A podcast of stories, ideas, and speculations Produced & Hosted by Dr. Brian Keating
With NASA planning to send Artemis astronauts farther into space than ever, should they be worried about the deadly effects of the Van Allen belts? Here, I describe to James Altucher what the claims are and what the real concerns should be.
My response to Moon landing denial claims by Kim Kardashian, Candace Owens, and Bart Sibrel
I answer all the big questions:
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Timestamps
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My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA
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#universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #intotheimpossible #briankeating
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Matt Kaplan is a science journalist at The Economist and a trained paleontologist. His new book I Told You So!: Scientists Who Were Ridiculed, Exiled, and Imprisoned for Being Right is a candid investigation into how science actually works — and why the engine of discovery is badly in need of a tuneup.
In this conversation, we discuss why the pandemic exposed science's dirty secrets to the public, how Ignaz Semmelweis discovered handwashing saved lives and was thrown in an asylum for it, why Katalin Karikó survived where others didn't, the replication crisis and how funding models are making it worse, whether older scientists should control research dollars, why Galileo was never actually tortured, and what journalists and scientists must do differently before public trust collapses entirely.
Matt Kaplan also recently discussed science communication and dysfunction on other outlets — in this conversation, we go deeper on the replication crisis, the Semmelweis story, and why the funding model is quietly corrupting the scientific process.
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INTO THE IMPOSSIBLE — where Nobel Prize winners, physicists, and bold thinkers explore the biggest questions in science.
Key Takeaways
00:00 Why the pandemic was science's most damaging moment of exposure
03:30 The scientific-industrial press complex — and who's really to blame
06:50 How science journalism fails the public 85% of the time
10:00 Ignaz Semmelweis: the man who proved handwashing saves lives and was destroyed for it
20:10 Why infection rates dropped from 21% to zero — and nobody listened
24:30 What Katalin Karikó had that Semmelweis didn't: shelter
28:00 The replication crisis — why nobody is funding the most important work in science
33:00 How funding models force scientists to run experiments they've already won
40:30 Should older scientists control research dollars? A Nobel laureate weighs in
43:45 Why Galileo was never tortured — and why the myth won't die
47:00 The rhinoceros tooth: a paleontologist's lesson in confirmation bias
➡️ Follow Matt Kaplan
🌐 Website: https://www.somuchsciencesolittletime.com/about
📚 I Told You So! Scientists Who Were Ridiculed, Exiled, and Imprisoned for Being Right: https://www.amazon.com/Told-You-Scientists-Ridiculed-Imprisoned/dp/1250372275
✍️ Email: [email protected]
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Dialogue Concerning the Two Chief World Systems (audiobook): https://a.co/d/iZPi9Un
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Michael Wong recently discussed theory of evolution on TED: https://www.youtube.com/watch?v=DSrf7ErdHWA — in this conversation, we go deeper on the law of increasing functional information and what it means for life, complexity, and the future of science.
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INTO THE IMPOSSIBLE — where Nobel Prize winners, physicists, and bold thinkers explore the biggest questions in science.
Is there a second arrow of time? Astrobiologist and planetary scientist Dr. Michael Wong joins Brian Keating to explore the law of increasing functional information — a proposed new law of nature that may explain how complexity evolves across minerals, biology, AI, and the cosmos.
Dr. Michael Wong of the Carnegie Institution for Science has been working with a cross-disciplinary group of scientists — the "Missing Law Group" — to propose something bold: a new law of nature. Their law of increasing functional information argues that evolving systems, whether biological or not, tend toward greater complexity and function over time. In this conversation, Brian and Michael unpack what functional information actually means, how it differs from Shannon entropy, and why it may describe something fundamental about the universe we live in.
From the formation of minerals in stellar atmospheres to the evolution of life on Earth, Michael walks through how this framework applies across planetary science, astrobiology, and even cancer research. Brian pushes on the hard questions — the Fermi paradox, the boundary conditions of the law, its relationship to the second law of thermodynamics, and whether it truly qualifies as a "law" at all. Sean Carroll blurbed the book and later called it out on his podcast — Brian asks Michael about that tension directly.
They also get into panspermia, the contingent role of cosmic collisions in shaping Earth's evolutionary history, the search for biosignatures on Mars and beyond, and what the rise of generative AI looks like through the lens of selection for function. This is a wide-ranging, technically honest conversation about one of the most ambitious proposals in contemporary science.
Key Takeaways: 00:00:35 There May Be a Second Arrow of Time — and It Points Toward Complexity
00:01:35 The Law of Increasing Functional Information Explains How the Universe Evolves
00:07:15 Functional Information Measures How Well a System Performs a Specific Function
00:11:30 Three Universal Selection Pressures Drive All Evolving Systems 00:18:00 Mineral Evolution on Earth Is a Measurable Proof of the Law in Action
00:22:00 The Law Is a Tendency, Not a Guarantee — It Doesn't Resolve the Fermi Paradox
00:27:00 Life and Non-Life Contain the Same Building Blocks — the Difference Is in the Distributions
00:32:15 Cosmic Collisions Didn't Derail Evolution — They Opened New Possibility Spaces
00:50:00 Cancer Behaves Like an Evolving System — and That Could Change How We Treat It
01:05:15 AI Is a New Form of Evolving Life — and Without Stronger Selection Pressure, It's Dangerous
Featured Guest ➡️
Follow Michael Wong
🌐 Website: https://miquai.myportfolio.com/
📚 The book: Time’s Second Arrow (co-authored with Robert Hazen) : https://www.amazon.com/Times-Second-Arrow-Evolution-Nature-ebook/dp/B0FJ2ZJL53
🏄♂️ Twitter: https://x.com/miquai
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Brian Keating sits down with the ever-curious Avi Loeb for a mind-bending exploration into some of science's greatest mysteries and controversies. The conversation spans everything from the evolving understanding of comets and meteors—highlighting the false starts and surprising twists in scientific history—to the tantalizing possibilities of extraterrestrial life and the intrigue surrounding potential government disclosure.
Key Takeaways:
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Think Like a Nobel Prize Winner, with productivity tips from 9 Nobel Prize winners: https://a.co/d/03ezQFu
Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U
My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA
The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un
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#universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #AviLoeb #AlienTechnology #UFO #ExtraterrestrialLife #SETI #Astrophysics #SpaceDiscovery #UAP #Interstellar #ScienceExplained
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In this episode of The INTO THE IMPOSSIBLE Podcast, Brian Keating sits down with Andy Weir, the bestselling author of The Martian and Project Hail Mary, to explore the real science behind one of the most ambitious science fiction stories ever written. With the upcoming film adaptation of Project Hail Mary generating excitement among fans, we dig into the physics, astrophysics, and speculative biology that make the story so compelling.
Could the mysterious energy source known as astrophage actually exist? What does real astrophysics say about interstellar travel, relativistic journeys, and humanity’s chances of reaching nearby star systems? Andy Weir explains how he builds scientifically grounded worlds while still telling gripping stories, and Brian breaks down which elements of the novel are plausible according to modern physics.
The conversation also explores the process of writing hard science fiction, how scientific accuracy shapes storytelling, and why readers and scientists alike have embraced Project Hail Mary as one of the most scientifically informed sci-fi novels of the last decade. Along the way, Brian and Andy discuss the challenges of adapting such a technically rich story into a major Hollywood film and what audiences might expect when the movie arrives.
If you enjoy deep conversations about physics, astronomy, science fiction, and the boundary between imagination and reality, this episode will give you a fascinating look at how real science inspires great storytelling.
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Key Takeaways:
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Think Like a Nobel Prize Winner, with productivity tips from 9 Nobel Prize winners: https://a.co/d/03ezQFu
Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U
My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA
The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un
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David Sussillo spent years training neural networks at Google Brain
and now leads research at Meta Reality Labs. His verdict on the
path to artificial consciousness might surprise you.
In this conversation, we discuss why scaling transformers alone
won't produce conscious AI, how recurrent neural networks differ
from the transformer architectures powering today's LLMs, the
FORCE algorithm he developed to train RNNs, what his work on
Meta's EMG wristband reveals about AI and biological signals,
Rich Sutton's Bitter Lesson and whether we're locked into a
GPU-transformer paradigm, and why studying the brain may be
the only way out of AI's current limitations.
David is also the author of Emergence, a braided memoir that
tells the story of his path from foster care to the frontier
of neuroscience and AI research.
David Sussillo is a research scientist at Meta Reality Labs
and an adjunct professor at Stanford University. He completed
his PhD at Columbia University under Larry Abbott and previously
worked at Google Brain.
Key Takeaways:
00:00 Scale alone won't produce consciousness — here's why
00:25 The "bitter lesson": big data crushes every algorithmic invention
01:15 How hallucinations were discovered early at Google
05:00 The lock-in problem: why LLM + GPU may cap AI's ceiling
08:25 What Meta's neural wristband is actually trying to solve
11:20 Rich Sutton's bitter lesson explained
14:15 "More is Different" — why you can't reduce complexity upward
28:30 The book Emergence — two stories braided into one
36:00 Why mentorship matters more than intelligence for at-risk kids
47:00 Stability over intensity: what kids in foster care actually need
➡️ Follow David Sussillo
🌐 Website / Research: Meta Reality Labs
📚 Emergence (memoir): https://www.amazon.com/Emergence-Memoir-Boyhood-Computation-Mysteries/dp/1538768577
🎓 Stanford / Columbia / Carnegie Mellon Alumni
✍️ Email: [email protected]
🏄♂️ Twitter: https://x.com/SussilloDavid
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Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U
My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA
The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un
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Aswath Damodaran joins Brian Keating to argue that markets, universities, and financial models are all suffering the same disease — mistaking mechanical processes for genuine thinking — and explains why Nobel economists aren't billionaires, why academia is the most deserving target for disruption, and why every major asset class is now overpriced with nowhere left to hide.
➡️ Follow Aswath Damodaran
🌐 Website: https://pages.stern.nyu.edu/~adamodar/
📚 The Little Book of Valuation: https://pages.stern.nyu.edu/~adamodar/
📝 Musings on Markets (Substack): https://aswathdamodaran.substack.com
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Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U
My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA
The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un
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In this video, we discuss the rapidly evolving intersection of artificial intelligence and fundamental science and how AI is transforming the way physicists handle massive streams of data from modern observatories—while also explaining where its power ends and human creativity begins.
Tune in for insights, surprising stories, and a behind-the-scenes look at how scientists are navigating the AI revolution. 🚀
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Key Takeaways:
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Think Like a Nobel Prize Winner, with productivity tips from 9 Nobel Prize winners: https://a.co/d/03ezQFu
Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U
My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA
The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un
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#universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #artificialintelligence #aiinscience #physics #machinelearning #futureofscience #aiandscience #scienceexplained #aiuniverse
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Nick Lane joins Brian Keating to argue that life is not information running on chemistry but energy in motion—showing how a single ancient metabolic “transformer” predates genes, powers mitochondria, shapes aging and cancer, constrains alien life, and reveals why today’s AI excitement echoes a solution biology discovered billions of years ago.
00:00 — Defining life vs. death; membrane potential as the boundary between living and dead 00:50 — The title “Transformer” and parallels between AI transformers and biochemical transformation 03:22 — Schrödinger’s What Is Life? and why defining life is intrinsically slippery 06:25 — Why the Krebs cycle sits at the center of metabolism 08:45 — The reverse Krebs cycle, CO₂ fixation, and links to cancer metabolism 11:35 — Mitochondrial membrane potential and the electrical field that powers life 15:00 — Reverse Krebs cycle vs. Calvin cycle and the evolution of carbon fixation 18:00 — Endosymbiosis: origin of mitochondria and chloroplasts 30:02 — Metabolism before genes; CO₂ + hydrogen and prebiotic chemistry 59:49 — Rapid-fire Q&A: RNA world critique and big open questions in origin-of-life research
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➡️ Follow Nick Lane
🌐 Website: https://www.nick-lane.net
📚 Transformer: The Deep Chemistry of Life and Death: https://nick-lane.net/books/transformer-the-deep-chemistry-of-life-and-death/
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Think Like a Nobel Prize Winner, with productivity tips from 9 Nobel Prize winners: https://a.co/d/03ezQFu
Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U
My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA
The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un
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In this episode, I sit down with renowned Oxford mathematician, philosopher of science, and public intellectual John C. Lennox to explore the urgent questions surrounding artificial intelligence and humanity’s future.
We dive into the biggest questions about AI, consciousness, truth, faith, and what it means to be human in an age of accelerating technology. If you’re curious about whether AI is humanity’s greatest achievement, its greatest temptation, or something even more profound, watch the full conversation and join us as we explore the future of intelligence—and our place within it.
Key Takeaways:
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Think Like a Nobel Prize Winner, with productivity tips from 9 Nobel Prize winners: https://a.co/d/03ezQFu
Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U
My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA
The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un
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#universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #intotheimpossible #artificialintelligence #aiandethics #2084 #religionandscience #surveillancesociety #superintelligence #philosophyofscience #humanconsciousness
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In this conversation, I break down a provocative idea: science doesn’t “prove” ultimate truths — it eliminates what’s false. And if that’s how physics works, then the search for God (or the disproof of God) has to play by the same rules: hypotheses, predictions, and falsifiability.
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Think Like a Nobel Prize Winner, with productivity tips from 9 Nobel Prize winners: https://a.co/d/03ezQFu
Focus Like a Nobel Prize Winner, with life-changing interviews with 9 Nobel Prizewinners: https://a.co/d/hi50U9U
My tell-all cosmic memoir Losing the Nobel Prize: http://amzn.to/2sa5UpA
The first-ever audiobook from Galileo: Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican https://a.co/d/iZPi9Un
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#universe #podcast #briankeating #intotheimpossible #science #astronomy #cosmology #cosmicmicrowavebackground #intotheimpossible #briankeating
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