https://www.jayfeldmanwellness.com/healthy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes:
https://www.jayfeldmanwellness.com/non-toxic-product-recommendations-for-your-home-body-cookware-skincare-clothing-emfs-more/

Timestamps:

0:00 – intro 

0:53 – misconceptions regarding the Randle cycle in the alternative health world 

4:57 – what is the Randle cycle? 

7:06 – what most people get wrong about the Randle cycle 

10:44 – fat oxidation leads to increased ROS production and a decreased NAD+/NADH ratio 

16:29 – how fat oxidation inhibits the utilization of carbohydrates 

21:03 – the Randle cycle shows the benefits of burning carbs for energy 

25:56 – how fat oxidation inhibits the utilization of carbohydrates cont’d 

26:57 – metabolic dysfunction, not glucose, drives insulin resistance and aging 

32:07 – fat metabolism causes a buildup of citrate which reduces glucose uptake and utilization 

38:39 – how glucose oxidation inhibits the uptake and utilization of fats 

45:32 – whether you can “activate” or “deactivate” the Randle cycle 

47:22 – glucose oxidation leads to an optimal NAD+/NADH ratio and decreased ROS production 

52:08 – the protective effects of CO2 and why the brain can’t use fats as a fuel 

53:17 – whether we should strive for metabolic flexibility 

55:55 – fat metabolism and ketone production as a mechanism for energy conservation and glucose sparing 

1:00:02 – insulin resistance as a state of excess fat metabolism and decreasing fat metabolism or stress hormones improves this state 

1:05:28 – should we avoid eating carbs and fats together due to the Randle cycle? 

1:08:08 – different cells, tissues, and organs can use different fuels at the same time 

• How the Randle Cycle actually works

• Whether eating carbs and fats in the same meal causes weight gain and insulin resistance

• The efficiency of using fats as a fuel vs carbohydrate

• How stress impacts fuel usage in the mitochondria

• How to determine the optimal amount of carbs and fats in your diet

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes:
https://www.jayfeldmanwellness.com/eb-139-the-truth-about-the-randle-cycle-why-you-can-eat-carbs-and-fats-together/

Timestamps:

0:00 – intro 

0:53 – misconceptions regarding the Randle cycle in the alternative health world 

4:57 – what is the Randle cycle? 

7:06 – what most people get wrong about the Randle cycle 

10:44 – fat oxidation leads to increased ROS production and a decreased NAD+/NADH ratio 

16:29 – how fat oxidation inhibits the utilization of carbohydrates 

21:03 – the Randle cycle shows the benefits of burning carbs for energy 

25:56 – how fat oxidation inhibits the utilization of carbohydrates cont’d 

26:57 – metabolic dysfunction, not glucose, drives insulin resistance and aging 

32:07 – fat metabolism causes a buildup of citrate which reduces glucose uptake and utilization 

38:39 – how glucose oxidation inhibits the uptake and utilization of fats 

45:32 – whether you can “activate” or “deactivate” the Randle cycle 

47:22 – glucose oxidation leads to an optimal NAD+/NADH ratio and decreased ROS production 

52:08 – the protective effects of CO2 and why the brain can’t use fats as a fuel 

53:17 – whether we should strive for metabolic flexibility 

55:55 – fat metabolism and ketone production as a mechanism for energy conservation and glucose sparing 

1:00:02 – insulin resistance as a state of excess fat metabolism and decreasing fat metabolism or stress hormones improves this state 

1:05:28 – should we avoid eating carbs and fats together due to the Randle cycle? 

1:08:08 – different cells, tissues, and organs can use different fuels at the same time 

• How glucose and insulin decrease glycation

• Why ketogenic diets can be worse than high-carb diets when it comes to AGE formation

• How autophagy helps to clear AGEs, but increasing autophagy is not the answer

• The true primary drivers of AGE accumulation

• The best diet and supplements for minimizing glycation

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes:
https://www.jayfeldmanwellness.com/eb-138-low-carb-diets-increase-glycation-and-what-to-do-instead/

Timestamps:

0:00 – intro 

0:57 – how glycation products are detoxified and cleared from the body 

4:03 – glycation detoxification is impaired by oxidative stress and inflammation, as seen in type 2 diabetes 

7:56 – the benefits of carbohydrates for the detoxification of glycation products 

10:42 – the benefits of insulin for the detoxification of glycation products 

12:45 – how AGEs are cleared 

14:36 – increasing autophagy via hormesis is not the answer for clearing AGEs 

19:09 – autophagy can drive disease 

20:50 – ATP protects against oxidative stress and allows for proper autophagy when needed 

24:37 – impaired mitochondrial along with fatty acid oxidation impairs autophagy and increases oxidative stress 

26:54 – carbohydrates do NOT inhibit autophagy 

29:18 – adequate thyroid hormone supports proper autophagy 

30:15 – adequate ATP and mitochondrial function is needed for the UPS (ubiquitin proteasome system) 

32:56 – do high-carb diets actually impair metabolism and insulin sensitivity 

35:26 – is fructose really worse for blood sugar regulation and glycation? 

37:16 – are low-carb or ketogenic diets the solution to reduce glycation? 

40:32 – increased glycation and oxidative stress on ketogenic diets 

44:09 –low-carb diets don’t prevent glucose exposure 

47:56 – there are still considerable insulin and glucose excursions on low-carb diets 

50:06 – gluconeogenesis leads to same glycolytic intermediates as glucose metabolism 

51:52 –the main driver of AGE formation and impaired AGE clearance 

53:40 – the role of vitamin B1 (thiamine) and mitochondrial energy production in decreasing AGEs 

56:27 –endotoxin as a driver of glycation and increased AGE production 

58:12 – hypothyroidism as a driver of glycation and AGE accumulation 

59:37 – dietary solutions for reducing glycation and AGEs 

1:03:33 – how to support the glyoxalase pathway to support the detoxification of glycation products 

1:05:56 – avoid calorie restriction, low-carb diets, fasting, resveratrol, cold exposure, excess exercise, and iron overload to decrease glycation and AGEs 

1:07:33 – iron as a double-edged sword for oxidative stress 

• Why glucose and fructose are not the primary drivers of AGE formation

• Whether blood sugar spikes cause glycation

• How fats and ketones can cause glycation

• What’s really responsible for glycation in type 2 diabetes

• Whether fructose causes more glycation than glucose

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes:
https://www.jayfeldmanwellness.com/eb-137-what-really-causes-glycation-is-sugar-really-the-problem/

Timestamps:

0:00 – intro 

0:46 – common beliefs about carbohydrates and glycation 

2:35 – what are glycation and advanced glycation end products? 

6:57 – the process of glycation from glucose 

9:30 – is sugar the only source of AGEs? 

15:00 – primary drivers of glycation: dicarbonyls 

19:30 – how fatty acids, amino acids, and ketones cause AGE formation 

21:23 – how increased gluconeogenesis on low-carb diets increases AGE formation 

22:53 – glucose metabolism produces very few glycation products in the context of a healthy metabolism 

25:33 – omega-6s form AGEs more than 10x faster than glucose 

28:24 – the role of ALEs (advanced lipoxidation end products) in glycation and chronic disease 

30:36 – whether blood sugar spikes cause glycation 

38:52 – whether fructose causes more glycation (or fructation) than glucose 

47:05 – can glycation from fructose (fructation) be measured, and does this matter? 

52:06 – problems with research looking at fructose’s AGE formation in animal models 

• Whether there are benefits to taking massive amounts of glucose for healing  
• Whether there is a limit to the amount of glucose we should consume

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

2:10 – David Stephens’ claim that glucose can't harm you in any way, no matter the amount 

7:46 – the difference between glucose and fructose and whether fructose just gets converted to fat 

11:13 – whether extreme acidity, alkalinity, and corrosivity are what make substances harmful to humans 

15:14 – David Stephens’ claim that sucrose can't cross the blood-brain barrier  

18:59 – how authoritarianism shapes the health industry and the difficulties of verifying information with AI 

23:14 – whether the “chemical heaviness” of sucrose means that it can’t be helpful in the body 

25:51 – whether we agree with David Stephens on the benefits of glucose 

29:14 – whether anxiety, irritability, depression, autoimmune disorders, and diabetes are caused by a lack of glucose for your brain 

34:37 – what David Stephens misses about the large amounts of glucose he recommends – poor glucose utilization, gut issues, and blood sugar instability 

38:06 – whether glucose deficiency is possible and whether most people are eating enough carbs to thrive vs survive 

39:04 – David Stephens’ claim that it’s impossible for glucose to be harmful to the body in any way 

45:25 – why someone might feel better using large amounts of dextrose as their main carbohydrate source 

48:00 – how large quantities of glucose can lead to weight gain, blood sugar spikes, and cardiovascular problems 

52:27 – how to avoid dietary extremes and what balance really means 

58:41 – weight loss and recovery from mental health issues using a bioenergetic approach 

• Andrew Huberman’s ideas about what causes of nighttime wakings and what to do about them  
• How to meet all our nutrient needs

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:21 – what Huberman misses when it comes to nighttime wakeups 

4:50 – the most common causes of nighttime wakeups and how to resolve them 

9:44 –Huberman’s advice to go to sleep earlier is impractical for most people 

11:42 – what a healthy sleep schedule looks like and whether running out of melatonin is a concern 

13:38 – the relationship between blood sugar and sleep, and whether to have a bedtime snack 

16:21 – common drivers of sleep disturbances: gut irritation and elevated stress hormones 

19:25 – hidden stressors that could be impacting your sleep: SSRIs, EMFs, devices, and more 

22:13 – how to handle unavoidable stressors that interfere with sleep 

24:05 – strategies for improving sleep quality and circadian rhythm 

26:32 – whether to avoid drinking too many fluids before bed 

27:52 – the metabolism-suppressing effects of melatonin and whether supplementing with melatonin is a good idea 

29:48 – supplements that may interfere with sleep, and paradoxical reactions that occur while using medications such as SSRIs 

33:09 – sleep strategies for shift-workers and recovering from working night shifts 

36:33 – the effects of Wi-Fi, EMFs, and dirty electricity on sleep 

39:21 – how hormones impact sleep for post-menopausal women 

40:54 – evaluating whether supplements are affecting your sleep 

44:34 – how low-carb diets impair sleep and increase stress 

47:01 – improved thyroid function and weight loss on a bioenergetic approach 

48:14 – meeting daily micronutrient needs with food and supplementation 

52:57 – how to identify nutrient gaps and excesses 

55:37 – which labs to get to gauge micronutrient status and how thiamine (vitamin B1) impacts nutrient absorption 

1:00:00 – how concerned should we be with nutrient absorption? 

1:03:00 – how anti-nutrients like phytates and oxalates impact nutrient absorption 

1:04:37 – navigating different forms of nutrients (non-heme iron vs heme iron, retinol vs beta-carotene, and vitamin K2 vs vitamin K1), and how to know if gut issues are interfering with nutrient absorption 

1:07:42 – problems with dietary camps that demonize single nutrients (low vitamin A, low vitamin D, and iron overload) 

1:11:24 – how fear and stress deplete critical nutrients

• Whether Dr Ray Peat had it all wrong  
• Potential reasons why someone may be bloating from carbs
• How to add carbs back in following restrictive diet

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:32 – Justine Stenger’s claim that Dr Ray Peat had it all wrong 

6:15 – did Ray Peat ignore physics, structured water, and light? 

11:41 – carbs vs fat: which fuel produces more ROS? 

16:50 – Justine Stenger’s claim that carbs act as a crutch for a damaged metabolism, and restoring redox is the solution 

21:58 – carbs vs fat: which fuel produces more ATP? 

25:27 – conflicting health information on social media and why the “Ray Peat diet” doesn’t work 

31:55 – common challenges with implementing Ray Peat’s work 

34:09 – Justine Stenger’s mischaracterization of Ray Peat’s work as a “dietary roadmap for people with a broken metabolism” 

41:20 – why you shouldn’t outsource critical thinking to social media influencers or AI 

45:17 – Ray Peat’s generosity with freely sharing advice and information 

46:21 – improvements on a bioenergetic approach without extreme restriction 

47:31 – why you may experience bloating from carbs and what to do about it 

54:52 – what to do about gut dysbiosis and biofilms 

56:56 – how to restore gut health and digestion when transitioning away from keto

• Whether you should be concerned about low T3 or high glucagon on low-carb diets
• Whether insulin resistance is a problem of excess glucose metabolism or excess fat metabolism
• Whether a low metabolic rate allows you to live longer
• Whether high-carb diets cause overeating and insulin resistance
• Whether you should be concerned about glycation on a high-carb diet
• And much more

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes:
https://www.jayfeldmanwellness.com/eb-136-eric-westman-debate-follow-up-part-2-high-carb-diets-cause-insulin-resistance-overeating-and-glycation/

Timestamps:

0:00 – intro 

1:02 – Isabella Cooper paper: does shifting from a low-carb diet to a high-carb diet increase inflammation? 

9:12 – whether you should be concerned about low T3, low testosterone, or high glucagon on a low-carb diet 

16:53 – how we know that the brain does not use fat as a fuel source 

20:59 – whether a low metabolic rate on a low-carb diet allows you to live longer 

25:13 –increased fatty acid oxidation drives insulin resistance 

31:12 – increased fat metabolism in the heart occurs in type 2 diabetes, heart disease, and heart failure, and decreasing this fat metabolism improves cardiovascular health and insulin sensitivity 

36:37 – whether babies being born in ketosis means that being in ketosis is beneficial for adult humans 

40:29 – do high-carb diets cause glycation? 

41:56 – low-carb diets don’t eliminate blood sugar and insulin spikes 

46:10 – evidence that high-carb diets don’t cause chronically high blood sugar and insulin levels 

49:56 – the benefits of high-carb diets on insulin resistance 

55:33 – are carbs inherently addictive? do they cause overeating? 

• The mitochondrial effects of low-carb diets, and whether they’re actually worse for energy production
• The downstream hormonal effects of low-carb diets
• Whether insulin resistance is a problem of excess glucose metabolism or excess fat metabolism
• Whether high-carb diets cause overeating and insulin resistance
• And much more

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes:
https://www.jayfeldmanwellness.com/eric-westman-debate-follow-up-the-research-on-low-carb-vs-high-carb-diets/

Timestamps:

0:00 – intro 

1:05 – why I’m recording this debate follow-up 

3:38 – how the body responds to carbohydrate restriction and the broader biological context 

9:47 – the mitochondrial effects of low-carb diets: glycolysis vs beta-oxidation, NADH/FADH2 ratios, NAD+/NADH ratios, and effects at the electron transport chain 

15:16 – fat oxidation leads to slower rates of ATP production and higher rates of ROS production 

18:14 – how fat oxidation blocks glucose utilization, slows mitochondrial respiration, and reduces carbon dioxide production 

20:58 – ketone vs. glucose metabolism  

21:52 – glucose metabolism confusion, glycolysis, and whether ketones are beneficial  

24:25 – the hormonal effects of low-carb diets 

28:13 – how do we know that fat metabolism is less efficient than glucose metabolism? 

34:09 – whether research on fat metabolism in rodents applies to humans and other animals 

37:02 – the research showing that fat oxidation increases ROS production and reduces mitochondrial efficiency in various animals (including humans) 

40:31 – the research showing the mechanisms of increased ROS production and reduced efficiency of ATP production with fatty acid metabolism 

47:41 – mitochondrial uncoupling increases during fat metabolism due to increases in oxidative stress 

49:19 – are there adaptations on a keto diet that would prevent the harmful effects of fat metabolism? 

52:48 – are there biopsies done on long-term ketogenic diets showing that fat oxidation doesn’t lead to a decreased NAD+/NADH ratio and more ROS production? 

59:17 – whether increased fatty acid oxidation enzymes would reduce ROS production in the mitochondria as Dr. Westman suggested 

1:02:58 – low-carb and ketogenic diets in rodents cause increased oxidative stress and less efficient ATP production  

1:11:41 – do ketones protect against ROS? 

1:16:18 – do the potential positive effects of ketones outweigh the negative effects of ketogenic diets? 

1:27:47 –low-carb and ketogenic diets cause oxidative stress and insulin resistance in humans1:36:30 – the evidence that glucagon is a stress hormone 

1:39:45 – low-carb and ketogenic diets cause physiological stress in humans 

1:43:46 – the effects of low-carb and ketogenic diets on cortisol 

1:48:29 – low-carb and ketogenic diets decrease thyroid activity 

1:53:54 – effects of low-carb and ketogenic diets on reproductive hormones

• Ryan Fischer’s claim that the body only changes weekly, not daily  
• Whether all calories are created equal
• How to fix lactose intolerance

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:18 – why Ryan Fischer’s claim that the body only changes weekly is false 

6:38 – major problems with the “calories in, calories out” model of weight loss  

11:27 – Ryan Fischer’s claim that it takes 3,500 calories to gain one pound 

15:07 – whether it’s possible to have more “freedom” on the weekends without wrecking your health 

18:11 – Jesse James West & Jeff Nippard on apples vs Sour Patch Kids: are calories all that matter? 

24:29 – what calories actually represent and their true role in health 

29:03 – is sugar always bad for you? 

32:25 – whether tracking calories has any real value 

34:21 – problems with equating weight loss with health 

38:15 – how to know if excess calories are actually an issue for you 

45:33 – why high FODMAP fruits like apples may cause bloating and which fruits would be a better option 

49:40 – strategies for reversing lactose intolerance 

56:35 – what really drives lactose intolerance and how to tell if it’s affecting you 

58:34 – factors that affect lactose intolerance and additional strategies to reverse lactose intolerance 

1:04:18 – do leafy greens, digestive enzymes, or slippery elm help with lactose intolerance?

• Jay Campbell, Hunter Williams, and Mark Bell’s supplement stacks for staying insulin sensitive on the sugar diet  
• Whether using Metformin while on the sugar diet helps improve insulin sensitivity  
• The major differences between the sugar diet and the bioenergetic approach  
• Real-life examples of weight regain and other negative experiences after the sugar diet

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:24 – the costs of metformin: mitochondrial toxicity, increased lactate, inefficient ATP production, and slowed metabolism 

5:22 – is using Metformin a good idea on the sugar diet? 

10:30 – the dangers of increasing FGF21 while on Metformin 

13:53 – increasing FGF21 activity is counter to the bioenergetic view of health 

20:23 – Hunter Williams’ supplement stack for insulin sensitivity: metformin, Jardiance, retatrutide, and dihydroberberine 

21:42 – the negative effects of Jardiance 

24:59 – whether retatrutide and other GLP-1 agonists are healthy from a bioenergetic perspective 

27:30 – whether there are any benefits to using medications like metformin, Jardiance, retatrutide, and dihydroberberine 

31:54 – how increasing FGF21 with the sugar diet could lead to heart problems such as arrhythmias and atrial fibrillation (AFIB) 

38:58 – does the sugar diet boost metabolic rate the same way the bioenergetic approach does? 

46:27 – examples of how the sugar diet downregulates metabolism through stress 

50:51 – the cumulative effects of stress: how much stress can we handle? 

55:15 – how to recover from the negative effects of the sugar diet 

58:24 – is stress beneficial? is it possible to avoid stress altogether? 

59:51 – problems with dropping fat too low, especially in lean individuals 

1:03:50 – the risks of rapid weight loss and the importance of keeping long-term goals in mind 

1:08:02 – why cutting out entire macronutrient groups can backfire and what to do instead 

1:11:20 – how extreme diets prime our bodies for weight regain 

1:14:54 – real-life examples of weight regain after the sugar diet and why it happens 

1:20:18 – is there a smarter way to do the sugar diet? 

1:24:01 – are there legitimate benefits to the sugar diet?