This is the last Covid 19/SARS-CoV 2 podcast before the summer vacation. Listen and learn more about differentiated expression of the ACE2 gene gives different disease outcomes. A new version of SARS- CoV2 has emerged. It is not surprisingly more infectious. On the other hand it does not not seem to be more pathogenic. It is getting better and better here in Denmark with fewer and fewer getting hospitalised. On the other hand is the situation in the US getting worse. Several states are closing down beaches, businesses and activities again.
Have a nice and safe summer

The week 25 podcast highlights are: The new old drug against Covid 19. The elevated risk of having blodclots when infected with SARS-CoV2. New Genome Wide Association Study (GWAS) shows areas in the humane genome that have an impact on the disease outcome. Finally a little on how the epidemic is progressing in Denmark

Listen to this weeks update on the SARS-CoV2/Covid-19 situation and learn more about a new and apparently efficient vaccine being developed in Denmark. In this part I say GMP means Good Manufacturing Process - it is Good Manufacturing Practise! Next part is about exome sequencing and machine learning. There is a part about how the pandemic is raging in parts of India and Brazil. There seems to be a second wave in Iran and parts of the US. Finally things are still better and better in Denmark with less than 100 hospitalized.

Today about a new study, that sheds new light on the origin of the SARS-CoV2 virus. What is a superspreader and why does that seem to be an important factor in the Covid-19 pandemic. Since the beginning of the pandemic it has been observed that more men than women are infected and with a worse outcome. Some of the difference can be explained by the fact that women have a better immune system than men do. However, it also seems that male sex hormones (androgens) have a role. Listen and hear how.

In this weeks podcast is a follow up on the first results from 3 different vaccine trials. Kawasaki syndrome is seen more often in areas with Covid-19 clusters. Here in Denmark we have seen a dramatic drop of something more than 90% of babies born before 28 weeks of preganacy. Finally we are now more than two weeks into the reopening. What are the observations.

A week with a lot of good news in the Covid-19/SARS CoV2 pandemic. The antiviral drug Remdesivir seems to have a quite signifikant positive effect on the mortality if it is given in time. There also seems to be a beneficial effect of giving Inter Leukin 76 (IL-7) to patients. Tests will start to see if the Calmette tuberculosis vaccine will have a positive impact on infection. The company Moderna reported that their mRNA vaccine did stimulate the formation of SARS-CoV2 neutralising antibodies. Denmark is going to open museums, theaters, cinemas and zoo's. At the same time the number of people getting hospitalized continues to drop here in Denmark.

Listen and hear about CRISPR used in diagnostics. Children do not get Covid-19 very often but do they spread the disease? A story about where the virus comes from and why there are so many viruses i bats. Finally Denmark passed a milestone in the epidemic.

In this update for week 19 we are covering the following subjects. There is a promising study, which shows a Monoclonal Antibody (MAB) that seems to neutralize SARS-CoV2. They have found a new Patient Zero in France who had the disease in December. This despite that the epidemic in France started in late January. Can you monitor the pandemic by sequencing virus from wastevater. Researchers from the DTU think so. And finally Denmark is opening even more up from May 11th. Unfortunately Universities and University Colleges have to wait until August 1st.

This weeks pod deals with the fact that men are seen more frequently at ICU's, in the ventilators and die more often of Covid-19 than women. Another story is that it seems the antiviral drug, Remdesivir, works. Finally a story about vaccines. What are the different types and what are the problems we might have when the vaccine is there.

In this weeks update you can hear about the adaptive immune response to SARs-CoV 2. You will hear the explanation how a lasting immunity can be created . We all hope this is the case for SARS-CoV2 but nobody knows for sure yet. There is a story about the SARS-CoV 2 receptor called ACE 2 and the possible impact genetic variation and expression variation might have on the infection. Finally a little about Vitamin D and face masks. Enjoy

The weekly update pod on Covid-19/SARS-CoV2. Listen and hear more about the diverging theories on SARS-CoV2's origin. See the phylogenetic reconstruction of the Covid-19 pandemic here: https://nextstrain.org/ncov/global
The SARS-CoV2 receptor and why patients get different symptoms. Children have a much milder disease progression, and Denmark continues to open up. You can get a haircut, a tatoo and get your teeth fixed.