AUA2026 Spotlight: PARP-Inhibitor Combination Treatments for the Urologic Care Team CME Available: https://cme.auanet.org/URL/PARP26ONL LEARNING OBJECTIVES: At the conclusion of this CME activity, participants will be able to: 1. Integrate biomarker and genetic testing principles into clinical workflows for patients with metastatic prostate cancer, including when to order testing, how to interpret HRR mutation results (inclusive of BRCA and non-BRCA), and how to address barriers to testing through multidisciplinary coordination. 2. Explain the mechanism of action of PARP inhibitors and the biological and clinical rationale for their use—both as monotherapy and in combination approaches—in the treatment of mPC. 3. Evaluate emerging efficacy and safety data on PARPi combinations, including patient subgroup analyses, sequencing strategies, and the role of combination therapy in different stages of mPC. 4. Apply best practices for side effect monitoring and mitigation in patients receiving PARP inhibitors alone or in combination, leveraging the multidisciplinary team for optimal therapy management and patient quality of life. 5. Implement guideline-concordant care strategies in practice, including genetic testing workflow implementation, coordination among care team members, and patient engagement in shared decision-making and clinical trial enrollment. 5. Utilize current evidence-based guidelines to select and sequence PARP inhibitor therapy for patients with mPC, optimizing oncologic outcomes while individualizing care based on molecular profile and patient-specific factors. ACKNOWLEDGEMENTS: Support provided by independent educational grants from: Astrazeneca Merck & Co., Inc Pfizer, Inc.

Update Series (2026) Lesson 15: Case-Based Testicular Cancer Clinical Practice Guidelines Now in its 45th installment, the AUA Update Series is renowned for delivering high-quality lessons to practicing urologists, fellows and residents. All content is developed by internationally recognized experts in urology, making the AUA Update Series the most professional and sought-after self-study program available. Improve your practice and patient care by staying abreast of the latest treatments and surgical techniques in urology. For more information or to subscribe to the AUA Update Series, please visit cme.auanet.org/URL/US2026

AUA Guidelines: Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia Host: Mark L. Gonzalgo, MD, PhD, MBA Guest: Jaspreet S. Sandhu, MD To access the full guideline, please use the following link: https://www.auanet.org/guidelines-and-quality/guidelines/bph-guideline. Please note that access to the full guideline requires user login. If you do not already have an account, you can create a free login.

AUA2026: Society of Women in Urology Meeting Host: Mark L. Gonzalgo, MD, PhD, MBA Guest: Amy N. Luckenbaugh, MD, FACS To register for AUA2026, please visit auanet.org/AUA2026/register!

AUA2026: Society of Urologic Oncology Meeting Host: Mark L. Gonzalgo, MD, PhD, MBA Guest: Dr. Kelvin A. Moses, MD, PhD & Dr. Mark A. Preston, MD, MPH To register for AUA2026, please visit auanet.org/AUA2026/register!

AUA2026: Society of Benign Prostate Disease Meeting Host: Mark L. Gonzalgo, MD, PhD, MBA Guest: Kevin Thomas McVary, MD, FACS To register for AUA2026, please visit auanet.org/AUA2026/register!

AUA Guidelines: Early Detection of Prostate Cancer Host: Mark L. Gonzalgo, MD, PhD, MBA Guest: Simpa Salami, MD, MPH Lin DW, Carlsson S, Filson CP, et al. Updates to Early Detection of Prostate Cancer: AUA/SUO Guideline (2026).J Urol. 0(0).10.1097/JU.0000000000004995. https://www.auajournals.org/doi/10.1097/JU.0000000000004995

AUA2026: Sexual Medicine Society of North America Meeting Host: Mark L. Gonzalgo, MD, PhD, MBA Guest: Landon Trost, MD, To register for AUA2026, please visit auanet.org/AUA2026/register!

AUA2026: Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (SUFU) Meeting Host: Mark L. Gonzalgo, MD, PhD, MBA Guest: Anne Pelletier Cameron, MD, URPS To register for AUA2026, please visit auanet.org/AUA2026/register!

Update Series (2026): At-Home Diagnostic and Therapeutic Options in Men's Health Host: Mark L. Gonzalgo, MD, PhD, MBA Guest: Richard J. Fantus, MD Now in its 45th installment, the AUA Update Series is renowned for delivering high-quality lessons to practicing urologists, fellows and residents. All content is developed by internationally recognized experts in urology, making the AUA Update Series the most professional and sought-after self-study program available. Improve your practice and patient care by staying abreast of the latest treatments and surgical techniques in urology. For more information or to subscribe to the AUA Update Series, please visit CME.auanet.org

AUA2026: Research Programming Preview: Amplifying the Impact of Research for Career Development Host: H. Henry Lai, MD Guest: Naveen Kachroo, MD, PhD Joining us today for this special episode brought to you by the AUA Office of Research, Research Education Committee, are Drs. H. Henry Lai and Naveen Kachroo discussing the dynamic research education programming planned at AUA2026. Head to auanet.org/AUA2026/register to check out the new and exciting programming at AUA2026 and to register!