In this World Shared Practice Forum Podcast, co-authors Dr. Barry Markovitz and Ms. Ann Schrooten discuss their book, Shared Struggles: Stories from Parents and Pediatricians Caring for Children with Serious Illness. They share personal experiences and narratives from families and clinicians to explore the unique partnership between families and healthcare providers caring for children with serious illness and medical complexity. Lastly, they highlight the importance of communication, empathy, trust, and humility in building meaningful relationships that support children and their families throughout their care journey. LEARNING OBJECTIVES - Describe the role of parent-physician partnerships in caring for children with serious illness and medical complexity - Recognize strategies for effective communication with children who are nonverbal and the importance of incorporating parents' expertise in clinical decision-making - Discuss how empathy, compassion, and active listening contribute to trust and help build therapeutic relationships between healthcare providers and families - Examine the value of shared decision-making in delivering family-centered pediatric and palliative care AUTHORS Barry Markovitz, MD, MPH Professor of Pediatrics University of Utah Spencer Fox Eccles School of Medicine Intermountain Primary Children's Hospital Ann F. Schrooten, JD Attorney Fitzgibbons Law Offices, P.L.C Jeffrey Burns, MD, MPH Emeritus Chief Division of Critical Care Medicine Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Professor of Anesthesia Harvard Medical School DATE Initial publication date: September 22, 2026. REFERENCES - Schrooten A, Markovitz BP. Just Because I Can't Talk Doesn't Mean I Have Nothing to Say. Pediatr Crit Care Med. 2025;26(6):e860-e861. - Schrooten AF, Markovitz BP, eds. Shared Struggles: Stories from Parents and Pediatricians Caring for Children with Serious Illnesses. Copernicus Books; 2021. TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/as/8w9gnk94ctgww7bq3b3qszs7/20260917_WSP_Markovitz_and_Schrooten_transcript Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: [email protected] CITATION Markovitz BP, Schrooten A, O’Hara J, Burns JP. Pediatric Medical Complexity: Shared Insights. 09/2026. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/pediatric-medical-complexity-shared-insights-by-b-markovitz-and-a-schrooten-openpediatrics

This podcast provides viewers with an overview of pediatric cough including how to conduct a thorough patient history, identify significant physical exam findings, and generate a differential diagnosis emphasizing the difference between acute and chronic cough causes. LEARNING OBJECTIVES - Conduct a thorough history for pediatric patients presenting with a cough. - Explain the significance of key physical exam findings in evaluating pediatric cough. - Discuss a broad differential diagnosis for cough in pediatric patients. AUTHORS Christina Callas, MD Pediatrician University of California, Davis Children's Hospital Eli C. Freiman, MD Pediatric Emergency Medicine Physician Mass General Brigham/Newton Wellesley Hospital DATES Initial Publication: September 17, 2026. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access, thus at no expense to the user. For further information on how to enroll, please email: [email protected] Please note: OPENPediatrics does not support or control any related videos in the sidebar; these are placed by YouTube. We apologize for any inconvenience this may cause. CITATION Callas C, Freiman E, Fantasia K, McFee AM, Wolbrink TA, Wills K. Approach to Cough. 09/2026. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/approach-to-cough-by-c-callas.

In this Complex Care Journal Club podcast episode, Dr. Jason Zamkoff discusses a quality-improvement cohort study of a surgical hospitalist co-management program (Surgical Hospitalist Assisted Recovery/SHARe Team, or “Pink Team”) for children with medical complexity at Children’s Hospital Colorado. They describe how patients are selected using an internal complexity score and the institutional trust-building needed to launch the program, resulting in fewer post-operative emergency transfers to intensive care. Next steps include developing an externally validated complexity scoring tool and extending hospitalist involvement into the pre-operative period.‌ SPEAKER Jason Zamkoff, MD Professor of Pediatrics University of Colorado School of Medicine Pediatric Hospitalist Children's Hospital Colorado HOST Kilby Mann, MD Associate Professor, Director of Pediatric Rehabilitation University of North Carolina School of Medicine DATE Initial publication date: September 8, 2026. JOURNAL CLUB ARTICLE Zamkoff J, Acker SN, Martin A, Anderson L, Bennett H, Thysens J, Thomas JJ, Conant M, Kurtz M, Gupta R, Scarberry J, Burke M, Koehler R, Rolison E, Whitney G, Ziniel SI, Carney KP, Wilcox D, Lockwood JM. Surgical Hospitalist Assisted REcovery (SHARe): Preventing Post-Operative Emergency Transfers. Hosp Pediatr. 2026 Jul 21:e2025008778. doi: 10.1542/hpeds.2025-008778. Epub ahead of print. PMID: 42476571. OTHER ARTICLES REFERENCED Martin A, Acker S, Hankinson TC, Zamkoff J. Perspectives on Interdisciplinary Perioperative Care for Children with Medical Complexity. Pediatr Clin North Am. 2026 Apr;73(2):513-524. doi: 10.1016/j.pcl.2025.12.003. Epub 2026 Feb 26. PMID: 42020046.‌ TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/as/9c5mmqqq86knpmsgss5xrm8/Zamkoff_transcript_9-1-26‌ Clinicians across healthcare professions, advocates, researchers, and patients/families are all encouraged to engage and provide feedback! You can recommend an article for discussion using this form: https://forms.gle/Bdxb86Sw5qq1uFhW6. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: [email protected] CITATION Zamkoff J, Mann K. The Pink Team Effect: Reducing Postoperative Emergency Transfers in Complex Care. 08/2026. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/the-pink-team-effect-reducing-postoperative-emergency-transfers-in-complex-care

This video provides an overview of pediatric septic shock, including definitions, pathophysiology, management, and the use of the sepsis bundle to guide timely management.‌ LEARNING OBJECTIVES • Describe patients who present with signs and symptoms of septic shock, including exam features that support early recognition and assessment. ‌‌• Review the arterial oxygen content formula and strategies to optimize oxygen delivery to the tissues. • Apply current sepsis definitions to clinical care to identify, evaluate, and guide the management of patients with suspected sepsis or septic shock.‌ • ‌‌Explain the role of the sepsis bundle in optimizing timely management, improving adherence to evidence-based interventions, and supporting better patient outcomes.‌ AUTHORS Jill O'Hara, MD, MPH Assistant in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine‌ Boston Children's Hospital Kate Madden, MD, MMSc‌ Assistant in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine‌ Boston Children's Hospital DATES Initial Publication: September 4, 2026. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access, thus at no expense to the user. For further information on how to enroll, please email: [email protected] Please note: OPENPediatrics does not support or control any related videos in the sidebar; these are placed by YouTube. We apologize for any inconvenience this may cause. CITATION O'Hara JE, Brodie K, Madden K. Pediatric Septic Shock. 09/2026. OPENPediatrics. Online Video. https://on.soundcloud.com/xB071iR4TUcWNxUBIj.

In this World Shared Practice Forum Podcast, Drs. Danielle DeCourcey and Sabrina Derrington provide their insight on the methodology and development of the 2026 Guidelines on the Care and Management of Pediatric and Neonatal Intensive Care Patients at the End-of-Life, sharing actionable guidance for clinicians at the bedside. The authors review GRADE methodology and provide context behind the conditional recommendations. The speakers reflect on next steps including implementation, research, and addressing disparities in end-of-life care. LEARNING OBJECTIVES - Understand the design and methodology for the 2026 pediatric and neonatal end-of-life guidelines - Describe GRADE methodology and its impact on the guideline’s recommendations - Discuss practical applications of the guidelines for clinicians AUTHORS Danielle D'Emilia DeCourcey, MD, MPH Associate Chief, Division of Medical Critical Care Boston Children's Hospital Associate Professor of Pediatrics Harvard Medical School Sabrina Derrington, MD, MA, HEC-C, FAAP Director of the Center for Bioethics Children's Hospital Los Angeles Associate Professor of Clinical Pediatrics Keck School of Medicine, University of Southern California (USC) Jeffrey Burns, MD, MPH Emeritus Chief Division of Critical Care Medicine Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Professor of Anesthesia Harvard Medical School DATE Initial publication date: August 25, 2026. ARTICLES REFERENCED & ADDITIONAL REFERENCES - Derrington S, Broden Arciprete EG, Lin MC, et al. Executive Summary of Society of Critical Care Medicine 2026 Guidelines on the Care and Management of Pediatric and Neonatal Intensive Care Patients at the End of Life. Pediatr Crit Care Med. 2026;27(4):487-493. - The Correspondent by Virginia Evans - Pilgrim at Tinker Creek by Annie Dillard TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/as/v66vz9xj5t6qtmjwjkcrmr7/202608_WSP_Derrington_and_DeCourcey_Transcript Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: [email protected] CITATION DeCourcey DD, Derrington S, O’Hara JE, Burns JP. Pediatric End-of-Life Guidelines & Insights. 08/2026. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/pediatric-end-of-life-guidelines-and-insights-by-d-decourcey-and-s-derrington-openpediatrics.

This video discusses the preoperative, operative, and postoperative considerations for patients undergoing tracheostomy including: anatomy and pathophysiology, anesthetic and operative approach, and postoperative care. LEARNING OBJECTIVES - Explain the anatomy and pathophysiology - Describe the anesthetic management plan, including intraoperative management - Review common operative approaches - Describe postoperative considerations AUTHORS Roger Nuss, MD Associate, Department of Otolaryngology and Communication Enhancement Assistant Professor of Otolaryngology, Harvard Medical School Jennifer Perez, MD Fellow, Division of Critical Care Medicine Boston Children's Hospital Jessica Laird-Gion, MD Department of Pediatrics, Division of Cardiology Stanford Medicine DATE Initial publication date: August 12, 2026. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: [email protected] CITATION Laird-Gion J, Perez J, Nuss R, McFee AM, Marcley S, Wolbrink TA. Tracheostomy. 08/2026. Online Podcast. OPENPediatrics. https://soundcloud.com/openpediatrics/tracheostomy-by-r-nuss-j-perez/s-hIyYqiXKAId?si=25e19540480b43cbb133b57d067213f9&utm_source=clipboard&utm_medium=text&utm_campaign=social_sharing.

In this Complex Care Journal Club podcast episode, Ms. Emily Johnson and Dr. Florence Gagné discuss a scoping review of interventions to assess social needs for children with medical complexity. They describe the different approaches to screening and intervention in the five included studies, implications for practice, and opportunities to engage social workers in research. SPEAKERS Emily Johnson, MSW, LICSW Clinical Social Worker Boston Children's Hospital Florence Gagné, MD Pediatrician Montréal Children’s Hospital HOST Kristina Malik, MD Assistant Professor of Pediatrics Medical Director Pediatrician, Special Care Clinic‌‌ ‌University of Colorado School of Medicine KidStreet Children’s Hospital Colorado DATE Initial publication date: August 11, 2026. JOURNAL CLUB ARTICLE Johnson ER, Hadge SM, Wachter SM, Gagné F. Interventions to assess social needs for children with medical complexity and their families: A scoping review. Patient Educ Couns. 2026;148:109555. doi:10.1016/j.pec.2026.109555. OTHER ARTICLES REFERENCED Ming DY, Jones KA, Sainz E, Tkach H, Stewart A, Cram A, Morreale MC, Dizon S, deJong NA. Feasibility of implementing systematic social needs assessment for children with medical complexity. Implement Sci Commun. 2021 Nov 21;2(1):130. doi: 10.1186/s43058-021-00237-3. PMID: 34802465; PMCID: PMC8606226. TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/as/3sgvpf2qjsvt9zqxvf37xspz/Gagne_and_Johnson_Final_Transcript_8-3-26 Clinicians across healthcare professions, advocates, researchers, and patients/families are all encouraged to engage and provide feedback! You can recommend an article for discussion using this form: https://forms.gle/Bdxb86Sw5qq1uFhW6. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: [email protected] CITATION Johnson ER, Gagné F, Malik K. Screen and Intervene: Meeting Social Needs for Children with Medical Complexity. 08/2026. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/screen-and-intervene-meeting-social-needs-for-children-with-medical-complexity.

In this podcast, recorded at the Top Articles of 2025 Session at PEDICRITICON 2025, Dr. Traci Wolbrink interviews Drs. Ashish Agarwal and Ramesh Kumar Ramachandran about two randomized controlled trials. These studies comparing 0.9% normal saline with Ringer’s lactate in diabetic ketoacidosis and the efficacy of high flow nasal cannula versus nasal prong bubble CPAP in bronchiolitis. The conversation reveals challenges in resource-limited settings, emphasizing the importance of protocol adherence, mentorship, and resource management. Valuable insights into fluid management, respiratory support, and research execution are offered for healthcare professionals keen on advancing clinical practice and research knowledge. Learning Objectives - Recognize the limitations of using normal saline in diabetic ketoacidosis - Understand the physiological benefits of balanced fluids like Ringer’s Lactate - Identify the logistical challenges in conducting trials in resource-limited settings - Appreciate the role of teamwork and protocol adherence in research success AUTHORS Ashish Agarwal, MD Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India Ramachandran Rameshkumar, MD, DM, FRCPCH Division of Pediatric Critical Care, Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India Pediatric Intensive Care Unit, Department of Pediatrics, Mediclinic City Hospital, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates Traci Wolbrink, MD, MPH‌ Co-Director, OPENPediatrics Senior Associate in Critical Care Medicine Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Associate Professor of Anesthesia Harvard Medical School DATE Initial publication date: July 1, 2026. ARTICLES REFERENCED Agarwal A, Jayashree M, Nallasamy K, Dayal D, Attri SV. 0.9% Saline versus Ringer's lactate as initial fluid in children with diabetic ketoacidosis: a double-blind randomized controlled trial. BMJ Open Diabetes Res Care. 2025;13(2):e004623. https://pubmed.ncbi.nlm.nih.gov/40194836/ Maya M, Rameshkumar R, Selvan T, Delhikumar CG. High-Flow Nasal Cannula Versus Nasal Prong Bubble Continuous Positive Airway Pressure in Children With Moderate to Severe Acute Bronchiolitis: A Randomized Controlled Trial. Pediatr Crit Care Med. 2024;25(8):748-757. https://pubmed.ncbi.nlm.nih.gov/38639564/ TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/as/szcrpthcfg3w4398gkvf9ch/202606_Pedicriticon_Podcast_2025_Transcript Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: [email protected] CITATION Agarwal A, Rameshkumar R, Wolbrink TA. PEDICRITICON 2025: Top Articles in PICU Research. 07/2026. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/pedicriticon-2025-top-articles-in-picu-research.

In this World Shared Practice Forum Podcast, first authors Drs. Frances Balamuth and Chanu Rhee describe the objectives and methodology for their study “National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data” published in the March 2026 edition of JAMA. They discuss the process of modifying the Phoenix Sepsis Criteria to an electronic health record-based Pediatric Sepsis Event (PSE) definition and the methods for validating this definition. The authors share salient findings from their study, noting the limitations, and share their hopes for the future direction of sepsis surveillance research. LEARNING OBJECTIVES - Understand the derivation for the Pediatric Sepsis Event definition for electronic health record-based pediatric sepsis surveillance - Review the validation process for the Pediatric Sepsis Event definition - Compare the Pediatric Sepsis Event definition to the Phoenix Sepsis Criteria - Discuss the results and limitations of the electronic health record-based study design - Express the goals for the future direction of pediatric sepsis surveillance research AUTHORS Frances Balamuth, MD, PhD, MSCE Professor of Pediatrics, Chief of Pediatric Emergency Medicine University of Pennsylvania Perelman School of Medicine Children's Hospital of Philadelphia Chanu Rhee, MD, MPH Associate Professor of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Traci Wolbrink, MD, MPH‌ Senior Associate in Critical Care Medicine; Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Associate Professor of Anesthesia Harvard Medical School DATE Initial publication date: June 23, 2026. ARTICLES REFERENCED Rhee C, Balamuth F, Dysart K, et al. National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data. JAMA. 2026;335(15):1321-1331. https://pubmed.ncbi.nlm.nih.gov/41865411/ TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/as/swj4kvkgg686b6p9whmbht/20260622_WSP_Rhee_and_Balamuth_Transcript Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access, thus at no expense to the user. For further information on how to enroll, please email: [email protected] CITATION Balamuth F, Rhee C, O’Hara JE, Wolbrink TA. National Estimates of Pediatric Sepsis. 06/2026. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/new-national-estimates-of.

In this Complex Care Journal Club podcast episode, Patricia Basualto discusses a qualitative study of service provider perspectives on access to disability services for children with neurodevelopmental disabilities in British Columbia, Canada. She describes the importance of cross-sectoral collaboration, actionable policy and program recommendations, and next steps from this work.‌ SPEAKER Patricia Basualto, MHP, PhD Candidate Assistant Professor, Physiotherapist Pontificia Universidad Católica de Chile PhD Candidate in Kinesiology (Rehabilitation) University of Calgary HOST Kathleen Huth, MD, MMSc Pediatrician, Complex Care Service, Division of General Pediatrics Boston Children's Hospital Assistant Professor of Pediatrics Harvard Medical School DATE Initial publication date: June 8, 2026. JOURNAL CLUB ARTICLE Basualto P, Senevirathna AM, Seth A, Dimitropoulos G, Zwicker JD. Improving Equitable Access to Disability Services and Support for Children With Neurodevelopmental Disabilities: Service Provider and Decision-Maker Perspectives. Child Care Health Dev. 2026 Jan;52(1):e70213. doi: 10.1111/cch.70213. PMID: 41457809; PMCID: PMC12746062. TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/as/7wvf65c7rjcxkvvt4vjspx9v/Basualto_Final_Transcript_5-27‌ Clinicians across healthcare professions, advocates, researchers, and patients/families are all encouraged to engage and provide feedback! You can recommend an article for discussion using this form: https://forms.gle/Bdxb86Sw5qq1uFhW6. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: [email protected] CITATION Basualto P, Huth K. Opening a Wider Door: Access to Services for Children with Neurodevelopmental Disabilities‌‌‌. 06/2026. OPENPediatrics. Online Podcast.

In this World Shared Practice Forum Podcast, Drs. Mark Peters and Scott Weiss provide their expert insight on the methodology and development of the 2026 International Surviving Sepsis Campaign guidelines. They discuss challenges encountered during the process and review notable changes to these guidelines compared to previous iterations. The authors share the recommendations that will most impact their personal practice for patients with sepsis, and reflect on how we can improve global research infrastructure to address salient knowledge gaps in pediatric critical care. LEARNING OBJECTIVES - Understand the design and methodology for the 2026 Surviving Sepsis Campaign guidelines - Review notable changes in the 2026 sepsis guidelines compared to the 2020 edition - Discuss the implications of the altered recommendations for clinical practice changes - Consider methods to improve global pediatric research infrastructure and data organization AUTHORS Mark Peters, MBChB, PhD, MRCP, FFICM, FRCPCH Professor of Paediatric Intensive Care NIHR Senior Investigator UCL Great Ormond St Institute of Child Health Hon. Consultant Paediatric Intensivist Paediatric Intensive Care Unit and Children’s Acute Transport Service Great Ormond St Hospital Scott Weiss, MD, MSCE Professor of Pediatrics and Pathology & Genomic Medicine, Division Chief of Critical Care, Vice-Chair of Research for the Department of Pediatrics, Nemours Children's Hospital, Sidney Kimmel Medical College at Thomas Jefferson University Jeffrey Burns, MD, MPH Emeritus Chief Division of Critical Care Medicine Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Professor of Anesthesia Harvard Medical School DATE Initial publication date: May 26, 2026. ARTICLES REFERENCED & ADDITIONAL REFERENCES - Weiss SL, Peters MJ, Oczkowski SJW, et al. Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026. Pediatr Crit Care Med. 2026;27(4):379-434. https://pubmed.ncbi.nlm.nih.gov/41869844/ - Balamuth F, Weiss SL, Long E, et al. Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock. N Engl J Med. Published online April 24, 2026. https://pubmed.ncbi.nlm.nih.gov/42028918/ - Weiss SL, Balamuth F, Long E, et al. PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial. Trials. 2021;22(1):776. Published 2021 Nov 6. https://pubmed.ncbi.nlm.nih.gov/34742327/ - Steven Pinker "Enlightenment Now” - https://stevenpinker.com/publications/enlightenment-now-case-reason-science-humanism-and-progress - Blood Poison: The Untold Story of Sepsis - https://amplifypublishinggroup.com/product/nonfiction/health-medicine-and-wellness/general-health-medicine-and-wellness/blood-poison/ TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/at/r9q8w9vhsbpg7wwzn35kbmz/202605_WSP_Peters_and_Weiss_Transcript.pdf Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge among healthcare providers worldwide who care for critically ill children across all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access, thus at no expense to the user. For further information on how to enroll, please email: [email protected] CITATION Peters MJ, Weiss SL, O’Hara J, Burns JP. Pediatric Surviving Sepsis: Insights From the Leadership. 05/2026. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/pediatric-surviving-sepsis-insights-from-the-leadership-by-m-peters-s-weiss-openpediatrics.