Prodromal autonomic dysfunction has emerged as an important area of research in understanding Lewy body diseases, including Parkinson's disease, and dementia with Lewy bodies. Dr. Michelle Matarazzo sits down with three experts in the field, Dr. Abhimanyu Mahajan, Dr. Alison Yarnall, and Dr. David Goldstein to discuss the current evidence behind various disturbances and how they may precede classic motor and cognitive symptoms, such as cardiovascular, gastrointestinal, urinary, and thermoregulatory disturbances. Together they discuss how these early non-motor manifestations may be considered integral features of the disease process. Read the Scientific Issue on this topic.

Genetic ataxias have many non-motor features, such as fatigue, sleep disorders, and cognitive dysfunction. In this episode, Dr. Orlando Barsottini and Dr. Christofer Stephen discuss the most common non-motor symptoms and how to approach them.

Dr. Michele Matarazzo sits down with Dr. Rebecca Wallings to discuss  how two of the most important genetic forms for Parkinson's disease, LRRK2 and GBA1, influence immune response to bacterial simulation. Their discussion highlights a potential link between genetics, environment, and inflammation in Parkinson’s disease. Journal CME is available until March 18, 2027
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In this episode, Dr. Orlando Barsottini and Dr. Malco Rossi discuss the main imaging findings and clues for the the diagnosis of genetic and sporadic ataxias.

In this episode Dr. Hugo Morales Briceno and Dr. Ai Huey Tan discuss how to approach deafness-dystonia syndrome and its etiological differential diagnoses. Read the discussed case.

In this interview, Dr. Orlando Barsottini and Dr. Divyani Garg discuss the main forms of sporadic ataxias, how to approach them, and what steps not to miss.

Dr. Mattia Rosso joins Dr. Sara Schaefer to discuss the historical use of videography in movement disorder clinical practice and education, and how it influenced the evolution of the field. Read the article.

Cases of late-onset cerebellar ataxias are a challenge for neurologists. In this episode Dr. Orlando Barsottini and Dr. José Luiz Pedroso discuss new advances on the investigation of late-onset cerebellar ataxias and identification of new genes.

Dr. Michele Matarazzo interviews Prof. Hesheng Liu about his recent Nature paper proposing a major conceptual shift: Parkinson’s disease as a somato-cognitive action network (SCAN) disorder. Together they discuss how a large multimodal dataset suggests a characteristic pattern of hyperconnectivity between SCAN cortical areas and subcortical nuclei in Parkinson’s disease, how this signature changes with effective therapies, and why personalized SCAN targeting may help refine non-invasive stimulation and circuit-guided interventions. The conversation explores implications for biomarkers, patient-specific targeting, and key unanswered questions that will shape the next generation of studies. Read the article.

In this episode, Dr. Orlando Barsottini and Dr. Bart van de Warrenburg discuss the importance of precise neurological examination and classification of ataxias. The further discuss the rational etiological investigation for cases of ataxia and how to utilize different clinical assessments.

In this episode, Dr. Kirsten Müller-Vahl explores one of the first long-term follow-up studies of mass social media–induced functional tic-like behaviors (MSMI-FTLB). She discusses what their findings mean for clinical counseling, why early diagnosis appears to improve outcomes, how factors such as psychiatric comorbidity and secondary gain influence recovery. She also examines the surprising finding that reduced screen time did not significantly affect prognosis and what this suggests about social media as a trigger versus a maintaining factor. Read the article.