In this episode, we focus on biosignaling and cover how cells communicate through systems like voltage-gated and ligand-gated ion channels, using real-world examples such as neuronal signaling and muscle contraction.

We also break down the role of enzyme-linked receptors, specifically receptor tyrosine kinases (RTKs), and explore how these pathways are involved in cell growth and cancer. Additionally, we take a detailed look at G-protein coupled receptors (GPCRs) and their role in activating secondary messenger systems like cyclic AMP (cAMP).

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Jump into the conversation:

(00:00) Intro

(00:32) Overview of Biosignaling

(01:05) Introduction to Biosignaling and its Importance

(01:49) Stimulus-Response Concept: Fight or flight, glucose homeostasis, transcription regulation

(02:34) Voltage-Gated Ion Channels: Activated by changes in membrane potential

(03:29) Action Potential: Sodium channels and signal propagation

(05:01) Ligand-Gated Ion Channels: Role in neuron-to-neuron signaling

(06:01) Muscle Contraction: Acetylcholine's role in skeletal muscle contraction

(07:29) Misconception on Calcium: Sodium initiates muscle cell depolarization, not calcium

(08:33) Enzyme-Linked Receptors: Focus on receptor tyrosine kinases (RTKs)

(09:39) RTKs and Cancer: How RTK signaling pathways are linked to cancer

(12:00) G-Protein Coupled Receptors (GPCR): Structure and function of GPCRs

(14:43) Adenylate Cyclase and cAMP: Role of GTP in activating adenylate cyclase and producing cAMP

(18:10) Quiz Question 1: Ion specificity in potassium channels

(22:54) Quiz Question 2: Hypertension treatment and G-protein pathways

(25:00) Biosignaling as the foundation for cellular responses

In this episode, guest host Alex Starks introduces the Metabolism series by examining glycolysis, a fundamental biochemical pathway for energy production. The discussion covers glucose digestion, the role of insulin and glucose transporters, and the step-by-step breakdown of glucose within cells. Alex also offers a detailed explanation of how glucose is processed to generate energy and outlines the key reactions involved. This episode provides a thorough overview of glycolysis offers valuable study strategies for mastering this topic on the MCAT.

Visit MedSchoolCoach.com for more help with the MCAT.

Jump into the conversation:

(00:00) Intro

(01:08) Overview of metabolism and starting the series

(02:41) Digestion and absorption of glucose into the bloodstream

(04:10) The liver’s role in glucose transport and GLUT2

(05:05) The role of insulin in glucose uptake by muscles and fat cells

(07:48) Trapping glucose in the cell with glucose phosphorylation

(09:32) Glycolysis Step-by-step breakdown of glycolysis

(17:41) NADH and ATP production during glycolysis

(22:30) Pyruvate and NADH fates in anaerobic and aerobic respiration

(25:12) Quiz: Metabolism quiz and study tips for the MCAT

One of the most fundamental biochemical processes is the Krebs cycle. This metabolic pathway plays a critical role in both the Chem Phys and Bio/Biochem sections of the MCAT, so understanding it is key.

In this episode, our guest host, Alex Starks, walks us through the transformation of pyruvate into acetyl CoA via the Pyruvate Dehydrogenase Complex (PDC). We’ll explore how thioester bonds help transfer energy within the cycle, how acetyl CoA combines with oxaloacetate to form citrate, the difference between enzymes like synthetases and synthases, and how GTP is produced. We’ll also make connections to the electron transport chain and discuss how the TCA cycle influences blood pH through CO2 production.

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Jump into the conversation:

(00:00) Intro

(01:05) Recap of glycolysis and pyruvate

(02:45) Pyruvate dehydrogenase complex (PDC)

(03:40) Role of acetyl CoA in the Krebs cycle

(05:37) How citrate is formed 

(07:17) How isocitrate is formed

(10:00) How alpha-ketoglutarate is formed

(13:42) How  succinate and GTP are formed

(16:28) How succinate, fumarate and oxaloacetate are formed

(18:23) Fumarate converted to malate

(21:53) Recap of the Krebs cycle and ATP yield

(25:00) Regulation of the Krebs cycle

(26:16) Quiz

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In this episode, we cover the respiratory system, an important topic for the MCAT Bio/Biochem section. We'll go over the anatomy of the respiratory system, highlighting key structures such as the lungs, bronchi, bronchioles, and alveoli, and explain how they contribute to respiratory functions.

You'll also learn about the main roles of the respiratory system, including gas exchange, thermoregulation, particle filtration, and maintaining blood pH. We’ll break down the mechanics of breathing, including the role of the diaphragm and intercostal muscles, and how pressure changes drive air into and out of the lungs. We also cover the importance of pulmonary surfactant in preventing alveolar collapse and how partial pressures influence gas movement.

Visit MedSchoolCoach.com for more help with the MCAT.

Jump into the conversation:

(00:00) Intro

(01:02) Overview: Functions of the respiratory system

(01:28) Main Functions: Gas exchange, thermal regulation, particle filtration, pH control

(02:20) Upper Respiratory Tract: Nose, nasal cavity, sinuses, larynx, trachea

(05:00) Lower Respiratory Tract: Lungs, bronchi, bronchioles, and alveoli

(09:28) Airflow Pathway: How air travels through the respiratory system

(10:23) Gas Exchange: Oxygenation and CO2 removal

(11:27) Breathing Mechanics: Diaphragm and intercostal muscles

(13:04) Pressure Differentials: How pressure changes drive airflow

(15:01) Surface Tension in Alveoli: Importance of pulmonary surfactant

(18:17) Lung Compliance and Elasticity: How lung tissue stretches and returns to shape

(21:48) Gas Exchange Process: Partial pressures of oxygen and carbon dioxide

(24:59) Partial Pressure Explained: Role in moving gases during respiration

(30:31) Thermoregulation: Maintaining body temperature through respiration

(35:59) Particle Filtration: Nasal hairs and mucous cilia system

(39:44) pH Regulation: How breathing controls blood pH

(41:18) Respiratory Control: Involuntary and voluntary mechanisms, brainstem functions

In this episode, we dive into psychological disorders, a crucial topic for the Psych/Soc section of the MCAT. We’ll start by defining what a psychological disorder is, highlighting key concepts like significant stress and deviant behavior, and discussing how they’re classified using the DSM-5.

You'll learn about various categories of disorders, including anxiety disorders, obsessive-compulsive disorders, trauma and stressor-related disorders, and more. We’ll explore the biopsychosocial and biomedical approaches to understanding these conditions, providing insight into the biological, psychological, and social factors that contribute to mental health issues.

By the end of this episode, you'll have a comprehensive understanding of the different types of psychological disorders and how they are categorized and treated, helping you tackle related questions on the MCAT.

Visit MedSchoolCoach.com for more help with the MCAT.

Jump into the conversation:

(00:00) Intro: Med School Coach promotion and podcast introduction

(01:03) Overview of Psychological Disorders: Episode topics and structure

(02:13) Defining Psychological Disorders: Significant stress and deviant behavior

(05:29) Biopsychosocial vs. Biomedical Approaches: Holistic vs. traditional perspectives

(09:18) DSM-5 Classification of Psychological Disorders: Overview of main categories

(10:37) Anxiety Disorders: Fear and anxiety beyond normal levels

(16:43) Obsessive-Compulsive Disorder: Obsessions and compulsions explained

(18:20) Trauma and Stressor-Related Disorders: PTSD and related disorders

(19:19) Somatic Symptom Disorders: Physical symptoms causing mental distress

(22:01) Bipolar and Related Disorders: Mood swings and differentiating Bipolar I and II

In this episode, we focus on the lymphatic system, a crucial topic for the Bio/Biochem section of the MCAT. We'll cover the structure of the lymphatic system, including lymphatic vessels, lymph nodes, and major organs such as the bone marrow and thymus. You'll also learn about the system’s primary functions: returning fluid to the blood, supporting the immune system, and absorbing fats and fat-soluble nutrients.

Hosts Sam Smith and Alex Starks break down how the lymphatic system plays a vital role in immunity, nutrient absorption, and fluid balance. By the end of this episode, you'll gain a deeper understanding of the lymphatic system's anatomy and physiology, helping you prepare for MCAT-related questions.

Visit MedSchoolCoach.com for more help with the MCAT.

Jump into the conversation:

(00:00) Intro: Med School Coach MCAT Tutoring Promotion

(01:01) Episode Introduction: Lymphatic System Overview

(01:07) Co-Host Introduction: Sam Smith and Alex Starks

(01:19) Episode Outline: Structure and Functions of the Lymphatic System

(02:39) Structure of the Lymphatic System: Vessels, Nodes, and Organs

(04:06) Lymph: Composition and Role in the Body

(04:44) Lymphatic Vessels and Their Role in Transport

(06:50) Primary and Secondary Lymphoid Organs: Bone Marrow, Thymus, and Lymph Nodes

(09:10) Bone Marrow and B-Cell Maturation

(09:45) Thymus and T-Cell Maturation

In this episode, guest host Alex Starks dives into Gas-Phase Concepts for the MCAT. He breaks down the physical properties of gases, explores the ideal gas law, and unpacks the ABCD laws of gases. Alex also covers key conditions that influence molecular collisions in gases and highlights the most important takeaways to help you excel in this section of the exam.

Visit MedSchoolCoach.com for more help with the MCAT.

Jump into the conversation:

(00:00) Intro: Med School Coach promotion and podcast introduction

(02:01) Physical properties of gases

(06:03) The ideal gas laws

(09:40) Conditions that promote molecular collisions in gases

(10:34) The ABCD gas law

(13:02) The Van der Waals equation

(14:33) Gas laws quiz

(16:29) Key takeaways

Aging is an essential topic for the MCAT, and in this episode, we’ll explore it from multiple angles. We start with the biological aspects of aging, including key processes like telomere shortening, cell senescence, and mitochondrial dysfunction—each providing insight into how and why cells age. From there, we dive into how aging impacts the brain, including the types of memory and cognitive functions that either decline or improve with age. Lastly, we’ll cover the sociology of aging, focusing on the life course theory, the social significance of aging, and demographic changes.

Expect a comprehensive breakdown of these concepts, with real-world applications and examples to reinforce your understanding.

Visit MedSchoolCoach.com for more help with the MCAT.

Jump Into the Conversation:

(00:00) Intro

(02:30) Cellular markers of aging: Protein aggregation and telomere shortening

(04:55) Exploring cell senescence and autophagy dysregulation

(07:20) Mitochondrial dysfunction and its role in cellular aging

(09:10) Deep dive into telomeres and the Hayflick Limit

(12:30) Introduction to aging in the brain

(13:45) Memory and cognitive functions that remain stable with age

(15:30) Brain functions that improve as we age: Crystallized intelligence and emotional intelligence

(17:00) Brain functions that decline with age: Episodic memory and processing speed

(19:30) Causes of changes in brain function: Brain size, vasculature, and neurotransmitter levels

(22:15) Introduction to the life course theory and its relation to aging

(24:45) The social significance of aging in different cultures

(26:00) The aging population and its impact on healthcare

In this episode, we break down aromatic compounds, a crucial topic for the Biochem and Chem/Phys sections of the MCAT. You’ll learn what makes a compound aromatic, how to identify them using Huckel’s Rule, and the difference between aromatic, antiaromatic, and nonaromatic compounds.

Sam Smith covers key examples like benzene, toluene, and phenol, and explains their role in biological systems like DNA and the electron transport chain. With practical tips and MCAT-focused insights, you'll be ready to tackle questions on aromatic compounds with confidence.

Visit MedSchoolCoach.com for more help with the MCAT.

Jump into the conversation:

(00:00) Introduction and Med School Coach Promotion

(01:03) Introduction to the Topic: Aromatic Compounds

(02:08) Definition of Aromatic Compounds and Electron Delocalization

(04:43) Explanation of Huckel’s Rule and Aromaticity Criteria

(07:59) Introduction to Antiaromatic Compounds

(09:58) Definition of Polycyclic and Heterocyclic Aromatic Compounds

(12:02) Common Aromatic Compounds to Know: Benzene, Toluene, Phenol, Aniline

(14:54) Properties of Aromatic Compounds: Physical, Stability, Fluorescence, Basicity

(20:15) Aromatic Compounds in Biology: Amino Acids, DNA/RNA, Electron Transport Chain

(28:14) Conclusion and Outro

In this episode, we focus on the structure and role of key social institutions for the MCAT Psych/Soc section. We'll break down the five major institutions—health and medicine, education, family, religion, and government—and explain how each shapes societal norms and individual behavior.

You’ll learn about concepts like medicalization, the sick role, and how healthcare is delivered, as well as the hidden curriculum and educational segregation. We’ll also cover family structures, kinship types, and how religion influences social change. Lastly, we’ll touch on political systems and the difference between power and authority, all of which are important for the MCAT.

By the end, you’ll be equipped to understand how these institutions impact society and approach related MCAT questions with confidence.

Visit MedSchoolCoach.com for more help with the MCAT.

Jump into the conversation:

(00:00) Intro

(01:03) Introduction to Social Institutions

(01:54) Definition of Social Institutions

(04:24) Formal vs. Informal Institutions

(05:03) Health and Medicine: Structure and Function

(07:49) Medicalization and the Sick Role

(09:56) Delivery of Healthcare

(12:18) Illness Experience

(13:59) Social Epidemiology

(17:05) Education: Structure and Function

(19:37) Educational Segregation and Stratification

(24:03) Teacher Expectancy

(25:06) Family: Structure and Function

(28:46) Violence in the Family

(29:26) Religion: Structure and Function

(32:25) Religion and Social Change

(35:43) Government and Economy: Structure and Function

(37:11) Power vs. Authority

(38:23) Types of Political Systems

(41:06) Division of Labor