Kelsey Grammer returns to "Literally” for a moving episode. The "Frasier" and "Cheers" star joins Rob Lowe to discuss his deeply cathartic new book, "Karen: A Brother Remembers," the tragic loss of his sister, his return to the world of "X-Men" and Marvel, why he still finds joy in acting, and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

It’s always outrageous when Rob and Chelsea Handler get together! Comedian, writer, and host of the “Dear Chelsea” podcast Chelsea Handler joins Rob Lowe to discuss their perspectives on aging, the ski season, what she’s looking for in an “international boyfriend,” Rob’s early days of sobriety, and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Filmmaker Gavin O'Connor joins Rob Lowe to discuss casting Kurt Russell in the classic hockey film "Miracle," his collaborations with Ben Affleck, working with Keri Russell on "The Americans," the genius of Paul Newman, favorite Broadway performances, his new film "The Accountant 2," and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Jason Isaacs and Rob Lowe are fighting over Patrick Schwarzenegger! The “White Lotus" and "Harry Potter" actor joins Rob Lowe to discuss his brushes with injury on the set of “White Lotus,” the Duke University controversy, his belief in ghosts, TV kids vs. your real-life kids, and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Fortune wants to enjoy some cigars with Rob and Arnold! Comedian, actress, and "Handsome" co-host Fortune Feimster joins Rob Lowe to discuss their mutual friend Arnold Schwarzenegger, the North Carolina accents in “White Lotus,” her hilarious (and disastrous) marriage proposal, why she has no interest in mixing comedy and politics, and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Harry Bosch himself, actor Titus Welliver (star of the hit shows “Bosch” and “Bosch: Legacy”), joins Rob Lowe to discuss the glory days of New York City nightlife, singing with John Lennon as a kid, the time Titus almost left acting, watching your children find their passions, and how a bit of luck led him to the iconic role of Harry Bosch. Plus, Rob tries to convince Titus to write a memoir!

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

It’s a bro-fest when Rob and the Madden brothers get together! Rob’s good friends Benji and Joel Madden (founding members of the rock band Good Charlotte) join Rob in-person in Santa Barbara to discuss male friendship, their three incredible wives (Sheryl Lowe, Cameron Diaz, and Nicole Richie), music, and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Actor Chazz Palminteri (A Bronx Tale, The Usual Suspects, Modern Family) joins Rob Lowe to discuss taking his career into his own hands, his work with Robert De Niro, his beloved Yankees, and much more.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

It’s a “Parks & Rec” reunion! “Severance” star Adam Scott joins Rob Lowe to discuss shooting the second season of the hit Apple show, their memories together on the set of “Parks & Rec,” why Rob loves Adam’s fashion sense, and much more. 

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Rob Lowe's impression of Robert Wagner was so good that Mike Myers included it in “Austin Powers 2!” The legendary Robert Wagner joins Rob Lowe to talk about their decades-long friendship, his bond with Frank Sinatra, his experiences working with Spencer Tracy and Paul Newman, the secret to staying sharp and happy at 95 years old, and much more. Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!

Kristin and Rob made a movie together in Africa! “Sex and the City” star Kristin Davis joins Rob Lowe to talk about their experience shooting the Netflix movie “Holiday in the Wild” in Zambia and South Africa (featuring snakes, sharks, lions, and elephants), her incredible animal activism, why they both signed up for the thriller “Atomic Train” in the ‘90s, her new podcast “Are You a Charlotte?,” their sobriety journeys, and much more. Plus, Rob tries to guess the identity of Kristin’s mystery ex.

Make sure to subscribe to the show on YouTube at YouTube.com/@LiterallyWithRobLowe! Got a question for Rob? Call our voicemail at 323-570-4551. Your question could get featured on the show!