The Great Antidote
Juliette Sellgren
Adam Smith said, "Science is the great antidote to the poison of enthusiasm and superstition." So join us for interviews with the leading experts on today's biggest issues to learn more about economics, policy, and much more.
- 36 minutes 33 secondsThe Story of The Great Antidote: A Conversation with Veronique de Rugy
In this final episode of The Great Antidote, I sit down with my mom, Veronique de Rugy (does this feel like a Mr. Big name reveal for some of you?!), to reflect on the podcast and the remarkable journey of the past five years. Together, we revisit how the show started, the ideas that shaped it, the moments that changed me, and the people whose support made everything possible. This episode is a reflection on learning, growth, and gratitude—and a thank-you to everyone who has been part of this project.
Veronique de Rugy is the George Gibbs Chair in Political Economy and Senior Research Fellow at the Mercatus Center at George Mason University. She is also an incredible mother (just ask me (if you don't trust me, you can ask my sister)).
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Follow us on Facebook, Twitter, and Instagram.19 December 2025, 11:00 am - 49 minutes 37 secondsHow Definitions Change Debates: Freedom, Rights, and Equality with Rebecca Lowe
Philosopher Rebecca Lowe (Mercatus Center) joins me to do an ideas-only deep dive: what freedom really is, why it matters, how it intersects with equality, and how to tell coercion from choice. We talk charitable argument (steelmanning), the social value of clear definitions, and Rebecca’s agent-focused view of freedom—plus why doing something freely can have value even when the act is bad.
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Follow us on Facebook, Twitter, and Instagram.5 December 2025, 11:00 am - 54 minutes 8 secondsInnovation on Trial: Jack Nicastro on Empower’s Fight to Exist
Why is D.C. trying to shut down a rideshare app that pays drivers more and charges riders less? Jack Nicastro of Reason joins to unpack Empower’s battle with regulators, what “innovation vs. permission” means in real life, and how markets—not mandates—keep people safe.
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Follow us on Facebook, Twitter, and Instagram.21 November 2025, 11:00 am - 51 minutes 55 secondsTech Panic, Then and Now: Judge Glock on AI, Regulation, and Real Harms
Is tech panic new—or just history on repeat? Judge Glock (Manhattan Institute) walks through what past tech scares (lead gasoline, CFCs, TV) got right and wrong, why “externalities” matter more than vibes, and how to think about AI regulation today—transparency mandates, liability vs. preclearance, “AI pauses,” and realistic optimism. We end with his own journey from socialism to markets.
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Follow us on Facebook, Twitter, and Instagram.7 November 2025, 11:00 am - 47 minutes 17 secondsWhy Markets Run on Trust: Tawni Ferrarini on Honesty, Reputation, and Decentralization in the Information Age
Markets don’t work without trust. Tawni Ferrarini joins Juliette Sellgren to explore how honesty and reputation make exchange possible — from medieval trade networks to blockchain and Amazon reviews — and why decentralized trust systems matter in today’s economy of polarization, misinformation, and weak institutions.
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AEI Economist Derek Scissors joins Juliette Sellgren to unpack the reality of China’s economy, U.S.–China relations, and whether China is truly a threat. From demographics to debt and political control, Scissors explains what’s really driving China’s trajectory, and why it matters for America’s future.
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Follow us on Facebook, Twitter, and Instagram.10 October 2025, 10:00 am - 47 minutes 2 secondsEmpowering the Next Generation: Economics Olympiad & Common Sense Economics
This week, Juliette Sellgren sits down with Martina Bacik, the 21-year-old founder of the Economics Olympiad that has grown to 120,000 students in 35+ countries, and Tawni Hunt Ferrarini, coauthor of Common Sense Economics. Together they explore why teaching economics early matters, how competitions and books ignite curiosity, and what inspiring young people can teach us about building a hopeful, prosperous future.
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Follow us on Facebook, Twitter, and Instagram.26 September 2025, 10:00 am - 51 minutes 10 secondsWhy Freedom Matters: Tom Palmer on Authoritarianism and January 6th
Why does freedom matter? How can we defend it in an age of rising authoritarianism? In this episode, I sit down with Tom Palmer to explore the ideas, virtues, and strategies that keep liberty alive.
We cover:
· The rise of authoritarian movements and global threats to liberty
· The morality of freedom: how to know what to fight for and when
· January 6th as a failure of duty, and what true constitutional leadership requires
· Trump, responsibility in office, and the role of virtue in political life
· How persuasion, clarity, and even humor (à la Bastiat) can advance freedom
Palmer draws on decades of experience—from supporting dissidents in the USSR before the Berlin Wall fell to working in Ukraine’s struggle against Russia today, and fighting for self-defense rights, marriage equality, and freedom from conscription in the U.S.
The through line is clear: defending freedom takes more than theory—it requires virtue, duty, and clarity of purpose to make liberty resilient and worth fighting for.
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Follow us on Facebook, Twitter, and Instagram.12 September 2025, 10:00 am - 34 minutes 29 secondsIt’s Not Goodbye, It’s See You in September with Amy Willis
In this special episode of The Great Antidote, Amy Willis of Liberty Fund takes the mic to interview Juliette Sellgren, the voice behind the show. Together, they reflect on the evolution of the podcast—from its early days to the hundreds of guests it has featured—and how Juliette herself has grown in the process.
They talk about what it means to foster curiosity, how Juliette approaches reading (and recommends you do, too), and what makes for a great question. They also discuss the future of the podcast, the future of Juliette, and how The Great Antidote continues to explore the ideas of liberty and flourishing through meaningful conversation.
We explore questions like:
- What have been the most surprising lessons from interviewing economists, philosophers, and thinkers about liberty?
- How has Juliette’s own worldview changed since the podcast began?
- What is her approach to reading—and how does it fuel her curiosity?
- If she could have dinner with any past guest (or figure), who would it be?
Juliette Sellgren is the creator and host of The Great Antidote, a podcast by Liberty Fund that explores the ideas, institutions, and people behind a free society. She’s a researcher, writer, and lover of questions whose work bridges classical liberal ideas and public conversation.
Whether you're a longtime listener or just tuning in, this behind-the-scenes episode offers an honest, reflective look at the voice behind the mic—and what’s next.
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Follow us on Facebook, Twitter, and Instagram.23 May 2025, 10:00 am - 47 minutes 32 secondsThe Limits of Liberty: Buchanan’s Case for Constitutional Rules with Edward Lopez
What happens when people stop trusting rules—and start rewriting them?
In this episode, we are joined by economist Edward Lopez about the life and legacy of James M. Buchanan, the Nobel Prize-winning founder of public choice economics. We begin by unpacking Buchanan’s biography and intellectual roots: what shaped his worldview, who influenced his thinking, and why his work remains foundational to understanding government, rules, and freedom.
From there, we dive into the rich ideas in The Limits of Liberty—a dense but powerful book in which Buchanan asks: How can free individuals live together without descending into chaos or coercion? Lopez shares with us Buchanan’s key questions, his analytical framework, and the underlying principles that guide his work—especially his emphasis on rules, consent, and the boundaries of state power.
We explore questions like:
- Who was James Buchanan, and why does his work matter today?
- What makes Buchanan a “consummate Smithian” and a classical liberal?
- What are the central ideas in The Limits of Liberty—and why are they still so relevant?
- How does public choice theory reshape how we understand politics, institutions, and individual freedom?
Edward Lopez is a professor of economics and the BB&T Distinguished Professor of Capitalism at Western Carolina University. He directs the Center for the Study of Free Enterprise and is the past president of the Public Choice Society. His work focuses on the intersection of law, economics, and political processes, especially in the tradition of public choice and constitutional political economy.
If you’ve ever wondered what holds free societies together—or what happens when the rules start to break—this episode is for you.
Want to explore more?
- Intellectual Portrait Series: A Conversation with James Buchanan
- Pierre Lemieux, Lessons and Challenges in The Limits of Liberty, at Econlib.
- Randy Simmons on Public Choice, a Great Antidote podcast.
- Sandra Peart on Ethical Quandaries and Politics Without Romance, a Great Antidote podcast.
- Edward Lopez, Socialism from the Bottom Up: Where Lawson and Powell Meet Hayek and Buchanan, at Econlib.
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Follow us on Facebook, Twitter, and Instagram.16 May 2025, 10:00 am - 1 hour 2 minutesWhy Some States Succeed: Mobility, Markets, and the Freedom to Flourish with Justin Callais
What makes some states thrive while others trap people in place? And what does it really mean to be free to move, grow, and flourish?
In this episode, I talk with economist Justin Callais about the deep connections between personal fulfillment, economic mobility, and institutional quality. We begin with the personal: why real change starts internally, and how self-mastery and agency are prerequisites for meaningful, external progress. Then, we zoom out to ask: what kinds of systems make it easier for people to rise?
We explore questions like:
- What is economic mobility—and what does it look like in practice?
- Why is Utah the top-performing states on the Archbridge Institute’s Social Mobility Index, while Louisiana lags behind?
- How do factors like governance quality, opportunity, and freedom of movement shape people's life outcomes?
- What role do individuals, institutions, and state policies play in promoting (or restricting) upward mobility?
Justin Callais is the chief economist at the Archbridge Institute. He studies development economics, polycentric governance, and the institutional roots of freedom and flourishing.
If you’ve ever wondered why where you live matters—or what it takes to build a society where people can truly move up in life—this conversation is for you.
Want to explore more?
- James Heckman on Inequality and Economic Mobility, an EconTalk podcast
- Raj Chetty on Economic Mobility, an EconTalk podcast
- Arnold Kling, The Kids Are...Different, at Econlib
- Kerianne Lawson on Equal Economic Freedoms, a Great Antidote podcast
- Jeremy Horpedahl on the Real Cost of Thriving Index, a Great Antidote podcast
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