now in NEW Glass Jars - This isn't regular honey. Manukora's bees collect nectar from the Manuka tea tree, which packs 3x more antioxidants and prebiotics than normal honey. Plus it naturally contains MGO, that rare antibacterial compound. Head to MANUKORA.com/NAT to save up to 31% plus get $25 worth of free gifts with the Starter Kit.

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Today, I'm joined by Lucas Aoun, from Australia, supplement formulator, and self-described human guinea pig. Lucas and I dive into his personal journey from working behind the counter at his father's pharmacy, to experimenting with early nootropic formulas, and ultimately becoming a sought-after educator in the world of biohacking.

Episode Timestamps:

Podcast introduction and guest welcome ... 00:00:00

Lucas Aoun's journey into biohacking ... 00:04:13

Innovative supplement formulation and teacrine ... 00:10:00

Dopamine's role in motivation and productivity ... 00:32:09

Bioindividual supplement responses and AI in health ... 00:17:00

Alcohol alternatives and social nootropics ... 00:39:52

Optimizing exercise timing and performance ... 00:48:49

Testosterone, thyroid, and men's health fundamentals ... 00:53:01

Diet diversity: carnivore, vegan, and healthy fats ... 00:59:19

Catwaba Pure: origins, benefits, and uses ... 01:13:12

Our Amazing Sponsors:

Nootropept by LVLUP - an advanced cognitive enhancement formula that combines fast-acting neuropeptides, cholinergic support, and mitochondrial-boosting compounds to sharpen mental clarity, memory, and long-term brain performance. Visit https://lvluphealth.com/ and use code NAT at checkout for 20% off.

PW1 protein powder is third-party tested for more than 200 contaminants, and Puori was the only brand that earned the Clean Label Project Transparency Certificate. That level of disclosure is rare. And refreshing. If you want protein that supports your goals — without the guesswork — go to Puori.com/NAT and use code NAT for 32% off your first subscription or 20% off anything on the site.

NEW Timeline Gummies: Urolithin A supports muscle strength and cellular energy. It's about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you'd get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase.

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