In this episode, we explore whether we can predict which bipolar disorder treatments will work for specific patients before months of trial and error. Could your patient's clinical profile, family history, or even their own neurons hold the key to finding the right medication sooner?

Faculty: Kristin Raj, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CMEs: Quick Take Vol. 81
• Can We Predict Who Responds to Mood Stabilizers?

In this episode, we explore when and why long-acting injectable antipsychotics (LAIs) should be considered for patients with schizophrenia, covering approved indications, ideal candidate profiles, and the critical role of shared decision-making in treatment planning.

Faculty: Brian Miller, M.D., Ph.D., M.P.H. Host: Richard Seeber, M.D.

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• Earn 0.75 CME: Use of Long-Acting Injectable Antipsychotics in Schizophrenia
• Understanding When to Prescribe LAIs

In this episode, we explore a striking new Nature study suggesting that lithium deficiency may play a central role in the onset of Alzheimer's disease. Could a simple, overlooked supplement be the key to prevention? Dr. Scott Beach unpacks the science, the promise, and the important caveats.

Faculty: Scott Beach, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CME: Quick Take Vol. 81
• Lithium Orotate: Breakthrough Treatment for Alzheimer's Disease?

In this episode, we explore the nuanced challenge of managing ADHD with stimulant medications during pregnancy. Is stopping the medication always the safer choice — or does untreated ADHD carry risks of its own? Dr. Amanda Koire breaks down the latest evidence to help clinicians make truly informed decisions.

Faculty: Amanda Koire, M.D., Ph.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CME: Prescribing in Pregnancy: What Every Clinician Should Know
• Pregnancy, ADHD, and Stimulants: Making an Informed Choice

In this episode, we examine a surprising repurposing of ondansetron — a common antiemetic — as a potential adjunctive treatment for the notoriously hard-to-treat negative symptoms of schizophrenia. Could a nausea medication help restore motivation and emotional engagement in your patients with residual symptoms despite stable antipsychotic therapy?

Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CMEs: Quick Take Vol. 81
• Is Ondansetron Effective for Negative Symptoms in Schizophrenia?

In this episode, we explore how to manage SSRI treatment in pregnant patients — addressing common fears around fetal malformations, medication switching, and neonatal withdrawal. Can stopping an antidepressant actually do more harm than continuing it?

Faculty: Amanda Koire, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CME: Prescribing in Pregnancy: What Every Clinician Should Know
• SSRI Treatment During Pregnancy: A Clinical Case

In this episode, we explore a landmark meta-analysis that challenges decades of fear surrounding IV haloperidol and cardiac risk. Could one of medicine's most persistent myths be costing patients their best treatment option for delirium? Dr. Scott Beach breaks down the evidence.

Faculty: Scott Beach, M.D. Host: Richard Seeber, M.D.

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• Earn 0.75 CMEs: Quick Take Vol. 80
• IV Haloperidol: Are Cardiac Safety Concerns Overblown?

In this episode, we explore the complex risk-versus-risk decision of using lithium during pregnancy and breastfeeding. How do you weigh the near-certainty of mood relapse against fetal cardiac risks? Dr. Amanda Koire provides a practical framework every clinician needs when managing bipolar disorder in reproductive-age women.

Faculty: Amanda Koire, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CME: Prescribing in Pregnancy: What Every Clinician Should Know
• Lithium in Pregnancy and Breastfeeding

In this episode, we explore new international guidelines for clozapine monitoring following the FDA's REMS rescission. Should patients on stable clozapine continue lifelong monthly blood draws, or can we safely reduce monitoring after two years? Dr. Seeber discusses how these evidence-based recommendations balance patient burden with safety.

Faculty: Oliver Freudenreich, M.D. Host: Richard Seeber, M.D.

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• Earn 0.75 CMEs: Quick Take Vol. 79
• New Guidelines for Clozapine ANC Monitoring

In this episode, we explore how pregnancy reshapes the pharmacokinetics of psychiatric medications — and what that means for your patients. Can stopping a mood stabilizer actually put a pregnancy at greater risk than continuing it? Dr. Amanda Koire breaks down the evidence.

Faculty: Amanda Koire, M.D. Host: Richard Seeber, M.D.

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• Earn 0.5 CME: Prescribing in Pregnancy: What Every Clinician Should Know
• Pregnancy's Impact on Medication Efficacy and Dosing Considerations

In this episode, we explore bright light therapy (BLT) as a powerful adjunctive treatment for bipolar depression — examining the neuroscience behind it, how to implement it clinically, and why it may work faster than medication alone. Could something as simple as light reshape how we treat mood disorders?

Faculty: Kristin Raj, M.D. Host: Richard Seeber, M.D.

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• Earn 0.75 CMEs: Quick Take Vol. 80
• Bright Light Therapy for Bipolar Depression: ISBD Clinical Recommendations