Rapid Sequence Intubation (RSI): Part II

Special Guest: Christine Groth, PharmD, FCCM, BCCCP @GrothChristine

Angela Slampak-Cindric, PharmD, BCPS, BCCCP, FCCM @AngelaSlampak

Kevin Kaucher, PharmD, BCCCP

04:05 – Guideline development/involvement

12:50 – 2024 guideline overview

25:10 – Pharmacotherapy recommendations/considerations

42:40 – Non-pharmacologic recommendations/guideline insights

70:30 – Research ideas/conclusions

Reference List: https://pharmacytodose.files.wordpress.com/2024/05/rsi-part-ii-references.pdf

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Trial of the Week: ESETT

Special Guest: Ashley McCormick, PharmD, BCPS, BCCCP

Ashley McCormick joins to discuss the April Trial of the Week “Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus” the ESETT study, published in NEJM in 2019.

We set the scene by reviewing ASM PK/PD properties and discussing if there was a standard of care first-line treatment. Then we do a deep dive into the ESETT trial of the week. Did the 75kg dose cap influence results? How appropriate was the BZD dosing? How does this % of seizure cessation compare to other studies? Where did this dosing scheme come from? Trial fun facts, medication safety considerations, and much, much more.

Reference list: https://pharmacytodose.files.wordpress.com/2024/04/esett-trial-of-the-week-references.pdf

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Thrombolytic Dosing in PE: Versus Series

Special Guest: Lauren Igneri, PharmD, BCPS, BCCCP, FCCM

05:20 – High-risk PE

23:00 – Intermediate-risk

37:10 – Cardiac arrest

52:30 – Closing arguments

57:15 – Bonus: TNK v. tPA

Reference List: https://pharmacytodose.files.wordpress.com/2024/04/thrombolytic-dosing-in-pe-references.pdf

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Trial of the Week: SEPSISPAM

Special Guest: Katherine Spezzano, PharmD, MBA, BCCCP @KatSpazPharmD

Katherine Spezzano joins to discuss the April Trial of the Week “High versus Low Blood-Pressure Target in Patients with Septic Shock” the SEPSISPAM study, published in NEJM in 2014.

We set the scene by reviewing the concept of autoregulation, guideline recommendations, and pre-SEPSISPAM research assessing BP goals in sepsis. Then we do a deep dive into the SEPSISPAM trial of the week. Would we see these same results with other vasopressors? Did each group meet their BP goal range? How do we balance AKI prevention and longer ICU LOS? What do our guidelines recommend now? Trial fun facts, alternate trial acronym ideas, and much more!

Reference list: https://pharmacytodose.files.wordpress.com/2024/04/sepsispam-trial-of-the-week-references.pdf

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Glycemic Control in the Critically Ill: Part II

Special Guests: Judi Jacobi, PharmD, FCCP, MCCM, BCCCP @JudiJacobi

Michael Sirimaturos, PharmD, BCNSP, BCCCP, FCCM @MSirimaturos

04:10 – Becoming panel members

11:50 – Guideline scope and PICO questions

21:35 – 2012 v. 2024 guidelines

28:05 – Effect of TGC-FAST

30:40 – 2024 guideline deep-dive

42:00 – Clinical decision support tools

50:00 – Pediatric recommendations

54:40 – Important future research topics

66:05 – Guideline manuscript writing

76:10 – Take-home points

Reference List: https://pharmacytodose.files.wordpress.com/2024/04/glycemic-control-in-the-icu-part-ii-references.pdf

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Literature Review Series

November 2023

Special Guests: Arjay Mendoza, PharmD, BCPS, AAHIVP

Brock Townsend, PharmD @Townsend_PharmD

04:30 – Featured Articles

35:25 – Cardiology

48:05 – Precision-based medicine potpourri

58:50 – Infectious Diseases

69:10 – PharmD

Reference List: https://pharmacytodose.files.wordpress.com/2024/04/november-lrs-2023-references.pdf

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Trial of the Week: SOAP II

Special Guest: Jessica Casey, PharmD, BCPS, BCCP @jmc_cardspharmd

Jessica Casey joins to discuss the April Trial of the Week “Comparison of Dopamine and Norepinephrine in the Treatment of Shock,” the SOAP II study, published in NEJM in 2010.

We set the scene by reviewing catecholamine vasopressor receptor physiology, guideline recommendations, and pre-SOAP II research. Then we do a deep dive into the SOAP II trial of the week. Did including all forms of shock help or hurt? How does the mortality in this study compare with others? Would this have been as positive of a study in 2024? What do the guidelines recommend now? Is dopamine dead? Will anyone take norepinephrine’s throne? Jessica and I review trial fun facts, stand-out supplementary materials, and much, much more.

Reference list: https://pharmacytodose.files.wordpress.com/2024/04/soap-ii-trial-of-the-week-references.pdf

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Trials of the Week: Landmark Nimodipine Studies

Special Guest: Salia Farrokh, PharmD, BCCCP, FNCS @salia_farrokh

Salia Farrokh joins to highlight two landmark studies with nimodipine, “Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage” published in NEJM in 1983 and “Effect of Oral Nimodipine on Cerebral Infarction and Outcome after Subarachnoid Hemorrhage: British Aneurysm Nimodipine Trial” published in 1989 in BMJ.

We review aSAH treatments in the 1970’s and 1980’s and what evidence existed for nimodipine use before highlighting our two trials of the week. How does the study methodology compare from then to now? Where did our nimodipine dosing regimen come from? Is the term cerebral artery vasospasm out of date? Is it still appropriate to use evidence from the 1980’s in the 2020’s? Is there more to research with respect to nimodipine? What to do with missed nimodipine doses? We do a deep dive into all things nimodipine for aSAH, discussing the above and much more.

Reference list:  https://pharmacytodose.files.wordpress.com/2024/04/nimodipine-trial-of-the-week-references.pdf

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Norepinephrine Position Paper and Sepsis Research Priorities

Special Guests: Brittany Bissell Turpin, PharmD, PhD, FCCM, BCCCP @BissellBrittany

Patrick Wieruszewski, PharmD, BCCCP @pwierusz

Seth Bauer, PharmD, FCCM, FCCP, BCCCP @SethRBauer

07:30 – Norepinephrine position paper introduction

11:35 – When did we realize this and what are the implications?

36:00 – Key task force take-aways

51:00 – SSC Research Committee history

56:00 – Submitting and ranking research questions

27:00 – Top 5 clinical sepsis research priorities

62:00 – Basic science priorities

Reference List: https://pharmacytodose.files.wordpress.com/2024/04/norepi-position-paper-and-sepsis-research-references.pdf

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Final Four Preview and More: 2024 Critical Care Trials March Madness Bracket

Sepsis/Fluids Bracketologist: Clay Small, PharmD, BCCCP

CV/Pulm Bracketologist: Jolie Gallagher, PharmD, BCCCP

Bleeding/BG Bracketologist: Jason Hecht, PharmD, BCPS, BCCCP, FCCM

Neuro/PADIS Bracketologist: Karen Berger, PharmD, FASHP, FCCM, BCPS, BCCCP

06:10 – Region recaps

32:10 – Final Four preview and predictions

45:30 – Revisiting pre-tournament predictions

PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf

Listener Bracket: https://pharmacytodose.com/2024/04/01/final-four-2024-critical-care-trials-march-madness-bracket-preview-and-recap/

2024 Critical Care Trials March Madness blank bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/

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Literature Review Series

October 2023

Special Guests: Hailey Burns, PharmD @Hailey_rx36

Caitlyn Simonson, PharmD

03:45 – Featured Articles

38:15 – Neuro

50:10 – EM/Tox/Trauma

61:50 – Renal/Endocrine

66:38 – PharmD

70:10 – Sweet Emotion

Reference List: https://pharmacytodose.files.wordpress.com/2024/03/october-lrs-2023-references.pdf

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