GLP-1 medications have changed how we treat obesity and metabolic disease. But as their use has exploded, so have questions about side effects, muscle loss, long-term use, and whether patients are receiving the support they need to use them safely.

In this episode, I reconnect with metabolic health and regenerative medicine expert Dr. Tyna Moore to revisit our conversation from two years ago and examine what we’ve learned since.

We discuss:

• How to tell when your GLP-1 dose may be too high

• What you can do to protect your muscle and bone during weight loss

• Which metabolic and nutritional markers should you check before and during treatment

• Why weight can sometimes return after stopping a GLP-1

• What emerging research suggests about GLP-1s beyond weight loss

GLP-1s can be life-changing, but a lower number on the scale isn’t the same as better health. Ultimately, how these medications are used—from dosing and monitoring to nutrition and strength training—matters just as much as whether they’re used at all.

Additional resources:

Join Dr. Tyna Moore’s community

Listen to Dr. Tyna Moore’s previous appearance on The Dr. Hyman Show

View Show Notes From This Episode

Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link

Get Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Sign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Join the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive

This episode is brought to you by Seatopia, Perfect Amino, Cozy Earth, Timeline, Sunlighten, and Made In.

Find a cleaner source of seafood. Check out seatopia.fish and use code HYMAN for free shipping on your first order.

Get daily protein support at bodyhealth.com and use code HYMAN20 for 20% off.

Head over to cozyearth.com to save 20% and upgrade all of your daily essentials today.

Support healthy aging and get 20% at timeline.com/drhyman with code HYMAN.

Discover why so many people are using sunlighten.com and use code HYMAN to save up to $2,100 today with free shipping.

Upgrade your cookware at madeincookware.com and save 10% off your first order with code HYMAN-HIVE.

(0:00) Introduction, Dr. Hyman's evolving views, and episode goals

(0:43) Sponsor: Rose Nutrition Liposomal NAD

(1:42) Sponsor: Seatopia clean seafood box

(2:44) Disclaimers and Lyme disease preview

(4:04) Guest Dr. Tina Moore reintroduced

(4:30) GLP-1s: Effects after years and microdosing strategies

(7:14) Risks of high-dose GLP-1s and misconceptions about muscle/bone loss

(13:09) Functional deficiencies and microdosing approaches

(17:05) Sponsor: Made In stainless clad cookware

(18:02) Sponsor: Timeline with Mitopure

(18:58) Broader and additional benefits of metabolic health and GLP-1s

(21:48) GLP-1s for immune and brain health; genetic differences

(27:59) Introduction to peptides and GLP-1 drugs

(32:36) Gray market concerns and weight regain after stopping GLP-1s

(37:14) Long-term safety, cost, and personalizing GLP-1 treatment

(40:57) Emotional blunting and recent concerns about GLP-1s

(46:30) Functional medicine approach: addressing root causes

(46:46) Sponsor: Sunlighten Sauna

(47:20) Sponsor: Magnesium Breakthrough from Bio Optimizers

(48:17) Dr. Hyman’s evolving perspective on GLP-1s

(49:19) Hormonal effects of GLP-1s for men and women

(55:02) Baseline lab markers and tests before GLP-1s

(57:10) New and next-gen GLP-1 therapies

(59:43) Telemedicine, gray market issues, and importance of reputable practitioners

(1:05:57) Rapid fire: Alcohol, common mistakes, misconceptions, and eligibility for GLP-1s

(1:08:16) Key lab tests and surprising non-weight benefits

The number on your scale tells you almost nothing about your actual health. You can lose weight while becoming less healthy—or stay the same weight while dramatically improving your metabolism, reducing your risk of disease, and adding years to your life.

In today's episode, I discuss:

• Why the scale can completely miss what's happening inside your body and the hidden health risks it can't measure
• The dangerous difference between muscle and visceral belly fat, and why one protects you while the other drives disease
• The five health markers I pay attention to instead of body weight—including one simple measurement you can do at home
• How insulin resistance develops years before diabetes and the early warning signs you can catch before it's too late

The goal isn't simply to lose weight; it's to build a healthier metabolism. The healthiest body isn't always the lightest one—it's the one that's functioning the way it was designed to.

Resources Mentioned:

• Want to dive deeper into why muscle is the key to longevity? Listen to my full conversation with Dr. Gabrielle Lyon here
• Track your health with Function Health: https://functionhealth.com/mark (Use code MARK2026 for $50 off your membership.)
• Have a question you’d love answered on Office Hours? Submit it here

(0:00) Rethinking weight loss: muscle, metabolism, and key health metrics

(7:17) Chronic inflammation, insulin resistance, and metabolic health

(11:00) Five metrics that matter more than weight

(13:17) Shifting focus: Prioritizing health over weight loss

(15:14) Muscle and longevity with Dr. Gabrielle Lyon

Heart disease is still the leading cause of death worldwide. Yet many people assume it only happens to those who are older, out of shape, or obviously unhealthy.

In this episode, I sit down with cardiovascular surgeon Dr. Jeremy London, whose own heart attack challenged many of the assumptions we make about heart health. We discuss why prevention isn't always as straightforward as it seems—and how understanding your personal risk can help you take a more proactive approach to your health.

We cover:

• Why some healthy people still develop heart disease

• The difference between standard cholesterol tests and a more complete assessment

• How to better understand your personal cardiovascular risk

• The lifestyle changes that can help lower your long-term cardiovascular risk

Interested in more comprehensive lab testing? Learn more at Function and use code MARK2026 to save $50 on your membership.

Heart disease is often preventable—but only if you know what to look for. Listen to my conversation with Dr. Jeremy London to learn how a better understanding of your personal risk can help you protect your long-term heart health.

View Show Notes From This Episode

Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health

https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link

Get Free Weekly Health Tips from Dr. Hyman

https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Sign Up for Dr. Hyman’s Weekly Longevity Journal

https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Join the 10-Day Detox to Reset Your Health

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Results

https://drhyman.com/pages/hyman-hive

This episode is brought to you by Paleovalley, Pique, Perfect Amino, Seed, BON CHARGE, and Cozy Earth.

Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order.

Elevate your daily wellness ritual at piquelife.com/hyman and enjoy 20% off plus free gifts.

Help fill protein gaps at bodyhealth.com and use code HYMAN20 for 20% off.

Support your gut health daily at seed.com/hyman and use code 25HYMAN for 25% off your first month.

Explore red light products at boncharge.com/hyman  and enjoy 15% off with code HYMAN.

Upgrade your sleep setup with cozyearth.com and enjoy 20% off  with code HYMAN.

What if one of the most powerful anti-aging tools wasn't a supplement, medication, or expensive biohack—but the way you exercise? While many people think of exercise as a way to lose weight or burn calories, its greatest benefits happen deep inside your cells.

In today's episode, I discuss:

• The two most effective forms of exercise for healthy aging and longevity
• What happens inside your cells when you challenge your muscles and cardiovascular system
• The often-overlooked factor that can determine whether you stay strong and independent as you age
• The minimum amount of exercise needed to support your muscles, metabolism, heart, and brain
• How and why you should measure your VO2 max

Healthy aging isn't about finding the latest longevity hack—it's about consistently giving your body the signals it needs to adapt, grow stronger, and stay resilient.

Resources Mentioned:

• Track your metabolic health with Function Health: https://functionhealth.com/mark (Use code MARK2026 for $50 off your membership.)
• Have a question you’d love answered on Office Hours? Submit it here

(0:00) The role of exercise, types of exercise, and debunking strength training and HIIT myths

(2:05) Mitochondria, aging, and chronic disease

(4:24) Movement, mitochondrial health, and essential types of movement for longevity

(5:54) Prioritizing strength training and muscle as a longevity organ after age 40

(8:17) Building a resilient immune system

(10:27) HIIT, VO2 max, and interval training routines

(13:24) Combining strength training and HIIT; starting from scratch and common questions

(15:17) Movement as medicine and closing remarks

Living with chronic illness can feel like collecting diagnoses without getting real answers. Symptoms are treated one at a time, but the underlying causes can easily be missed. What if asking a different question is the first step toward feeling better?

In this episode, I’m joined by Dr. Richard Horowitz, an internationally recognized Lyme disease expert and author of the new book Ending Chronic Illness. After caring for thousands of patients over more than four decades, he explains why many seemingly unrelated conditions share common underlying drivers—and why thinking like a medical detective may help uncover them.

We discuss:

• Why treating the diagnosis isn't always the same as treating the problem—and how to start looking deeper

• How hidden infections, environmental toxins, gut health, and other overlooked factors can quietly drive chronic illness

• What new research may reveal about the links between infection, inflammation, and brain health

• How to begin uncovering what's really driving persistent symptoms

Our bodies are constantly communicating with us. The challenge isn't that they're silent—it's that we haven't always known how to listen. Sometimes finding better answers begins with asking different questions.

Continue Exploring

If you'd like to explore Dr. Horowitz's work further, here are two great places to start:

• Take his Symptom Assessment Quiz to better understand what may be contributing to your symptoms.

• Subscribe to his Medical Detective Substack ****for ongoing insights into chronic illness, Lyme disease, and root-cause medicine.

Interested in getting tested?

Many of the lab tests discussed in this episode are available through Function, making it easier to get a more comprehensive picture of your health.

View Show Notes From This Episode

Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link

Get Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Sign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Join the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive

This episode is brought to you by Timeline, Cozy Earth, Seatopia, Perfect Amino, BON CHARGE, and Made In.

Support healthy aging and get up to 20% off when you subscribe on top of the new starting price of $79 at timeline.com/drhyman.

Upgrade your sleep setup with cozyearth.com and enjoy 20% off  with code HYMAN.

Find a cleaner source of seafood. Check out seatopia.fish and use code HYMAN for free shipping on your first order.

Help fill protein gaps at bodyhealth.com and use code HYMAN20 for 20% off.

Explore red light products at boncharge.com/hyman  and enjoy 15% off with code HYMAN.

Explore kitchen essentials at madeincookware.com and save 10% off your first order with code HYMAN-HIVE.

(0:00) Infections and toxins as root causes of chronic illness; Dr. Horowitz's background and journey to functional medicine

(5:37) Discovering and treating various infections, toxins, and Dr. Hyman's personal health story

(9:16) Root causes of chronic disease, inflammation, and testing for infections and toxins

(15:11) Sponsor: Seatopia and PerfectAmino

(16:42) Importance of diet, addressing multiple health factors, and autoimmune misdiagnosis

(19:26) Role of infections, toxins, microbiome, and leaky gut in autoimmune diseases and inflammation

(21:06) Treating underlying causes and neuroinflammation in chronic diseases

(24:37) Nutritional deficiencies, COVID-19, and the importance of sleep in chronic illness management

(30:19) Plant medicines, supplements, and dapsone in treating neuroinflammation, Lyme, and Alzheimer's

(41:30) Use of methylene blue in treatment protocols

(44:56) Sponsor: Bon Charge

(45:58) Sponsor: Made In

(46:43) Evolution of treatment protocols and six principal causes of inflammation

(50:18) Importance of adrenal function and hormone treatment in chronic illness

(52:17) Differential diagnosis vs. root cause analysis and root cause testing

(56:38) Horowitz's questionnaire and protocols for treating chronic infections

(58:39) Addressing mold-related health issues and Dr. Hyman's personal experience

(1:01:01) Mold testing, detoxification, and controversies in treatment

(1:07:47) Insurance challenges and HHS innovation grant for chronic illness research

(1:09:04) Importance of root cause medicine and Mark Hyman's upcoming book on longevity

(1:11:56) Personalized medicine, reversing Alzheimer's biomarkers, and research funding priorities

(1:15:02) Influence of Buddhist principles and personal experiences with chronic illness

(1:16:01) Hope for patients, resources for learning, and closing remarks

What if the fatigue, brain fog, joint pain, or mysterious symptoms you've been chasing for years weren't caused by stress, aging, or burnout—but by a tick bite you never even noticed? Lyme disease is one of the most misunderstood illnesses in medicine. But Lyme is rarely just one infection—it's often part of a much bigger picture involving co-infections, immune dysfunction, inflammation, gut health, and environmental triggers.

In today's episode, I walk through a functional medicine approach to Lyme disease and tick-borne illness, including:

• Why Lyme disease is so often missed—and the hidden role of co-infections like Babesia, Bartonella, Ehrlichia, and Anaplasma
• The limitations of conventional testing and treatment, and how functional medicine looks beyond the infection to understand why some people recover while others remain chronically ill
• The role of herbs, antibiotics, gut repair, detoxification, immune support, and mitochondrial health in a comprehensive recovery plan
• What the latest evidence says about emerging therapies like ozone, hyperbaric oxygen therapy, and hyperthermia—as well as practical strategies to prevent tick-borne illness in the first place

Lyme disease isn't always just an infection—it's often a whole-body disruption. By addressing the underlying drivers of inflammation, immune dysfunction, gut health, and cellular resilience alongside the infection itself, you give your body the best chance to heal and recover.

Resources Mentioned:

• Track your metabolic health with Function Health: https://functionhealth.com/mark (Use code MARK2026 for $50 off your membership.)
• Have a question you’d love answered on Office Hours? Submit it here

(0:00) Introduction to Lyme disease, overview, and Dr. Hyman's experience

(4:13) Functional medicine's approach and comprehensive treatment strategies

(10:51) Innovative therapies for Lyme disease

(14:08) Managing die-off reactions and restoring gut health

(17:18) Supporting the immune and nervous systems; prevention strategies

(19:29) Future research, persistent symptoms, and conclusion

(21:15) Alzheimer's disease, neuroinflammation, and call to action

For decades, depression has often been described as the result of a chemical imbalance in the brain. But how strong is the evidence behind that idea? This episode explores one perspective on an area of medicine that continues to be actively debated and is intended to encourage thoughtful discussion—not to provide individualized medical advice. Today on The Dr. Hyman Show, I'm joined by psychiatrist and researcher Dr. Joanna Moncrieff to examine the science behind the serotonin theory and explore how it shaped modern mental health care. Together, we consider why rethinking our assumptions may open the door to a more complete understanding of depression and recovery. We discuss: • Whether depression is best understood through the lens of a chemical imbalance—or something far more complex • How the serotonin theory shaped modern psychiatry and why it's increasingly being questioned • What current research says about antidepressants, emotional numbing, and informed consent • Why lifestyle, nutrition, trauma, and social connection deserve a larger role in supporting mental health • How a more individualized, whole-person approach could change the way we think about depression and recovery Mental health treatment is deeply personal, and this episode explores one perspective on an area of medicine that continues to evolve. If you're currently taking antidepressants or other prescription medications, don't stop or change your treatment based on this discussion alone. Instead, use it as a starting point for an informed conversation with your healthcare provider. Learn More: Dr. Moncrieff recently participated in an FDA Expert Panel on SSRIs and Pregnancy. If you'd like to explore another perspective on the evidence discussed in this episode, you can watch the panel here.

View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health

https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link

Get Free Weekly Health Tips from Dr. Hyman

https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Sign Up for Dr. Hyman’s Weekly Longevity Journal

https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Join the 10-Day Detox to Reset Your Health

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Results

https://drhyman.com/pages/hyman-hive This episode is brought to you by BIOptimizers, fatty15, Rho, Paleovalley, Pique, and Big Bold Health. Go to bioptimizers.com/hyman and use code HYMAN to save 15% off your order, plus get a free gift.  Head to fatty15.com/hyman today and use code HYMAN for 15% off your 90-day subscription Starter Kit. Explore science-backed products at rhonutrition.com and use code HYMAN for 20% off the entire site. Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order. Elevate your daily wellness ritual at piquelife.com/hyman and enjoy 20% off plus free gifts. Go to bigboldhealth.com/drhyman and use code HYMAN15 to save 15% on your first order.

(0:00) The impact of the chemical imbalance theory and myths of mental illness

(2:02) Disclaimers and introduction of Joanna Moncrieff

(3:00) The serotonin myth, antidepressant use, and marketing of SSRIs

(16:12) Risks, side effects, and wrong-headed approaches to mental health

(21:00) Societal, biological, and lifestyle factors in mental health

(27:13) Commercial determinants of health

(30:49) The rise and implications of psychedelic treatments in psychiatry

(43:21) Drug-centered vs. disease-centered models in mental health

(45:40) The role of the brain and alternative approaches to treating depression

(50:00) Addressing severe depression and strategies for deprescribing antidepressants

(54:41) Reframing mental health narratives and future outlook

(57:09) Encouraging self-education, debate, and discussion in medicine

(59:23) Closing remarks, disclaimers, and gratitude to sponsors

Do you hit a wall every afternoon around 2 or 3 p.m.? If your energy disappears, your brain gets foggy, and you need caffeine or sugar just to finish the day, it isn't a lack of willpower—it's a sign that something deeper is driving your energy crash. In this episode, I explain the three biggest drivers of the afternoon slump and the simple changes that can help you maintain steady energy all day long.

In today's episode, I discuss:

• The three hidden causes of the afternoon energy crash
• Why skipping breakfast, relying on coffee, sugary smoothies, or carb-heavy meals sets you up for an inevitable drop in energy later in the day
• How to build meals with protein, healthy fats, and fiber to stabilize blood sugar and create lasting energy instead of quick spikes and crashes
• Simple daily habits that can dramatically improve your energy and focus

That afternoon crash isn't something you have to accept as part of modern life. When you stabilize your blood sugar, support your body's natural rhythms, and reduce chronic stress, your energy becomes more consistent, your focus improves, and you stop relying on caffeine and willpower just to make it through the day.

Resources Mentioned:

• Track your metabolic health with Function Health: https://functionhealth.com/mark (Use code MARK2026 for $50 off your membership.)
• Have a question you’d love answered on Office Hours? Submit it here

(0:00) Understanding the afternoon crash and blood sugar's role in energy

(4:36) Importance of circadian rhythm

(8:06) Environmental toxins and health

(9:36) Impact of stress on energy and caffeine use

(12:55) Rapid fire Q&A

(15:08) Key takeaways for steady energy

We all experience stress. The real challenge isn't stress itself—it's whether we recover from it. Over time, chronic stress can quietly affect everything from inflammation and metabolism to sleep, digestion, and healthy aging. This week on The Dr. Hyman Show, I talk with nervous system educator and HRV expert Salim Najjar to explore what heart rate variability (HRV) can reveal about your body's ability to recover from stress and build resilience. Together, we unpack: • How to use HRV to better understand your body's response to stress • Why some stress makes you stronger while chronic stress wears you down • How to get more value from your wearable without obsessing over the numbers • Five daily habits that can help your nervous system recover and become more resilient • How your nervous system influences inflammation, healing, and healthy aging Our bodies are constantly responding to the demands we place on them every day. The good news is that resilience can be built, and the strategies in this conversation can help you recover from stress more effectively and support long-term health. To help you get started, Salim has created a free HRV guide that includes a personalized quiz and AI coach exclusively for listeners.

View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health

https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link

Get Free Weekly Health Tips from Dr. Hyman

https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Sign Up for Dr. Hyman’s Weekly Longevity Journal

https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Join the 10-Day Detox to Reset Your Health

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Results

https://drhyman.com/pages/hyman-hive This episode is brought to you by Perfect Amino, Cozy Earth, Timeline, Sunlighten, Made In, and Seatopia. Get daily protein support at bodyhealth.com and use code HYMAN20 for 20% off. Head over to cozyearth.com to save 20% and upgrade all of your daily essentials today. Support healthy aging and get 20% at timeline.com/drhyman with code HYMAN. Discover why so many people are using sunlighten.com and use code HYMAN to save up to $2,100 today with free shipping. Upgrade your cookware at madeincookware.com and save 10% off your first order with code HYMAN-HIVE. Find a cleaner source of seafood. Check out seatopia.fish and use code HYMAN for free shipping on your first order. -  https://seatopia.fish/hyman

(0:00) Introduction to HRV

(3:43) Introduction to Salim and his HRV expertise

(4:18) What is HRV and how is it measured

(5:32) Chronic stress, stress regulation, and sovereignty

(9:52) Why HRV is an important health metric

(20:31) Deeper dive into HRV as a health indicator

(25:43) Salim's HRV coaching, website, and personal journey

(28:49) Salim’s framework and steps for improving HRV

(30:07) The role of sleep and hormetic stress in HRV

(33:12) Tools and tracking for HRV measurement

(37:22) The art framework and five pathways for HRV

(38:17) Salim’s injury, reframing, and HRV improvement

(46:22) Viktor Frankl, intentionality, and alignment

(51:46) Community and its role in health and HRV

(55:02) Practical steps for building community and emotional regulation

(58:18) Emotional processing, elite athletes, and HRV performance

(1:00:35) Sovereignty, compassion, and daily nervous system practices

(1:03:18) Awareness, parasympathetic activation, and reframing HRV

(1:05:01) Closing remarks, social media, and gratitude

(1:05:51) Disclaimer and sponsor acknowledgments

Histamine isn't just about seasonal allergies or a runny nose. It influences your brain, gut, hormones, immune system, and nervous system—and when your body can't regulate it properly, it can show up as everything from anxiety and migraines to insomnia, digestive issues, skin rashes, and brain fog. In this episode, I explain why histamine overload happens, how it relates to Mast Cell Activation Syndrome (MCAS), and what a root-cause approach looks like for calming an overactive immune system. In today's episode, I discuss: * Why MCAS and histamine intolerance are different—and how overactive mast cells can drive symptoms ranging from migraines and anxiety to digestive issues, hives, and heart palpitations * The hidden triggers behind mast cell activation, including gut dysfunction, chronic infections, mold exposure, hormone imbalances, stress, and environmental toxins * Why many "healthy" foods like avocados, spinach, tomatoes, kombucha, and bone broth can temporarily worsen symptoms when your histamine bucket is already full * A root-cause approach to calming the immune system using nutrition, targeted supplements, medications when needed, nervous system regulation, and addressing the underlying drivers of inflammation MCAS isn't simply a histamine problem—it's a sign that your immune system has become dysregulated. Instead of just suppressing symptoms, the goal is to understand why your mast cells are overreacting in the first place. When you lower the overall inflammatory load and restore balance to the gut, immune system, hormones, and nervous system, you create the conditions for lasting healing rather than temporary symptom relief. Resources Mentioned: * Track your biomarkers with Function Health: https://functionhealth.com/mark (Use code MARK2026 for $50 off your membership.) * Have a question you’d love answered on Office Hours? Submit it here  

For decades, we've thought about conditions like Alzheimer's disease, depression, and Parkinson's disease as disorders of the brain. But what if that's only part of the story? Emerging science is revealing that many of the factors driving cognitive decline, mental illness, and neurodegenerative disease may begin far outside the brain itself—in our metabolism, our immune system, our gut microbiome, our hormones, and even the environment we're exposed to every day. As part of our summer series, we're revisiting some of the most important conversations we've had on the topic of brain health. In this special compilation episode, you'll hear from leading experts Dr. Richard Isaacson, Dr. Chris Palmer, and Drs. Ray Dorsey and Michael Okun as they explore the new science of brain health and what it means for preventing cognitive decline, supporting mental health, and protecting our brains as we age. What I find most encouraging about this research is that it challenges the idea that brain decline is simply an inevitable part of aging. Instead, it suggests that many of the biggest drivers of brain health are things we can influence through the choices we make, the environments we create, and the ways we care for our bodies long before symptoms ever appear. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health

https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link

Get Free Weekly Health Tips from Dr. Hyman

https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Sign Up for Dr. Hyman’s Weekly Longevity Journal

https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Join the 10-Day Detox to Reset Your Health

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Results

https://drhyman.com/pages/hyman-hive This episode is brought to you by Timeline, Sunlighten, Seed, BIOptimzers, Paleovalley, and Pique. Support healthy aging and get 20% off at timeline.com/drhyman with code HYMAN. Discover why so many people are using sunlighten.com and save up to $2,100 today and free shipping with code HYMAN. Make your microbiome part of your daily routine with seed.com/hyman and save 25% with code 25HYMAN. Go to bioptimizers.com/hyman and use code HYMAN to save 15% off your order, plus get a free gift.  Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order. Elevate your daily wellness ritual at piquelife.com/hyman and enjoy 15% off for life plus free gift

(0:00) Understanding brain dysfunction, inflammation, and lifestyle interventions

(0:21) Heavy metals, toxins, and Parkinson's disease

(3:30) Introduction to the summer series on brain health

(4:02) The MIND diet, precision nutrition, and brain-healthy fats

(9:06) Vitamins, supplements, and caloric intake for cognitive health

(11:23) Vitamin D, B complex, and reversing mild cognitive impairment

(14:05) Additional supplements and intensive lifestyle interventions

(17:18) Importance of magnesium and metabolic health

(18:24) Multimodal treatments, hormone replacement therapy, and individualized care

(26:49) Biopsychosocial factors, stress, and the gut-brain connection

(32:30) Inflammation, energy dysregulation, and metabolism in brain health

(42:33) Parkinson's disease: causes, history, and environmental factors

(46:02) Leaky brain, blood-brain barrier, and Parkinson's as a whole-body disease

(49:00) Closing remarks, disclaimer, and gratitude to sponsors