Credits: 0.25 AMA PRA Category 1 Credit™
 
CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-483

Overview: Human papilloma virus (HPV) vaccination can prevent most cases of cervical cancers, yet global coverage remains critically low. In this episode, we discuss the latest evidence on single-dose vs. two-dose HPV vaccination regimens, empowering you to counsel patients and families with confidence, address barriers to series completion, and maximize cancer prevention in your adolescent population.

Episode resource links:

• Noninferiority of One HPV Vaccine to Tow Doses.  The New England Journal of Medicine.  2025.  Kreimer AR, Porras C, Liu D, et al.
• Cancer Prevention and Early Detection Facts and Figures.  American Cancer Society (2025).  2025.  Rick, Alteri, Deana Baptiste, Emily Butler Bell, et al.

Guest: Anne Powell, MD
 
Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at [email protected] 

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™
 
CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-482

Overview: In this episode, we discuss how stress—specifically cumulative stress—exposure throughout a lifetime can contribute to negative health concerns and outcomes. While stress impacts everyone, its effects highlight racial disparities in mortality between Black and White adults. Listen in as we discuss evidence on how structural factors shape health outcomes and how we can address stress-related disease burdens in clinical practice.

Guest: Mariyan L. Montaque, DNP, FNP-BC
 
Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at [email protected] 

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™
 
CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-481

Overview: Expand your prevention toolkit with new recommendations for cardiovascular disease screening. Listen in as we discuss how high-sensitivity C-reactive protein (hs-CRP) can guide screening for ongoing inflammation in patients who are at risk, the evidence behind primary and secondary prevention applications, and key limitations to keep in mind when applying these recommendations in practice.

Episode resource links:

• Mensah GA, Arnold N, Prabhu SD, Ridker PM, Welty FK. Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology. J Am Coll Cardiol. 

Guest: Alan M. Ehrlich, MD, FAAFP
 
Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at [email protected] 

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™
 
CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-480

Overview: Tune in as we discuss nonsurgical options for managing knee osteoarthritis in primary care. This episode reviews current guidelines and highlights new research on yoga as an effective alternative to traditional strengthening exercises. Gain practical insights to help patients reduce pain, improve function, and delay surgery—all while expanding your integrative treatment toolkit.

Episode resource links:

• Abafita BJ, Singh A, Aitken D, et al. Yoga or strengthening exercise for knee osteoarthritis: a randomized clinical trial. JAMA Netw Open. 2025;8(4):e253698. doi:10.1001/jamanetworkopen.2025.3698
• Brophy, Robert H. MD; Fillingham, Yale A. MD. AAOS Clinical Practice Guideline Summary: Management of Osteoarthritis of the Knee (Nonarthroplasty), Third Edition. Journal of the American Academy of Orthopaedic Surgeons 30(9):p e721-e729, May 1, 2022. | DOI: 10.5435/JAAOS-D-21-01233

Guest: Jillian Joseph, MPAS, PA-C

Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at [email protected] 

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™
 
CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-479

Overview: Listen in as we discuss how candesartan, an angiotensin receptor blocker (ARB), may offer a well-tolerated, cost-effective option for migraine attack prevention—even in normotensive patients. Learn to assess benefits, monitor for hypotension, and expand your preventive migraine toolkit with evidence-based insights that may improve adherence and access for patients struggling with traditional therapies.

Episode resource links:

• The Lancet. Neurology. 2025;24(10):817-827. doi:10.1016/S1474-4422(25)00269-8.
• Cephalalgia : An International Journal of Headache. 2023;43(6):3331024231183166. doi:10.1177/03331024231183166.

Guest: Robert A. Baldor MD, FAAFP
 
Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at [email protected] 

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™
 
CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-478

Overview: As glucagon-like peptide-1 receptor agonists (GLP-1 RAs) become increasingly common in managing obesity, it is important for clinicians to recognize lesser-known adverse effects. This episode highlights the potential link between GLP-1 RAs and alopecia, equipping you to better evaluate, counsel, and manage patients reporting hair loss.

Episode resource links:

• Alsuwailem OA, Alanazi R, Almutairi HM, Asiree RH, Almutairi W, Almutairi TM, Zamandar A, Alkhames S. Hair Loss Associated With Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Use: A Systematic Review. Cureus. 2025 Sep 16;17(9):e92454. 

Guest: Alan M. Ehrlich, MD, FAAFP
 
Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at [email protected] 

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™
 
CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-477

Overview: With rising administrative demands, many clinicians are considering artificial intelligence (AI) scribes—this episode unpacks what you need to know before incorporating this technology. We explore key benefits like reduced burnout and improved workflow, along with ethical, legal, and safety considerations to help you make informed decisions about integrating AI scribing into your practice.

Episode resource links:

• Cohen IG, Ritzman J, Cahill RF. Ambient Listening—Legal and Ethical Issues. JAMA Netw Open.2025;8(2):e2460642. doi:10.1001/jamanetworkopen.2024.60642
• Olson KD, Meeker D, Troup M, et al. Use of Ambient AI Scribes to Reduce Administrative Burden and Professional Burnout. JAMA Netw Open. 2025;8(10):e2534976. doi:10.1001/jamanetworkopen.2025.34976
• https://www.healio.com/news/dermatology/20251210/ai-scribes-hold-transformative-potential-for-improving-physician-burden-patient-care

Guest: Jillian Joseph, MPAS, PA-C
 
Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at [email protected] 

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™
 
CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-476

Overview: Melatonin is widely used and often perceived as a safe, natural solution for insomnia. However, a new preliminary study raises concerns about long-term melatonin use and increased risk of heart failure, hospitalization, and all-cause mortality in patients with chronic insomnia. In this episode, we review the findings, discuss how they fit with existing evidence, explore limitations, and offer practical guidance for clinicians counseling patients about sleep supplements.

Episode resource links:

• American Heart Association Scientific Sessions 2025 – Abstract 4371606
  AHA Scientific Statement: Multidimensional Sleep Health and Cardiometabolic Risk (Circulation, 2025)
• Li et al. Lancet Diabetes & Endocrinology, 2024
• American Academy of Sleep Medicine Clinical Practice Guidelines
• AHA Life’s Essential 8 & Sleep Health Resources
  
  

Guest: Mariyan Montaque, DNP, FNP-BC
 
Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at [email protected] 

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™
 
CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-475

Overview: A prescribing cascade occurs when adverse effects of a medication are mistaken for a new condition and treated with additional drugs. Older adults experiencing polypharmacy are most at risk. The impact of prescribing cascades can be substantial, leading to falls, organ injury, unnecessary imaging and tests, and more. Join us as we explore how to recognize and prevent these harmful cascades in your patients.

Episode resource links:

• Adrien  O, Mohammad  AK, Hugtenburg  JG,  et al.  Prescribing cascades with recommendations to prevent or reverse them: a systematic review.   Drugs Aging. 2023;40(12):1085-1100. doi:10.1007/s40266-023-01072-yPubMedGoogle ScholarCrossref

   

• Brath  H, Mehta  N, Savage  RD,  et al.  What is known about preventing, detecting, and reversing prescribing cascades: a scoping review.   J Am Geriatr Soc. 2018;66(11):2079-2085. doi:10.1111/jgs.15543PubMedGoogle ScholarCrossref

   

• Daunt R, McGettigan S, Kelly L, Curtin D, O'Mahony D. Detection of Potential Prescribing Cascades in Multimorbid Older Patients Hospitalised with Acute Illness-An Observational Prospective Prevalence Study. Drugs Aging. 2025;42(6):535-546. doi:10.1007/s40266-025-01201-9

   

• Growdon ME, Tjota N, Campbell R, et al. Decision-Making and Downstream Outcomes of the Gabapentinoid-Diuretic Prescribing Cascade. JAMA Netw Open. 2025;8(12):e2545274. doi:10.1001/jamanetworkopen.2025.45274

   

• McCarthy  LM, Savage  R, Dalton  K,  et al.  ThinkCascades: a tool for identifying clinically important prescribing cascades affecting older people.   Drugs Aging. 2022;39(10):829-840. doi:10.1007/s40266-022-00964-9PubMedGoogle ScholarCrossref

   

• O’Mahony, D., Cherubini, A., Guiteras, A.R. et al. STOPP/START criteria for potentially inappropriate prescribing in older people: version 3. Eur Geriatr Med 14, 625–632 (2023). https://doi.org/10.1007/s41999-023-00777-y

   

• Rochon, P.A., O’Mahony, D., Cherubini, A. et al. International expert panel’s potentially inappropriate prescribing cascades (PIPC) list. Eur Geriatr Med 16, 1573–1584 (2025). https://doi.org/10.1007/s41999-025-01215-x

   

• Young EH, Pan S, Yap AG, Reveles KR, Bhakta K. Polypharmacy prevalence in older adults seen in United States physician offices from 2009 to 2016. PLoS One. 2021;16(8):e0255642. Published 2021 Aug 3. doi:10.1371/journal.pone.0255642

Guest: Susan Feeney, DNP, FNP-BC, NP-C
 
Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at [email protected] 

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™
 
CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-474

Overview: Depression affects many people with dementia, but some evidence suggests certain antidepressants may accelerate cognitive decline. This episode explores the potential risks of antidepressants in people with dementia, which medications require careful consideration, and how to make informed prescribing decisions that optimize patient outcomes while minimizing potential cognitive harm.

Episode resource links:

• Mo M, Abzhandadze T, Hoang MT, et al. Antidepressant use and cognitive decline in patients with dementia: a national cohort study. BMC Med. 2025;23(1):82. 

Guest: Alan M. Ehrlich, MD, FAAFP

Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at [email protected] 

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™
 
CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-473

Overview: Join us as we review long-term outcomes from a recently published trial on prostate-specific antigen (PSA) testing and prostate cancer mortality. Learn how updated evidence informs shared decision-making and balances early detection with potential harms. Equip yourself to guide patients through nuanced discussions on PSA testing’s limitations, mortality data, and meaningful clinical impact.

Episode resource links:

• N Engl J Med 2025;393:1669-80. DOI: 10.1056/NEJMoa2503223
• Recommendation: Prostate Cancer: Screening | United States Preventive Services Taskforce

Guest: Robert A. Baldor MD, FAAFP

Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at [email protected] 

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.